Methods and compositions for integration of a dna construct

ABSTRACT

Provided herein are methods and compositions for integrating a large DNA construct into a genome in a cell. Also provided herein are methods and compositions for producing a synthetic genome.

CROSS-REFERENCE

This application claims the benefit of U.S. Provisional Application No. 63/321,561 filed on Mar. 18, 2022, and U.S. Provisional Application No. 63/322,664 filed on Mar. 23, 2022, each of which is incorporated by reference herein in its entirety.

STATEMENT AS TO FEDERALLY SPONSORED RESEARCH

This invention was developed with support from the Government of the United States of America under AI154417 and AI148008 awards by the National Institutes of Health. The Government of the United States of America may have certain rights in this invention.

SEQUENCE LISTING

The instant application contains a Sequence Listing which has been submitted electronically in XML format and is hereby incorporated by reference in its entirety. Said XML copy, created on Mar. 15, 2023, is named 59725-710_201_SL.xml and is 389,788 bytes in size.

BACKGROUND

Manipulation of genomes such as genome editing or rewriting is an important technology in developing therapeutics such as gene therapy, cell immunotherapy (e.g., T cells, CAR-T cells, etc), and regenerative medicine (e.g., induced pluripotent stem cells) to treat diseases such as cancer, autoimmunity, and neurodegeneration, or for tissue/organ replacement and rejuvenation. There are many challenges and limited approaches for manipulating genomes or site-specifically integrating large DNA constructs into human and other mammalian cells. For example, there are no straightforward approaches for integrating large (sub-megabase) constructs sequentially, to allow for megabase scale DNA integrations, e.g., placing the large DNA constructs anywhere in the genome or in any cell types. In addition, there are limited approaches for providing “scarless” or “nearly scarless” large DNA integrations, i.e., no remnants of unwanted DNA such as selectable markers. The ability to integrate large DNA constructs into the human genome, especially in human iPSCs, would facilitate the rewriting of the genome, delivery of large genetic circuits, and provide a platform for producing cellular therapies and regenerative medicines.

Cellular therapies hold great promise for combating previously intractable diseases (e.g., cancer, organ failure, neuropathy, etc.). While autologous (patient-derived) cells generally are optimal, this route remains limited for many applications, cost-prohibitive, and burdensome. Allogeneic (donor-derived) pluripotent stem cells (PSCs), which can be differentiated to any cell type, provide greater scalability and cost savings. However, the allogeneic approach is limited by Human Leukocyte Antigen (HLA) immune-matching, as without HLA immune-matching, the transplanted donor cells will be rejected by a patient's immune system. There is a need for developing a technology to provide personalized stem cells for both immunotherapy and regenerative medicine applications, leading to safer and more efficacious cell-based treatments.

SUMMARY

In some aspects, provided herein is a method of integrating a DNA construct into a genome, the method comprising: a) contacting the genome in a sample with one or more agents, wherein the one or more agents are capable of cleaving the genome at a locus; b) integrating a first nucleic acid sequence into the genome at the locus; and c) integrating the one or more second nucleic acid sequences into the first nucleic acid sequence in the genome, thereby integrating the DNA construct into the genomes, wherein each of the one or more second nucleic acid sequences comprises a cargo sequence.

In some aspects, provided herein is a method of producing a synthetic genome, the method comprising: a) obtaining a cell from a sample, wherein the cell comprises a genome; b) contacting a first nucleic acid sequence at a first locus on the genome with a first set of one or more agents, wherein the first nucleic acid sequence encodes a first plurality of antigens and wherein the first locus comprises one or more binding sites for a first set one or more agents; and c) contacting a second nucleic acid sequence at a second locus on the genome with a second set of one or more agents, wherein the second nucleic acid sequence encodes a second antigen, and wherein the second locus comprises one or more binding sites for a second set of one or more agents, thereby producing the synthetic genome.

In some aspect, provided herein, is a method of producing a synthetic genome, the method comprising: a) obtaining a cell from a sample, wherein the cell comprises a genome; b) contacting a nucleic acid sequence encoding an antigen at a locus on the genome with a set of one or more agents, wherein the locus comprises one or more binding sites for the set of the one or more agents; c) integrating a synthetic sequence to the locus on the genome, wherein the integrating the synthetic sequence to the locus on the genome preserves regulatory components for gene expression, thereby producing the synthetic genome.

INCORPORATION BY REFERENCE

All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, or patent application was specifically and individually indicated to be incorporated by reference.

BRIEF DESCRIPTION OF THE DRAWINGS

The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.

The features of the present disclosure are set forth with particularity in the appended claims. A better understanding of the features and advantages of the present disclosure will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the disclosure are utilized, and the accompanying drawings of which:

FIG. 1 depicts a schematic of sub-megabase-scale genome writing design. First, a landing pad sequence 105 is integrated into or in place of a locus of interest in a genome 101 in a cell derived from a sample 130 with one or more agents 120. Then, a DNA construct 102 comprising one or more cargo sequences 110, 111, 112 and a selective marker 125 is prepared and delivered to the cell 130. Next, the DNA construct 102 is integrated into the landing pad sequence 105 at the locus of interest in the genome 101. This step can be repeated to integrate multiple DNA constructs sequentially to the megabase-scale.

FIG. 2A depicts an exemplary diagram of the REcombinase WRiting of Iterative DNA and Trap Excision (REWRITE) for landing pad sequence (LPneo) for a single (sub-megabase) large DNA payload delivery.

FIG. 2B depicts an exemplary diagram for a configuration of the REWRITE landing pad sequence (LPneo) for iterative large DNA payload delivery to the megabase-scale.

FIG. 3A depicts a Landing Pad 1 (LP1) plasmid schematic with figure legend. Plasmid backbone markers (ampR, ura3, and CEN) enable propagation in both E. coli and budding yeast for recombineering.

FIG. 3B depicts a diagram of LP1 integration into the murine ROSA26 locus. ROSA26 is a ncRNA flanked by the genes Setdb5 and Thumpd3. Homology arms to ROSA26 were cloned via recombineering into LP1 and integrated using a CRISPR/Cas9 gRNA.

FIG. 3C depicts a Polymerase Chain Reaction (PCR) verification of 5′ and 3′ junctions (jxn) of Clone #2 and Clone #4. LP: landing pad.

FIG. 3D depicts a Polymerase Chain Reaction (PCR) verification of the 3′ junction (jxn) of an integrated 10 kb (HLA-A) payload delivery into the landing pad of the same in FIG. 3C. the left lanes are negative controls. C: Clone.

FIG. 3E depicts a Polymerase Chain Reaction (PCR) verification of the 5′ junction (jxn) of an integrated 10 kb (HLA-A) payload delivery into the landing pad of the same in FIG. 3C. the left lanes are negative controls. C: Clone.

FIG. 3F depicts a demonstration of the “Flp-OUT” component of REWRITE to provide scarless insertions, where Flp recombinase is induced after Payload delivery. Induction of Flp recombinase (using 4-OHT, 4-hydroxytamoxifin) from within the payload excises the gene cassettes via FRT recombinase-mediated excision. Because the cassettes express Thymidine Kinase, only full excision is resistant to Ganciclovir (GCV), whereas those not excising die off. Stem cell clones are shown after payload delivery in FIGS. 3B-D, induction of 4-OHT, and selection by GCV. This indicates the clones only have the payload as shown in the diagram (bottom, right).

FIG. 3G illustrates an overview of the entire workflow of single integration REWRITE, from payload delivery, Flp-OUT induction, to scarless clone selection.

FIG. 4A depicts flow cytometry data and fluorescence imaging of (top) unmodified mouse embryonic stem cells (mESCs); (middle) landing pad-modified mESCs grown in the presence of blasticidin; and (bottom) landing-pad modified mESCs grown in the absence of blasticidin.

FIG. 4B depicts three derivative landing pad designs with different promoters (eflp; enh; ucoe) driving expression.

FIG. 4C depicts landing pad-modified mESCs from FIG. 4B grown in the presence (left) or absence (right) of blasticidin.

FIG. 5A depicts a diagram for Human Leukocyte Antigen (HLA) locus (left) and class −1 HLA (HLA-1) diversity (right). The 3 megabase HLA locus is the most genetically diverse region in the genome.

FIG. 5B depicts a diagram for HLA-A/B/C deletion and landing pad integration, based on chr6 location. Final output: reusable blank iPSC: HLA-A/B/C−/− with landing pad.

FIG. 5C depicts a diagram of construct design and assembly of 115 kb synHLA (REWRITE compatible). HLA-A has been relocated within the 78-kb intergenic region between HLA-B/C (see FIGS. 6A-6C).

FIG. 6A depicts an illustration of how a synHLA can be integrated.

FIG. 6B depicts an illustration of how HLA expression can be measured by qRT-PCR and immunoblots.

FIG. 6C depicts images of iPSCs, pre- and post-delivery of synHLA (top) and an illustration of human iPSCs (bottom, left), blank accepter human iPSCs with HLA deletion (bottom, middle) and rewritten human iPSCs with synHLA (bottom, right).

FIG. 7 depicts complete removal of HLA-A from human iPSC. Shown on top is PCR verification of complete genomic removal of HLA-A locus from human iPSC. The A PCR amplicon will only amplify if at least one genomic allele of HLA-A has been deleted. The PCR amplicons for internal 1 (In1), internal 2 (In2), and internal 3 (In3) will only amplify if at least one allele of HLA-A is retained. HLA-A(−/−) shows that both alleles of HLA-A locus are removed. HLA-A(−/+) shows that one allele is removed, but that one allele remains intact. The HLA-A locus was removed by a Site-specific nuclease (SSN) in this specific case CRISPR ErCas12a (Mad7).

FIG. 8A depicts an exemplary miniature synHLA construction. (Top left) Order of HLA genes as constructed on mini-synHLA. (Right) Field-Inversion Gel Electrophoresis showing the correct DNA size for the assembled mini-synHLA product. Lane 1—uncut DNA construct. Lane 2—linearized DNA construct. L—NEB midsize DNA ladder. (Bottom left) Integrated Genome Viewer view of the complete sequence of mini-synHLA after sequencing on an Illumina NextSeq.

FIG. 8B depicts the number of clones/colonies obtained after delivering mini-synHLA to a human iPSC containing the REWRITE landing pad and inducible (by doxycycline) iCre. (Top) Dox—doxycycline (no dox −0 dox, 2 days of dox −48 h dox, and 1 day of dox on day 2-24 h day 2 dox) of payload to hiPSC landing pad line. (Bottom) loxFAS or loxF66 containing landing pads with or without co-transfected plasmid with constitutive iCre.

FIG. 9 depicts class-I HLA haplotypes (HLA-A, HLA-B, HLA-C) that would provide immunological matches to various ethnic populations across the world. The 12 listed haplotypes would cover over 50% of northwest Europe and southern China. The table on right shows the percent coverage of various countries across the world.

FIG. 10A depicts the assembly of 115 kb synHLA in yeast. A 10 kB fragment of the HLA-A locus was placed within the 78 kb intergenic region between HLA-B and HLA-C from a BAC clone, and these were assembled into the Payload Vector (PV1f) in yeast.

FIG. 10B depicts a field-inversion gel electrophoresis showing the size of synHLA compared to mini-synHLA.

FIG. 11 depicts a strategy to bi-allelically remove large genomic regions using the REWRITE landing pad and second Deleter construct, expressing Hygromycin resistance and Thymidine Kinase under a PGK promoter. The Deleter construct is flanked by two alternative FRT sites (FRTm) for eventual cassette removal.

FIGS. 12A-12G depict an installation and functional validation of the REWRITE Landing pad in U2OS cells. FIG. 12A shows a simplified schematic drawing of the REWRITE Landing Pad plasmid and minimal REWRITE Payload plasmid. In order to prepare the plasmid for installation at a particular genomic location, location specific homology arms were inserted at the flanking BsaI sites by Golden Gate Assembly. It is important to note that one BsaI site at the 3′ end of the landing pad can be methylated in bacteria. Thus the Landing Pad plasmid must be propagated in Dam/Dcm−/− bacteria prior to adding homology arms. FIGS. 12B-12D shows testing of REWRITE recombination at a REWRITE Landing Pad installed in U2OS cells, the minimal REWRITE Payload was transfected into cells that had been treated with doxycycline and tamoxifen. Cells were observed with a fluorescent microscope nine days post-transfection. A field of cells were imaged in bright-field (FIG. 12B), GFP (FIG. 12C) and RFP (FIG. 12D) channels. FIGS. 12E-G shows groups of cells that have undergone REWRITE recombination outlined in white. Cells that have undergone REWRITE recombination show expression of mNeon Green in the GFP channel (FIG. 12F), but lack mScarlet expression when examined in the RFP channel (FIG. 12G).

FIGS. 13A-13B shows mono-allelic insertion of the REWRITE Landing Pad at the site of HLA-B/C deletion in human iPSCs. FIG. 13A shows coverage map depicting Capture-seq data aligned to the 5′ end of the AHLA-B/C locus with the REWRITE Landing Pad inserted. Coverage in the landing pad region is observed in Clones C12, E5, and E2, at roughly half the level of the surrounding genomic HLA-B/C region indicating mono-allelic insertion of the landing pad. FIG. 13B shows coverage map depicting Capture-seq data aligned to the 3′ end of the AHLA-B/C locus with the REWRITE Landing Pad inserted. Coverage in the landing pad region is observed in all 5 clones, at roughly half the level of the surrounding genomic HLA-B/C region indicating mono-allelic insertion of the landing pad. Based on this data, only Clones C12, E5, and E2 have mono-allelic insertion of a full Re-Write Landing Pad at the HLA-B/C deletion site.

DETAILED DESCRIPTION

Provided herein are methods and compositions for integrating a DNA construct into a genome, the method comprising contacting the genome in a sample with one or more agents capable of cleaving the genome at a locus, integrating a first nucleic acid sequence into the genome at the locus, and integrating one or more second nucleic acid sequences into the first nucleic acid sequence in the genome, thereby integrating the DNA construct into the genome, wherein each of the one or more second nucleic acid sequences comprises a cargo sequence. In some aspects, provided herein are methods and compositions for integrating a large (sub-megabase) DNA construct, e.g., a DNA construct with at least 10-500 kilobases. In some aspects, methods described herein comprises integrating a landing pad sequence into a genome at a locus and integrating one or more cargo sequences into the landing pad sequence in the genome. In an exemplary workflow, a schematic of megabase-scale genome writing design is shown FIG. 1 . In stage 1, a first nucleic acid sequence or a landing pad sequence 105 is integrated into a locus of interest in a genome 101 in a cell derived from a sample 130. This step utilizes one or more agents 120. In stage 2, a second nucleic acid sequence or a DNA construct 102 comprising one or more cargo sequences 110, 111, 112 and a selective marker 125 is prepared and delivered to the cell 130. Finally, the second nucleic acid sequence or the DNA construct 102 is integrated into the first nucleic acid sequence or the landing pad sequence 105 at the locus of interested in the genome 101. This final step can be repeated to integrate multiple DNA constructs sequentially.

Definitions

As used in this specification and the appended claims, the singular forms “a,” “an,” and “the” include plural referents unless the content clearly dictates otherwise. It should also be noted that the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise. The terms “and/or” and “any combination thereof” and their grammatical equivalents as used herein, can be used interchangeably. These terms can convey that any combination is specifically contemplated. Solely for illustrative purposes, the following phrases “A, B, and/or C” or “A, B, C, or any combination thereof” can mean “A individually; B individually; C individually; A and B; B and C; A and C; and A, B, and C.” The term “or” can be used conjunctively or disjunctively, unless the context specifically refers to a disjunctive use.

The term “about” or “approximately” can mean within an acceptable error range for the particular value as determined by one of ordinary skill in the art, which will depend in part on how the value is measured or determined, i.e., the limitations of the measurement system. For example, “about” can mean within 1 or more than 1 standard deviation, per the practice in the art. Alternatively, “about” can mean a range of up to 20%, up to 10%, up to 5%, or up to 1% of a given value. Alternatively, particularly with respect to biological systems or processes, the term can mean within an order of magnitude, within 5-fold, and more preferably within 2-fold, of a value. Where particular values are described in the application and claims, unless otherwise stated the term “about” meaning within an acceptable error range for the particular value should be assumed.

Throughout this disclosure, numerical features are presented in a range format. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of any embodiments. Accordingly, the description of a range should be considered to have specifically disclosed all the possible subranges as well as individual numerical values within that range to the tenth of the unit of the lower limit unless the context clearly dictates otherwise. For example, description of a range such as from 1 to 6 should be considered to have specifically disclosed subranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6 etc., as well as individual values within that range, for example, 1.1, 2, 2.3, 5, and 5.9. This applies regardless of the breadth of the range. The upper and lower limits of these intervening ranges may independently be included in the smaller ranges, and are also encompassed within the invention, subject to any specifically excluded limit in the stated range. Where the stated range includes one or both of the limits, ranges excluding either or both of those included limits are also included in the invention, unless the context clearly dictates otherwise.

As used in this specification and claim(s), the words “comprising” (and any form of comprising, such as “comprise” and “comprises”), “having” (and any form of having, such as “have” and “has”), “including” (and any form of including, such as “includes” and “include”) or “containing” (and any form of containing, such as “contains” and “contain”) are inclusive or open-ended and do not exclude additional, unrecited elements or method steps. It is contemplated that any embodiment discussed in this specification can be implemented with respect to any method or composition of the present disclosure, and vice versa. Furthermore, compositions of the present disclosure can be used to achieve methods of the present disclosure.

Reference in the specification to “some embodiments,” “an embodiment,” “one embodiment” or “other embodiments” means that a particular feature, structure, or characteristic described in connection with the embodiments is included in at least some embodiments, but not necessarily all embodiments, of the present disclosures. To facilitate an understanding of the present disclosure, a number of terms and phrases are defined below.

Certain specific details of this description are set forth in order to provide a thorough understanding of various embodiments. However, one skilled in the art will understand that the present disclosure may be practiced without these details. In other instances, well—known structures have not been shown or described in detail to avoid unnecessarily obscuring descriptions of the embodiments. Unless the context requires otherwise, throughout the specification and claims which follow, the word “comprise” and variations thereof, such as, “comprises” and “comprising” are to be construed in an open, inclusive sense, that is, as “including, but not limited to.” Further, headings provided herein are for convenience only and do not interpret the scope or meaning of the claimed disclosure.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present disclosure, suitable methods, and materials are described below.

Rewrite

There are limited approaches for site-specifically integrating very large DNA constructs (e.g., >10 kilobases) into human and other mammalian cells, especially primary cells like induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs). Furthermore, there are no straightforward and portable (e.g., placed anywhere in the genome including silenced DNA and in any cell type) approaches for integrating large constructs sequentially, to allow for megabase scale DNA integrations. Finally, there are limited approaches for providing “scarless” or “nearly scarless” large DNA integrations, i.e., no remnants of unwanted DNA such as selectable markers like neomycin resistance cassettes. The ability to integrate large DNA constructs into the human genome, especially in human iPSCs, would facilitate the rewriting of the genome, delivery of large genetic circuits, and provide a platform for producing cellular therapies and regenerative medicines. Genome rewriting may provide a tool to create synthetic pathways, synthetic genomes, synthetic cells, or human patient DNA, and a tool for disease modeling.

Recombinase Mediated Cassette Exchange (RMCE) is a general approach for integrating large DNAs into the genome of mouse embryonic stem cells. However, there have been no demonstrations or approaches optimized for integrating large DNA into human stem cells such as iPSCs. RMCE uses tyrosine recombinases (including, but not limited to, Cre or Flp recombinase) and 2 incompatible recombinase recognition sites (including, but not limited to, Cre or Flp recognition sites). For example, a commonly used approach using Cre recombinase uses the incompatible recognition sites loxP and lox2272.

Provided herein is a new RMCE landing pad approach called REcombinase WRiting of Iterative DNA and Trap Excision (REWRITE). In some aspects, REWRITE has optimal features allowing for complete portability to any mammalian cells, including but not limited to, human iPSCs and mouse ESCs; any place in the genome including, but not limited to, silenced regions; allows for sequential integration of large DNA constructs towards the megabase scale; and includes a self-excising selection cassette for rapid and seamless removal of genetic scars, including but not limited to selectable markers. In some aspects, REWRITE landing pad can be placed at any region of the genome. In some embodiments, site-specific nucleases (SSNs) or homology-directed recombination (HR) can be used to place REWRITE landing pad. In some embodiments, SSN comprises meganucleases, zinc-finger nucleases (ZFN), TAL effector nucleases (TALEN), and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system.

These four major classes of gene-editing techniques, namely, meganucleases, ZFNs, TALENs, CRISPR/Cas systems share a common mode of action in binding a user-defined sequence of DNA and mediating a double-stranded DNA break (DSB). DSB may then be repaired by HR, an event that introduces the homologous sequence from a donor DNA fragment, or by non-homologous end joining (NHEJ), when there is no donor DNA present.

CRISPR-Cas system may be used with a guide target sequence for genetic screening, targeted transcriptional regulation, targeted knock-in, and targeted genome editing, including base editing, epigenetic editing, and introducing double strand breaks (DSBs) for homologous recombination-mediated insertion of a nucleotide sequence. CRISPR-Cas system comprises an endonuclease protein whose DNA-targeting specificity and cutting activity can be programmed by a short guide RNA or a duplex crRNA/TracrRNA. A CRISPR endonuclease comprises a caspase effector nuclease, typically microbial Cas9 and a short guide RNA (gRNA) or a RNA duplex comprising a 18 to 20 nucleotide targeting sequence that directs the nuclease to a location of interest in the genome. Genome editing can refer to the targeted modification of a DNA sequence, including but not limited to, adding, removing, replacing, or modifying existing DNA sequences, and inducing chromosomal rearrangements or modifying transcription regulation elements (e.g., methylation/demethylation of a promoter sequence of a gene) to alter gene expression. As described above CRISPR-Cas system requires a guide system that can locate Cas protein to the target DNA site in the genome. In some instances, the guide system comprises a crispr RNA (crRNA) with a 17-20 nucleotide sequence that is complementary to a target DNA site and a trans-activating crRNA (tracrRNA) scaffold recognized by the Cas protein (e.g., Cas9). The 17-20 nucleotide sequence complementary to a target DNA site is referred to as a spacer while the 17-20 nucleotide target DNA sequence is referred to a protospacer. While crRNAs and tracrRNAs exist as two separate RNA molecules in nature, single guide RNA (sgRNA or gRNA) can be engineered to combine and fuse crRNA and tracrRNA elements into one single RNA molecule. Thus, in one embodiment, the gRNA comprises two or more RNAs, e.g., crRNA and tracrRNA. In another embodiment, the gRNA comprises a sgRNA comprising a spacer sequence for genomic targeting and a scaffold sequence for Cas protein binding. In some instances, the guide system naturally comprises a sgRNA. For example, Cas12a/Cpf1 utilizes a guide system lacking tracrRNA and comprising only a crRNA containing a spacer sequence and a scaffold for Cas12a/Cpf1 binding. While the spacer sequence can be varied depending on a target site in the genome, the scaffold sequence for Cas protein binding can be identical for all gRNAs.

CRISPR-Cas systems described herein can comprise different CRISPR enzymes. For example, the CRISPR-Cas system can comprise Cas9, Cas12a/Cpf1, Cas12b/C2c1, Cas12c/C2c3, Cas12d/CasY, Cas12e/CasX, Cas12g, Cas12h, or Cas12i. Non-limiting examples of Cas enzymes include, but are not limited to, Cas1, Cas1B, Cas2, Cas3, Cas4, Cas5, Cas5d, Cas5t, Cas5h, Cas5a, Cash, Cas7, Cas8, Cas8a, Cas8b, Cas8c, Cas9 (also known as Csn1 or Csx12), Cas10, Cas10d, Cas12a/|, Cas12b/C2c1, Cas12c/C2c3, Cas12d/CasY, Cas12e/CasX, Cas12f/Cas14/C2c10, Cas12g, Cas12h, Cas12i, Cas12k/C2c5, Cas13a/C2c2, Cas13b, Cas13c, Cas13d, C2c4, C2c8, C2c9, Csy1, Csy2, Csy3, Csy4, Cse1, Cse2, Cse3, Cse4, Cse5e, Csc1, Csc2, Csa5, Csn1, Csn2, Csm1, Csm2, Csm3, Csm4, Csm5, Csm6, Cmr1, Cmr3, Cmr4, Cmr5, Cmr6, Csb1, Csb2, Csb3, Csx17, Csx14, Csx10, Csx16, CsaX, Csx3, Csx1, Csx1S, Csx11, Csf1, Csf2, CsO, Csf4, Csd1, Csd2, Cst1, Cst2, Csh1, Csh2, Csa1, Csa2, Csa3, Csa4, Csa5, GSU0054, Type II Cas effector proteins, Type V Cas effector proteins, Type VI Cas effector proteins, CARF, DinG, homologues thereof, or modified or engineered versions thereof such as dCas9 (endonuclease-dead Cas9) and nCas9 (Cas9 nickase that has inactive DNA cleavage domain). In some cases, the compositions, methods, devices, and systems, described herein, may use the Cas9 nuclease from Streptococcus pyogenes, of which amino acid sequences and structures are well known to those skilled in the art.

In some aspects, described herein, are methods for contacting a genome from a sample with one or more agents capable of cleaving the genome at a locus. In some embodiments, the contacting may occur in vitro. In some embodiments, the contacting may occur in vivo, e.g., in a cell. In some embodiments, the one or more agents comprise a polypeptide, a polynucleotide, or a combination thereof. In some embodiments, the polypeptide comprises an enzyme, e.g., a site-specific nuclease. Examples of a site-specific nuclease are shown above. In some embodiments, a site-specific nuclease comprises an engineered homing endonuclease or meganuclease, a zinc-finger nuclease (ZFN), a transcription activator-like effector nuclease (TALEN), a clustered regularly interspaced short palindromic repeat (CRISPR/Cas), or a combination thereof. In some embodiments, the polynucleotide comprises a guide RNA (gRNA). In some embodiments, the one or more agents comprise a site-specific nuclease and a gRNA (e.g., CRISPR/Cas system).

Agents described herein can be delivered into cells in vitro or in vivo by art-known methods or as described herein. Delivery methods such as physical, chemical, and viral methods are also known in the art [63]. In some instances, physical delivery methods can be selected from the methods but not limited to electroporation, microinjection, or use of ballistic particles. On the other hand, chemical delivery methods require use of complex molecules such calcium phosphate, lipid, or protein. In some embodiments, viral delivery methods are applied for gene editing techniques using viruses such as but not limited to adenovirus, lentivirus, and retrovirus. In some embodiments, agents described herein can be delivered via a carrier. In some embodiments, agents described herein can be delivered by, e.g., vectors (e.g., viral or non-viral vectors), non-vector based methods (e.g., using naked DNA, DNA complexes, lipid nanoparticles, RNA such as mRNA), or a combination thereof. In some embodiments, a carrier can comprise comprises a vector, a messenger RNA (mRNA), double stranded DNA (dsDNA), single stranded DNA (ssDNA), or a plasmid. In some embodiments, agents can be delivered directly to cells as naked DNA or RNA, for instance by means of transfection or electroporation, or can be conjugated to molecules (e.g., N-acetylgalactosamine) promoting uptake by cells.

In some embodiments, vectors can comprise one or more sequences encoding one or more agents described herein. Vectors can also comprise a sequence encoding a signal peptide (e.g., for nuclear localization, nucleolar localization, or mitochondrial localization), associated with (e.g., inserted into or fused to) a sequence coding for a protein. As one example, vectors can include a Cas9 coding sequence that includes one or more nuclear localization sequences (e.g., a nuclear localization sequence from SV40). Vectors described herein can also include any suitable number of regulatory/control elements, e.g., promoters, enhancers, introns, polyadenylation signals, Kozak consensus sequences, or internal ribosome entry sites (IRES). These elements are well known in the art. Vectors described herein may include recombinant viral vectors. Any viral vectors known in the art can be used. Examples of viral vectors include, but are not limited to lentivirus (e.g., HIV and FIV-based vectors), Adenovirus (e.g., AD100), Retrovirus (e.g., Maloney murine leukemia virus, MML-V), herpesvirus vectors (e.g., HSV-2), and Adeno-associated viruses (AAVs), or other plasmid or viral vector types. In some embodiments, agents described herein may be delivered in one carrier (e.g., one vector). In some embodiments, agents described herein may be delivered in in multiple carriers (e.g., multiple vectors).

In addition, viral particles can be used to deliver agents in nucleic acid and/or peptide form. For example, “empty” viral particles can be assembled to contain any suitable cargo. Viral vectors and viral particles can also be engineered to incorporate targeting ligands to alter target tissue specificity. Non-viral vectors can be also used to deliver agents according to the present disclosure. One example of non-viral nucleic acid vectors is an nanoparticle, which can be organic or inorganic. Nanoparticles are well known in the art. Any suitable nanoparticle design can be used to deliver agents described herein (e.g., nucleic acids encoding such agents).

In some embodiments, agents described herein can be delivered as a ribonucleoprotein (RNP) to cells. An RNP may comprise a nucleic acid binding protein, e.g., Cas9, in a complex with a gRNA targeting a genome/locus/sequence of interest. RNPs can be delivered to cells using known methods in the art, including, but not limited to electroporation, nucleofection, or cationic lipid-mediated methods, for example, as reported by Zuris, J. A. et al., 2015, Nat. Biotechnology, 33(1):73-80.

Landing Pad Sequence

Provided herein is a method of integrating a DNA construct into a genome, the method comprising contacting the genome from a sample with one or more agents capable of cleaving the genome at a locus, integrating a first nucleic acid sequence into the genome at the locus, and integrating one or more second nucleic acid sequences into the first nucleic acid sequence in the genome, thereby integrating the DNA construct into the genome, wherein each of the one or more second nucleic acid sequences comprises a cargo sequence. In some embodiments, the contacting and/or the integrating may occur in vitro. In some embodiments, the contacting and/or the integrating may occur in vivo, e.g., in a cell. In some embodiments, the first nucleic acid sequence comprises a landing pad sequence. A landing pad sequence as described herein may comprise a gene, a regulatory element, or a combination thereof. Details of a landing pad sequence is described in Example 1. In some embodiments, a regulatory element may comprise a promoter, a terminator, an enhancer, a recombinase recognition site, or a combination thereof. Examples of a promoter can include but are not limited to a universal chromatin opening element (UCOE), human EF1α promoter, Cytomegalovirus (CMV) promoter, simian virus 40 (SV40) promoter, a CAG promoter, or a combination thereof.

In some embodiments, a promoter may be an inducible promoter, a cell specific promoter, a developmental specific promoter, or a tissue specific promoter. Examples of tissue specific promoters include, but are not limited to, a FABP promoter, an Lck promoter, a CamKII promoter, a CD19 promoter, a Keratin promoter, an Albumin promoter, an aP2 promoter, an insulin promoter, an MCK promoter, a MyHC promoter, a WAP promoter, or a Col2A promoter. In some embodiments, the exogenous promoter may be a CMV promoter, an RSV long terminal repeat (LTR) promoter, a simian virus 40 (SV40) promoter, a dihydrofolate reductase (DHFR) promoter, a beta-actin promoter, a phosphoglycerate kinase (PGK) promoter, or an elongation factor-1 alpha (EF1a) promoter. In some embodiments, a promoter may comprise a promoter system comprising one or more promoters, enhancers, or regulatory sequences. For example, a promoter may comprise a cytomegalovirus early enhancer element, a first exon and first intron of chicken beta-actin gene, or a splice acceptor of rabbit beta-globin gene (the CAG promoter system). In some embodiments, a promoter may comprise one or more translational enhancer sequence of human telomerase reverse transcriptase (hTERT), a simian virus 40 (SV40) enhancer sequence, or a CMV enhancer sequence (the SGE promoter system). Promoter systems as described in Watanabe et al. Ocol Rep. 2014 31(3): 1089-1095 is incorporated herein by reference in its entirety. In some embodiments, a promoter may be a CMV promoter. In some embodiments, a promoter can comprise an enhancer region, a TATA box, and a transcription start point. In particular embodiments, a promoter may comprise a CAG promoter system. In another embodiment, a promoter is a SGE promoter system. In some embodiments, a promoter may be constitutive or inducible. In some embodiments, a promoter is a mammalian specific promoter.

Examples of a terminator can include but are not limited to simian virus 40 (SV40) terminator, human growth hormone (hGH) terminator, bovine growth hormone (BGH) terminator, or rabbit beta-globin (rbGlob) terminator. In some embodiments, a landing pad sequence may comprise a gene encoding estrogen receptor 2 (ERT2) or a variant thereof, a gene encoding P2A or a variant thereof, a gene encoding a recombinase or a variant thereof, a blasticidin resistance gene, or a gene encoding a fluorescent protein or a variant thereof. In some embodiments, the ERT2 gene is fused with a gene encoding a recombinase. In some embodiments, the ERT2 gene is fused with a gene encoding a tyrosine recombinase. In some embodiments, the ERT2 gene is fused with a gene encoding a Cre recombinase, a Flp recombinase, a variant thereof, or a combination thereof. In some embodiments, the ERT2 gene is induced by tamoxifen. In some embodiments, a promoter may comprise a human EF1α promoter combined with a universal chromatin opening element (UCOE). In some embodiments, a human EF1α promoter combined with a universal chromatin opening element (UCOE) may serve as a highly active gene promoter.

In some embodiments, a landing pad sequence may comprise one or more restriction enzyme site sequences. Examples of restriction enzyme site sequences can include, but are not limited to, restriction site sequence of restriction enzymes including, but not limited to, AarI, AatII, Acc65I, AccI, AclI, AcuI, AfeI, AflII, AflIII, AgeI, AhdI, AjuI, AleI, AlfI, AloI, AlwNI, ApaI, ApaLI, ApoI, AscI, AseI, AsiSI, AvaI, AvrII, BaeGI, BaeI, BamHI, BanI, BanII, BarI, BbsI, BbvCI, BcgI, BciVI, BcII, BdaI, BfuAI, BglI, BglII, BlpI, Bme1580I, BmeT110I, BmgBI, BmrI, BmtI, Bp1I, BpmI, Bpu10I, BpuEI, BsaAI, BsaBI, BsaHI, BsaI, BsaWI, BsaXI, BseRI, BseYI, BsgI, BsiEI, BsiHKAI, BsiWI, BsmBI, BsmI, BsoBI, Bsp1286I, BspDI, BspEI, BspHI, BspMI, BspQI, BsrBI, BsrDI, BsrFI, BsrGI, BssHII, BssSI, BstAPI, BstBI, BstEII, BstXI, BstYI, BstZ17I, Bsu36I, BtgI, BtgZI, BtsI, ClaI, CspCI, DraI, DraIII, DrdI, EaeI, EagI, Earl, EciI, Eco53kI, Eco57MI, EcoNI, EcoO109I, EcoP15I, EcoRI, EcoRV, Fall, FseI, FspAI, FspI, HaeII, Hin4I, HincII, HindIII, HpaI, KasI, KflI, KpnI, MauBI, MfeI, MluI, MmeI, MreI, MscI, MslI, MspA1I, NaeI, NarI, NcoI, NdeI, NgoMIV, NheI, NmeAIII, NotI, NruI, NsiI, NspI, PacI, PaeR7I, PasI, PciI, PflFI, PflMI, PfoI, PluTI, PmeI, Pm1I, PpiI, PpuMI, PshAI, PsiI, PspFI, PspOMI, PspXI, PstI, PvuI, PvuII, RsrII, SacI, SacII, SalI, SapI, SbfI, ScaI, SexAI, SfcI, SfiI, SfoI, SgrAI, SmaI, SmlI, SnaBI, SpeI, SphI, Srfl, SspI, StuI, StyI, TaqII, TatI, TsoI, TspMI, TstI, Tth111I, XcmI, XhoI, XmaI, XmnI, ZraI. In some embodiments, a landing pad sequence may comprise a BsaI restriction enzyme site sequence.

In some embodiments, a landing pad sequence may comprise a gene encoding a recombinase. In some embodiments, the recombinase may be codon-optimized. In some embodiments, the recombinase may be codon-optimized for mammals. Any codon-optimization methods well known in the art can be used. In some embodiments, the recombinase may lack CpG sites. In some embodiments, the recombinase may be codon-optimized for mammals and lack CpG sites. In some embodiments, recombinase expression may be induced. In some embodiments, an inducible gene expression system may be used. Inducible gene expression systems are well known in the art. Examples of inducible gene expression systems can include, but are not limited to, tetracycline-controlled operator system (e.g., LacR/O-based systems, lacR-VP16 chimeric system, Tet-on/Tet-off system, etc.), cumate-controlled operator system, protein-protein interaction-based chimeric system (e.g., rapamycin system, abscisic acid-regulated interaction system, light-induced protein-protein interaction system, etc.), tamoxifen-controlled recombinase system, and riboswitch-regulatable expression system (e.g., bacteria-derived RNA aptamers linked with hammerhead ribozymes (aptazymes), etc.). In some embodiments, inducible gene expression systems described herein may be combined with RNA interference or CRISPR/Cas9 system. In some embodiments, recombinase expression may be induced by a tetracycline-controlled operator system. In some embodiments, recombinase expression nay be induced by a Tet-on/Tet-off system. In some embodiments, a Tet-on/Tet-off system comprises a promoter. In some embodiments, a Tet-on/Tet-off system comprises a TET-On 3G promoter (TRE3G). In some embodiments, recombinase may be induced by tetracycline or a derivative thereof. In some embodiments, recombinase expression may be induced by doxycycline.

In some embodiments, a landing pad sequence may comprise a gene encoding a fluorescent protein. For example, a landing pad sequence may comprise a gene encoding a red fluorescent protein (RFP), a green fluorescent protein (GFP), a yellow fluorescent protein (YFP), a blue fluorescent protein (BFP), or a cyan fluorescent protein (CFP), or any other fluorescent protein known in the art. In some embodiments, a landing pad sequence may comprise a GFP. In some embodiments, a landing pad sequence may comprise an RFP. In some embodiments, a landing pad sequence may comprise an mNeongreen (GFP).

In some embodiments, a landing pad sequence may comprise a recombinase recognition site. Examples of a recombinase recognition site can include, but are not limited to, a Cre recognition site, or a Flp recognition site. Examples of a recombinase recognition site can include, but are not limited to, loxP, loxM, lox2722, loxFAS, lox5171, frt, a variant thereof, or a combination thereof. In some embodiments, a landing pad sequence described herein may comprise a recombinase recognition site placed downstream of or 3′ 5′ to a promoter. For example, a landing pad sequence described herein may comprise a loxP site placed downstream of or 3′ to an EFα promoter. In some embodiments, an incompatible recombinase recognition site may be used. In some embodiments, an incompatible Cre or Flp recombinase recognition site may be used. In some embodiments, one, two or more incompatible recombinase recognition sites may be used. In some embodiments, an incompatible recombinase recognition site may comprise loxP or lox2272. In some embodiments, incompatible recombinase recognition sites loxP and lox2272 may be used.

In some embodiments, a landing pad sequence described herein may comprise a gene encoding a recombinase. A recombinase may be a site-specific recombinase. A site-specific recombinase may include, but are not limited to a Cre recombinase, a Hin recombinase, a Tre recombinase, or a Flippase (Flp) recombinase. A recombinase may comprise a tyrosine recombinase or a serine recombinase. In some embodiments, a recombinase may be induced. In some embodiments, expression of the recombinase may be induced. Inducible gene expression systems described herein or any inducible gene expression systems known in the art can be used. In some embodiments, the recombinase may be doxycycline inducible. Doxycycline-inducible gene expression systems are well known in the art. In some embodiments, a recombinase is constitutively expressed. In some embodiments, the recombinase may be codon-optimized. In some embodiments, the recombinase may be codon-optimized for mammals. Any codon-optimization methods well known in the art can be used. In some embodiments, the recombinase may lack CpG sites. In some embodiments, the recombinase may be codon-optimized for mammals and lack CpG sites. In some embodiments, the recombinase may comprise Cre recombinase. In some embodiments, the recombinase may comprise codon-optimized Cre recombinase. In some embodiments, the recombinase may comprise a doxycycline inducible codon-optimized Cre recombinase (iCre). In some embodiments, the iCre recombinase is expressed from a plasmid comprising a sequence of SEQ ID NO: 13.

In some embodiments, the recombinase may be self-excisable. In some embodiments, the recombinase may comprise Flp recombinase. In some embodiments, the recombinase may be fused with a tamoxifen inducible estrogen receptor (ERT2). In some embodiments, the Flp recombinase may comprise a self-excising Flp recombinase. In some embodiments, the Flp recombinase may be an inducible Flp recombinase. In some embodiments, the Flp recombinase may be fused with a tamoxifen inducible estrogen receptor (ERT2). In some embodiments, the Flp recombinase may be a self-excising inducible Flp recombinase may be fused with a tamoxifen inducible estrogen receptor (ERT2).

In some embodiments, the landing pad sequence may not comprise a gene encoding a recombinase. In the embodiment where the landing pad sequence does not comprise a gene encoding a recombinase, a recombinase may be transiently expressed from a separate delivery vehicle. A delivery vehicle may be any standard expression vector. In some embodiments, a recombinase may be transiently expressed from a plasmid. In some embodiments, a landing pad sequence may comprise a sequence comprising SEQ ID NO: 2, SEQ ID NO: 5, SEQ ID NO: 6, or SEQ ID NO: 7.

The present disclosure also encompasses a Deleter construct. A Deleter construct can be assembled by standard cloning methods using the same backbone as the REWRITE landing pad. A Deleter construct can comprise a recombination recognition site, a promoter, a marker gene for selection, a sequence that can induce ribosome skipping, a kinase gene, a polyA sequence, or a combination thereof. For example, a Deleter construct can comprise an FRTm (F5) sequence, a PGK promoter (e.g., a constitutive PGK promoter), a hygromycin resistance gene, a P2A sequence, a thymidine kinase gene, an SV40 polyA sequence, and another FRTm (F5) sequence. In some embodiments, a Deleter construct can comprise one or more restriction enzyme digestion sites for cloning. For example, a Deleter construct can comprise BsaI sites for golden gate cloning. In some embodiments, a Deleter construct can comprise homology arms or sequences for genomic integration. In some embodiments, a Deleter construct can comprise a sequence of SEQ ID NO: 15.

Cargo Sequence

In some aspects, provided herein are methods for integrating multiple DNA constructs into a genome. Also provided herein, in some aspects, are methods for sequentially integrating one or more large DNA constructs. In some aspects, methods described herein may comprise contacting the genome from a sample with one or more agents capable of cleaving the genome at a locus, integrating a first nucleic acid sequence into the genome at the locus, and integrating the one or more second nucleic acid sequences into the first nucleic acid sequence in the genome, thereby integrating the DNA construct into the genome, wherein each of the one or more second nucleic acid sequences comprises a cargo sequence. In some embodiments, the integrating may occur in vitro. In some embodiments, the integrating may occur in vivo, e.g., in a cell. In some embodiments, the one or more second nucleic acid sequences may be integrated sequentially. In some embodiments, the one or more second nucleic acid sequences, each comprising a cargo sequence, may be integrated sequentially. In some embodiments, methods described herein can comprise integrating a first nucleic acid sequence comprising a landing pad sequence and then integrating one or more second nucleic acid sequences each comprising a large DNA “payload” delivery construct or a cargo sequence into the landing pad sequence. In some embodiments, the one or more second nucleic acid sequences may comprise 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 nucleic acid sequences.

In some aspects, provided herein, are methods for integrating a large DNA construct. In some embodiments, the integrating may occur in vitro. In some embodiments, the contacting and/or the integrating may occur in vivo, e.g., in a cell. A DNA construct can be inserted into a suitable expression vector or a vector comprising an expression cassette known in the art. A vector can include a transcriptional unit comprising an assembly of a genetic element or elements having a regulatory role in gene expression, for example, promoters or enhancers, a structural or coding sequence which is transcribed into mRNA and translated into protein, and appropriate transcription initiation and termination sequences. In some embodiments, the one or more second nucleic acid sequences are provided by one or more vectors configured to carry a kilobase-sized or megabase-sized (e.g., 10 to 500 kilobases or 10-1000 kilobases) nucleic acid sequence. In some embodiments, vectors described herein can include expression vectors such as mammalian expression vectors. Any suitable expression vector known in the art can be used for delivery. In some embodiments, vectors described herein may comprise a marker. In some embodiments, vectors described herein may comprise a marker that is devoid of a promoter. In some embodiments, vectors described herein may comprise a marker that is devoid of a start codon. In some embodiments, vectors described herein may comprise a marker that is devoid of a promoter and a start codon. In some embodiments, a marker comprises a selectable marker. Examples of a selectable marker can include, but are not limited to an antibiotic marker, a fluorescent marker, or a autotrophic marker. In some embodiment, a marker comprises an antibiotic marker. Examples of an antibiotic marker can include, but are not limited to, neomycin (G418), puromycin, hygromycin, blasticidin, ampicillin, tetracycline, zeocin, kanamycin, bleomycin, chloramphenicol, spectinomycin, streptomycin, carbenicillin, bleomycin, erythromycin, and polymyxin B. Examples of a fluorescent marker can include, but are not limited to, a green fluorescent protein (GFP), a red fluorescent protein (RFP), a yellow fluorescent protein (YFP), a blue fluorescent protein (BFP), or a cyan fluorescent protein (CFP). In some embodiments, a fluorescent marker may comprise a GFP. In some embodiments, a fluorescent marker may comprise a mNeongreen (GFP). In some embodiments, a vector for delivering a DNA construct or a DNA payload may not comprise a promoter. In some embodiments, a vector for delivering a DNA construct or a DNA payload may comprise an antibiotic marker that may not comprise a start codon.

In some aspects, a “promoter trap” system may be used. “Promoter trap” systems are well known in the art and can include a promoter-less and/or start codon (i.e., ATG)-less reporter gene so that reporter gene expression can occur only when the insertion is within a transcriptional unit and/or in a correct direction. In some embodiments, a “promotor trap” system may comprise a marker. In some embodiments, a “promotor trap” system may comprise an antibiotic marker a fluorescent marker, or a autotrophic marker. In some embodiments, a “promotor trap” system may comprise a promoter-less and/or ATG-less antibiotic marker. In some embodiments, a promoter-less and/or ATG-less puromycin resistance marker may be used. In some embodiments, a “promoter trap” system may comprise a GFP. In some embodiments, a “promotor trap” system may comprise a mNeongreen (GFP). In some embodiments, a “promotor trap” system may comprise a promoter/ATG-less puromycin resistance marker and mNeongreen (GFP).

In some embodiments, a vector may be prepared based on a copy-number inducible Bacterial Artificial Chromosome (BAC), Yeast Artificial Chromosome (YAC), or a combination thereof. In some embodiments, a vector may comprise the “promoter trap” described herein. Any suitable vector system described herein can be used to deliver a cargo sequence. In some embodiments, one or more vectors each comprising a cargo sequence can be introduced to a cell or a genome sequentially or serially. In some embodiments, the last vector comprising a cargo sequence may comprise a final “exit” markers or elements. In some embodiments, the final exit markers or elements may include a tamoxifen inducible Flp-ert2 (Flp) and/or a second frt site.

In some embodiments, a cargo sequence (also referred to as a DNA payload, a DNA construct, or “Big-DNA” herein) may comprise at least 10 kilobases. In some embodiments, a cargo sequence may comprise at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370, 380, 390, 400, 410, 420, 430, 440, 450, 500, 510, 520, 530, 540, 550, 560, 570, 580, 590, 600, 610, 620, 630, 640, 650, 660, 670, 680, 690, 700, 710, 720, 730, 740, 750, 760, 770, 780, 790, 800, 810, 820, 830, 840, 850, 860, 870, 880, 890, 900, 910, 920, 930, 940, 950, 960, 970, 980, 990, or at least 1000 kilobases. In some embodiments, a cargo sequence may comprise approximately 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370, 380, 390, 400, 410, 420, 430, 440, 450, 500, 510, 520, 530, 540, 550, 560, 570, 580, 590, 600, 610, 620, 630, 640, 650, 660, 670, 680, 690, 700, 710, 720, 730, 740, 750, 760, 770, 780, 790, 800, 810, 820, 830, 840, 850, 860, 870, 880, 890, 900, 910, 920, 930, 940, 950, 960, 970, 980, 990, or approximately 1000 kilobases.

In some embodiments, a cargo sequence may comprise at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 60, 70, 80, 90, 100, 120, 140, 150, 160, 180, 200, 22, 240, 250, 260, 280, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, or at least 1000 megabases. In some embodiments, a cargo sequence may comprise approximately 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 60, 70, 80, 90, 100, 120, 140, 150, 160, 180, 200, 22, 240, 250, 260, 280, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, or approximately 1000 megabases.

In some embodiments, a cargo sequence may comprise approximately 350 kilobases. In some embodiments, a cargo sequence may comprise approximately 500 kilobases. In some embodiments, one or more cargo sequences may be integrated at each step sequentially into the landing pad within an iPSC or ESC or any other cell type. In some embodiments, a cargo sequence may be cloned into a payload delivery vector.

Locus

Landing pads, large DNA payloads, cargo sequences, or “Big-DNA” described herein can be integrated into any genomic locus. Genomic loci described herein can include, but are not limited to HLA, AAVS1, CCR5, hROSA26, CYBB, CD40LG, CDK6, TLR8, TRBC1, HPRT, or HOXA. Table 1 describes exemplary genomic loci. In some embodiments, a genomic locus may be a human genomic locus. Because it may be beneficial to replace any gene in a genome with a synthetic version, for example, to provide a disease-linked allele for functional testing in cell culture or an animal model, in principle any gene in a mammalian genome represents a reasonable position to install a landing pad. In some embodiments, a payload vector comprising a location specific homology arm sequences can comprise a sequence of SEQ ID NO: 16.

TABLE 1 Exemplary Human Genomic Locus Gene Locus Description HLA chr6 Silenced AAVS1 chr19 - 19q13.42 Safe harbor CCR5 chr3 - p21.31 HIV1 hROSA26 chr3 - p26.1 Safe harbor CYBB chrX - p11.4 Active region CD40LG chrX - q26.3 Silenced CDK6 chr7 - 7q21.3 Active region TLR8 chrX - p22.2 Silenced TRBC1 chr7 - q34 Silenced HPRT chrX Active HOXA Chr17 Silenced

Biological Samples and Cells

In some embodiments, a sample can be derived from a biological sample, i.e., extracted from a biological sample. In some embodiments, the biological sample can be from a virus, bacterium, mycoplasma, parasite, fungus, or plant. In some embodiments, the biological sample can be an animal. In some embodiments, the animal is a mammal. In some embodiments, the mammal comprises a human, non-human primate, rodent, caprine, bovine, ovine, equine, canine, feline, mouse, rat, rabbit, horse or goat. In some embodiments, a biological sample is obtained from a human subject. The human subject can be a patient. The human subject can be an adult, an adolescent, a pre-adolescent, a child, a toddler, an infant, or a neonate. In some embodiments, the biological sample can be a tissue sample or bodily fluid, such as a human bodily fluid. For example, the bodily fluid can be blood, sera, plasma, lavage, urine, cerebrospinal fluid (CSF), sputum, saliva, bone marrow, synovial fluid, aqueous humor, amniotic fluid, cerumen, breast milk, bronchoalveolar lavage fluid, semen, prostatic fluid, Cowper's fluid, pre-ejaculatory fluid, female ejaculate, sweat, tears, cyst fluid, pleural fluid, peritoneal fluid, pericardial fluid, lymph, chyme, chyle, bile, interstitial fluid, menses, pus, sebum, vaginal secretion, mucosal secretion, stool water, pancreatic juice, lavage fluid from sinus cavities, bronchopulmonary aspirate, blastocoel cavity fluid, or umbilical cord blood. A biological sample can comprise a cell, such as a stem cell, undifferentiated cell, differentiated cell, or a cell from a diseased subject or a subject suspected of having a condition or infection. A biological sample can be blood, a cell, a population of cells, a quantity of tissue, or fluid of a subject. In some embodiments, a biological sample comprises nasopharyngeal fluid, oropharyngeal fluid, saliva, blood, sera, plasma, lavage, urine, ear exudate, cerebrospinal fluid (CSF), sputum, saliva, bone marrow, synovial fluid, aqueous humor, amniotic fluid, cerumen, breast milk, auroral pharyngeal lavage fluid, bronchoalveolar lavage, bronchoalveolar lavage fluid, semen, prostatic fluid, Cowper's fluid, pre-ejaculatory fluid, female ejaculate, sweat, tears, cyst fluid, pleural fluid, peritoneal fluid, pericardial fluid, lymph, chyme, chyle, bile, interstitial fluid, menses, pus, sebum, vaginal secretion, mucosal secretion, stool, stool water, pancreatic juice, lavage fluid from sinus cavities, bronchopulmonary aspirate, blastocoel cavity fluid, or umbilical cord blood.

A biological sample can be collected by any non-invasive means, such as, for example, by a nasopharyngeal swab, a nasal swab, an oropharyngeal swab, or a buccal swab. A biological sample can be also collected by drawing, for example, blood or any other bodily fluid from a subject, or using fine needle aspiration or needle biopsy. A biological sample can be collected by the subject providing the sample to, for example, a doctor or lab technician. For example, the subject can provide a urine, stool, or saliva sample.

A cell described herein can be a bacterial cell, a yeast cell, a fungal cell, an insect cell, or a mammalian cell. In some embodiments, a cell may comprise a mammalian cell. Mammalian cells can be derived or isolated from a tissue of a mammal. In some embodiments, mammalian cells may comprise COS cells, BHK cells, 293 cells, 3T3 cells, NSO hybridoma cells, baby hamster kidney (BHK) cells, PER.C6™ human cells, HEK293 cells or Cricetulus griseus (CHO) cells. In some embodiments, a mammalian cell may comprise a human cell or a mouse cell. Examples of mammalian cells can also include but are not limited to cells from humans, non-human primates such as chimpanzees, and other apes and monkey species; farm animals such as cattle, horses, sheep, goats, swine; domestic animals such as rabbits, dogs, and cats; laboratory animals including rodents, such as rats, mice and guinea pigs, and the like. In some embodiments, a mammalian cell is a human cell. In some embodiments, a mammalian cell is a mouse cell. In some embodiments, a mammalian cell comprises an embryonic stem cell (ESC), a pluripotent stem cell (PSC), or an induced pluripotent stem cell (iPSC).

A cell described herein can be a primary cell or a derivative of a primary cell. Primary cells may be taken directly from a biological sample such as living tissue (e.g., biopsy material) and established for growth in vitro. In some embodiments, primary cells described herein may have undergone very few population doublings. In some embodiments, a primary cell comprises an embryonic stem cell (ESC), a pluripotent stem cell (PSC), or an induced pluripotent stem cell (iPSC). In some embodiments, a primary cell is an embryonic stem cell (ESC). In some embodiments, a primary cell is a pluripotent stem cell (PSC). In some embodiments, a primary cell is an induced pluripotent stem cell (iPSC).

Diseases and Conditions

Cellular therapies hold great promise for combating previously intractable diseases (e.g., cancer, organ failure, neuropathy, autoimmunity, etc.). Clinical trials are underway for immunotherapies (T-cells), Parkinson's disease (dopaminergic neurons), heart failure (cardiomyocytes), leukemia (cord blood), and organ transplantation [1-10]. For autologous cell therapies, the patient's own cells are extracted, genetically modified ex vivo, and re-infused as a cell-based therapeutic. While autologous (patient-derived) cells generally are optimal, this route remains limited for many applications as this process can be expensive, difficult to scale, and limited by the overall fitness, cell expansion capacity, and potential for engineering of the required cell type. Allogeneic (donor-derived) pluripotent stem cells (PSCs) or embryonic stem cells (ESCs) are a promising alternative as they can be differentiated to many therapeutic cell types and grown indefinitely, providing a potentially unlimited supply of therapeutic cells (e.g., retinal cells for ocular diseases; vascular progenitor cells for ischemia and vascular repair; cardiac progenitors for heart diseases; insulin-producing (3-cells for diabetes; diabetic retinopathy; chronic obstructive pulmonary disease (COPD); organ failure; critical limb ischemia; platelets, red blood cells and CAR-T/Natural Killer cells for cancer, transfusion and hematological disorders). Importantly, PSCs derived from healthy donors (allogeneic) can reduce costs, enable centralized manufacturing, and open new market possibilities and opportunities.

However, allogeneic cells are limited by the need to match Human Leukocyte Antigen (HLA) Class-1 alleles, the most genetically polymorphic region in humans. Mismatches in HLA Class 1 haplotypes lead to the “self vs non-self” immune response that can result in rejection of transplanted therapeutic cells. This process is mediated by genetically polymorphic HLA Class I proteins HLA-A, HLA-B, and HLA-C, (HLA-A/B/C), which are found on the surface of most somatic cells. HLA-A/B/C proteins complex with non-polymorphic beta-2-microglobulin (B2M) and together present intracellular peptide antigens to immune cells. Polymorphisms in HLA-A/B/C alter how these internal peptides are displayed; this gives many patients a unique cellular “fingerprint.” Thus, the immune system rejects allogeneic cells with foreign HLA haplotypes. As the HLAs are the most genetically diverse region in the genome, this leads to difficulty in matching allogeneic donors to patients in need.

This unmet need needs to be addressed by developing a technology to program any HLA haplotype into a PSC on-demand. Pre-immune matched iPSCs can provide an “off-the-shelf” source of cells for regenerative medicine. Provided herein are methods and compositions for “immune-matching” technology that can provide isogenic PSCs that are compatible with any individual, including, but not limited to those with rare HLA haplotypes under-served by PSC “banks.” Such engineered cells can be centrally manufactured into any differentiated cell type, including, but not limited to neurons, muscles, etc. Before differentiation, the PSC can also be modified with additional genetic safeguards and efficacy enhancing features beyond just HLA Class 1 genes, thus reducing time and effort.

Provided herein are methods and compositions for generating a blank human PSC line that is devoid of HLA-1 proteins and capable of accepting a new HLA-1 haplotype. In some embodiments, methods described herein may utilize gene editing technology well known in the art. Also provided herein are methods and compositions for reconfiguring and synthesizing HLA Class 1 as a single linked 115-kb locus, with modular assembly features for inputting any patient haplotype on-demand. Further provided herein are methods and compositions for integrating a 115-kb donor HLA Class 1 locus into a blank stem cell line, while preserving the native regulatory information and expression levels of the HLA Class 1 genes. The technologies described herein can provide personalized stem cells for both immunotherapy and regenerative medicine applications, leading to more efficacious and safer cell-based treatments. The technologies described herein can also provide a cost-effective resource for allogeneic cell therapies. The methods described herein for developing technologies to make “off-the-shelf” stem cells compatible with the immune system of any patient, especially underserved patients with rare immune determinants, as a source to make any adult cell-type suitable for numerous applications in immunotherapy and regenerative medicine.

Methods described herein for genetically engineering immune-matches using a single well-defined PSC, enabling centralized good manufacturing practice (GMP) “off-the-shelf” cells for differentiation to therapeutic cells. This is in contrast to three other approaches, each with major limitations, as described below (Table 1).

(1) Autologous iPSCs. Patient-derived iPSCs obviate the need for HLA matching. However, methods that generate bespoke iPSCs are inefficient and cost-prohibitive [11], largely because each new line must be validated against genetic abnormalities for clinical GMP safety and assessed for differentiation capacity [12,13]. Furthermore, any genetic modifications (e.g., genomic safeguards) would have to be introduced and verified anew each time.

(2) iPSC Banking. Initiatives to provide banks of iPSCs covering common HLA haplotypes are underway in the US, UK, and Japan, but at a cost of $250 million and screening of >160,000 people [14,15]. Further, each banked cell line will require cGMP safety testing as above. Finally, due to genetic and epigenetic differences, each line will vary in ability to differentiate to other cell types, making centralized manufacturing infeasible.

(3) “Immune-Cloaking” Technology. So-called “universal” allogeneic iPSCs can be generated by deleting the B2M gene, thus eliminating HLA Class I cell surface localization [16]. This “hides” cells from recipient T-cells, but instead induces the missing-self response, alerting natural killer cells to destroy HLA-less cells. Many companies attempt to circumvent this issue by expressing HLA-E/G [17], as these HLAs are immune-suppressing. However, this approach has a critical flaw: if these cells are infected by a virus, bacterium, fungus or become cancerous, they'll become invisible reservoirs of disease because the immune system fails to recognize this dangerous cell population as they no longer display any foreign antigens or neoantigens. Indeed, the loss of HLA expression is a very common mechanism by which cancer avoids elimination by the immune system [18,19]. For cell therapies, this issue poses a serious safety concern for long-term transplantation of immune-cloaked cells. And last but not least, many natural killer cells do not express NKG2A (which HLA-E inhibits); this population of natural killer cells is expected to eliminate HLA-E/G expressing cells [16,20,21].

TABLE 2 Comparison of Technologies iPSC B2M−/− synHLA HLA-match + + Off-the-shelf + + Isogenic + + cGMP compatible + + Scalable/low-cost + + NK-cell resistant + + Immune-surveillance + +

Provided herein are methods and compositions for “immune-matching” strategies that has crucial advantage of preserving essential immune surveillance capabilities as compared to the “immune-cloaking” approach described above. Strategies described herein simultaneously capture the major advantages offered by iPSC banks and immune-cloaking technology (Table 2). Furthermore, immune-matched iPSCs described herein can serve individuals from underrepresented minorities and those with rare HLA haplotypes, a critical unmet need. In addition, the greatest advantage of this off-the-shelf technology is its potential as a standardized platform cell: a uniform, isogenic cell that might be optimized for specific tasks and therapeutics. For example, cells could include ultra-safe features like kill-switches or immune modulating receptors [22-24].

A key innovation is that by reconfiguring HLA-A/B/C as a single linked synthetic locus (“synHLA”), custom HLA haplotypes can be delivered in a single shot directly into a blank acceptor cell (lacking HLA-AB/C). As iPSCs can be differentiated into any therapeutic cell type and can be a preferred cell type, in some embodiments. The inventors' platform technology enables the generation of 100+kb DNA (“Big-DNA”) and its integration into cells using highly specific recombinases or homology-directed repair using site-specific nucleases (CRISPR, TALENs, ZFNs) [25].

Finally, experimental evidence suggests that allogeneic transplants with a homozygous haplotype (e.g., a haplomatch) will be well tolerated [28,29]. This would allow generating a bank of pre-matched cells. A bank of 140 homozygous haplotypes has been estimated to cover 90% of the Japanese population, for example, but would require screening 160,000 individuals [15]; similar numbers are estimated for the UK population [30]. The HLA-matching technology described herein could, in principle, provide haplomatches rapidly and be installed in any cell type that is renewable in culture. It has been computationally determined that just 10 haplotypes can cover 30% of a diverse California population, and can be a reasonable first goal. 50% of people can be covered with just 46 haplotypes. Finally, only matching 2 HLAs may be required for transplants [31-33], and it has been calculated that using this method, a bank of 29 haplotypes could cover 73% of people. HLA haplotype data was taken from the website [34].

In some embodiments, HLA Class II protein deletion may not be necessary for most cell types, because HLA Class II protein are only expressed in professional antigen presenting cells [44,45]. In some embodiment, successful proof-of-principle for HLA-A/B/C could establish feasibility for HLA Class II, which would be useful for fully manipulating dendritic cell antigen presentation.

In some aspects, provided herein, is a method of producing a synthetic genome, the method comprising: a) obtaining a cell from a sample, wherein the cell comprises a genome; b) contacting a first nucleic acid sequence at a first locus on the genome with a first set of one or more agents, wherein the first nucleic acid sequence encodes a first plurality of antigens, and wherein the first locus comprises one or more binding sites for a first set one or more agents; and c) contacting a second nucleic acid sequence at a second locus on the genome with a second set of one or more agents, wherein the second nucleic acid sequence encodes a second antigen, and wherein the second locus comprises one or more binding sites for a second set of one or more agents, thereby producing the synthetic genome.

In some embodiments, the first plurality of antigens and the second antigens comprise a major histocompatibility complex (MHC) or a human leukocyte antigen (HLA). In some embodiments, the MHC or the HLA comprises class I MHC. In some embodiments, the HLA comprises an HLA-A gene, an HLA-B gene, an HLA-C gene, or a combination thereof. In some embodiments, the one or more binding sites comprise a target sequence for the first set or the second set of the one or more agents. In some embodiments, the first set and the second set of the one or more agents comprise a polypeptide, a polynucleotide, or a combination thereof. In some embodiments, the polypeptide comprises an enzyme. In some embodiments, the enzyme comprises a site-specific nuclease. In some embodiments, the site-specific nuclease comprises an engineered homing endonuclease or meganuclease, a zinc-finger nuclease (ZFN), a transcription activator-like effector nuclease (TALEN), a clustered regularly interspaced short palindromic repeat (CRISPR/Cas9), or a combination thereof. In some embodiments, the polynucleotide comprises a guide RNA (gRNA), a single-stranded oligodeoxynucleotide (ssODN), or a combination thereof. In some embodiments, the ssODN comprises at least 50 bp. In some embodiments, the ssODN comprises at least 80 bp. In some embodiments, the ssODN may comprise approximately 50-5000 bp. In some embodiments, the ssODN may comprise at most 5000 bp. In some embodiments, the ssODN may comprise a sequence comprising SEQ ID NO: 3. In some embodiments, the ssODN may comprise a sequence comprising SEQ ID NO: 4. In some embodiments, the first set and the second set of the one or more agents are delivered via a carrier. In some embodiments, the carrier comprises a vector, a messenger RNA (mRNA), double stranded DNA (dsDNA), single stranded DNA (ssDNA), or a plasmid.

In some embodiments, the first locus is at least 1 megabase away from the second locus. In some embodiments, the first nucleic acid sequence and the second nucleic acid sequence comprises at least 3 kilobases. In some embodiments, the first nucleic acid sequence comprises approximately 100 kilobases. In some embodiments, the second nucleic acid sequence comprises approximately 3 kilobases.

In some embodiments, the cell comprises a pluripotent stem cell (PSC) or an induced pluripotent stem cell (iPSC). In some embodiments, the sample comprises a biological sample. Examples of a biological samples is described in “Biological Samples and Cells section”.

In some embodiments, the method further comprises integrating a third nucleic acid sequence at the second locus on the genome after step c). In some embodiments, the integrating comprises homology-directed recombination (HR). In some embodiments, integrating comprises utilizing a recombinase. In some embodiments, the recombinase is constitutively expressed. In some embodiments, the recombinase is inducible, i.e., the expression of the recombinase is inducible. In some embodiments, the recombinase is a site-specific recombinase. In some embodiments, the recombinase comprises a Cre recombinase, a Flp recombinase, or a combination thereof. In some embodiments, integrating comprises utilizing an inducible or constitutive site-specific recombinase Cre, a Flp recombinase, or a combination thereof. In some embodiments, integrating comprises utilizing an inducible or constitutive site-specific recombinase Cre, an inducible or constitutive site-specific Flp recombinase, or a combination thereof. In some embodiments, the third nucleic acid sequence is linear. In some embodiments, the third nucleic acid sequence comprises a sequence homologous to the second locus on the genome. In some embodiments, the third nucleic acid sequence comprises a HLA-A gene, a HLA-B gene, a HLA-C gene, or a combination thereof. In some embodiments, the third nucleic acid sequence further comprises a regulatory element sequence. In some embodiments, the regulatory element sequence comprises a promoter sequence, an enhancer sequence, a terminator sequence, or a combination thereof. In some embodiments, the third nucleic acid sequence further comprises an intergenic sequence. In some embodiments, the intergenic sequence comprises at least about 50 kilobases. In some embodiments, the third nucleic acid sequence further comprises one or more loxP/loxM sites. In some embodiments, the third nucleic acid sequence comprises at least 20 kilobases. In some embodiments, the third nucleic acid sequence comprises at least 30 kilobases. In some embodiments, the third nucleic acid sequence comprises at least 100 kilobases. In some embodiments, a synHLA may comprise a sequence comprising SEQ ID NO: 1. In some embodiments, a synHLA may comprise a sequence comprising SEQ ID NO: 8. In some embodiments, a synHLA may comprise a sequence comprising SEQ ID NO: 14.

OTHER EMBODIMENTS

In some aspects, provided herein is a method of integrating a DNA construct into a genome, the method comprising: a) contacting the genome from a sample with one or more agents, wherein the one or more agents are capable of cleaving the genome at a locus; b) integrating a first nucleic acid sequence into the genome at the locus; and c) integrating the one or more second nucleic acid sequences into the first nucleic acid sequence in the genome, thereby integrating the DNA construct into the genomes, wherein each of the one or more second nucleic acid sequences comprises a cargo sequence.

In some embodiments, the first nucleic acid sequence comprises a landing pad sequence. In some embodiments, the landing pad sequence comprises one or more genes, regulatory elements, or combinations thereof. In some embodiments, the one or more regulatory elements comprise a promoter, a terminator, a recombinase recognition site, or a combination thereof. In some embodiments, the promoter comprises a universal chromatin opening element (UCOE), human EF1α promoter, phosphoglycerate kinase (PGK), or a combination thereof. In some embodiments, the terminator comprises simian virus 40 (SV40) terminator, bovine growth hormone (bGH) terminator, human growth hormone (hGH) terminator, or rabbit beta-globin (rbGlob).

In some embodiments, the one or more genes comprise a gene encoding estrogen receptor 2 (ERT2) or a variant thereof, a gene encoding P2A or a variant thereof, a Thymidine Kinase or a variant thereof, a gene encoding a recombinase or a variant thereof, a blasticidin resistance gene, a hygromycin resistance gene, or a gene encoding a fluorescent protein or a variant thereof. In some embodiments, the ERT2 gene is fused with a gene encoding a recombinase. In some embodiments, the ERT2 gene is induced by tamoxifen. In some embodiments, the recombinase comprises a tyrosine recombinase. In some embodiments, the recombinase comprises a Cre recombinase, a Flp recombinase, a variant thereof, or a combination thereof. In some embodiments, the recombinase is codon-optimized for mammals. In some embodiments, the recombinase lacks CpG sites. In some embodiments, the gene encoding the recombinase is induced by a gene expression system. In some embodiments, the gene encoding the recombinase is induced by doxycycline.

In some embodiments, the fluorescent protein is a red fluorescent protein, a green fluorescent protein, a yellow fluorescent protein, a blue fluorescent protein or a cyan fluorescent protein. In some embodiments, integrating in steps b) and c) comprises sequential integration. In some embodiments, the recombinase recognition site comprises a Cre recognition site, a Flp recognition site, or a combination thereof. In some embodiments, the recombinase recognition site comprises one or more loxP, loxM, lox2722, loxFAS, lox5171, frt, a variant thereof, or a combination thereof.

In some embodiments, the one or more second nucleic acid sequences are provided by one or more vectors configured to carry nucleic acid sequence that comprises approximately from 10 kilobases to 1,000 kilobases. In some embodiments, the one or more vectors comprise a marker, wherein the marker is devoid of a promoter and a start codon. In some embodiments, the marker comprises a selectable marker. In some embodiments, the selectable marker comprises an antibiotic marker.

In some embodiments, the genome in the sample is contained in a cell. In some embodiments, the contacting and integrating are performed in the cell. In some embodiments, the cell comprises a mammalian cell. In some embodiments, the mammalian cell comprises a human cell or a mouse cell. In some embodiments, the cell comprises a primary cell. In some embodiments, the primary cell comprises an embryonic stem cell (ESC), a pluripotent stem cell (PSC), or an induced pluripotent stem cell (iPSC).

In some embodiments, the one or more agents comprise a polypeptide, a polynucleotide, or a combination thereof. In some embodiments, the polypeptide comprises a site-specific nuclease. In some embodiments, the site-specific nuclease comprises an engineered homing endonuclease or meganuclease, a zinc-finger nuclease (ZFN), a transcription activator-like effector nuclease (TALEN), a clustered regularly interspaced short palindromic repeat (CRISPR), or a combination thereof. In some embodiments, the polynucleotide comprises a guide RNA (gRNA).

In some embodiments, the one or more agents are delivered via a carrier. In some embodiments, the carrier comprises a vector, a messenger RNA (mRNA), a double stranded DNA (dsDNA), a single stranded DNA (ssDNA), or a plasmid. In some embodiments, each of the one or more second nucleic acid sequences comprises at least 10 kilobases, 100 kilobases, or 1 megabase. In some embodiments, each of the one or more second nucleic acid sequences comprise approximately from 1 kilobase to 10 megabases.

In some embodiments, the sample comprises a biological sample. In some embodiments, the biological sample comprises a cell, tissue sample, or blood sample. In some embodiments, the biological sample is obtained from a subject. In some embodiments, the subject is a human.

In some embodiments, the integrating in steps b) and c) comprises homology-directed recombination (HR). In some embodiments, the integrating comprises utilizing an inducible or constitutive site-specific recombinase Cre, a Flp recombinase, or a combination thereof. In some embodiments, the cargo sequence comprises a sequence encoding one or more antigens. In some embodiments, the integrating in steps b) or c) comprise a self-excising recombinase. In some embodiments, the cargo sequence comprises 100 kilobases, 500 kilobases, or 1 megabase.

In some embodiments, the first plurality of antigens and the second antigens comprise a major histocompatibility complex (MHC) or a human leukocyte antigen (HLA). In some embodiments, the MHC or the HLA comprises class I MHC. In some embodiments, the HLA comprises an HLA-A gene, an HLA-B gene, an HLA-C gene, or a combination thereof. In some embodiments, wherein the one or more binding sites comprise a target sequence for the first set or the second set of the one or more agents.

In some embodiments, the first set and the second set of the one or more agents comprise a polypeptide, a polynucleotide, or a combination thereof. In some embodiments, the polypeptide comprises a site-specific nuclease. In some embodiments, the site-specific nuclease comprises an engineered homing endonuclease or meganuclease, a zinc-finger nuclease (ZFN), a transcription activator-like effector nuclease (TALEN), a clustered regularly interspaced short palindromic repeat (CRISPR/Cas), or a combination thereof.

In some embodiments, the polynucleotide comprises a guide RNA (gRNA), a single-stranded oligodeoxynucleotide (ssODN), or a combination thereof. In some embodiments, the ssODN comprises at least 50 bp or at least 80 bp. In some embodiments, the first set and the second set of the one or more agents are delivered via a carrier. In some embodiments, the carrier comprises a vector, a messenger RNA (mRNA), double stranded DNA (dsDNA), single stranded DNA (ssDNA), or a plasmid.

In some embodiments, the first locus is at least 10 kilobases or at least 1 megabase away from the second locus. In some embodiments, the first locus and the second locus are on different chromosomes. In some embodiments, the first nucleic acid sequence and the second nucleic acid sequence comprises at least 3 kilobases. In some embodiments, the first nucleic acid sequence comprises approximately 100 kilobases. In some embodiments, the second nucleic acid sequence comprises approximately 3 kilobases.

In some embodiments, the cell comprises a pluripotent stem cell (PSC) or an induced pluripotent stem cell (iPSC). In some embodiments, the sample comprises a biological sample. In some embodiments, the biological sample comprises a cell, tissue sample, or blood sample.

In some embodiments, the method further comprises integrating a third nucleic acid sequence at the second locus on the genome after step c). In some embodiments, the integrating comprises homology-directed recombination (HR). In some embodiments, the integrating comprises utilizing an inducible or constitutive site-specific recombinase Cre, a Flp recombinase, or a combination thereof.

In some embodiments, the third nucleic acid sequence is linear. In some embodiments, the third nucleic acid sequence comprises a sequence homologous to the second locus on the genome. In some embodiments, the third nucleic acid sequence comprises a HLA-A gene, a HLA-B gene, a HLA-C gene, or a combination thereof. In some embodiments, the third nucleic acid sequence further comprises a regulatory element sequence. In some embodiments, the regulatory element sequence comprises a promoter sequence, an enhancer sequence, a terminator sequence, or a combination thereof.

In some embodiments, the third nucleic acid sequence further comprises an intergenic sequence. In some embodiments, the intergenic sequence comprises at least about 50 kilobases. In some embodiments, the third nucleic acid sequence further comprises one or more loxP/loxM sites. In some embodiments, the third nucleic acid sequence comprises at least 10 kilobases. In some embodiments, the third nucleic acid sequence comprises at least 30 kilobases. In some embodiments, the third nucleic acid sequence comprises at least 100 kilobases.

In some aspect, provided herein, is a method of producing a synthetic genome, the method comprising: a) obtaining a cell from a sample, wherein the cell comprises a genome; b) contacting a nucleic acid sequence encoding an antigen at a locus on the genome with a set of one or more agents, wherein the locus comprises one or more binding sites for the set of the one or more agents; c) integrating a synthetic sequence to the locus on the genome, wherein the integrating the synthetic sequence to the locus on the genome preserves regulatory components for gene expression, thereby producing the synthetic genome.

In some embodiments, the antigen comprises a major histocompatibility complex (MHC) or a human leukocyte antigen (HLA). In some embodiments, the MHC or the HLA comprises class I MHC. In some embodiments, the HLA comprises an HLA-A gene, an HLA-B gene, an HLA-C gene, or a combination thereof. In some embodiments, the one or more binding sites comprise a target sequence for the set of the one or more agents. In some embodiments, the set of the one or more agents comprises a polypeptide, a polynucleotide, or a combination thereof. In some embodiments, the polypeptide comprises a site-specific nuclease. In some embodiments, the site-specific nuclease comprises an engineered homing endonuclease or meganuclease, a zinc-finger nuclease (ZFN), a transcription activator-like effector nuclease (TALEN), a clustered regularly interspaced short palindromic repeat (CRISPR/Cas), or a combination thereof.

In some embodiments, the polynucleotide comprises a guide RNA (gRNA), a single-stranded oligodeoxynucleotide (ssODN), or a combination thereof. In some embodiments, the ssODN comprises at least 50 bp or at least 80 bp. In some embodiments, the set of the one or more agents are delivered via a carrier. In some embodiments, the carrier comprises the carrier comprises a vector, a messenger RNA (mRNA), double stranded DNA (dsDNA), single stranded DNA (ssDNA), or a plasmid.

In some embodiments, the nucleic acid sequence comprises at least 1 kilobases. In some embodiments, the nucleic acid sequence comprises approximately 100 kilobases. In some embodiments, the nucleic acid sequence comprises approximately 3 kilobases. In some embodiments, the cell comprises a pluripotent stem cell (PSC) or an induced pluripotent stem cell (iPSC).

In some embodiments, the sample comprises a biological sample. In some embodiments, the biological sample comprises a cell, tissue sample, or blood sample. In some embodiments, the integrating comprises homology-directed recombination (HR). In some embodiments, the integrating comprises utilizing an inducible site-specific recombinase Cre, a Flp recombinase, or a combination thereof. In some embodiments, the synthetic sequence is linear. In some embodiments, the synthetic sequence comprises a sequence homologous to the locus on the genome. In some embodiments, the synthetic sequence comprises a HLA-A gene, a HLA-B gene, a HLA-C gene, or a combination thereof.

In some embodiments, the synthetic sequence further comprises a regulatory element sequence. In some embodiments, the regulatory element sequence comprises a promoter sequence, an enhancer sequence, a terminator sequence, or a combination thereof. In some embodiments, the synthetic sequence further comprises an intergenic sequence. In some embodiments, the intergenic sequence comprises at least about 50 kilobases. In some embodiments, the synthetic sequence further comprises one or more loxP/loxM sites. In some embodiments, the synthetic sequence comprises at least 10 kilobases. In some embodiments, the synthetic sequence comprises at least 30 kilobases. In some embodiments, the synthetic sequence comprises at least 100 kilobases.

EXAMPLES

These examples are provided for illustrative purposes only and not to limit the scope of the claims provided herein.

Example 1: Design and Testing of REWRITE Landing Pad in Mouse Embryonic Stem Cells (mESCs)

A Recombinase Mediated Cassette Exchange (RMCE) landing pad (LP) approach was designed to write large DNA into the genome of human iPSCs, which, when repeated consecutively, enables megabase genome engineering (FIG. 3G). The ideal landing pad would: permit 100-300+kb integrations consecutively; contain all necessary components; be placed anywhere in the genome; and not leave behind transgene markers (“scarless” delivery). By using CRISPR/Cas9 guide RNAs (gRNA) for homology-directed repair, the landing pad may be site-specifically placed over any amount of DNA (FIG. 2A), thereby enabling the reintroduction of “designer” DNAs of any size. The approach precisely delivers large DNA payloads by using an in-frame “promoter trap,” thereby limiting non-specific genome integrations. The approach moves unidirectionally as new integrants are brought in (FIG. 2A). Finally, the promoter trap and transgenes would be “self-excisable” during early clonal expansion, enabling rapid scarless genome engineering.

The initial LP design (FIGS. 3A-3G) was tested at the murine Rosa26 locus in mouse embryonic stem cells (mESCs), as mESCs are more amenable to genetic modification. The 5.7 kb LP1, in order, (FIG. 3A) consists of: (i) one Flp recognition sequence frt; (ii) constitutively expressed human EF1α promoter; (iii) tamoxifen inducible double ert2 (estrogen receptor) fused Cre recombinase; (iv) ribosome skipping P2A; (v) Cre recognition sequence loxP; (vi) a blasticidin resistance marker (vii) ribosome skipping T2A; (viii) mScarlet (rfp); (ix) SV40 terminator; and (x) a Cre-lox mutant site. Two landing pads were built to test if the pairing of loxP/loxFAS enables higher integration frequencies in human cells than the loxP/lox2272 pairing as previously reported [58]. Both LPs were integrated at Rosa26 using homology-directed repair, using homology arms of −450 bp, and assisted by a single Rosa26 Cas9 gRNA. For each LP, 10-20 clones that were blasticidin resistant and mScarlet positive were identified. Correct genomic integration was assessed through PCR genotyping, using primers that amplify the novel integration junctions (FIGS. 3C-3E). The process of inducing Flp recombinase after payload delivery to provide scarless insertions (“Flp-OUT”) is illustrated in FIG. 3F. Induction of Flp recombinase using 4-hydroxytamoxifin (4-OHT) from within the payload excises the gene cassettes via FRT recombinase-mediated excision. Because the cassettes express Thymidine Kinase, only full excision is resistant to Ganciclovir (GCV), whereas those not excising are not resistant to GCV. GCV resistant stem cell clones are shown in FIG. 3F after payload delivery (as described in FIGS. 3B-3E), induction of 4-OHT, and selection by GCV. These clones only have the payload as shown in the diagram in FIG. 3F, bottom right. An overview of the entire workflow or REWRITE, from payload delivery, Flp-OUT induction, to scarless clone selection is illustrated in FIG. 3G.

Large DNA payloads (100 kb+) are integrated using a Payload Vector (PV) (FIGS. 2B and 3A-3E). The Payload Vector used herein is based on a copy-number inducible Bacterial Artificial Chromosome (BAC) [60] and Yeast Artificial Chromosome (YAC), enabling megabase-sized DNA carrying capacity. The “promoter trap” contains a promoter/ATG-less puromycin resistance marker and mNeongreen (GFP), that only functions by capturing the EF1α promoter by precisely integrating in-frame over the landing pad via Cre RMCE (FIG. 3B, middle). Payloads are brought in serially, and the final “exit” PV includes a tamoxifen inducible Flp-ert2 (Flp) and a second frt site. This enables near simultaneous excision of the markers, thereby leaving a scarless (except one each of lox and frt sites) rewritten locus (FIGS. 2A-2B and 3B, middle). In some embodiments, a payload vector may comprise a sequence comprising SEQ ID NO: 9 or SEQ ID NO: 10. In some embodiments, a payload vector may comprise a sequence comprising SEQ ID NO: 11 or SEQ ID NO: 12.

It was found that the tamoxifen inducible double ert2 Cre fusion in LP1 (FIG. 3A) was not active. The attempt to integrate a 10 kb human genome segment at Rosa26 in mESCs produced zero puromycin-resistant cells. It was thought that double ert2 (a configuration meant to reduce background Cre activity) leads to low Cre activity in mammalian cells. In order to test the promoter trap itself, the experiment was re-performed by co-transfecting a plasmid constitutively expressing Cre. In addition, a version of Cre that has been mammalian codon-optimized and lacks CpG methylation sites to prevent gene silencing, called “iCre” was also tested [61]. Both loxFAS and lox2272 containing LP1s were tested. It was found that loxFAS out-performs lox2272 for wt Cre-mediated RMCE, as 33 puromycin-resistant and mNeongreen+clones for loxP/loxFAS were found, but only 2 clones were found for loxP/lox2272. These were also now negative for blasticidin and mScarlet. Furthermore, recoded iCre substantially out-performed wt Cre, as over 270 clones in the loxFAS LP1 were found (FIGS. 4A-4C). In conclusion, iCre with the loxP/loxFAS pairing was found to provide optimal conditions for large DNA genome integrations.

It was also found that LP1 was rapidly silenced without continued use of blasticidin antibiotic in the media, as mScarlet expression diminished within 3 days (FIG. 4A), despite Rosa26 being a “safe-harbor”site. As the goal is for the LP to be placed at any genomic site, the promoter was redesigned to prevent gene silencing. To minimize the silencing effect, two new landing pads (LP2 and LP3) were built to add either the enhancer regions of the EF1α promoter, or a Universal Chromatin Opening Element (UCOE) upstream of the EF1α promoter, previously shown to limit silencing with EF1α [66]. LP2 and LP3 were integrated into Rosa26 in mESCs as before and new stable clones were obtained. To determine whether these modifications reduced silencing, LP1-3 were initially grown with blasticidin selection, and then without blasticidin selection for an additional 6 days (FIG. 4C). Whereas mESC clones with LP1 and LP2 both showed silencing of mScarlet, LP3 containing the UCOE remained fluorescent after 6 days without blasticidin selection (FIG. 4C).

Based on these results, the landing pad was reconstructed to a final configuration called LPneo, which represents the most common REWRITE landing pad configuration (FIG. 2B). To provide optimal Cre activity, the LP was engineered to contain iCre (with SV40 nuclear localization signals) driven by the low background 3rd gen TET-On 3G system (TRE3G; Tet-On® 3G Bidirectional inducible Expression System (with ZsGreen1)). The TRE3G promoter for iCre was cloned as a bidirectional promoter in reverse to the EF1α promoter. The TRE3G activator protein TET-ON, which is inactive without doxycycline, was constitutively expressed from the EF1α promoter. The promoter trap was otherwise unmodified. Type IIS restriction sites BsaI were also introduced to enable Golden Gate assembly of homology arms for rapidly redeploying the LP to new sites. Thus, the final landing pad was constructed to be an “all-in-one” construct with the potential to be used anywhere in the genome.

Example 2: Integration in Human Induced Pluripotent Stem Cells (iPSCs)

To show that REcombinase WRiting of Iterative DNA and Trap Excision (REWRITE) enables Big-DNA delivery into human induced pluripotent stem cells (hiPSCs), a REWRITE landing pad was generated to remove a 100 kilobase genomic region covering the HLA-B and HLA-C genes on chromosome 6 in iPSCs. Two CRISPR gRNAs for erCas12a, also called MAD7, were designed to generate double strand breaks spanning a 100 kilobase region. The REWRITE landing pad was successfully integrated over this 100 kilobase genomic locus, as the iPSCs were both Blasticidin resistant and mScarlet+.

Using the methods described herein, REWRITE landing pad was inserted at the site of HLA-B/C deletion in human iPSCs (FIGS. 13A-13B). AHLA-B/C locus with mono-allelic REWRITE Landing Pad insertion was sequenced using next-generation sequencing platform method, Capture-seq. Capture-seq data aligned to the 5′ end of the AHLA-B/C locus with the REWRITE Landing Pad insertion shows that Clones C12, E5, and E2 have coverage in the landing pad region at roughly half the level of the surrounding genomic HLA-B/C region, which indicates mono-allelic insertion of the REWRITE landing pad (FIG. 13A). Capture-seq data aligned to the 3′ end of the AHLA-B/C locus with the REWRITE Landing Pad insertion shows that Clones B5, C12, E5, E2, and E3 have coverage in the landing pad region at roughly half the level of the surrounding genomic HLA-B/C region, which indicates mono-allelic insertion of the REWRITE landing pad (FIG. 13B). Based on this data, Clones C12, E5, and E2 were confirmed to have mono-allelic insertion of a full REWRITE Landing Pad at the HLA-B/C deletion site.

A 115 kilobase synthetic version of the human HLA locus, called synHLA, was assembled into our Payload Vector (PV). The 115 kilobase PV was introduced into the REWRITE iPSCs via nucleofection, and the iCre expression module was then activated for 3 days using Doxycycline. After 3 days, successful integrants was selected using Puromycin. After 10 days, −30 distinct colonies indicative of Big-DNA delivery were observed. Under fluorescent microscopy it was confirmed that all clones were mNeongreen+in addition to Puromycin resistant. This confirms that the REWRITE landing pad approach enables the delivery of Big-DNA of at least 115 kilobases.

Example 3: Engineering a Blank (HLA-Less) iPSC by Replacing HLA-A/B/C with a Landing Pad

A well-characterized iPSC (PGP1) from the Coriell Intitute was acquired [50] for this experiment; however, any human iPSC can be used. Starting with this iPSC line, a “blank” iPSC devoid of HLA-A/B/C and encoding the Recombinase Mediated Cassette Exchange (RMCE) landing pad will be constructed (FIG. 5B). The blank iPSC allows testing precise single-copy integration of synHLAs. Following HLA deletion, the blank iPSC will be evaluated for potential off-target mutations by deep sequencing and karyotype analysis. No issues associated with bi-allelic deletion of HLA-1 genes in human iPSCs are expected because HLA-less mouse ESCs readily generate healthy mice [51].

The 100 kb HLA-B/C locus will be replaced with the RMCE landing pad (5.5 kb) described earlier by CRISPR or TALEN or ZFN (heretofore “Site-Specific Nucleases” or “SSNs”) DNA-cut stimulated homology-directed recombination (HR). The other allele will be cleanly deleted with a commercially synthesized 100 bp single stranded oligodeoxynucleotides (ssODN) deletion fragment [46,47]. Two SSN guide RNAs will be introduced, one upstream of HLA-C and one downstream of HLA-B. The landing pad construct will be introduced as linear dsDNA designed with homology arms to the region (FIG. 5B). The Site-Specific Nuclease will be delivered transiently on plasmids. The HLA-B/C deletion genotype will be confirmed by PCR, Southern Blotting, immunoblots after IFN-γ HLA induction [17] (PSCs don't express HLA), karyotyping, and potential predicted off-target mutations will be evaluated by deep sequencing.

The final step in preparing the blank iPSC requires deleting HLA-A (3.6 kb) (FIG. 5B), as it is located 1.3 Mb away from HLA-B/C on chromosome [6]. The two HLA-A alleles will be deleted using two flanking SSNs and a commercially synthesized 100 bp ssODN [46,47]. The clones will be verified for HLA-A deletion as detailed in the above for HLA-B/C deletion. HLA-A allele removal from human iPSC using an SSN, CRISPR ErCas12a (Mad7) is shown in FIG. 7 .

Alternative Methods:

-   -   1. Instead of a iPSCs, a hESC (H1) cell line with another         landing pad inserted in X-chromosome.     -   2. A single MAD7 targeted to an exon for mutagenic         non-homologous end-joining (NHEJ) can be used for HLA-B/C         deletion.     -   3. Deletions can be repeated using multiple alternative MAD7         gRNAs in parallel.

The second allele can also be deleted using a Deleter construct expressing Hygromycin resistance gene and Thymidine Kinase under a PGK promoter (FIG. 11 ). The Deleter construct was assembled by standard cloning methods into the same backbone as the REWRITE landing pad. It comprises an FRTm (F5) sequence, followed by the constitutive PGK promoter, a Hygromycin resistance gene, a P2A sequence, a Thymidine Kinase gene, an SV40 polyA sequence, and the another FRTm (F5) sequence. The Deleter construct is flanked by two alternative FRT sites (FRTm)—BsaI sites—used for golden gate cloning and insertion of homology arms for genomic integration, in the same way that is used by the REWRITE landing pad. The construct is co-transfected with the landing pad and uses the same reagents. Clones with bi-allelic deletions are selected using Blasticidin and Hygromycin simultaneously. The Deleter construct sequence is shown in SEQ ID NO: 15.

Example 4: Designing and Building a Designer HLA-A/B/C (synHLA)

Big-DNA can be assembled up to 1 Mb by co-opting the naturally efficient homologous recombination (HR) machinery of budding yeast using techniques described earlier. Multiple linear DNA fragments can be stitched by using HR into a vector with yeast artificial chromosome (YAC) and bacterial artificial chromosome (BAC) replication sites, capable of carrying up to 1 Mb of DNA. Here the goal is to reconfigure HLA-A/B/C into a single locus of −115 kb (synHLA) or miniature version of ˜36 kb (mini-synHLA).

The HLA-A gene, including regulatory information (FIG. 5A), will be relocated centrally within the 78-kb intergenic region between HLA-B and C (FIGS. 5B-5C). The HLA-A core promoter maps within 1000 bp [52,53], and in silico analysis by Genehancer [54] (which integrates all public epigenetic, Hi-C, RNA expression, DNase hypersensitivity, eQTL data, etc) shows enhancers within just 2 kb of the gene body. To permit wild-type HLA-A expression, safety will be emphasized and the construct will encode up to 10 kb flanking region for the promoter/enhancer and 1 kb for the terminator in the design. This synthetic configuration enables single-step integration of HLA-A/B/C haplotypes into the blank iPSC, while preserving native regulatory information for cell-specific gene expression.

Both synHLA and mini-synHLA may be constructed from smaller 4-kb DNA pieces with −180 bp of overlap (genomic PCR of the iPSC DNA and/or commercial synthesis). Sections may also be captured through Transformation Assisted Cloning using yeast from readily available Bacterial Artificial Chromosomes (BACs) containing human genetic loci. Examples of personalized HLA genic DNAs (˜3.4 kb) will be commercially synthesized from an HLA haplotype database. The amplicons will be transformed into budding yeast with the linearized YAC/BAC vector, assembled by HR, and identified by selecting for the plasmid auxotrophic marker (e.g., HIS3) (FIG. 5C). Correct assemblies will be verified in yeast using junction PCR analysis and by deep sequencing. The 115-kb or 36-kb plasmid will be extracted from yeast and transformed into E. coli for DNA scale-up.

Using the methods described above, a mini-synHLA comprising HLA-A/B/C (FIG. 8A, top left) was constructed. Assembled mini-synHLA was analyzed by Gel Electrophoresis to confirm that it has the correct DNA size for the assembled mini-synHLA product (FIG. 8A, right) and sequenced using Illumina Miseq™ system (FIG. 8A, bottom left). Next, mini-synHLA was introduced to human iPSCs containing the REWRITE landing pad and inducible (by doxycycline) iCre via nucleofection. The iCre expression module was then activated by treating cells with doxycycline for up to 2 days to induce integration of HLA-A/B/C to the landing pad and the number of clones/colonies is shown in FIG. 8B.

Using the methods described above, 115 kb synHLA comprising HLA-A/B/C was assembled in yeast. A 10 kB fragment of the HLA-A locus was placed within the 78 kb intergenic region between HLA-B and HLA-C from a BAC clone, and these were assembled into the Payload Vector (PV1f) in yeast (FIG. 10A). Assembled synHLA was analyzed by Field-Inversion Gel Electrophoresis to confirm that it has the correct DNA size and the size was compared with that of mini-synHLA (FIG. 10B).

Example 5: Personalizing Blank iPSC with synHLA and Evaluating Expression

Personalizing class-I HLA haplotypes would provide immunological matches to various ethnic populations across the world (FIG. 9 ). To achieve this, a synHLA haplotype will be delivered to the blank iPSC using recombinase mediated cassette exchange method (RMCE) (FIGS. 6A-6C). The integration of 101 kb DNA has been shown using the related method Inducible Cassette Exchange (ICE) in mESCs [42]. The 115 kb synHLA will be delivered into an RMCE landing pad site within the blank iPSC. The RMCE strategy uses heterotypic loxP/loxM sites and an inducible site-specific recombinase Cre for “gene-trapping” as described earlier. The cassette is then excised using the Flp recombinase. The integrant will be verified using PCR and then confirmed of genetic integrity by 30x coverage whole genome sequencing (WGS). Then it will be tested to see if synHLA is expressed by adding IFNγ17 (PSCs don't express HLA), which induces HLA expression in iPSCs, to both personalized and wild-type iPSCs, and measuring the HLA expression by qRT-PCR and immunoblotting.

It is important to note that RMCE methods insert DNA without size-limitations, with high specificity, and reduce the need for whole genome sequencing or equivalent validation of each new cell line [25], as nuclease-assisted HR would require [26,27]. Only a single correct clone needs to be isolated as PSCs can be expanded indefinitely, therefore, high integration efficiency is not required.

Alternative methods:

-   -   1. synHLA can be retro-fit with ICE markers and delivered to         pre-existing cell lines with the ICE landing pad.     -   2. CRISPR/MAD7 can be used to introduce synHLA by         homology-directed repair.     -   3. synHLA can be randomly integrated to any locus as synHLA         comprises all required regulatory sequences.

Authentication of Key Resources and Reproducibility

-   -   1. Human induced pluripotent stem cells (iPSCs): iPSCs were         obtained from the Coriell Institute and the donor's race noted.         The iPSC will be verified by karyotype analysis of chromosome         number, microscopy, and whole genome sequencing at 30x coverage.         A sensitive PCR test will be used to ensure that Mycoplasma is         not present in the cultures. Finally, the cells will be grown on         feeder-free conditions using commercial substrates (e.g.,         Matrigel, Laminin 521, etc), and prevented from spontaneous         differentiation by including FGF2 or LIF.     -   2. Sex as a biological variable: The iPSC line in this work will         be a male line. In future work, both male and female versions of         cells will be included. This is because male cells have a         sex-specific antigen (H-Y) that causes transplant rejection in         females.     -   3. Reproducibility of experiments: The iPSC experiments will be         carefully controlled to enable reproducibility. Temperature,         humidity, liquid volume, and similar glassware will be used to         reduce environmental variation during experiments. Furthermore,         it will be noted which lots each batch of specific reagents         (FBS, Media, Growth Factors, Antibodies) come from and these         will be used uniformly. At least 3 biological replicates will be         routinely performed for every experiment, and replicate         experiment will be performed over time when possible. Finally,         the use of commercial substrates for the iPSCs will ensure         greater reproducibility compared to using a fibroblast feeder         layer.     -   4. Other reagents: Examples described herein use standard         biochemical and molecular biology reagents that are not expected         to vary significantly. However, it will be noted specific         vendors and batches for commercial reagents and the same will be         used for internal controls to re-establish specific activities         before using all reagents.     -   5. Control experiments routinely performed. All Big-DNAs will be         fully sequenced. Standard controls will be used for immunoblots         (tubulin and histones), karyotyping, and for qRT-PCR         (housekeeping genes).     -   6. Statistical analysis. The experiments outlined in this         proposal will utilize statistically sound numbers, usually         experimental or biological replicates greater than three. Whole         genome sequencing results will have at least 30x coverage, a         standard in the field.

Example 6: Preliminary Data Supporting Described Technology

Expertise Deleting Genomic DNAs (Example 3):

The inventors have technology to delete big genomic DNA regions to homozygosity, including the HLAs (H2K), from 5 kb to 200 kb in mouse embryonic stem cells (mESCs) at frequencies between 2-50%, without the use of any selectable marker (Table 3). These deletions were achieved using two targeted CRISPR gRNAs and a 100 bp single-stranded oligonucleotide (ssODN) to induce homology-directed repair [46,47]. In some embodiments, Inscripta's MAD7 CRISPR system can be used [48].

TABLE 3 Example mESC Genomic Deletions Homozygous Δ Gene - DNA size Frequency Major Histocompatibility Complex Class I, K 50% (H2K) - 5 kb Cluster of Differentiation 8 (CD8) - 55 kb 20% T-cell receptor beta (TCRβ) - 200 kb  2%

Expertise Building Big-DNA (Example 4):

Big-DNA assembly technology leveraging yeast homologous recombination and developed by the inventors enables fusion of multiple linear DNAs into one large Big-DNA with success in configurations so far up to 1 Mb [39]. A high-throughput automated workflow for the design, assembly, and verification (1536 qPCR and deep sequencing) can be used [43]. Assembling Big-DNAs in the HLA size-range is a routine task (Table 4).

TABLE 4 Example of DNAs generated Description Organism Length Human biologic Human   88 kb HPRT* Human  101 kb Alpha globin Mouse   90 kb HOX** locus Rat  170 kb Chromosomes Yeast  1.4 Mb *HPRT: Hypoxanthine-guanine phosphoribosyltransferase **HOX: Homeobox

Demonstration of 101 kb DNA Delivery to Mammalian Cells (Example 5):

Big-DNA assembly and delivery have been reduced to practice using Recombinase Mediated Cassette Exchange (RMCE). RMCE uses recombinases (Cre and others) to integrate large DNA payloads site-specifically. Mutant heterotypic recognition sites based on lox series (loxM, loxP, etc.) ensure unidirectional DNA insertion. A 101 kb DNA comprising the human HPRT locus has been integrated into mouse ESCs, as described previously [42] using a RMCE method called Inducible Cassette Exchange (ICE) [49]. A 170 kb DNA comprising rat HoxA locus has also been delivered to mESCs using the same method [62]. A 144 kb human Sox2 locus has been delivered to mESCs using “Big-IN” method [61]. ICE method can leave behind genomic scars such as transgenes used for positive selection.

Scarless DNA Integration with “REWRITE” (Example 5):

A robust and nearly scarless proprietary Big-DNA delivery method called REcombinase WRiting of Iterative DNA and Trap Excision (REWRITE), which leaves behind only 34 bp recombinase sites have been developed by the inventors. The REWRITE landing pad also co-delivers an inducible FLP recombinase gene for inducible excision of markers. This enables precise delivery of >100 kb DNA payloads (e.g., synHLA) without DNA scars (FIGS. 6A-6C).

Example 7: Installation and Functional Validation of the REWRITE Landing Pad in U2OS

REWRITE landing pad plasmid and REWRITE payload plasmid containing location specific homology arms inserted at the flanking BsaI sites by Golden Gate Assembly were generated (FIG. 12A). As one of the BsaI site at the 3′ end of the landing pad can be methylated in bacteria, it is important to propagate the landing pad plasmid in Dam/Dcm−/− bacteria prior to adding homology arms. To test REWRITE recombination at a REWRITE Landing Pad, a REWRITE Landing Pad was installed in U2OS cells, and a minimal REWRITE payload (pDT3) was introduced to U2OS cells that had been treated with doxycycline and tamoxifen via transfection. U2OS cells were analyzed by fluorescent microscopy nine days post-transfection and (FIGS. 12B-12G). A field of U2OS cells were imaged in bright-field (FIG. 12B), GFP (FIG. 12C), and RFP channels (FIG. 12D). Groups of cells that have undergone REWRITE recombination with the REWRITE payload plasmid are outlined in white (FIGS. 12E-G). Cells that have undergone REWRITE recombination show expression of mNeongreen in the GFP channel (Figure F) but lack mScarlet expression in the RFP channel (Figure G). The sequence of the minimal REWRITE payload (pDT3) is shown in SEQ ID NO: 16.

The examples and embodiments described herein are for illustrative purposes only and various modifications or changes suggested to persons skilled in the art are to be included within the spirit and purview of this application and scope of the appended claims.

SEQUENCES (HLA-B-A-C) SEQ ID NO: 1 ATAACTTCGTATAGCATACATTATACGAAGTTATCCGGAACCGAGTACAAGCCCACGGTGCGCCTCGCCACCCGCG ACGACGTCCCCAGGGCCGTCCGCACCCTCGCCGCCGCGTTCGCCGACTACCCCGCCACGCGCCACACCGTCGATCC GGACCGCCACATCGAGCGCGTGACCGAGCTGCAAGAACTCTTCCTCACGCGCGTCGGGCTCGACATCGGCAAGGTG TGGGTCGCGGACGACGGAGCCGCTGTGGCGGTCTGGACCACGCCGGAGAGCGTCGAAGCGGGGGCGGTGTTCGCCG AGATCGGCCCGCGCATGGCCGAGTTGAGCGGTTCCCGGCTGGCCGCGCAGCAACAGATGGAGGGCCTCCTGGCTCC GCACCGGCCCAAGGAGCCCGCGTGGTTCCTGGCCACCGTCGGAGTCTCGCCCGACCACCAGGGCAAGGGTCTGGGC AGCGCCGTCGTGCTCCCCGGAGTGGAGGCGGCCGAGCGCGCCGGGGTGCCCGCCTTCCTGGAAACCTCCGCGCCCC GCAACCTCCCCTTCTACGAGCGGCTCGGCTTCACCGTCACCGCCGACGTCGAGGTGCCCGAAGGACCGCGCACCTG GTGCATGACCCGCAAGCCCGGTGCCGCATGCCCCACGCTACTGCGGGTTTATATAGACGGTCCCCACGGGATGGGG AAAACCACCACCACGCAACTGCTGGTGGCCCTGGGTTCGCGCGACGATATCGTCTATGTACCCGAGCCGATGACTT ACTGGCGGGTGCTGGGGGCTTCCGAGACAATCGCGAACATCTACACCACACAACACCGCCTCGACCAGGGTGAGAT ATCGGCCGGGGACGCGGCGGTGGTAATGACAAGCGCCCAGATAACAATGGGTATGCCTTATGCCGTGACCGACGCC GTTCTGGCTCCTCATATCGGGGGGGAGGCTGGTAGCTCACATGCCCCGCCCCCGGCCCTCACCCTCATCTTCGACC GCCATCCCATCGCCGCCCTCCTGTGCTACCCGGCCGCGCGGTACCTTATGGGCAGCATGACCCCCCAGGCCGTGCT GGCGTTCGTGGCCCTCATCCCGCCGACCTTGCCCGGCACCAACATCGTGCTTGGGGCCCTGCCGGAGGACAGACAC ATCGACCGCCTGGCCAAACGCCAGCGCCCCGGCGAGCGGCTGGACCTGGCTATGCTGGCTGCGATTCGCCGCGTTT ACGGGCTACTTGCCAATACGGTGCGGTATCTGCAGTGCGGCGGGTCGTGGCGGGAGGACTGGGGACAGCTTTCGGG GACGGCCGTGCCGCCCCAGGGTGCCGAGCCCCAGAGCAACGCGGGCCCACGACCCCATATCGGGGACACGTTATTT ACCCTGTTTCGGGCCCCCGAGTTGCTGGCCCCCAACGGCGACCTGTATAACGTGTTTGCCTGGGCCTTGGACGTCT TGGCCAAACGCCTCCGTTCCATGCACGTCTTTATCCTGGATTACGACCAATCGCCCGCCGGCTGCCGGGACGCCCT GCTGCAACTTACCTCCGGGATGGTCCAGACCCACGTCACCACCCCCGGCTCCATACCGACGATATGCGACCTGGCG CGCACGTTTGCCCGCGAGATGGGGGAGGCTAACGAGCTCGGCAGTGGAGAGGGCAGAGGAAGTCTGCTAACATGCG GTGACGTCGAGGAGAATCCTGGCCCAAGCCAGTTCGACATCCTGTGCAAGACCCCCCCCAAGGTGCTGGTGCGGCA GTTCGTGGAGAGATTCGAGAGGCCCAGCGGCGAGAAGATCGCCAGCTGTGCCGCCGAGCTGACCTACCTGTGCTGG ATGATCACCCACAACGGCACCGCCATCAAGAGGGCCACCTTCATGAGCTACAACACCATCATCAGCAACAGCCTGA GCTTCGACATCGTGAACAAGAGCCTGCAGTTCAAGTACAAGACCCAGAAGGCCACCATCCTGGAGGCCAGCCTGAA GAAGCTGATCCCCGCCTGGGAGTTCACCATCATCCCTTACAACGGCCAGAAGCACCAGAGCGACATCACCGACATC GTGTCCAGCCTGCAGCTGCAGTTCGAGAGCAGCGAGGAGGCCGACAAGGGCAACAGCCACAGCAAGAAGATGCTGA AGGCCCTGCTGTCCGAGGGCGAGAGCATCTGGGAGATCACCGAGAAGATCCTGAACAGCTTCGAGTACACCAGCAG GTTCACCAAGACCAAGACCCTGTACCAGTTCCTGTTCCTGGCCACATTCATCAACTGCGGCAGGTTCAGCGACATC AAGAACGTGGACCCCAAGAGCTTCAAGCTGGTGCAGAACAAGTACCTGGGCGTGATCATTCAGTGCCTGGTGACAG AAACCAAGACAAGCGTGTCCAGGCACATCTACTTTTTCAGCGCCAGAGGCAGGATCGACCCCCTGGTGTACCTGGA CGAGTTTCTGAGGAACAGCGAGCCCGTGCTGAAGAGAGTGAACAGGACCGGCAACAGCAGCAGCAACAAGCAGGAG TACCAGCTGCTGAAGGACAACCTGGTGCGCAGCTACAACAAGGCCCTGAAGAAGAACGCCCCCTACCCCATCTTCG CTATCAAGAACGGCCCTAAGAGCCACATCGGCAGGCACCTGATGACCAGCTTTCTGAGCATGAAGGGCCTGACCGA GCTGACAAACGTGGTGGGCAACTGGAGCGACAAGAGGGCCTCCGCCGTGGCCAGGACCACCTACACCCACCAGATC ACCGCCATCCCCGACCACTACTTCGCCCTGGTGTCCAGGTACTACGCCTACGACCCCATCAGCAAGGAGATGATCG CCCTGAAGGACGAAACCAACCCCATCGAGGAGTGGCAGCACATCGAGCAGCTGAAGGGCAGCGCCGAGGGCAGCAT CAGATACCCCGCCTGGAACGGCATCATCAGCCAGGAGGTGCTGGACTACCTGAGCAGCTACATCAACAGGCGGATC ACCGGTTGCGTACGCGGATCCTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAAC GCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCC CATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCA GACAGGGAGCTGGTTCACATGATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGG TCCACCTTCTAGAATGTGCCTGGCTAGAGATCCTGATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGTGAA GCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATGTGTAGAGGGCATGGTGGAGATCTTCGAC ATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTGCCTCAAATCTATTA TTTTGCTTAATTCTGGAGTGTACACATTTCTGTCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATCCACCG AGTCCTGGACAAGATCACAGACACTTTGATCCACCTGATGGCCAAGGCAGGCCTGACCCTGCAGCAGCAGCACCAG CGGCTGGCCCAGCTCCTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATCTGTACAGCA TGAAGTGCAAGAACGTGGTGCCCCTCTATGACCTGCTGCTGGAGGCGGCGGACGCCCACCGCCTACATGCGCCCAC TAGCCGTGGAGGGGCATCCGTGGAGGAGACGGACCAAAGCCACTTGGCCACTGCGGGCTCTACTTCATCGCATTCC TTGCAAAAGTATTACATCACGGGGGAGGCAGAGGGTTTCCCTGCCACAGCTGGCTCCGGCGAGGGCAGGGGAAGTC TTCTAACATGCGGGGACGTGGAGGAAAATCCCGGCCCAGTGAGCAAGGGTGAGGAGGATAACATGGCCTCTCTCCC AGCGACACATGAGTTACACATCTTTGGCTCCATCAACGGTGTGGACTTTGACATGGTGGGTCAGGGCACCGGCAAT CCAAATGATGGTTATGAGGAGTTAAACCTGAAGTCCACCAAGGGCGACCTCCAGTTCTCCCCCTGGATTCTGGTCC CTCATATCGGGTATGGCTTCCATCAGTACCTGCCCTACCCTGACGGGATGTCGCCTTTCCAGGCCGCCATGGTAGA TGGCTCTGGATACCAAGTCCATCGCACAATGCAGTTTGAAGATGGTGCCTCCCTTACTGTGAACTACCGCTACACC TACGAGGGAAGCCACATCAAAGGAGAGGCCCAGGTGAAGGGGACTGGTTTCCCTGCTGACGGTCCTGTGATGACCA ACTCGCTGACCGCTGCGGACTGGTGCAGGTCGAAGAAGACTTACCCCAACGACAAAACCATCATCAGTACCTTTAA GTGGAGTTACACCACTGGAAATGGCAAGCGCTACCGGAGCACTGCGCGGACCACCTACACCTTTGCCAAGCCAATG GCGGCTAACTATCTGAAGAACCAGCCGATGTACGTGTTCCGTAAGACGGAACTCAAGCACTCCAAGACCGAGCTGA ACTTCAAGGAGTGGCAAAAGGCGTTTACCGATGTGATGGGCATGGACGAGCTGTACAAGTGAATTCGATCATAATC AGCCATACCACATTTGTAGAGGTTTTACTTGCTTTAAAAAACCTCCCACACCTCCCCCTGAACCTGAAACATAAAA TGAATGCAATTGTTGTTGTTAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTT CACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGG CTCGAGGGAAGTTCCTATACTCTAGAAAGAATAGGAACTTCAAAGGAAGTGCTTCAGGGTGAAGGAAAATGATACT AGATGGTGACCCAGATATACAGAAAGGAACAATTAACAACAGAAATGATGCACATACACATGTCACATTCACACTC ATTTTCTTAATTTCCTGAAGACATATGGCTACTTGTTTAAAACAAAAAGTATTACACTGTATCATTGAGCTTATAA TATAGGTTGATGTAATATATACAACAATAATAGCACAATGGTAGGTTACAAGAAACTACACTGTTAGAAGTGTCCT TTATTTTCTGGATGCAGCTTAATATAACCTGAACTTCACTGTGAAAAGTCAAGGAATCGGGTTTCCATTCTTTGCT ATTGTGTAAAGAAATATAGCCAAAAGCCACTAGGAGAATTAAAACCATAAACTAAAAAATGTTTATTTGACACATA AGAAAGTAGTAAAGGAGGAACAGAAACAAAAAGATATGAGACAAATTGAAAACGTATAGCAAAATTGTAGACCAAA ACCCAACCATTGCAAGTGAAGAAATGACATGACCTGAGTCACATTAGCAGGACTGCTGAGCACTGTGGGGAGAACA GATATGGGCAGGAGGTGAGGGACAGTGTTAGTGCCACAATTCAGGAGGGAAAGGGTGGCAGGGACTAACGGGGGTG GTGTGAAGGATGAGAAGGGCAGACAGAAGGGCTGGAGAGGCAGGAGGAGAGGAAAAGGAGCAGGAGAAAGAATTCT AAAGCAGTGGAAGAGCCTGGCAGAGGGTTCTTTGCATTCGGTATTTAATACATTTTGTTGGACTTCCTAAAAACTA ATTGGCTCCTTATGATTAAAAAAAAAAGAGTTACAAAAATACCAAGTGTTCAGATAAAATATGCACACTGCTTGGA TGTGCAGAGTTCAGGAAAACAGGCAGTGCTTGAGCGCTGGTGAAGAGCATTGGGACTGCATGGAGCCCTCGCAACT TTGAGGTGATGACTACAGGTTCCCGGTTGCAATAGACAGTAACAAACCCTGCTTCTTTATATTCAGGAGATGTTCT GGACTCACACAGGGAAACTCAGGGTGGGGAATGAAGATAATTTTAAATGCAACAACCCAGAGTCACAGATCCATAG TCTGGGAAAGTAAAACTTAGGAGCTTTGAGAGTTTAATTGTAATGCTGTTTTGACACAGGTCTTTTGCAGATTGGA ATTCTAATCATTCAGGGATTACCAATATTGTGCTACCTACTGTATTAATAAACAAAAAGGAAACTGGTCTCTATGA GAATCTCTGTGTGGTGGCTTCAGACAAAACTTCGCCAGGTTTAGAGAGAAAACCCCTGTCTCTACACCTCCATTCC CAGGGCGAGCTCACTCTCTGGCATCAAGTTCTCCGTGATCAGCTTCCCTACACAAGANTCCAAGAGGAGAGGTAAG GAGTGAGAGGCAGGGAGTCCAGTTCAGGGACAGGGATTCCAGGAGGAGAAGTGAAGGGGAAGCGGGTGGGCGCAGC CTGGGGGTCTCTCCCTGGTTTCCACAGACAGATCCTTGTGCAGGACTCAGGCAGACAGTGTGACAAAGAGGCTGGT GTAGGAGAAGAGGGATCAGGACGAAGTCCCATGTCCCGGACGGGGCTCTCAGGGTCTCAGGCTCCGAGGGCCGCGT CTGCATTGGGGAGGCGCAGCGTTGGGGATTCCCCACTCCCACGAGTTTCACTTCTTCTCCCAACCTATGTCGGGTC CTTCTTCCAGGATACTCGTGACGCGTCCCCATTTCCCACTCCCATTGGGTGTCGGGTGTCTAGAGAAGCCAATCAG TGTCGCCGGGGTCCCAGTTCTAAAGTCCCCACGCACCCACCCGGACTCAGAGTCTCCTCAGACACCGAGATGCGGG TCACGGCACCCCGAACCCTCCTCCTGCTGCTCTGGGGGGCCCTGGCCCTGACCGAGACCTGGGCCGGTGAGTGCGG GTCGGGAGGGAAATGGCCTCTGTGGGGAGGAGCGAGGGGACCGCAGGCGGGGGCGCAGGACCCGGGGAGCCGCGCC GGGAGGAGGGTCTGGCGGGTCTCAGCCCCTCCTCGCCCCCAGGCTCCCACTCCATGAGGTATTTCTACACCGCCAT GTCCCGGCCCGGCCGCGGGGAGCCCCGCTTCATCGCAGTGGGCTACGTGGACGACACGCAGTTCGTGAGGTTCGAC AGCGACGCCGCGAGTCCGAGAGAGGAGCCGCGGGCGCCGTGGATAGAGCAGGAGGGGCCGGAGTATTGGGACCGGA ACACACAGATCTACAAGGCCCAGGCACAGACTGACCGAGAGAGCCTGCGGAACCTGCGCGGCTACTACAACCAGAG CGAGGCCGGTGAGTGACCCCGGCCCGGGGCGCAGGTCACGACTCCCCATCCCCCACGTACGGCCCGGGTCGCCCCG AGTCTCCGGGTCCGAGATCCGCCTCCCTGAGGCCACGGGACCCGCCCAGACCCTCGACCGGCGAGAGCCCCAGGCG CGTTTACCCGGTTTCATTTTCAGTTGAGGCCAAAATCCCCGCGGGTTGGTCGGGGCGGGGCGGGGCTCGGGGGACG GGGCTGACCGCGGGGCCGGGGCCAGGGTCTCACACTTGGCAGACGATGTATGGCTGCGACCTGGGGCCGGACGGGC GCCTCCTCCGCGGGCATAACCAGTTAGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGACCTGAGCTCCTG GACCGCGGCGGACACCGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGAGGCGGAGCAGCTGAGAGCC TACCTGGAGGGCACGTGCGTGGAGTGGCTCCGCAGATACCTGGAGAACGGGAAGGAGACGCTGCAGCGCGCGGGTA CCAGGGGCAGTGGGGAGCCTTCCCCATCTCCTATAGGTCGCCGGGGATGGCCTCCCACGAGAAGAGGAGGAAAATG GGATCAGCGCTAGAATGTCGCCCTCCCTTGAATGGAGAATGGCATGAGTTTTCCTGAGTTTCCTCTGAGGGCCCCC TCTTCTCTCTAGGACAATTAAGGGATGACGTCTCTGAGGAAATGGAGGGGAAGACAGTCCCTAGAATACTGATCAG GGGTCCTCTTTGACCCCTGCAGCAGCCTTGGGAACCGTGACTTTTCCTCTCAGGCCTTGTTCTCTGCCTCACACTC AGTGTGTTTGGGGCTCTGATTCCAGCACTTCTGAGTCACTTTACCTCCACTCAGCTCAGGAGCAGAAGTCCCTGTT CCCCGCTCAGAGACTCGAACTTTCCAATGAATAGGAGATTATCCCAGGTGCCTGCGTCCAGGCTGGTGTCTGGGTT CTGTGCCCCTTCCCCACCCCAGGTGTCCTGTCCATTCTCAGGCTGGTCACATGGGTGGTCCTAGGGTGTCCTATGA GAGATGCAAAGCGCCTGAATTTTCTGACTCTTCCCATCAGACCCCCCAAAGACACACGTGACCCACCACCCCATCT CTGACCATGAGGCCACCCTGAGGTGCTGGGCCCTGGGCTTCTACCCTGCGGAGATCACACTGACCTGGCAGCGGGA TGGCGAGGACCAAACTCAGGACACTGAGCTTGTGGAGACCAGACCAGCAGGAGATAGAACCTTCCAGAAGTGGGCA GCTGTGGTGGTGCCTTCTGGAGAAGAGCAGAGATACACATGCCATGTACAGCATGAGGGGCTGCCGAAGCCCCTCA CCCTGAGATGGGGTAAGGAGGGGGATGAGGGGTCATATCTCTTCTCAGGGAAAGCAGGAGCCCTTCTGGAGCCCTT CAGCAGGGTCAGGGCCCCTCGTCTTCCCCTCCTTTCCCAGAGCCATCTTCCCAGTCCACCATCCCCATCGTGGGCA TTGTTGCTGGCCTGGCTGTCCTAGCAGTTGTGGTCATCGGAGCTGTGGTCGCTACTGTGATGTGTAGGAGGAAGAG CTCAGGTAGGGAAGGGGTGAGGGGTGGGGTCTGGGTTTTCTTGTCCCACTGGGGGTTTCAAGCCCCAGGTAGAAGT GTTCCCTGCCTCATTACTGGGAAGCAGCATCCACACAGGGGCTAATGCAGCCTGGGACCCTGTGTGCCAGCACTTA CTCTTTTGTGCAGCACATGTGACAATGAAGGACGGATGTATCACCTTGATGGTTGTGGTGTTGGGGTCCTGATTTC AGCATTCATGAGTCAGGGGAAGGTCCCTGCTAAGGACAGACCTTAGGAGGGCAGTTGGTCCAGGACCCACACTTGC TTTCCTCGTGTTTCCTGATCCTGCCTTGGGTCTGTAGTCATACTTCTGGAAATTCCTTTTGGGTCCAAGACGAGGA GGTTCCTCTAAGATCTCATGGCCCTGCTTCCTCCCAGTCCCCTCACAGGACATTTTCTTCCCACAGGTGGAAAAGG AGGGAGCTACTCTCAGGCTGCGTGTAAGTGGTGGGGGTGGGAGTGTGGAGGAGCTCACCCACCCCATAATTCCTCC TGTCCCACGTCTCCTGCGGGCTCTGACCAGGTCCTGTTTTTGTTCTACTCCAGCCAGCGACAGTGCCCAGGGCTCT GATGTGTCTCTCACAGCTTGAAAAGGTGAGATTCTTGGGGTCTAGAGTGGGCGGGGGGGGGTGGGGTGGGGAGGGG GCAGAGGGGAAAGGCCTGGGTAATGGAGATTCTTTGATTGGGATGTTTCGCGTGTGTGGTGGGCTGTTTAGAGTGT CATCACTTACCATGACTAACCAGAATTTGTTCATGACTGTTGTTTTCTGTAGCCTGAGACAGCTGTCTTGTGAGGG ACTGAGATGCAGGATTTCTTCACTCCTCCCCTTTGTGACTTCAAGAGCCTCTGGCATCTCTTTCTGCAAAGGCACC TGAATGTGTCTGCGTCCCTGTTAGCATAATGTGAGGAGGTGGAGAGACAGCCCACCCCCGTGTCCACTGTGACCCC TGTTCCCATGCTGACCTGTGTTTCCTCCCCAGTCATCTTTCCTGTTCCAGAGGGGTGGGGCTGGATGTCTCCATCT CTGTCTCAACTTTATGTGCACTGAGCTGCAACTTCTTACTTCCCTACTGAAAATAAGAATCTGAATATAAATTTGT TTTCTCAAATATTTGCTATGAGAGGTTGATGGATTAATTAAATAAGTCAATTCCTGGAATGTGAGAGAGCAAATAA AGACCTGAGAACTTTCCAGAATCTGCATGTTCGCTGTGCTGAGTCTGTTGCAGGTGGGGTGTGGAGAAGGCTGTGG GGGGCCGAGTGTGGACAGGGCCTGTGCCCAGTTGTTGTTGAGCCCATCATGGGCTCTATGTGGTTAGTCCTCAGCT GGGTCACCTTCACTGCCCCATTGTCCTTGTCCCTTCAGCGGAAACTTGTCCAGTGGGAGCTGTGACCACAGAGGCT CACACATCGCCCAGGGTGGCCCCTGCACACGGGGGTCTCTGTGCATTCTGAGACAAATTTTCAGAGCCATTCACCT CCTGCCCTGCTTCTAGAGCTCCTTTTCTGCTCTGCTCTCCTGCCCTCTCTCCCTGCCCTGGTTCTAGTGATCTTGG TGCTGAATCCAATCCCAACTCCTGAATCTGTAAAGCAGAGTCTAATTTAGACTTACATTTGTCTGTGAAATTGGAC CCATCATCAAGGACTGTTCTTTCCTGAAGGGAGAACCTGATTGTGTGCTGCAGTGTGCTGGGGCAGGGGGTGCGGG GAGGGGGTTGCTGTAGAAAGAGGGATGGGGAGGGATGGCCTGAGGCTATGTTAATAAAGATACTGCCTTCAAAATA GGGAGGTGCTCTACAGTGATCATTCATTCAACTGACCTTTGTCATTGGCCAGACATAGGACAGAATGGTTCTGCAT CTGGGGAACACCACTGAAGTAAAATCAGAAAAATCTCTGGCCTTTTGTAGCATATGTTCCAGTGGGAAGAGGCAGA CGATAGATACACTATAACCAGAGTAAGGAAGGAAAGTGCTAGAAGGTGGTAAGTGCTGTGAGGCAGGTGATCCAGG ATGTGGGCAGTGGGGACAGGGAAGGTGGCTGTTGTGCTGGGTAGTCAGTGTGTGCCTTGTTGCAAAGGTGACTTTT GAGGAAAGATTTGAGAGACATGAGGATGTCTGGGGAAGTTCTTTCCAGGCAGAGGAAGCTCCAGTCCAAATGCACT ATGGCAGGAAGGTGTTTGTGTTCCCAGAAGAGCAAGGAGGCCAGGAGGGCTGGACGGAGAGAAACTGAGGTGAGGT CAGAGGTGCGGCCAGAACAGGTGGGCTTGAGGGGAGTGGGGTTGGATCTGGCCTTTGCTCTGAGTGGGATGGGGAG TTAGAGGACAGTTTTGAGCAGAAGAGAGCCATGATATGACTTCTGTTTTAAAAGGATCTCTCTGACGGCTGTGCTG AGAACAGAATTGAGAGGCAAGGGACGAGGGAGGCAGAAGGGAAAACAGTAGGAATCAAGTGCAGTATTCCAGGCTG GAGATGTCGGTTACCTTGACTGGGGCGTGAGCAGGGGAAATAGTGGGACGTGAGGGGATTCTGGATGCATTTGAAG ATGGACTCACAGCATTTGCCAATGGATTGTATCTGTGATGTGAGAAAGACGAATCAAGGACACCCATAGTTGTAAA ATGAGTGAGTAGAAGGATGGAGCTGCTGTCAGTGGAGATGGGGAGACTCTGGCAGGAGCGTCCTGAAGAGGGGACA TCACAGGCACTCAGTGGAGGAGATGTCTACTAGGAGGGCGGGTGGGGGAGCTGGGTGGAATTTGGACAGACAACTC CAGAGTTTAGGGGAAAGGACTGGGCTGGAGAAATAGATTTAGGAGGTCACACCATATATATGAGACTTAAAACCTC AAGCATGGATGAGGCACAAAGGGAGTGACTGACTATGGAAAAGAATGAGCACAAGGACTGAACCCTGGACCTCCAG TTCTAAGGGGTGTGATCAGATCACACCCAGAGCAGACTGCACAGTTCTGGCCCCATGTCTAGAGGACACTCAGACA AGGAAACCCCATGTGCACCAGGATCATCTGGATGTGGTGCTGAGATCCTGGAAGTCTGGAGTTGAGCAAGAGATTC TGGATTTATGACAAGGCTGGAGCTCATGTTGCTGGTCTCCAGATCACACTTGGAGTAGCAAGAACACCAGGATCCC ACACGTCTGAGCATCAGCCTCACCTCTAGGGCTTGTCATATAAATGATTCCTTGGTCTTGTGCATAATTCTCTGAG ACAAGGGTTCTGGGGAGTGGCCTGTGTATTTTCTAAGTCCCCACCAGCAATCCTATTGCTCAGACAGATTGGGAGC CACTGAGATCAGTGATCAGAGAGTGCCCAGGGTGGGTGGGTGGGGTGGGTTTTCAAACCCTGTTGAAAAGAGGATT TTTCTCACAGAAAGAAAAGGGAGGATGTATATCATCAGTTATGAGAGGTGATATTCTCTGTTGTTCTCTCCACCAT GGGGTAGAGGCCAGGTAGACAATTCAGGATGTGGCTCTCGCACAAAGAACACCTCTGAATGCCGCTCTCTGACACT CGCCCGCAGACTCATTTCTCACTCACTTCTTGGAGAAAACTATGGAAACCAAATTTCTGTAATGTACACATAAAGT TGTATATTGGTATTGGGGGCTAGTTTTATTGTGGGGAAGGCCACAGAACCAGGCTGGAAACTACACATCCAAGAAC AGAATTCACAGCCCACCCTGGATCAGGTCCCTCCTAGGAACAACTGCCCCTGCTGCTGAGCACAGACAGCACTGCT CACACCTCTGACATCCTGGTGCTGGACACTGGACCCTGAGGCTAGGACAGATGTCACTGCTGCACCTGGAAATTGG ACATCACTACTGTCACTCAGCCATCTTTACTAAAATGCTTTCTGCACAGTCCTAGCCTCTCTGTCACCTCATTCTG GCTGAGTCTGGCAGTGATATAGGAGTTAAGAAGAAATTATTTAGACAGGTAGTGAGGGTACGCAAGGCTTTTAATG GAAAGCAGGCTCCAAATTATTTTCTTTTCTAACAAGGAGCAGCCTGTAATATCAAGCTTCAGACATAGACAAGTAA GCTGGAAGTTTGCACGGGTGAATGCCAGCAGCTGTCCAATAGGAATAGGACGCCTGGGACTGGGCATGTTCACTAT GGCGGCTCCATCTTCCCTTCTCTTTGCCAGGCACGTTTATAGTAAGGAGCAGACAACATGTCACCGGCCAAGTGGA AAGCCCATTTGCATAATAGGATGAGGGTGGGGTGAACAGCCTTCCACACGCACTATGTAAATATCACACCTGGTAC AACCAACCTGTGGGCCCTACATAAATCAGACACCATCTCCTCAAGCCTGCCTGTAAAATCCGATGCACTCCATTCC AGGCTGGAATTCCCTTTTGGGTGCCCCTCTCTCTCACAAGAAGGAGCTGTTTCCCTTTGTCTTTCTTTTGCCTATT AAACCCTTTGATCCTAACTCACTCCTCGTGTGTCAGTGTCCTTAATCTTCTTGGCGTGAGATGACGAACACTTAGT ATTTACCTGAGACAATGACACCTCTTCAGCAGGTGGTCATCAGACTGGTGGAGCTTAAAATTCATGTCCATGATCA ACTGCAGGGGTGACTGGAGTGTTGTTGTCCTCTTCCAGGGAGGGAGGTGGTGTCTGTCTCCTCTCAACATTTTACA TGTTGTAAACCAAAAATAAACATCAAAGCCACCCCTTCCCAATCATTTTAATGGACACCCTCAGCCAGGGTGCTCA AAAGTTAACCTGAAAGAGTGGCTCAGGCCACCATGGGAAGCAGGTATTGAACATGTCTTATTATGCCCTCTTCCCT CTTGGAATTCAGGAAAAGTTGACCAGCATTTACCATCAACACAGACCTTCAGTCTGATCAGAAACATTTACAATCT ATTCTCTTTGAAGCCTGGCACCTGGAGGCGTCATCTGTATGAGAATTTTGGACTCCACAACCTTTTATCATAACCC AGACATTCCTTTCTATTGATAATAACAACCAATTGCCAATCAGAAAAATTAAAAATCTACTTATAACCCAGAAGCA CTACCCCGCAACCCTTGCTTGCTTCAAATTGTTCCAACTTTCTGGACCGAACCAATGTATAGCTTAAATGTATTTG ATTGATGTCTCATATCTTCCTTAAATGTGTAAAACCATGTATTTGATTGATGTCTCATATCTTCCTTAAATGTGTA AAACCAACCTGTGCCTCAACCACCTTGAGCACATGTTCTCGGTCTCCTGAGGGCTGTGTCATGGGCTGTGGTCACT CATTTTTGGCTCAGAATAAATCTCTTTAAATATGTTACTGCGTTTGACTCTTTTCATTGACAGTGTGGAATTTTGA TGTAGTAAGCGGGTTCAAGTGCTGGAGTGTGAGGGGTGGGGAAAAGTGACAAATTTTAATTCTTGGAGCAGTGATC CAGGACGAGAACTTTATCTAGTACCCAGTAGGCACGAAGAGTGGCTGAATGAACCAGTGACTAATAAATAACATAT TTCCACCCATTCCCTTGAGGATAGGTTTACATCAAGTTTTTGTCTATCCCAGTTTATAGTCTAGATTATTGGAGTG GCATTCTGTAATGATGAAATGATTATTCAAACCTCTTCCCTCAGCATGACTCTTACTAGGATTAAAACTCCCAGGT TTGTAAGATATCAGAGGTTCTGGTTCCACACGATGTTTTATATTAATATTTATATTTTCTTGTGTGTGGAAATATT TCTGGGGAGAGAATCTCTAACATTTATTAGTTTTTATGTGACACCCTCAAAGGCCTAAAAAATCCTAACTTCTAGA TTAAAGGTAGGACCACTCCACGTCTAGACAATGAACAGCTGGTAGCAACCTGTGTTTAGGGACATGAAACAAATGC TTACATTTGTTTATCTTTTCCTCTGGGACCAAAGAAGGTAGAGGTTTACTTGCTTACTCTTACTATAAGTTTCTCT CTGTGGGATGGTGATGGGGTTTTCTTCCACCCAAATAACTTTCTGATTCTCCAACAGCAGCTGGGAGTCCCACAAT TTGACTCAATTCTGACACTAACTACCTGGAGTTCGCCTCAGACTCTACAGGTTTACCAGCTCAGTCCTACAAGTCT GTCCTCACTTCAGAAGCAAGTCACAAGTATCGGGTCCCAGGTTACCTGCACTTCTGTCTAACATGGCTGCAAAGTC AGGGGTTTCTCACCTCCCAAGGATTGAGAATTCTTAAACTAACTCAAAGAACTCAGGAAGTTGCTATAGCCGTGTA AACCAAAAAACGTCTGAGACAGGTCTCAGTCAGTTTAGAAGTTTATTTTGCCAAGCTGAAGACGCACCTTGGAAAC AGAGACACAAATCATTGTAGCATCTGTGGCCCATGCTCTTTCCTAACAGGCTTTTGAGGACTTCAATATGTACAGG GGAAAGAGCAGCCAGGAGAGGAAAAAAATAGTCAACTATGCATTCATCTCATGCTCAGTAAATCTGCATTTTAAAT AAGATAAAGTAAACATTGGGTGGAAAAGTCAAATATGCGTTTGACTCTGGGTGGGTGGAGGGATGATTTCTAGTCT TGTCTTTGTCCTGTACCTGTGAAGATAAGCTGTTAATTTACATTGTCAGGGGAAAATTCAACAAAACTGTTTTAGG GTAAACACGTTGGGGCCCACAAGGAATTATCTTGTGAGCAGTTTGTGAGGGAGGCCACCTGGGGAGATATGTGGTC TTCTATCTTTGCAGTTATTTGTTTAGGAACGAAAGAAAGGCAGTTTTTCCATCAGTCTCCAAACTTAATTTTTCCT TTTGGTATAGTGAATTTGGAGTCCTGAAATTTTATTTTCTTTTCACACTCAGTATTGCAGTTTTTTATTGTTATAG CTTAAATCCCCACCTTTTTGGCACCTGGGACCGGTTTCATGGAAGACAGTTTTTCCATGGACTAGTGGAGGTGGTG GAGGGCAGAGGGAAATGGTTTCGGATGAAACTGTTGTACCTCAGATGATCAGGCATTAGCGCTTCATAAGGAGCAT GCAACCTAGATCTCTCGCATGCAGAGTTCACAATAGGGTTCGTGCTTCTATGAGAATCTAATTCCGCCACTGATCT GACAGGAGGCGGAACTCTGGTGTCATGCTCATGCTCTCTCACCCACTGATCACCTCCTGCTGTGCAGTCTGGTTCC TACCAGGCCAGGAACCTGTACCAGTCCGCAGCCCGGGGGTTAAGGACCCCTGGTTTAAATTATGCCACTAGAGCAG AACTCCTGAGACTGGATAACTTATAACAAACAGAAATTTGTCTCGTTCATGGTGTCGAGGATGAGAATTCCCAGAT CAAGGGACTCTATCTGGTAGAAAACAAAAGGACAAGAGAGGGTGAGAGGTGGGGGGAAAAGGAAGTCAAACTCACA GCCTCAGGTCCTTTTATCATGAGCCTTAGTCCATGAATGAAGGCAGAGCTCTGATGGTCCAATCACCTCTCAAAAG TCCCATTTCTTAAAAATGTTGCATTTGGGATGAAATATCCAACAGATGCTTTTTTGGGGAAACATTCAAACCATAG CAGTTATAAAGGATACCAAGGAGCAGCCAGATGAAGAGGTGCACAGGGTGAGGCCTGGAAGGGCTCTGAGCACAGG AGCCTCTGTCCCCATGGAGATGGGGCTCACCATCCTCCCAGCATGTGGACACACAGATGTGCTCTCCGAAACCCAA TCTCCAGAGGTTTCTATGGAAATTTCATTGTGGAGGCAAGACTAATTAAATCACTGGTCATTGTGTGACTGAACTC AACCTCGAACCTCTCTTTCCTTCCCAGACTTTAGGGATGGGGTTAACAGTTCCAATCCTCTAATCACAACTTCGTG TTTCTGGCAACCAGCCCCCATCCTGAAGCTATCTAGGAGCCCCTCACCCCATAGTCATCTCATTGCCATATTGAAC TCATGTTTATCACTGAGGAGATTGCAAATGTTTTAGAACCTGGTTGTCAGGAAACAGGGAAAAGACCAAATATTTT TATTGGACCACAGATCACACCCTGGTTTTGACCACATTATCTCTTTTTATAATATTTATTATTTTATTTTAGAGAT AATCTCTTGCTCTGTTGCCCAGGGTAGAATGCAGTGGCACAATCATAGCTCACTCTAACCTCGAATTCCTGGACTC AAGTGATCCTTCTGCCTCAGCCTCCTGAGTAGATAGCATTACAGGTGCACACCAACATGCCCAACTAATTTTTAAA TATTTTGTAGGAATGGGTCTCACTATTCTGCCCAGTCTGGTCTCAAACTCCTGGACTTAAACAATGTTCCTACCAT TGCCTCCCAAACTGATGGAATTATAAGTGTGAGCCACTGTGCCTGGCCAATCACAGATCTCCTACACCAGAAGAAT CATAACAGTGAAAAGATCCTGGCACATTACCAGAATCCTCTTTGGTCATTAACAATGATCCCAGTGCAATCCATAA ACAGGAATAGTTTCAGCAACATATGGCTGCACCCTTTCAGGCGTCTGGTAAAATTGAGCTAAGAGACAATATCATC TCTTGCTTATACCTTTTTCAAGTAGTTCATGTAACATTGGATTTTCCTCATTACATAACCCATTTATTCATTCATT TACCCTCAGCTACTATTTCTCCTTCCCTTCATTTATACTAAACATTTATAATTTTGGAAGGAACACTAGCTTCTGC TGCTGTGCTGGCTGAGACTGCAGGGACCAATAGAGTTCTAGCAAGTGTCTCCCGTCATCCATTCCAGTTCATAGAG GGTAGGGTTATACAGGTAGAGAACTGGTTGGCTATCTGATCCCAGGCAATATAGCTGCATTCAGTGTTAGCCCCAA CTTTGCCAGATGCAGTGAAGGCACAACCTACTTCTACAGGCCCTTAGGAATTATTACATAATGGACATAAAATATA TTTACAGTTTCTTGCTTAGGAATAATTCCTGTTTCTGAACTCTATTTGCATCCCTAGTCCTGGGACCACTGCATCA GGTATGAGAAAAGCAAGTTGAGGTGAATTACAGTCATCATTCCAGTGTCCTCCCACCTTGGGGAGGAATATATGTA GATCATACCAGCACCTTCCCCTGATCCACCAGGAAAAGAGAGGATACTCTCATGTCAAGTGTGAGCACACTCATGA AGGTGTATAAGCCCACCCTTTGTGCTTGTTTCCCCACTCTTTCCTTTACACACCCAATTGACTATTTTAATTCTCT ATGGAACTCTTCCTCTGAGGAGGATATCTCTCTGTGACCATTGTTGGACATTTTGAGCAGGTGCATTTTCTGGTGT AAAGAAATATGACTCGGTGGTCCACGTGGTTGCAGTACCTCCCATTCAAGTTCTTTTGTAACACTCGAGCATTTGC ATCTGAGATAAAGCAGGGACCTCTTTTAGAAGCCTGCCGGGGCCTCCCAATCTGGAAATAAAGAAAAACCTTCAGT TCCTTCAAGAGAAATTCCAGGCACCTAGCCAGCCCTAAAAAGTAAGTCGGTGACCTTATAAGCAAGAAGGAATGAT AGCTTGAAACAATAGCCAAGGAAGTTAGAGTCACAAGATGTTTCATTCTCTATAGAAACTAAAAATAACATCTTAA CATATGTCCCTGAGTTGTTTTTCAGAAACATGGATTCCCTCCTAATAGATCCACTGACAGGGAGACCTTATAAAGG GGAAACTGAGAACTGAACTCTGACCGCCGTTCTTTGTTCTAAATTTCTTCCTGAGGGACCTGGAGAGAGTCAAGCC CACAGGCCAGGCCTGAACATTCCTCTCTACTGCCCCCAACTGTGTAAGGAAGCTGTGTAAAGAAGCTTTGCTTCCT TATCTATCACAAATCAGAGAATCTTTAAATCTACCTAAGACCTGTAAGCTCCCTCATCAGGATATTCTACCTTTTA AGGCCAAAGCAGTGTAACTTGTATGCATTGATTTATGATGTTGCCTGTAACTCTGCTTTCCCGAAATTTGCCCCTG CCTTTAAAAATTCTTGCTTGTGAGCCATCAAAAANGTTGGGTCTTAAGCGTGAGCTGCCTGATTCTCCTTGTTTGG CGCCCTACACATAAATGCCCTCCTTTGTCCCACTACAATCTCAGTGTGGATGTTTGCTTTTACTGCCCCAGGTGAG TGGACCCCAGTTCAGTTTGGTAACACACCTACCACCAGCTGAACAAAGCCCACTCCAGGGTGAGGATCTATTCCTG CCAAGACCCGTTTGCTGCTTCCTGGGGCTACTGGTATCAGTCTAACTTGCCAGCTATGTATTTTCAAGGCCCTCCC ATAAAAGAATCTGCCACATAGCCATATGCTATCTCTCTTTTTTTTTGTTAAAGAAAGGACTTCTTATGTGTATTTT GTGCCTGTGATGTGTGGAATGCAAGAGGACTATGTCTTGATTCCACCTATCTCTGCATTGCTACAGCCCCAATGTC TACTTATTTCATGGACTCAGGTGATCACCACAAGCAAACCTGGATTTTTTGTTGTTGTTGTTTTTGAGATGTGGTC TTGATATGTTTCCCTGGCTGGCCTCAAATGTTGCTCAGGTTAAACTCTAACTCCTGGACTCAAGATATCCTTCTGC CTCAGCCGCTCTCATAGCTGGAATTACAAGTGCACCTGGCAAACACTTGGAGATAAATTCTTGTTGATTTCAATCA CTTTCCAAACCTGAAAGGGAGTTATTCTGAAGGACACTGAACAGCACTGAGGGGACGGTGCTAAACCATTCATGAG AAACTGACCTCGTGATCCAACCACCTCCCTCCCTCCAGGCCCCACCTATAATGCTGGGGATCACATCTCGACATGA GATCTGCACAAGAACAACATCCAATCTATATCAGGCATCAACAGATCTTACATTAATGAACCCCTCAAATTACCAT AGTGATTTCTGTGGGACTTGGCTCATATGGGCATTCTTTTCATAGGCAAGTTTTTCATTGCTTTCCTGATTAATTA TACGGCCAGGCCATTAGTCACTCCCTGTAAGTCAGTAAAAACTAAAACGTAGGAGCTTTATCATTGTTCAATTCTT CCACCACTGCTAAGAAAACACCATGCAATTAAGTCCACAACAGCTTTTCTGTTTTTACCTTCTTTGATCAAAGAGG TGGACTTCCAAACAGTATGTTGTCCATTCATCTTGCAAATGCTGTACACAAACCAACCAGCTGTTAGTGGGTCAGT TGACTGATACTGCAGTTCAAATCCCAGCGCTGTCTGCTACAGAGTTCCATCTTGCTCAAGAGAGGTCAGTGTTTTG TTTAATTTACACCTTCAGTGAATTGAATGAAGCCCACTCACATTATAGACATTAATCTACTTTATTCAAAGTCTGG CTATTTATGTGTTAATCTCATCCAACAAACATCCTCACAAATCATCCAGAATAATGCTTGACCACCTCTCCAGGCA CGATGCTTTACCCAAGATGACCAATAAATTTTTTTTTATTATTATACTTTAAGTTCTAGGGTACATGTGTACAACG TGCAGGTTTGTTACATATGTATACATGTGCCATGTTGGTCTGCTGCACCTGTTAACTCATTATTTACATTAGGTAT TTCTCCTAGTACTATCCCTCCCCACTGCCCCCACCCCACGACAGGCCCCGGTGTGTGATGTTCCCCCCTGTGTCCA AGTGTTCTCATTGTTCAATTCCCACCTATGAGTGAGAACATGCGGTGTTTGGTTTTCTGTCCTTGTGATAGTTTGA ACAATGAGAACACTTGGACACTTGTGATAGTTTGCTCAGAATGATGGTTTCCAGCTTCATCCACGTCCCTGCAAAG GACATGAACTCATCCTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTGACACATTTTCTCCCAGCACCTGTT GTTTCCTGACTTTTTAATGATCGCCATTCTTACTGGTGTGAGATGGGATACCATTGTGGTTTTGATTTGCATTTCT CTGATGGCCAGTGATGATGAGCATTTTTTCATGTGTCTGTTGGCTGCATAAATGTCTTCTTTGGAGAAGTGTCTGT TCATATCCTTTGCCCACTTTTTGATGGGGTTGTTTGATTTTTTCTTGTAAATTTGTTTGAGTTCCTTGTAGATTCT GGATATTAGCCCTTTGTTAGATGGGTAGATTGTAAATATTTTCTCCCATTTTGTAGGTTGCCTGTTCACTGTGATG GTAGTTTCTTTTGCAGTGCAGAAGCTCTTTAGTTTAATTAGATCCCATTTGTCAATTTTGGTTTTTGATGCCATTG CTTTTGGTGTTTTAGTCATGAAGTCCTTGCCCATGCCTATGGCCTGAAAGGTATTGCCTAGGTTTTCTTCTAGGGT TTTTATGGTTTTAGGGATGATCAGTAAAATTAATTATGACATTCTTCAATATAAGAATACTCTGAGGAAATTAGCC TGTGATCTAATAAAACAAGGAGCAAACAACTGTTTCTAAAAATTTATAACAAATAGTCAAAAAGCCCTCGCTAGAG ATTGTTTCTCACATTCACTCTATAATTCTGGGTAAAAAAAAAAGCACGTATTTGTTGAAAACCACAGAAGAAGAGA AAATTGAAAAAGCAGAAAGTGAAAAAAATAAGAATAATAATAAAGATGACAGCAGTTATTTCATTGGAAACAATGC AAATGAGGAGACAGATGAGCAACATCTTTAGAGTCCTAAAAGGAAAATGCTGTGAAACTAGATTCTATTCCCAGAA AATAATACCTTTTTCAAATATATATGTATAGTTTTAATTGACAAAGTATAATACATTCATGAGATATTGTTTGATG TATTGATATATGTGTACCCTATGTAATGATTAAATTAAGCTAACACACCTTGAATATATCTATCAAAAAATAAAGG GATTTTAGGCCAGGCATGGTGGCTCATGTCTGTCATCCCAACACTTTGGGAGGCCAAGGTAGGTAGATCACGAAGT CAGGAGTCAAAACCAGCCTGACCAACATGGTGAAACCTCGTCTCTACTAAAAATACAAAAATTAGCTAGGCATGGT GGCATGCTCCTGTAATTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACATGGGAGGCGGAGGTTGC AGTAGGCCAATATCACACCATTGCACTCCAGCCTGGGCAGTAGAGTGAGACTCTGTCTCAAAAATAAACAAACAAA CAAACAAACAAACAAACAAATGGATTTTAGACATACAGGGAGTGAAAAAATAACCAGCAGACCTAAACTATAATAA ATGTTTCAGTCCTATAGGCAAAAAGAAAATTAAGGGACTAGTTGGCACAGCATTTAACGATGAAGAGACAGCTTCA TCGCCCCCTCCCACTGAGACAGAGAACACAGCCCCAGGGCCTGGGAATTCCTCAACCCAATCCACCACCTTGGGCA CCTGTGCACTCCTCCTGGGTACCTGAGGTTGGATGCAATCACCTTAGCTATCACCTACCTGCAAACACCACCTATG GGCATCCCACCCAGCCTATCGCATCTGCTGCTAACAATGCACACTGCTTGGGACCCAGAGAAGCAGCCCACGACTG CCACTGCCAAGCTGGTTGCCCAGGAGCTGAAGTCCCCAGCACCTACCGAGTCAACCACTGCCACTACTGCCATCCA AGCAAGCCACCTGGAGGTCCAGGAATCAGCCCACCAGTAACCACCAATACAAATGCCAGTATATACCACCTTGGGG CACAAAGATAGGAACACTCAGCACACCACTGCCACCACTGGAGCCTGAAGACTGTCTCATGTGGCATCCCAGTCCC CAGCACATTTTCACCACAGCCTCACTAATAACCACACCCTAATGCACAGAAGAAATCACAGATACCATTAACACTG TCTACAGCCAAAGAAATTATACAGAGACCATAGTACTCTACTATGTACTACACCCAGAATCAAATCCAAAGTACCC CAGGCAACCAACACCATAGACTCATCTTCAGGAAAATGCTCTCCACTATGAAACAAAATTCAAAAATAGGAAGAAC TGACTGTTATATCAGATGCAAAAATATTAATGTTAGGACACAGAAACATGAAAAAGCAAAAAAGAAAAAAAAAGCC GCAAAGGAAGACAATAGATCTTAATCAAAAAGAAATTTTCAAGATTCTAGATAAAGGACTCAAAACATTTATTTTA CAGAAGTTCAGTGAGATACAAAAGAATTCTGAAAAAAAAAATACAAAGAAAACATAAAAATAATTCAGGATACAAA TAAGAAGTTTACAAAAGATATAGATTTAAAAAAAAACAACAGAAATTCTGGAATTAAAGAATACATGACATGAAAT TCCAAATACATTTGAAAGCTTCAACAATATACTAGGTCAGGCAGAAGGAAGAATTCCAAAACTTGAAGATATACAT TGTGAAATAATTCAATAAGACAAAAACACACACAAAAAAAGAATGAGCAAAGCCTTTGTGACATTTGGTACAATAT AAACAACCAAATATTCAAATTATTGGTATCCTCAAGAGCGAAGAGACAAAGAACAGATTAGAAAACCTATTTAATG AAAGAATAGATGAATAATTCCCAACTCTAGCAAGTGATTTAGACATTCAGATACAAAATATTCAACAATTCTGAGA AAAATACAATGCAAAAAGTTCCTCTCCATGGCATATAATCAGACTTTCTATAGTATAAGGTAAAATGCAAATCCTA AAAATAGCAAGAGGAAAGTGTTTAGTCACCTATAAAGGAAACCCCATCAGACTAACAGCAGATTTCTTTTTCTTTT TTCTTTCTTTTTTTTTTTTTTGAGACGGAGTCTCGCTGTGCTGCCAGGCTGGAGTGCAGTGGCGTGATCTCGGTTC ACTGCAACCTCTGCCCCCTGGGTTCAGGTGATTCTCCTCCCTCAGCCTCCCAAGTAGCTGGGATGACAGGCACATG CCACCACACACAGCTAATTTTTTTTTTTTTGTATTTTTAGTAGAGACAGGATTTCACCAAGTTGGCCAGGATGGTC TCAATCTCTTGACATCATGATCCGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCC AGCTCTAACAGCAGATTTCTTNGCAGAAATCTTACAGGCCAGAAGAGAATAGGATAGCATAATCAAAGTCCTGAAA GAAAAGAACTGCCAAGCCAAGAGTAATAAACCAAACATAAATTATTCTTCATAATTGAAAAAGAAATTATCTTTCC AAGACAAGCAAATGCTGAAAGGCTTCATTACCACTAGACAGGGCCTACAGGAAATGCTCAAGAAAGTCCTAAACCT GGAATTGAAAGGACAACATTTTCAACATTTCCACATTATCACCATGAGAACATACACAAGTATAAAACTCACTGGT AAAGCAATCACACAAAAGAGGAAGAGAAAGTTCTCAGATGGTCCTACTACAGAAATCCACCAAAGCATAATGACAA GCAATAAGAGAAAAAGACAATAACAAAAGACATATAAAACAACCAGAGAACAACAATGTGAAAGGAACAAAGCTGT TGGGAACAGGACCCCAAAAATCTGGCCATAAACTGGCCCCAAAACTGGCCATAAACAAAATCTCTGCAGCACTGTG ACATGTTAATGATGGCCATGACGCCCACACTGGAAGGTTGTGGGTTTACCAGAATGAGGGCAAGGAACACCTGGCC CACTCAGGGCAGAAAACTGCTTCAAGTTGTTCTTCAACCACCAACAATAGCATGAGCGATCTGTGCCTTAAAGACA TGCTCCTGCTGCAGATAACTAGCCAAACCTATCCTTTTATTTTGGCCCATCCCTTTGTTTCCCATAAGGAATACTT TTAGTTAATCTATAATCTATAGAAACAATGCTTATCACTGGCTTGAGTTAATAAATACGGGGGTAAATCTCTATTC GAGGCTGTCAGCTCTGAAGGCTGGGAGACCCCTGATTTCCCACTTCACACCTGTATATTTCTGTGTGTGTGTCTTT AATTTCTCTAGCGCCGCTGGGTTAGGGTCTCCCCAGCTGAGTTGGTCTCAGCACAAAGCCTCACATATTAATAAAA ATCTGGAATGTAAACAGATTAAATTCTCCACTTATAAGATGTAGAATGGCTGAATGGGTAGAAAACATGATCTAAC TACATTCTGCTTACAAAAAAACTCACTGGTAATACCACCTCACCACAATCATAGAGACAGAAGGTAAAAGAATGGC AACAGGTTATCTATCGAAACCAAAAGTGAGCAGGAGTAGCTATACTTATAGCAGATAAAATAAACTGTAAGTCAAG AACAATTTTTTTAAAAGATAAGGAAGGCCATCACATAATCATAAAGAGATCCATCCAAGAAGAGAATAGAACAATT CTAAATATATATGCACTAAACATTGGAGCANCTAGATTCATAAAACAAATATTACTACATCTAACAAGAGAGATAG ACTCCAATACAATAATAGTGGGGGACTTCAACATCCCAACCTCAGCATAAGACAGATCACCTACACAGAAAATCAA GAAAGAAACATTGGATTTAAACTGAATTTTACACCAAATAAAGCTAACAGATATTTACAGAGCATTCTGTCTAACA CTACAGAATATACACTCTTTTCATGAACACATGGAACATTTTCCAGGAGAGAGCCTATGTTAAGCCACAAAACAAG TCTCAACAAATTTTCAAAAATTGAAATCATATTAAATATCTTCTCTGGCCACAATGGAATAAAACTAGAAATATAC ACCAAGAGAAATGTTGGCAACAAGACCAATACATGGAAATTAAACAACCTGCTCCTGAATAACCATTGAGTCAACA GAGAAATTAAGATGTAAATCAAAAAGTTTCTTGAAATAAATGAAAATGGAAACACAACATACCAAAACCTGTGCGA TACAGCTAAACAGGGCTAAAAGGGAGGTTTATAGCAATAAATACCCACCTAAGAAAAGTAGAAACATTACAAATTA ACAATATAACAATGAACCTCATGGAACCAGAAAAGCAAGAAAAAAAATATACAAAATTAGCAGAAAAGAAATAATA AAGATCATAGTAGAAATAAAGACTTTTAAAAACCATGTAAATGATCAACAAAGTGAAAAGTTTGTTCTTCAAAAAC ATAAACAAAATTGATAAACCACTAGCTAAACAAACCCAGAAAAAAAGAGAGAAAATTTATTAAGAATAAAAGTTCC TCTTCAAAGTTTTCCTTTTTGGTTTAGAATGATAAGTCTTAAGAAGATAGTTCCTCTTAAAAGCTTCCTTTAAGTT TCCCTCGCTCTTCATACTAACAAATCTTCTATTTTACTAATGACTCTTTATTGTGCCCCAAAGGAGTTGTTACATA CAGTAAANAAATAAACACATTCTATGTTCTTGTACTTGAACCAAGGCCTAACTCCTTTGTTCCCTAGTCTGCCTGG ATCTGCCTGGACACGCCCAGACATGTCACAGCTTGCAGCCTATGCTCTTTCCTTATTTGGAAATATTATTGTCTTC CTGGTTTCCCATAAGCGACCCCCTCCTTTCCTTGGTTCCCCATTGCGCCTTTACCTTATTTGGGAAAGTTTAAGTT TTTAGCCAACTGGGATCAGTTTAGATTGTGTGGTCCAGTTCCAGCCAATGGAGACAGGACACAATAGTAGAAACAA ATTGCGTTAGGAATAAAAACCCCTGCTTTCCTTTGTTCTGGTTGCTCTCGTGGCAATCAGGCTTACAGGTAGCAGC CTTCTGCAGAAGTAAAAATTGCCTTGCTGAGAAATCCTTTGATCAAGTGTTCATTTCCTTTGTGACTCCAAGCTTT ATTTCTAACTATTTTATGGGGGCTCTTCCAGGATTCCCATTCTCCTATGGGAAGGGGTCTTTGGTCACCCCATCTA GGGGAGGTGTACCCCACTGCAGTGGCCCCAGGGACGGGAGATTGAGACTACCCATTGTGATGAATAAATTCAGGCT CTCAGCAATGTGGAAGGAGAAGGCCCACAAGTACCACGATGACCAGCTAACTGTGCAGAGACCAAGGTAAAAAAAG TCACAAGGGCAACAGTATTTCCTTGGTGGTCGGGATATTCTGGAGGTTAAAGGGTGTGAAAGGTAACAAGCACTAC TGCTGTGCAGAGTGAGTGAGTTCAATCTGTGGTTCCGTGGTCACCTCATGTGGCTTATGATGGCCCTCTTGTAGGG ATCCTGACATTGGGGTTCATACAGTCCTGCTGATGCTAAGGGGAGCCTAATTTCCTCTGGGAAAGCAGCCAGAGTG GATGAAGCAAAAGGAGAAGATTGCAAGAAACCTCCAGGGTGGGGGTTAAACCTCCAGGGAAGGATAGGCAAGAAAT CTCTAGTTCGAGGGACTGAGCCTAACCAGTATTCAACATGGGAAATACCCTGAGTAAGACAGAAGGTAAAAAGGAA AAGGCAAACAGTGAAATCACCTCTGATAGTCCTTTAGGACTCATGTTAAAATATTGGAAGGATACAAGAGGACTAA ACATAAGAAAAAGCAACAGATGATAAAGTATTATTGTTTCATTTGGACCAAGGAACCTATTCTAAAGCCTTCAGTT TTCTGGCCAAAATTCGGGTCAAATGAGGCTTGGACTTGCCAACTTTTAATAGAATGTGTAAATGATAAGAGTCCTG TTTCCCAGGAGGAAATACATTATGCTCTGTGTTGGCAGCAAGGGCCCATCCTCCTTTGTCATCTAAAAACCAAAGG AGACAAGCCAGAAACTACTTCTCATGAAATTAATACCCCTTACTCCAAGAACCCCACCAACACGTGGGACGCCTTA GACCATCTTCCCCCAACAAAACTTCTTCCCCCCACCCAGTAGACCAACATCCCCCACCTCCCCCTTCAGTAGAAAT AACAGTCCCAGACCTTTCCCCTACTCAGACATTTTTTCCCTCCTTTTAACCCTGATTCTTGGGGTCATCCCCAGCT TGAATGCCCTCCCTCAGGAAGACTTCAACGTGAGTTAGAACAATGTAAAAATGATATCCAAAACTTCCCTTTTCCC CCTTCCTCTAGGGGTTTGGCTACAAACCTCTTCCCACTGAGGGAAGTGCCTCTAGGAGGAGCAGGCATTGGCTTTT TAAATGCTCCCCTGACCAGTTCGGAAGTCCAGAGCTTGAAGAGGGAACTCAAGCCACTCTTAGATGATCCCTATGG AGTGGCAGATCAAATTGATCAATTTTTAGCACCCCAGTTGTATACTGTGGCTGAGTTTATGTCCATCATAGGCATC CTTTTTTCAGGGGAAGAAAGGAGCATGATGCATAGGGCCGCTATGACCATTTGGGAGTGTGAGCATCCTCCCGGTC AAAACGTCCCTGCAGCCAAACAGAAATTTCCTGCTCAAGATCCCCAGTGGGATAACAACAACATAGCTCATAGGAG GAATATGAGAGACCTGCAAGAAATGATAATAAAAGGAATTAGATAATCAGTACCCTGCACCCAGAATATGACCAAA GCTTTTAATATACAGCAAGGAAAAGAAGAGGGGCCTATGGAATATTTTAATAGGCTTAAGGAACAAATGAGGAAAT ATGCTGGTTTAGATGGAGGAGACCCACTTGGACAAGGAATGTTAAAAGCTTCACTTTGTCACAAATAGCTGGCCAG ACGTTACCAAGAAATTACAAAAGATAGAAAATTGAAAGGACTGTCCCATAAAGGAACTCTTAAGGGAGGCCCAAAA GGTGTATGTACGAAGGGATGAAGAAAAGCAAAAGCACAAGGCAAAGATTATGCTGTTCTTAAAGCAGGGAACTCCC CAATAGACAGCTCAAAGAAATATCGCCGGTAAATCTTTTAGGTACCCGACTGCCAGACTCTATAATGGAGGTAAAG GAATCAAACCAGGGAACAAGGGAATAAAAAGAGGAATAGGGCAGAATAAATGCTTCAAATGTGGGAAGGAAGGTCA CTTTAAAGAGAATGCCCTGAATGGAAAAAAGAAAAAGAAATCACCCACTTATGATCTTTGAGGAGGAATGGGGGGC CAGGGGCTCTACTCTTTTTACCTCGAGTCCCACCAAGACTCCTTGATAAATTTAGAGGTGGGACCCAGACCTTTTT AATTGACTCAGGAGCTGCTGATTCCTCAGTTTGTTATCTTCCCCCTGGTGTAACTTGGTCACAAGAAGAACTTTTT ATTTTGGGAGCAAAAGGGGAGGGGTTTAAAGCAAAAGTCTTAGAAGAAACAAAAATTAAATATCAGAACCACTCAG TAAATATTAAACTTCTGTTAATCCTGGAGGCAGGAACAAACCTATTAGGAAGAGATTTAATGCTAAAATTAAACCT AGGCCTTTGTGTTAATCAAGGAAATCTCCTCCCCTCCTTAAATTTGCTTGCTACTCTAAATGAGGGATACATCCAT CCAGATGTATGGTCAAAGGAAGGAAACTGAGGAAAGTTACAAATTTCCCCAATCCAAGTTAAATTGAAAAACCTGG GGCAAGAGGTAAAAAGAAAACAATATCCAATTCCCTTAGAAGCTAAGATCAATTTAAAGCCCACAATAGAAAGCCT TCTCCATGGTGGACTCATTGAACCCTGTATGTCTCCTTATAACACTCCCATACTGCCTGTGAAAAAGCCAGAGGGG TCATATCGGCTAGTGCAAGATCTTCGATCTATTAATCAAATAGTTCAAACAACTCACTCTGTCGATCCTAATCCTT ATGCTATTATTAGTAAAATTCCTTACAACCATGAGTGGTTCACAGTAATAGATCTAAAGGATGCCTTCTGGGCTTG CCCACTAGCAAAGATAGACTTTGAATGGGAGGACCCTCACTCTGGTTGAAAATAACAGTATCGATGGACAGTTTTG CCCCAGGGATTTACAGAATCTCCAAATTTGTTTGGTCAAATACTAGAACAGATCATAGAAAAGTTTTACAAACCAC CATATATATGCCTGCTCCAATACATGGATAATATCCTTATTTCAGGGGAGGATAGACAAAAAGTAGAAGGATTTTC AATAGGTTTTTTAAAAATAATTTGCAACTGGAGGGGTTATGAGTGTCAAAAAAGCAAACTTCGGTTTGTAGAACCT GAAGTCAAGTATTTAGGGGACTTAATCAGTAAGGGCAAATGGAGAATTGGATTTGAATGGATTGAAGGCATCATAT CCTTCATATGATATCCTGAGACAAAGAAGGAACTTAGAAAGTTTTTAGGGTTAGTAGGGTATTGTTGCTTATAGAG AGACTCTTATGCTTTAGTAACCAAACCTCTACATAAAAAAAACTTACACAGGATGAATTGGACCCCCTTATATGGT TTTACAAGAAATACAGCAGATAAAAAAATTAAAAGAGTTACTAGTGACAGCCCATGTTCTAGCCTTACCCTCTTTA GAATTGCCCTTTCATCTTTTTGTTAATGTAGGTAATGAAGTAGCCTTAGGGGTACTTACTCAAACACACGGAGGCC ATTGGCAACCCATAGCCTTCTTGTCAAAAATTCTTCACCCAGTAGCCCATGGATGGCCCGAGTGTGTCCCATCAGT GGCAGCAACAGCCTTGCTCATAGAGGAGAGCAGAAAATTAACCTTTGGGGAAATCTTATCATTAGTACTCCTCAAC AAGTGAGAACAATTCTCAATCAGAAGGCAGGAAGGTGGCTTATTGATTCAAGAATTTTAAAGTATGAAGCCATCTT GTTAGAAAGAGATGATCTAATCTTAACCACTGATGACTCAATTAATCCAGCTGCTTTCTTAACAGGAAACCCCAAC CCACAGACCCCTGATCTTTGCCCAGAGCACAGATGTTTAGATTTAATTAGTTATCAAACAGAAGTTAGACCTGATC TAAATGAAACACCCTTTCATACTGGGAAACACCTGTTTGTAGATGGTTCCTCCCGAGTAATCAAAGGAAAAAGGCA TAACGAGTATTCAACGATAGATGGAGATACCCTCACAGAAATAGAGTCTGAAAGGTTACCAAATGACTGGTCTGCA CAAACATGTGAGTTGTTCACATTAAATCAGGCCTTAAAATTTCTGCAAATCAAGAAGCAACAATCTATACAGACTC CAGGTATGCCTTTGGAGTAGTCCATACTTTTGAAAAAATTTGGACTGAGCGGGGCCTCATTAACAGCAAAGGTCAA ATTTTAGACCATAGGGACCTAATAATACAAGTACTAGAAAATTTACAATTGCCAAAAGAAATAGCTGTTGTACATG TCCCACGACATCAAAGGAATCCTTTATTTGAAGGCCAGGGAAATAATCTCACTGACCAAATAGCCAAGCAAGCTGC CTCTTCTCCAGCAGAACCCATTTTTCGACTAACCCCTTGTCTTCCATCTTCAGCTGCACTCCCTATCTTCTCTCAA GCAGATCAGGAAAAACTGAAAAAAATAGGAGCTGAAGAAAACTCAAAAGGAAAGTGGGTATTACCAGATGGAAGGG AAATGTTACCCAAACTTTATGAGGGAAATATTGTCACAGCTTCATCAAGGATGTCACTGGGGTCCTCAAACCATGT GTGATGCAGTCCTTAGGGTTTATGGGTGCATAAGAATATACACCCTCGCCAAGCAAATGGTGGAAAGTTATATACT GTGCAGAAAATCTAATAAGCAGACCCTCAAAAGACAACCTCCCGGAGGGAGAAATCCTGGGTTAAGGCGATTTCAA AGTGTCCAAGTTGACTCTACTGAAATGCCCCCAGTAGGCCGCCTTAAGTATTTACCGGTAATAGTAGATCATCTTA CCCACTGGGTAGAAGCCATCCCCTTTCCAAGTTCAACAGCCAGTAATGTGGTCAAAGCTCTGTTAGAACATATCAT ACCCAGGTTTGGAATAATAGAGAACATTGATTCAGATAATGGGACCCAATTTACCGTGTACATTATTAAAAGACTA ATCCAAGTATTAGGGATAAAATGGGAATATCATACTTCCTGGCCTCCACCTTCATCTGGGAGAGTAGAAAGAATGA ATCAAACTTTAAAGAGTCATCTAACCAAATTAATTTTAGAAACTCGCCTACCATGGACAAAATCTCTTCCCATTGC TTTACTAAGAATCCAAACTTCTCCTCGGAGGGATCTTGGCTTGTCTCCTTATGAAATGCTTTATGGGTTACCTTAT CTAAACACTACTACTGACCTTCCTATGATCGAAACAAAAGATCAGTTCCTTAGAAATTATGTATTTGGTCTGTCTT CCACTCTTTCGTCCCTCAGGACTCAAGGTCTGGTAGCACAGACTCCACCCCTTGAATTCTGGGCCCACCAACATCA ACCCGGAGATCACACGTCCTTATCAAAGGCTGAAAAGAGGGAAAGCTTGAGCCTACCTGGGAAGGACCCTATCTGG TGCTCACAACAACTGAAACAGTAGTTCGGACCACTGAGAAAGGGTGGACCCATTATACTCGAGTCAAGTAGGCGTC ACCTTCTCCAGAGACATGGACCATTATTCCGTCAACTCCCACCAGAGTAACGATAAAAAGAAAAACTTAATCTATC TCTTTTTCTTCTTTTCTTTCCCTTAACTGCCCCCATCTCATCATTAATGTAACTAGATCAAGTTTGCCCAAAATTA TTACCTTTGATGCTTCTCTAGTCATGCCTTGTGGAAATTTACAGGACCAAAGACAGCTTACTGCCTCAGATAAATA TCTTTGTCCCTCTTGAACTTCCTCAGATTGGAAAGATATAACAAATTCTTGTAAAGATCATGATAACCCCAAAAAT AGTAGCTGTATGAACTGGTGGGAATGGGACTCTTGTCCCCTTAAAACAGAGTCCCTATGCTATACTTGGTCTAATG TCCTATGGAACACCAAAGGTCCAGGCTGGACTGCTCCCACCAGTCTTTGCCAGTCCTTAAAGCCATATATCCATTT TACAAAAGGGATTGCCTCTTCTAATTGTCCATATAACCAGTGTAATCCTATTCGGCTTACTATTACTATTGCAACA TCCCAAAACTCTTTCCCTTCATTAAGTCATATTTATAGCATAGGGGCCAACATCTTGGGAAAGGATCCTAGGGGAA TTTTTGAAATCTGCTTTATTGCCCCTTCCACCTCTCTAACACATCTTCCTCAAACCATCACCCCACCTATACCCAG TGACAAAACCAAAGTAGCTATAGTAGAAGTAAAAGACCTGAGGTAAACTCTAGCCACTGAAACAGGGTCTCAGGAT GCAAATGCCTGGCTGGAATGGATTAAATATTCCATCCACACTCAAAATAAGAGCGATTGTTATGCTTGGGCACAGG GCAGACCAGAGGCCCAAACTGTCCCCTTTCCACTCAGATGGTCTTGTAATAGACCAGATATGGACTGCATGGTAGC TCTGCTCCAAGACCTCACAGCCTGGGGTAATAAATCGTGTCAAAGACTTTCTTTGCTGTTCCCTGAGATCAGCCCC CAAAGGCCATTCAGCCTCCATCTTCTGGGACCAAATTTGCTTTGTGTCTCTCACAACAGGGAGAAAACTTGGCTTT CCTTGGAAACCTGACAGGATGCAGTGAGGTCAAGCACTTCCAAGAGCTAACCCATCAGTCCTCCCTTATCCATCCC CGAGCAGATGTATGGTGGTATTGTGGTGGACCTTTGTGGGAGACTCTGCCAAATAACTGGAGTGGTACTTGCACTC TAATTCAATTGGCTATCTCTTTCACCCTGACATTTCATTCACAAAAATATTAACAACTAGGCATCGTAGTACAAGA ACTGTTCCTGTGAGTCTTTTGATCCCAACGTTTATATAGATGCTATTGGAGTACCAGATGAATTTAAAGCTTGAAA CCAAATAGCTGCAGAATTTAAGTCATTATTCAGGTGGGTGACTATCAATAAAAATATAGATTGGATAGCCAGGCGC AGTGGCTCACGTCTGTAATCGCAGCACTTTGGGAGGCCAAGGCGGGCAGATCACGAGGTCAGGAGTTTGAGACCAG CCTGACCAACATAGTGAAACCCTGTTTCTACTAAAAATACAAAAATTAGCTGAGTGTGGTGGCACGCACCTGTAAT CCCAGCTACTCAGGAGAGTCACTTCAACCTGGGAGTTGGAGGTTGCAGTGAGCCGAGATCACACCACTGCACTCCA GCCTGGGCGACAGACTGAGACTCCATCTCGAAAAAAAAAATGTAGGTTGGGTAAATTATATTTACTACAATCAGCA ATGATTCATTAATTGCACAAGGGATGCTATGAGGGAATAGCTGAGCAACTAGGACCCACCAGTCAGATGACTTGGG AAAATAGAACAGCACTAGACATGATACTAGCAGAAAAAGGCAAGGTTTGTGTTATGATTGGAACTCAATGTTGTAC TTTTATCCTTAATAATACTGCCCCTGATCGAACTATAATAAAAGCACTACAAGGTCTTACTGCTTCATCAAATGAA CTAGCTAAAAACTCTGGAATAAATGATCCTTTCACTAGCTTAATGGAAAGGTGGTTTGCTAAGTGGAAAGGACTCA TGTCCTCAATTCTCACCTCACTGGCTCTCATAATCAGTGTACTTATCCTTGTAGAATGTTGTATTATATCTTGCAT TCATGGATTAGTGCAAAGGCTTATAGAAAAGGCTCTTACCAAAACCCCTTTCAATTCTCCTCACCCTTACTCAGAT AAGTTGTTCTTTCTAACTGATTAAGAAGAGCAACAAAATCAAGATATGTTAAGGAGATTTGAAGAGGAAGAACTGT AAAATCAAGAGGGGGAAACTGTAAAGAATAAAAGTACCTCTCCAAAGTTTTCCTTTTTGGTTAAGAATGATAAGTG TTAAGAAGATAGTTCCTCTTAAAATCTTTCTTTAAGTTTCCCTTACTCTTCATACTAACAAATCTTCTAATTTACT AATGATTCTTTATTGTGCTCCAAGTAGTTGTTACATACAGTAAAGAAATAAACACATTCTATGTTCTTGTACTTGA ACCAAGGCCTAACTCCTAGTCTGCCTGGATCTGACCAGACATGCCCAGACATGTCCCAGCTTGCAGCCTATGCTCT TGCCTTATTTGGAAATCTTATTGTCTTCCTGGTTTCCCATAAGTGACCCCCTCCTTTCCTTTGTTCCCCATTGCAC CTTTACCTTATTTAGGAAAGTTAAAGTTTTTAGCCAACCGGGATCAGTTTAGACTGTGCGGTCCAGCTCCAGCCAA TGGACACAGGACACAATAGTAGAAACAACTTGCGTTAGGAATAAAAACCCCTGCTTTCCCTTGTTCTGGGTGCTCT CGTGGCAATCAGGCTTACAGGTAGCACCCTTCTGCAGAAGTAAAAATTGCCTTGCTGAGAAATACTTTGTTCAAGT GCTCATTTTCTTTGTGACTTCGAGCTTTATTTCTAACAGACTCAAACAAAATCAGAAAAGAAAAGAGAAACATTAC AACTGATATTGCAAAAGTACAAAAGACCATCAGAGACTATTATGAACAATTGTGTACTGACAAACTGGAAAACCTG GAGGAAATGGATAAATTCCTGGAAACAAACAACCTGCCAAGATTACATTAGGAAGAATAGAAAACCTGAAGCCCTA ACATACATGAACCATTCTCACAGTGGTCCCAGTGGGCCCCTGACCTCTCTGTGATTATTTCCTCAGTGCTTGTTTG CATAATTGAAATAGACCTACTCAGCAACAGCCAAAATCCACAGATCAGTTCCTTTTTTTAACTTTTATTTTCAGTT CAGGGGTACAAGTGCAGGCTGTTTTACAGGTAAACTTGTGTTGTGGGAGTTTGGTACACAGATTATTTAATCACCC AGGTTTTAAGCCTATTACCCATTAGTTATTTTCCCTGATCCTCTTCTTCCTCCCACCCTCCACCTTCTGAAAGGCC CCAGTGCCCAGTGTGTGCTATTCCCCTCTATGTCTCTATGCATTCTCATCATTTAGCTCCCACATATAAGTGAGAA CATGCAGTATTTGGTTTTCTGTTTCTGCATTAGTTTGCTAAGGATAATGGCTTCCAGCTCCACCCATGTCCCTGCA AAGGACATGATCACATTCCTTTTTCTGGCTGCATAGTGTTCCATGGTATACATGTATCACGTTTTCTTTATCCAGT CTATAATTGGTGGGCATTTAAGTTGATTCCATGTCTTTGCTATTGTGAATAGTGCTGCAATGAACATATGTGTGCC TATGTCTTTATAATAGAATAATTTATATTCCTTTGGGTAGAATGGTATTTCTCTCTTTAGGTCTTCAAGAAATCAC CACACTGTCTTCCACAATGGCTGACCTAATTTGCACTTCCACCAAGAGTATATAAGTATTCCTTTTTCTCCACAAC TTTGCCAGCATCTGTTATTTTTTGACTTTTTAATAATAGCCATTCTGACTGGTGTGAAATGGCATCTCACTGTGGT TTAGATTTGCATTTCTCTAATCATCAGTGATGTTGAGCATTTTTTCATGTTTGTTGGCTGCATGTATGCCTTCTTT TGAGAAGTGTCTGTTTATATGCTTTGCCCACTTTTTAATGGGGTTGTTTTGTTTTTTCTTGTAAATTTGTTTAAAT TCCTTATAGATATTAGACTTTTGTCAGATGCATAGTTTGCAAAAAATTTTCCCCCATTCTGTAGGTTGTTTACTCT GTCGATAGTTTCTTTTGCTGTGCAGAGCTCTTTAGTCGAATTAGATCCCATTTGACAATTTTTGCTTGTGTTGCAC TTGCTTTTGGCATCTTTGTCATGAAATCGTTGCCCATACCTATGTCCTAAATGGTATTGCCTAGGTTCTGTTACGG TTTTTACAGTTTTGGATCTTACATTTAAGTCTTTAATCCATTTTGAGGTGATTTTGGTATATGGTGTAAGAAAGGG GTTCCATTTTAATCTTCTGCATATGGCTAGCCAGTTATCCCAGCACAATTTATGAATAGGGAATCCTTTCCCCATT GCTTGTTTTTGTCAGGTTTGTCAATGATCATAGTTTGTGTGGTCTTATTTCTGGGTTCTCTATTCTGTTCCATTGG TCTATATGTCTATTTTTGTACCAGTACCATGCTGTTTCGGTTACTGTAGCCTTGAAGTATAGTTGAAATCAGGTAG CATACACTGGACGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCAGAGGCAGGTGGATCATGAGGTCAG GAGTTCGAGACCAGTCTGGTCAACAAGGTGAAACCTTGTCTCTACTAAAGATACAAAAAATTAGCTGAGCGTGGTG GCATGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGAAAAGGAGAATCACTTGAACCCAGGAGGCAGAGGTTGCA GTGAGCCAGGATTACACAATTGCACCCCAGCCTGGATGACAGGGTGAGACTCCATCTCAAAAAAAAAAAAAAAAAA TCAGGTAGTGTAATGCCTCCAGCTTTGTTCCTTTTGTTTAGGATTGCCTTGGCTATTCAGGCTCTTTTTTGGTTCC AGGTGAATTTTAAAATAGTTTTTTCTAGTTCTGTGAAGAATGTCAGTGGTAGTGGCCGGGCACGGTGGCTCACGCC TGTAATCCCAGCACTTTGGGAGGCTGAGGCAGTGGATCATGAGGTCAGGAGATGGAGACCATCCTGGCTAACGGGG TGAAACCCCATCTTTACTAAAAGTACAAAAACTTAGCCCAGCATGGTGGCGGGTACCTATAGTCCCAGCTACTCGG GAGGCTGAGGTAGGAGAATAAAAAAAACCTCCTGAATTCGTTGATCTTTTGAGTGGTTTTTCATGTCTCTGTCTCC TTCAGGAGACAATACCTTTGTTAATTTTTTATTATTACGTCTTGTCTTCTGCTAGCTTAGGGATATGTTTGCTCTT TGTTCTCAAGTTCTTTTGGTTGTGATTTTAGGTTGTTAACTTGAAATCTTTCTAACTTTTTGATGTGGGCATTTAA TGCTATAAATTTCTCTCTTAACACTGCCTTAGCTCTTTCCCAGAGATTCTGGTACATTGTATCTTTGTTCTAATTA TCTTCAAAGAACTTCTTGATTTGTGCCTTAATTTCATTATTTACCCAAAAGTCGTTCAAGAACAGGTTATTCAATT TCTATGTAATTGTATGGTTTGAGTGAATTTCTTAGTCTTTATTTTGAATTTGATTGCACTGTGGTCCAAGTGACTA TTTGTTATGATTTCAGTTCTTTTGCATTTGCTGAGGAGTGTTTTACTTCCAATTGTGTGATTGATTTTAGAGTAAG TGCCATGTGACAATGCAAAAAATGTATATTCCATTGCTTTGGGGTGAAGACTTCTGTAGATATTTATCAGGTCCAT TTGATGCAGGGCTGAGTTCAGGTCCTGAATATCTTCGTTAATTTTCTGTCTTGATAATCTGTCTAATATTGTCAGT GGAGTATTAAAATCTCTTACTATTATTGTGTGAGATTCTAAGTCTCTTTGAAGGTCTCTAGGAACCTACTTTATGA ATGTGGGTGTTCCTGTATAGGATGCATATATATTTCAGATAGTTAGATCTCCTTGTTGAATTGAACCCTTTACCAT TATGTAATGCCCTTCTTTGTCTTTTTTTTATCTTTTTTGGTTTAACACCTGTTTTGTCAGAAACAAGAGTTGCAAC CCTGGCTTTTTTTCTGCTTTCCATTTGCTTGGTAAATTTTCTTCCATCTTTTTGTTTTGAGCCTATGTGTGTCATT GCATGTGAAATGGGTGTATTGAAGACAGCATACTGATAGGTCTTGGTTCTTTATCCAGCTTGCCACTCTATGTCTT TTAAATGGGGCATTTAGCCCATTTACATTTAAGGTTAGTATTGATATGTATGGATTTGATCCTATCATCATGATGT TAGCTACTTACTTTGCAGACTTTCTTATGTGGTTGCTTTATTGTGTCACTAGTCTGTGTACTTCATTGTGTTTTTG TAGTGGCTGGTAACTGTCTTTCCATGTTTAGTGCTTCCTTCAGGAGTTCTTGTAATGCAGGTCTGGTAGTAATGAA TTCCCTTGGCATTTGTTTGCCTGAAAAGAATCTGATTTCTCCTTTGCTTATGAAGCTTAGTTTGTTTGGATATGAA ATTCTGGGTTGGAAACTCTTTTCTTTGAGAATGTTGAATACTGGACCTCAGTCTCTTCTGGCTTGTAGGATTTCCA CTGAGACATCCACTGTTAGTCTGATGGGCTTCCCTTTGTAGGTGATCTGGCCTTTCTCTCTGGATACCCTTGACAT TTTTTCTTTCATTTTAACCTTGGAGCATCTGATGATTATTTGTCTTGGGGATGATCTTCTCATGGAGCAGCTTACT GGGGTCCTCTGCATTTCTGAATTTGAATGTTGGCCTGTCTAGCTAGGTTGGGGAAGTTCTCATGGATCATATCCTG AAATGTTTTCCAAATTGGTTCCATTCTCCCCATCTCTTTCAGGTACACCAATCATTCATACATTTGTTTCTTTACA TAATCCCATGTTTTTCAGATGTTTTGTTCATTCCTTTTCATTCTTTTTTCTCTAGTCTTGTCTTCTTGTCTTATTT CAGAAAGCCAGTCTTCAAGCACTGAGATTCTTTTCTCCACTTGCTCTATTCTGCTATTAATACTTGTGAGTGCACC ACGAAATTCTTATAAAGTGTTTTTTACCTCTATCAGGTTGGTTATCAGATTCTTTTGCTGATTCCTTCTCATCTCT ATGGGCTTATCTACCCTCAATCTTTGAGGTTGCTGACCTTTGAGTGGATTTTTTTTCTCTTCTTTTGTTTTCTCTT TTAACAGTCTGGCCACTTTTCTATAGGGCTGTACAGTTTGCTAGGGGCCTGCTACAGTCCCTAGTTGCCTCAGATT TTCCAGTACCTGAAGGTATCACCAGTGAAGGCTATGTAACAGCAAAGATGGCAGTCTGCCCCTTCCTCTGGGAGGT CTGTTCCAGGAAAGTACAGACTTGTTGCCAGCCTGAACACACCTGTAGGAGGTGCTGGAGACCCTGGTTGGGAGGT CTTGCCCAGTCAGGAGGAACAGGATCAGGATCTAGAGGTTTACTAAAGGAGGAATGCTCCCACAGGAGACACAGAA ATGAACCATTGAGCTGGAAGCTAAGACAGCTACCCAGGCCCTTCAGAGCCTCATGATTCTGAATCAACAAAGGAAG GAGTTACTGCACTGTCTGGGGTGATTGGTCCTGGCCATCAGGGGGAATTGGTCTACTACTACACAATGGCAGTAAA TAGGACTGTGTCTGGAACACAGGAGATCTTTTAGAGCATCTCTTAGTAATACTCTGCCGTATAATTAAAGTCAATA AAAACGGCAACAACCCAAGTCAGGTAGGACTAGTAATGACACATACCCTTCAGGAATGAAGGTTTGAGTCACCCAA GCAGGAAAAGAAACCTGATCAGCTGACGGACTTGCTGAAAGAAATGGGAATATGGGATGGTTAGTGAAAAACAACA AAAAAAGTATTTATAAATACTAGTTGTGGCCGGCACAGTGGCTTGTGCCTGTAATCCCAGCACTTTGGGAGGCGGA GGCAGGTGGATTGCTTAAGTCTAGGAATGTGAGACCAACCTGAGCAAAATGCTGAAACTCCATCTCTACTGAAAAT AAATACAAAAAATTAGTCAGACTTGGTGGTGTGCTTGTAGTCCCAGCTACTTAGGAGGTTGAGGTAGGAGGATCAC TTGTGCCCAGGAGGTGGAGGTTGTAGTGAGCCAAGGTAATGCCACTGCACTCCAGCCTGGGCAACAGAACAAGACC CTGTCTCAAATAAATAAGTAANTAANTAAGTAAATAAATAAATAAATAACCAGCTGTAACCATGTGAGCACTTACA GAAATAAAGACAGTAAATGTTATCAGCATTACTTCTTTATGTTTTTATAATGATATTTATGTCTGTGTGTATGTAT CCTTACATGTATTGAGCAAATACCTTTCTTTTCATCTTTTCCTGATGATCTGTAATAAAACATAAGATGTGCTAAC AATAATTCCCTTTTATTAATAAAAGTTAACTTTTATTACGCATGGTATTTAGGTTACAGTATATCAAAGAGAAGAG TGCATATCATGCATCTTTTTCTGTGGAAAGGGTTAGTGTGTTTCTAGTTGGATGCAAGTTAATTGTATCATCTTTG GCAAAAGTAAGACTTTATAATTGTTTTTATTTGGAGACGAAGTAAGGTTTAAGGAAAATGTTAATGGGTGCCAAGT TCACAAGCATGGACTGGGATGGTGGGTCTTATGTGTCAATTTTACTAAACCATAGCACCTAGTTATTTAATCAAAC ACTAAATTTATATGTTGATATGATGGTGTTTTGCAGTTGTGATTAAAATCTGATATCAGTTGATTTCATGAAAAGG AAATTACCCTAAAACATGTGGGTGGGACTTTTTGAATCACTTGAAGGCCTTTGGGCGAAATGTGAGTCTTCCCAGA GAAGAAAAAATTCTGCCTCAAGATGACAGTAGCAACTACACTTTAGGTTTCCAATCTGCCAGCCTGGTCTACAAAT TTTAGATTGAAGGCTGCAACATTATGACTTTCCAGCCTTCCAGCCTGCCGAGGTGTAACTTGTGACATCAATAACG TAAAATGAGGGGTGGGAAAAGATGTAAAGAAGCAGAGTTTCATATTGATTTCAGTTCAAGATTGTTATAACTGTAT TGTTATATATAATACCACAGTAATCACAAAGAAATATACATAAAATATACACAAAAGAAAATGAGAAGGCAGTTAA AACATATCACTAGAAAAAAATCGACTAAATGAAAAATGACTAAAAACAAAAGAAGGTTGGAATGAAGGAGATGAAG GACAAAACAGCTATAAGACATGCATAAAACCAACATCACAATTACAGAAGTAAATCCTTCCTTATCAGTAATTACT TTAAATGTAAATGTAAATGGATTAAACTTCCCAATCAGAATTCAGAGATTATCACAATGGACAGAATAAAAAGGAT CTGGCTGGGCACGGTGGCTCACACTTTTAATCTCAGCACTTTGGGAGACGGTGGCTGGCAGATCACAAGGTCAGGA GTTCGAGACCAGCCTGGCCAACATGATGAAACCCCGTCTCTACTAAAAATAGAAAAAAATTAGCCGGGTGTAGTGG CAGGTGCCTGTAATCTCAGTTACAAGGGAGGCTAAGGCAGGAGAATTGCTGGAACCGGGGAGGCAGAGGTTTCAGT GAGCTAAGATCGTACCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCCGTCTCAAAAAAAAAAAAAAAAGATT CTCACTTTGGATCTAACGACACACAGAAGTTGAAATTGGAAAGACAGAGAAGGATATTCACAAAAATAGTAACTAA GAATTTTTAATGATCTCTTATAGGGTTCTATGTGTTGGCTGGGCTCAGATGATGGCCTGGGAGTGTTACATGGTCC AGGGATTGAAGTGGAAGGAACCAGACGCAGGCAGGATGGTTAACAGCAGTGCCCAGACTGACACAGCCACACTTCT GCCATATTTTATTGGGTAACGCAGATATCAGATCTGCTTATGTTTAAGGAGTGGAGAGAACTTACCTCTTGATGAG GGAGTGGTGGGTCAAACTAAAGAAAAGCAAGTGCGATGGAAGATATTTAGATATTTTTGCAGCCCTCTTTGGAAAA TACATGCAATTCAAAACATCCTATCTGCCAGAAAGGAAGAACACCATTACGCCTTACCCCTCCAGTTTAAGCCCTG TGATTCTATAGTATCCTGGGGAAGGATCATGTCTTAGGAAGCAGGTGGGGAGTCGAAGCTCTAAATAAAGCCCCAT CTACACCCACAATTTCACTTTATTTTGATGAAATTTTGTGTCATTTTTGATGAAATGGGGGCTCACAAATCTCTCT TCAGGGATCTCTCCAGTGGCGGGGACGATATGCTCCCTTCTCCACAGTTCTACTTTATAGATAAGTGGAACTAGAT CTCAGTTTCAGTTATTTAAAACACCAGAGACTTGGATGCATGCATGTCACAAAAAGGTGAAAGAATGCTCTCTGTC ACTTTCCCTTCTCTCACTCACTGCGCCCTGAACAAGAACCTGCTCTACCCTGACCTTTTGAATGAGGAGGAGGGTC GCACTCCTGCCTAACCTTCAACTTTCCAGAGATAAACCTCCTGCCCAAACAGCATGGTTCATTATAAAGACCAAAC CCTACACCAAGAGCTCTCCCCTTATCCACCATGGCAGAAACTGAATCCTATGGAAAGGCCCAGAAAATTCTGGCTC GAAATGACCAGCGTCATGTCCCTTCCACCAAAATAAAGCCAACATATTCATCACAACATGGGGTATTGATAAGGAT ATCAAAATGATTACCAAAAAAATTTGACAAATATGTTCTTTTTATTACATCAACTTTTGTTTCCCTCCAAATATAA GAATCACTAGAATGGAACAAGGGTTTCTGGTATGACACAGCACCAGGTCTTGGGGCAGCCAGAGTTAGGGAGGGCT CACCCTCTGGGTGACACCAACCTTTGGTTCTCCATTTTTTTGTTCTCATTGCAAGAACAAAATTTCAGAGTATCAG AGCCAAAGAAATTTACTCTATTTTATTCTTTAGAAAATGCAATCTCAAGGATAATCAGACTGTTATGGGCTAAATT GTATCCCCCCAAAATTGGCATGTTGATGTCCTAACCCCCAGTACCTGAGAGAGTGACTGCATTTGGAGAGGTTTTA AGGAGGTCATTAAGGTAAAATGAGGTCATGTGAGTGTGCCCTAATTCAATGTGACTAGTGTCTTCATAAAAAGAGA AGATTAGACACAGACAGATACGGAGGAATGACCATGTGAAGACAGAGAGAGAACACATCTACAAGCCAAGGAAAGA ACCTTAGAAGAAATCAGCACTGCCAACACCATGATCTTGAACTTCCAGCCTCCAGAACTGTGAGACAATGAATTTC TGTTGTTTAAGTCACCCAGTGTGTGGTACTTTGTTATGGCAGCTCTAGCAAATTAAAACAAACATATTATATTGCC CAATGGAGAGTTTTACCTGACTCCACTCTGGCTCCAATTTGATTAAGGTCTATATGCTCTGGGACCTCTCCAGCTC CTCATGAGAAATGACAAAGAATGCCATGTCCAGCTCCTGGGGTCCCTGATGGCAGTGAGAGGCAGCTCCTAATCGA GGGAGCTTTGGGGTGACGAAGGCCTCATAGACTTCATCACTGTTGGGCCACTTGGCTTCAGTCCCCTGACCACAAT GGATCCATGGGCCTGGATTCACCTCTGACATTCGTGTCTTTTTTTTCCACAAGTGGTCTCTGGTAGAGATGGAGGG AAAGGACACAGGGATTCAAAATCCTGACTATCCTAGTGTCCTCCCCTCACTTCCACTCAGAGACAACACGGCCATT TCTCTAAACTCCTGAGGACGTGGCCAACATAAGTAATGGAGCACGGGGAGGTGCCTTGAACAGAGCTGCATGGAAG GGTGGCTGGTGGCCTCTAGACCCTTTGTCTATACGTGCTGGGCTTCTTTAGTATGAAATGTCCCAGAGACAGCCAC ATTCTATGCTTGGATCCTCAAACCAAAATGTGTGAGGGTCTTAGCCCTGGCCAACTGAGCACTGAATTCAAGAGAG ACCAGGAAACCTTCTGAATATTGGGACACTTTATTCCTGAATCCTGAATCCTGGAAGTTGGCTTCTGGCCAGGGAG GCAGGTGTCATTATATCTGGGCTGCCTCTGTGAGGCCTCTTTTCCCTCTGCCTTTCACATCTTTCTACCCCTGTTA AAATCCCAGAACAGATAGAAACATTCTGCCTTCTTAGATGCCTCTTGCTACAAATTTCAATGCCATTTGATTGAAT TAATAAATGAAAGCAACTTTAATACAAGATGAGGTTTAAAGAATGGTATTTGACATGGGTTTAGAATGAATAAATG TAAATGATTCCAAATTAATACAAAAAAGTGCAATCACAAATGTATGAATGCCCAGAAGTGTGAATGAGGGGCAATG CACACAAGAAAAAAGGTGTGCACAGGAAGAAATTCTTCATTCCACGTTTTTACTGATCCCTCTGGTCAAGATGGGC TAAAAGTCCAAAAATCTGCTTTCCTCACATGGTCAAATGATTCAGCATAAAATACAACTGACTGAACACAATTATC AATGCTTTAAATATATTAGAAAAAATCAATAAGGAAAAATAATCCTACCATCACTAAGATTTTAAGTTATAATAAA ATAAAGCCTAGAAACGTATCGTTTGTTCCCAATTCCAATGATTATAGGATTGCAGTGTTTGGCTTTCAAAAGACCA TTTAAAACAACTCAGGGAAGTTTTCTTAACAAACTCTATAGCAGGACCACAGCTAAACCTATGAGTAGTAGTAGAA GTAAACAATGACACTGTCTTTAAAATTTCATTTTGAAAAACATGTTTGAAAGTGGCTGACTGGCTCCTAATTTAAC CACTACCATTTGAAGTCATATGTTAGATTGGCAAAGTCGTCGTAATTTTTATGTATTTTATTTTTGTAATGCAAGT GCTTCACTCTGCTATCTGATAAAAGAAAATACCAAGCCAGGCATGGTGATGCATGCCTTGTAGTCCCAGCTACTCA AGAGCCTGAGGCAGGAGGTTCCTTCAGCCCAGGAGTTCAAGGCTGCAGCAAGCTATGATGGTGCCACTGCACTCCA GCCTGGGCAACAGATAATGCAATTTTAATGTAAAATTTTAGTGTTAGGAGTTCAACCTTGAACTGATTCTGTGAGA TCCTATTTGAGAGAAGCTGTTGTGTACAATGAAGTTTGGGGAATATCAACAAGAAGTAAATGCCTACCTTGTTTCT AATTTACAAACTAAAAGGAAATTCCATAAACTTTTAATGCTAAGCTAAATCATTGTAGAATGAATGACAAAAAAAT TATCCTACAAAACATAACTAGTTGCTAGATATATTTGAACATTAATTAGAAAAAAGATGAATGAAAGCCATGTTTT AGGAATAAAAACTACAAAAGAACTGTAAAAGCTTATCATGCCCTTGGCTGGAGTTACGCAAAGTTACTACTCACCC GTAAATTGGGATTAGCATGGTGGCTACTTCTTAAAGTTGATACAAGGATTAAATGTGTTTTAATGCATCAAAAGCA TCTAGAAAAGTGCCTGAGACATAGTAAGTGCTAAAGTCTCTCTAAGTAAATAAAAAATATATAAAAGTGATGCTAA ATTCACGATTCTGATCCTCTGTGCACACCCAATGTGTTTAAAATTCTGTTCATCTTCCCTTCCACATTCACAGTGA AATGTTTCTGATTAATTTAATGGGCTGTGTGAGGTGTTCATTATCTTTTACATTAAACTTGGTACATTGTACAACA CTCTTATATTGTGATAATTTACCAAGCTAACACAGGCTTACCTTGTTTTTAATCCTTTTCACACACAGCATAGAAT TATATTGCTATATTTTTAAATTTCAGATGATTTGAAAAATATTTACACTATAGTAGCCAAACAGTAATAATTATAA GCAACTTGGATAAAACATTTGAAATTAGAGAACTATATTTAGAATAAATTTCTCACCTTACAGAAAAATTTCCCAT TGAAAACCCCTTTATTTCGCATACAAATAAGAATTCAGCATGTTTTTCTATACCCAGAGAGAACAGAGATAAACAG GGTCCTTTCGTGTGGTTTGGGTATTTTATTAGATGCTGAGTTCAAGAAAGTCTCACCCCTGAAGAAGCTGAAATTC CATTTTTCGAAGCTTGCTCCTCAATTCCACATGCTTATCATAGATATCAAGCAGTGCCCTTGCTGTCTGCCCATCT TTTCTGACCCTGGGACACCACCCTTTATTTACTTTCCCCACAACTCCTTGAAGGTCAAGCCCCCTTGGCTGATACT CTGGGTTATCACAGTAAATGTGCCCTCTATCTTTTGCAGGTCACTGGAAAGGAGGGTTCCTAAAGCATTCACTCCT GACCCTGAGGGAGGTGGGTGCACTCACTCCAGGACTCAGGTTCACCACAGATAAGCAAAAAAGTCCTCACATTCAA AATTGTCCTGGGCCACATGCAGCCCACGAGCCGCGGGTTGGACAAGCCTGCATCTAGAACGTATGCACCATAACCC CAGACATTTTTCTGTTTTTACTTTAAGGATGCTTTCTAAATGCAAAAGCAGTCATATCCCTAGCAGACAACAAATG TCAGTTGAATGAATGATCACTGTAGAGCACCTCCCTATTCTAAAGCCCATATCTTTATTAATGTAGCCACAGGGCA AATGCTGTTTTGTGGCAGCTAAAGAACATAAGTTCACGTGGACATCCATGCCGCCAGTGCTTTTCTCACCAGGGCT GCTTGTGTGTCCTCCCTCCTCCCACACCAACCCTCCTGCACACTTCAGCACAAAACTATATATTTCTCTTCAGGAA CAATAACCCTAGCCTTATGGGTACAATTTTCCAACCACATATGAATCTAAATTAGACTCTGCTTTATAAATCTATG AGTTTGGATTGGAGCCAGCACTAGGATTACTACAACTCAGAGCAGGAAGAAGAGTAGGAGGGCAGAAGAGGAGTTC CAACAGAAAGTTAACCATGATGAGAAACTATGGGACCCCTCCTCTCTGCAAATGTCACAATCTGGTTCCTTTAAAA AGATTGGAGAAAAATCGAAAATACCATTAAGGAAAAAGCCCTGGGAGGAAGGCAAGACCTGGACAGGTCTGAAAAT TTGTCTCTTGATACCACAAGGAGATTTGTATGCAGGGACCACCCTAGGTGACATCCAACTCCCTGTGATCACAGGT CTTGGTGGGACAAGGTTCTACTGAAGGGCCAAGGACAATGGAGCAGCAAAGATGACCCAGGTGAGCTGTGACCACA TAAAGCCCATGGTGGCCAGAACAGAAACTGGGCACAGCCCCATCTACTCTCCTCCCCTGCAACAAATCAGCACAAG AAACACGTGGACTCTGGAAGGTTCTCATGTCTTCCATTTATTTTGTCTCTCAAATTTTAGGAATCTTCTCCTTTAA TTAACTCATCAACCTCTCATGGCAAGAATTTGAGAAAGTAAATTTATACTCAGGTTCTAATTTTAATAGGGAAGGA AGAAGTTACAGCTCAGTGCACCATGAAGTTGAGACAGAGATGGAGACACCTCAGCCCCACCTCTCTGGAACAGGAA AGATGATTGGGGAGGGAGCACAGGTCAGCGTGGGAAGAGGGTCATGGTGGACATGGGGGTGGGGTGGTCTCCCCAC CTCCTCACATTATGCCTACACGAACACAGACACATGCAGGTGCCTTTGCAGAAACAAAGTCAGGGTTCTTCAAGTC ACAAAGGGAAGGGCAGGAACAACTCTTGCCTCTCAGTCCCACACAAGGCAGCTGTCTCACACTATAGAAAAAAATA TTCATGAACAAATTCATATCCATCACAGTGAGGGGTCACACCTTAAACAGCCCATCGCATGCTCAATACATCCAAT GCAAAGAAACCCCATAGCACAGCTGTGTCCACTGTTCCGCCCAACACCCAACACACATTAGGTCCTCCAAGCTCTC ACCTTTACAAGCTGTGAGAGACACATCAGAGCCCTGGGCACTGTCACTGCCTGGGGTAGAACAAAAACAGAACCTG GTCAGATCCCACAGAAGATGTGGCTAGAGGAGGAATTGTGGGGTGGGTGAGCTCCCCCATGGGCTCCCAAACACAA TATCCCAAGGACCTCAGGCATCAGCCTCCTTCATACTTACTTGCAGCCTGAGTGTAACTCCCTCCTTTTCTATCTG TGAGAAGAAAATGTCCTGTGAGATACCAGAAAGGAGCCAGGGCCTTAAGGTCCTAGAGGAACCTCCTAGTCTTGGA CCCCAGAGAAGTTTCCAGAAATGTGTGACTGCAGACCCAGGGCGGGATCAGGAAACATGAAGAAAGCAGGTGTGGG TCCTGGACCAATAGCCCTCCTGAGGTCTGTCCTCAGGGACCTTCCCCTGTGACTTGTGACTGCTGGGATCAGGTCC CATCACCGCCGTAATCAAGGTGATAAATCTGTCCTTCATTTTAACAGGTGCTTTACAAAAGAGTAAGTGCTGGCAC ACAGGGCCCAGGCTGGGTAGGCCCATGATTGTGGATGGTGCTTCCCAGTAATGAGACAGGGCACATTTCTAGCTGG GGCTTGGAACCCTCAGTGAGACAAGAAATCTCAGACCCCACCCTTCACCCCTTCTCCACCTGAGCTCTTCCTCCTC CACATCACGGCAGCGACCACAGCTCCAGTGATCACAGCTCCAAGGAGAACCAGGCCAGCAATGATGCCCACGATGG GGATGGTGGGCTGGGAAGACAGCTCTGGGAAAAGAGGGGAAGGTGAGGGGCCCTGACCCTGCTAAAGGTCTCCAGA GAGGCTCCTGCTTTCCCTAAGAGACATGACACCCCCATCTCCCTCCTTACCCCATCTCAGGGTGAGGGGCTTGGGC AGACCCTCATGCTGCACATGGCAGGTGTATCTCTGCTCCTCTCCAGAAGGCACCACCACAGCCGCCCACTTCTGGA AGGTTCCATCCCCTGCAGGCCTGGTCTCCACGAGCTCCGTGTCCTGGGTCTGGTCCTCCCCATCCCGCTGCCAGGT CAGTGTGATCTCCGCAGGGTAGAAGCCCAGGGCCCAGCACCTCAGGGTGGCCTCATGGTCAGAGATGGGGTGGTGG GTCATATGTGTCTTGGGGGGGTCTGACGGGAAGAGTCAGAAAATTCAGGCATTTTGCATCTGTCATGGGACACTCC ACCAGCACGCATGTGGCCATCTTGAGAATGGACAGGACACCCGGGATGGGGAAGAGAGCACAGAACCCAGACACCA GCCTGGACACAGGCACCTGGGATAATCTTCTATTCCCTGAGAAGGGAACAGCGACTTCTGGTCCTGACCTGAGTGG AGGCTGAGGGACTCAGAAGTGCTGGACTCAGACCCCCACACACATTGAGTGTGAAGCAGAGAACAAGGCCTGAGAG GAAAAGTCACGGGCCCAAGGCTGCTGCCGGTGTCAAAGGGAACCACTCATCAGTATTCGAGGGATCGTCTTCCCGT CACTCCTTCAGAGATTTTATCCCTTAATTGTGTCAGAGAGCAGGGCGGAACCTCAGAGTCACTCTCTGGTACAGGA TCTGGAAACCCAGGAGGATTCCTCTCCCTCAGGACCAGAGGGAGGGTGATATTCTAGTGTTGGTCCCAATTGTCTC CCCTCCTTGTGGGAGGCCAGCCCGGGAGATCTACAGGCGATCAGGAAGGCGCCCCGTGGCCCCTGGTACCCGTGCG CTGCAGCGTCTCCTTCCCGTTCTCCAGGTATCTGCGGAGCCACTCCACGCACGTGCCCTCCAGGTAGGCTCTCAAC TGCTCCGCCCAACGGGCCGCCTCCCACTTGCGCTGGGTGATCTGAGCCGCCATGTCCGCCGCGGTCCAAGAGCGCA GGTCCTCGTTCAGGGCGATGTAATCCTTGCCGTCGTAGGCGTGCTGTTCATACCCGCGGAGGAAGCGCCCGTCCGA CCCCACGTCGCAGCCATACATTATCTGGATGGTGTGAGAACCTGGCCCCGACCCCGCGGTCAGCCCAGTCCCCCGA GCCCCGCCCAGCCCCGACCAACCCGGGGGAATTTTTGGCCTAAACTGAAAATGAAACCGGGTAAAGGCGCCTGGGC CTCTCCCGGGTCAAGGGTCTCGGGGTCCCGCGGCTTCGGGGTGGATCTCGGACCCGGAGACTGTGGGCGACCTGGC CCGTCCGTGGGGGATGAGGGGTCGTGACCTGCGCCCCCGGCCGGGGTCACTCACCGGCCTCGCTCTGGTTGTAGTA GCCGCGCAGGGTCCCCAGGTCCACTCGGTCAGTCTGTGACTGGGCCTTCACATTCCGTGTCTCCTGGTCCCAATAC TCAGGCCTCTCCTGCTCTATCCACGGCGCCCGCGGCTCCATCCTCTGGCTCGCGGCGTCGCTGTCGAACCGCACGA ACTGCGTGTCGTCCACGTAGCCCACTGCGATGAAGCGGGGCTCTCCACTGCCGGGCCGGGACACGGATGTGGAGAA ATACCTCATGGAGTGGGAGCCTGGGGGCGAGCAGTGGCTGAGACCTGACCGACCCTCCTCCCGGCGCGGCTCCCCC GGTCCTGCGCCCCCGCCAGGAGGGCCCCTTGCTTCTCCCCGCAGAGGCGGTTTCCCTCCCGACCCCGCACTCACCC GCCCAGGTCTGGGTCAGGGCCAGGGCCCCCGAGAGTAGCAGGAGGAGGGTTCGGGGCGCCATGACGGCCATCCTCG GCGTCTGGGGAGAATCTGAGTCCCGGTGGGTGCGTGCGGGCTTTAGAACAGCGACCGCGACGACACTGATTGGCTT CTCTGGAAACCCGACACCCAATGGGAGTGAGAACTGGGTCCGCGTCGTGAGTATCCAGGATGAAGGACCCTACGTA GGTTGGGAGAGGGAGAAAAGAAACTGCGGAGTTGGGGAATCCCCAAGGCTGTGACTCCCCAATCCATACACCGCCT TCGGGGCCTGAGACCCTGAGAGCCACGCCTGGGGCCCTGGGACTTCGCCCTGACCCCTCTGCTCCTGTGCGAAGCG CTCTGTCTCAATGTCTCCCTGAGTCTTGGCCCAAGAGCTGTCTGAGAAACAAGGGAGAAACCCTCGGTTCACTTTT CATCCCATTATCTCTGTCCCTGAACTGGACTCCCTGACTCCCACTCCTTACCTGTCCACCTGGACTCTTCTAGAAG AAAAATCACCCCATGGAGTTTGGTGCCAGAGAGTAAGCTTGCTCTGGGAATGGAGGTGTAGATTTTTGTTGTTGTT GTTTTTGTTTTTAATCCGGAAAAGTTGTGCCTGAGTGCATGAGACAGAATAGAGACCAATTTGCTCTTTGTTTATT AACTACAGTGGGTAGCAGAATCTTGGTAACCCCTGAATGATCAGGAATCTAATAGGTAAAAAAATGTGACTTTGGC CCCTTAATGTATAAATGTGTCCAAAAGCATTACAACAGGACTCACAAAGCTACTAAGTTGCACTTTCCCAGACAAT GTATCTGTGACTCCTGCTTGTCTTACTTTAAATTTGCCATCATTCCTTAGCTCTGAGTTTCTGTGTGAGTCCACGA CATCTCCTCAATACAAAGTAGCCACTGTGTTCCTATATGTTGCAACCAGAAGCCATTACAGGCTTTATTCACCTCA AAGTTGCAACTGTTCAAGGCAGTCACAATGCCCCTCACTAGTGCTCATGCACTGCCTGTTTTTAGGAAGTATCCAC TTCTAAGTGTTGTGTATATTTTATAGGAACACTTAGTAATTTTTAAACCTGATTAACATAAAAAATAGTTTTTAGG CAGACCCACATGAGGTATTAAAAGACAACTGCCAAGGACACCCTGCTAGGCTCTGTAGATTGATGTATTAAAATCC ATAAAACAATGTCTTTAAACCTAAGAATTCTGCTGCTTTCAAATTCTTTCCTCTGCTCCTTTTCCTCACCTCCTGC TTCTCCAGCCCTTCCCTCCATCCTTCTCATCCTTCAGGCCCTCCTCTCCCCTTAGTCCCCACCACACTGTCACTCA TGAATTGTGACACTAGCACTGTCCCATGACCTGCTACGTAACTGTTCTTTTCACAGTGGCCCTGCTCCTGTGAGTC GGAGTGTGTCATTTCTCCACTTAAAACACTCCAGTGTCTCCACCTCGGTCTTGTGAAGCTTCTGGAGTGTCAGGCA CTTGAGCATATGAGGGGATACCTCGTTCATTGTAGGGACTAAGTTAATTTTTGTTGACTTAATGAATGAAATATGA GTGTATTAAATTGCATCACAGATAATTATAAACTGTAAAACACTGAAAAAGTTCAGAAAGATTTTATTTTATGCAA CTAGTGTGTATATCAATTCATCAATTCATTCGCACACTACCATGCCTGGCAAAACAACACACATTTATCTGCTTAT AGTTCCTTGGTCAGAAATCTGGGCAAGATGTGGATAGAATCTCCATTCTGGGCTTCCAAAAGCTGTGTTTTCATTT TGAATCCTCCTTCGGGTTTATACAGAGGTGGCAGAATGCAGTTTCTTGCAGTTGTAAGACTGAGGTCCCTGTTCCT GGCTAGCTGTCAATGTAGAGAACTGGGAGGGGCTCAATTCCCGGTGCTCACCAGCGTTCTTTCCTACACAGCCCCT TAATTTTTCTTTTTTTTTTTTTTTTTGAGACGGAGTCTGGCTCTGTAGCCCAGGCTGGGGTACAGTGGCCCAATGA TCTCTGCTCACTACAAGTTCTGCCTCCTGGGTTCACACCATTCTCCTGTCTCAGTCCCAAGTAGCTGGGACTACAG GCGCCCACCACTATGCTCTAATTTTTTTTTTCTTAGTAGAGACAGGGTTTCACCTTGTTAGCCAGGATTGTCTCGA CCTCCTGACCTCATGATCCGCCCGCCTCGGCCTCCCAAAGTGTCGGGATTACAGGCGTGAGCCACCGCGCCCGGCC CATAGCCCCTTCCTTTTCAAAGCCCATGGTGGAGGAAACCCCTCATGCTGAGTCCCTTTCACACTGTAAGTCTCTA TGCTCATGAAGAACCCAGTCCTTTCAAGGGCTCACCTGATTAGGACAGTCCAAGCAGGATAAACCCAGCATAAAGT CAACTAATTGAGACCCTTAATTATATCTGCTAAATCCCTTCACAGCAGCACCTACATTAGAGTTGGTTGAATAACT GGAGGAAGGTGAATGACCAGGAGCTGCTTGTTGAGGCCATCATAGAATCAGCCTAGCAAGGGTTGGATCTTCCTTT TGTGTTTAATTGGGACACAGTTGGAAAGTGAAGTTCAAGTAACGTGATCATTGTGAATGGTCATAAAATACATCCT CTTCAGCCATGGAAATTGTCCTTACTTTTTAAAACTAAGTTACATGTTTAATATCTTATAATTAATTTAGGCCAGG TGTGGTGGCTCACATCTGTCATCCTAGCACTGTGGAAGGCAGAGGAATGGAGATTTGTTGACTCCAGAAGTTCAAG ATCAGCCTGGGCAAAACCTCCATCTATACAAAAAATTAGAAAATTAGCCAGGCATGGTAGTTCATGATGGTAGTCG CAGCTACTCAGGAGGCTGAGGTCAGAGAGTCCCTTGACCCCAGGAGTTCGACACTGCAGTGCATGGTGATCATGCC ACTGCATTCCAGCCTGGGTGACAGAGCAAGACCCTGTCTCAAAAATAATAATGATGATGATGACACATTTAGAGCA AATGCAATTTGATGTGTAATAATACATCCTCTCTTGTGAAAATATATTATTTACTGTTGCATAACAAATTACGTAA AACTTAGCTCGAAACAACAAATGTTTCTCATCTCCCACAGTTTCCAATCGTCAGGAATCCAGGAGAGGTTTCCCTG AGTGCTTCCTGCTCAGGGCCTCTCACAAGGTTGCACTCCAGTTGTCAGCCAGGGGCCGCAGCATCTGAGGGCTTCG CTGGGGCTGGGAATTCACAAGAAACATGGATCAGTCACATGGCTGTTGGAAAAGGCCTGGTTCCTTGTTGTCTGTT CCCAGAAGGCCTCAGTTCTCAGTCATGTGGACCTTCCTGCAGGGCTGCTTATGGCACAGCGGCTGGCTTCCCCAAG AGCTCATGATCCCAGATTCAGAGAGAGAGAAGGTGGAAGCCGCAGTTAGTTTTATGTTCTACACCCAGAGTCACAA ACTGTTATGTTGGCACTATTCTATAAGTTAGAAGTTGTATTAGTCCATTCTCACACTGCTATAAAGAAATACCTGA GACTGGGTAATTTATAAAGGAAAGAGGTTTAATTGACCCACAGTTCTGCATGACTGAGGAGGCTGCCCCAGGAAAC TTACAGTCATGGCAGAAGTGGAAGCAAACCCGTCCTTCTTCATGTGGTGACAGGAGAGAGAAATGCACAATGAAGC AGGGAAAAGCCCCTTATAAAACCATCAGATCTCATGAGTATTCCCTCAGCATCAGGAGAACAGCATGGGGGCACCG TCCCCATGATCCAATCAACTCCCATGAGGTCCCTCCCCCAATAGGTAGGGATTACAATTTGCATAACAACTCAAGA TGACATTTGGGTGGGAACACAGAACCAGGCCATTTCAGAAGTGCCTCATTAAGTCCAAGCCACACTCAAGAGAGGG AATTAAGCTGCACCTCCAGAAAGGAACAGTATCAAAGGATTTGAATATATGTTAAAAGCAAAATTATAACTATTGT TTCAGGTTTCTGAAAATCAAAGTCTTCTTGTATCTAATTATTTTTCATTAACTCTTTAAGCTTGTCTTTTAATTTA ATTTTTTTTTTAAGTTCCAGGGTACATGTGTAGGATGTGCAGGTTTGTTACATAGGTAAATGTGTGCCATGTTGGT TTGCTGCACCTGTCAACTCATCACCTAGGTATTAACCCTGGCATGCATTAGCTATTTTTGCTAATGATCCTCTCAT CACCACCCTCCCCCAACAGGCCCCAGTATGTGTTGTTCCTCTCCCTGTGTCCATCTGTTCTCATTGCTCAGTTCCC AGTTATATATGAGAACATGTGGTGTTTGGTTTTCTGTTCCTGTGTGAGTTTGCTGAGGATAATGGCTTCCACCTTC ATCCATATCCCTGCAAAGGACTTGATCTCCTTCCTTTTTATGGCTGCATAATATTCCATGGTGTATATGTACCATA TTTTCTTTATCCAGACCATCATTGATGGGCATTTGGGTTGATTCCATGTCTTTGCTATTGTGAATAGTGCTGCCAT GAATGTAAACATGCATATGTCTTTATAATAGAATGATTTATATTCCTTTGGGTATATACCCTGCAATGGGATTGCT GGGTCAAATGGTATTTCTGGTTCTAAATCTTTGAGGAATCGCCACACTGTCACTGTCTTCCACAATGGATTAACCA TTTACTTTTCCACCAACAGTGTAAAAGCATTCCTATTTCTCCGCAACCTTGCCAGCATCTGTTGTTTCTTGACTAT TTAATAATTGCCATTCTGACTGGCATAAAATGGTATCTCATTTGTCGTTTTGATTTGCATTTCTCTAATGATCAGT GATGGGAGCTTTCTTTTTCATATTTTTGTTGGCCACATGTATGTCTTCTTTAGAAGTGTCTGTTCATGTTCTTTGT CCACTTTTTAATGAAGTTTTTTTTCATGTAAATTTGCTTAAGTTCTTTGTGGATTCTGAATACTAGACTTTTGTCA GATGAACAGATGGCAAAATTTTTCTCCCATTCTGTAGCATGTCTGTTCACTCTGATTGATGATAGTTTCTTTTGCT GTGCAGAAAAAAATTGCCTAATCTGATTGCTTTTCATTTACAAAAATGAGAATCTCATACTTCAGTTAACACATCT AGCTTAGCATGATGCCAATAATTTTGGCTTGATGCTGTAGCCCGAAATGGTTAGCTCGAATTGAGAGACAAGTTAT TTTCAAAAACTGGCTATCCGATGGGCATTCTATAACACACTTAACATCTTTTGTTGTGGTATTGAATGAGATGTGA TAGAAGTGATTTGGACACCACTATGATTCTAAATAGCACTGCTATTATGTGCTTCTGAATTTTTTTTCTTTTTAGC AGTCCTATTCTGTTTCCATTCATATTTGCTATTCCATCACTGGGTATTCCTTCCTACTCTTTTCATGTTTCATTTA TTTTGATCAGTGATGTGCATTTCCAATTCTGTAAAAGTTTAATTCAGTTGTATGTGTGGTAAAATGTAACATAGAA TCTTTGCAAGATGAAATTACCTTGCACAGCATATTGAACATTGTATTATTGAAAATCTAGAGAGATGCCAGTGAGC CAAGGATCGAATGACCTATATGTAGCCAAGGCCGTTTTCATGGCATCCTGGTCCTCTCTGTCACATAGCTCCTTAC AATTCTCTGTGGTTTTCTTCCAATGTAAGTAGTTCTTGTTAAGAATCTTTGCAATGAACTTTGAAATTCTTTTCTT TTTCATTGCTATAAAAAACAGGTATATTTTAATTTGGAAAACTCTGTTTAAGGAATTATAATCAAGTAACTACCAG GGGGCCCAGCACTGGTGTAAAACACAAAACTGTAAAACTACCCTGGGCTGCTACCCTTCGAAATGGGGTCTTTTCA AAGTTAGTAACAATGAAGCTGTCATTCACACGATGCATGGCTGAACAAAAAGACAGAGACAGCGGGTGCTGCATTT TATTTTTGTAATGTTGCCTTGTCCACAAGACACTATTTACACTTAAATCAATTAAAATTATATTAATTTTAAAAGT CAGTTTTCCCAGTTTCTCATTTGTACTAGCCACATTTCAAATACTCAGAATTCATGGGTGGCCGGTGACTGACGTA ATGAACAGCACAGATATAGGCATTCCATCACTACAGAAGGGAGCTGGACAGCAGTGTGCCAATGTTTTAAGGACAG AATCCTGAGTAGAATTATAGGATGATGACAATTCCGAGTTCCCATTCCAATTCATGGTCTCTTCTCTGATGAGTGG TGTAGGGGGAAATCCATCTCTTTTGTGAGTAAAGGTTAATTTTTCCAACTACAGATAAATAATTAACATTACTTTT TTTAAAACCAGTTTTACACTGTTAAGTTACAACCAAAAGTGAAGGGCTTGAATTACATTTACATTTTAACACATGG TTTTAAAGGGAAGATCCGTGTGAAAAAGAAACAAAACTCAGAAAAAAAACCCAGAAGTTTTCATACCAATTCCCAT AGCAATAACAATCCCTTTTCTGTCGTTAGAGTTCACCCTCATTCTGATTTCATAGTAATCCTGTTCATGTCTTTCT TTAAAGCTTTACCCCATGCATATATTTCTAAAACAACACAGGTTATCTCAAACTTTATATAAATTTTGAATTTTTC ATACAAATGGAATCATGCTGTGTATATTCTTACAAGACCTCATTTTAGATCAAATGTATGTTTGCTAAGTTTTTAT AGGTGTCTGTATTCATGTTTATTATTTGTAACATTTCATTGAATAAATACATCATATATTAAATTAACCCTTCTCT CGTTTATGGTCATTTCATTTGTTGTCAGATTTTTTAAAATTACAAGCAATGCTGTTACAAGTCTTCTAGCACTAGT CTGTTGGCACAATGGGCACATATCTGTCAAAATTATACACCTAGGAGTGGAGTTACTGGTATATGTGTATGATATC CCACTCAAAGAGATGATGCCACACTGCTAGATAAAGTGGCTGTGGCAAGCAATGTGTGGTAGATCTTGATGGTCTG TATTCTCATCAGTGTTTGGAAAACTCAATAATTTTAATATAGAAATTCTAGTGCATTTTTCAAAATATCTCATTAT GTTTTCCTCATTAAACTTTATTGAGATATAAATCACATACTACTCACCCATCTAAAGTATGCAATTCAATGGTTTT TCACATATTCAGAGTTTTAAATCTGCATATTTAATTTTAGAACATTTTCATCATCCCAAGATAATCAACGGCTTTA TAATATGTCTCTCTATACAATGAAGTAAATCCATAAATTTTGAGTTTTCACTTCAGGAGTGTTTTTTCTATCATTG GCAACTTTCCTAGCTTGACAGGCACCTTTCCAAGTACCTTTAACAATTTTATTTTTAATAGAGATTTCATTCAGTA ATCAGATTTGGAGAGCACTGACAAATTTTGCCACATTGAGACTTATAATTCATGAACATGTAATGTTTACTTATTA AATACTCTTAAATAAAGTATTGCTGGTTTTACTTGTGCATCTTTTAGTAGATTTATTCCAAAGATCTTGAAATATG GTGCTAGTGTTCACAGTATCTCTTTCTTTGTTGAATTTCAGTGTTGGTTGTGGTATGTATAAATATAAATAATTTT ATATAGTTTTAATTCAATGACTTTGCTTAAAGCTTTTATTAATTCATGTAGTTGATATATTCTGTTGCCTGATTGC ACTAGCTAGGAAATCCAGTGTGATTTTGAGTGCAATGGAGAGGGCAGGTCTGCTGGTATCTTCTCTGTGCACTCCT GATCCACACTCCATGTACTCTCCCTGCTCCGTGTCCTGGACACTGTGCTGCATGGCCTGCTGGACCACAAAAGGCA GCCTTGCTTTCTGGCTTTTATTTGGGATCGGCTAAATGGGAGCATCATCACGGAGAGAGTGATGAGGAGCACTGGT TGGAGGGATTTCTCCCCATAGCTTTCAGTATTGACATAGGGAGAAATGAGATGTGATTGGCCTGGATTCATCAATA TGGGATCTTCACCCAGTATCTTAGATTAAATGTGTTATTTTGAACACCTAAGAGTGATGTTAATAGTCAGCCAGGT TAGCTAATTAAAACCCGAATTCAACTGTGGCCTAGCACAGTGTTTCTCAAATTTGACTGAGCTTTCCATCACGTGG GAGATTTTAAATAGCCCCAGGTCTAGATCAACATGTAAAACCAATGAAATCTAATTCATCAAAAGTAGGATCCTGG AAACAGTATTGTTCCTAAAACTCTCCAGGTTTGACTCCAATCAACAGCCAAGTTAAAAACTAGTAGCTCAAAGCAG TGGTTCTCAATATTTGGTATGTATCAAAATCATCTGGGAATTGTAGCAAAACTACACAGGCCCAGATATTATTCTA ATTTAACAGGCTAGAGCCTTGAGTTTATTAAAACAAATCATCTCTCCAGATTTTGCTATATGCAACAGTTTGTGAA AACCACTAGCCTATATCAACAGAATCCCTATCACAGGCATACTGCAGAGGAAAGTGTCTGAACACAGCTCAGAGAG ACGGAAAAGTGGGAATGTATCCATTATGTGCAACCTACTTAACATCTCCTAACCACATCTCCCGGGAGGGCTGAGA GGATGCCCCCCTTACCAAGGCATTAAGGTGCCACATGACACATACAGGTATAAAAACTGCTAGGTCTGCTGAGCAG TCACCAATCTTGAGTCCTGGATATTCAGAAATTCTTATCCAGTAGCTACACCAAAGCCAGCTGATATGTCAGAGCC CCTCAAATAAGCAGAAGGCTGGTGCCCTTGAGAAAGGACCCTATAATTCACTCTGAGATAAATTCTTTTTACAGGA CTTTCCCAGAGGAACATTTAGTCATTTATCGCTGTCCACTGGGGAATGGAAAACCCCAAATAATCTGGGAGCTCAA CTTTAATGTCTTTAATCCTGTCAAAGATTACCCTGGGGTTAATACTTTGTTGTAACCTGCATAAAAATCTTTCCCT ACACTAAAGTAATGAAGATATTCTACTATATTACTGTAAAGAGATGAGTACAATCACATTTTTTTACAAGAGATGA GTACAATTGCATTTTTCCAGATAGATAACCAATTGTTGTTAAATTATTTTCTAAATCGTTTTCCTTTACCCACTGA TCTGTAATGTTGCCTCTGCTCTACATACGTTCAGGGCTTTCTATTCTGTTCCCAAGTTCTAGTTTACTACCCTGTC TCAACATCTCGACTCTCTTAATTAAAATAACTCTAACATAAGTCTTAATATCTGCTAAGGAAATTCTCTCTGCTTA TTATTCTTATTTAGAGTGTCATAGCTACTTTTTCTCTTTCATATTTCAATATAAGGCTTAAAATTGGCTTACTATG TGTTGCAAAAATGCTTGATAAACATTTGATTGAGATGTGTTTGAGTTCTTAGAGTACTGTAGGAAATTAATGTCAT TATTATATTGAACCATCCAAGCCAGGATCCTGGTAAATTGATTCAGTTAATTCACTGTCTTCTTTAATTACTGTCT TCTATTATTACTCAGTAGGGTTTTTTAAATATCCCAATTGATATCTTGTACAGAATTTGTTAGGTTTAGTTTTAGA AGTTTATATGTACGCACTTTTGCTGAATCAATTTTTTAAAATTTTCATTTTATATCTGTGCAAAACAGCTCTATAA TTTCTTCTACCTACCAAGCAAAAATATCTTATTAACTTCCGGATCACGAGGTCAGGAGATCAAGACCATCCTGGCT AACATGGTGAAACCCCATCTCTACTAAAAATACAAAAAATTAGCCGGGCATGGTGGCGGGCGCCTGTAATCCCAGC TACTCGGGAGGCTGAGGCAGGAGAATGGCCTAAGTAAATCTGGGAGGCGGAGCTTGCAGTGAGCCGAGATCTCGCC ACTGCACTCCAGCCTGGGCGACAGAGCGAGACTCCNTCTCAAAAAAAAAAAAAAAAAAAAAAAATATATATATATA TATATATAAATATATTTATATATATATGTATCTTATTAACTTCAAGAGTGTTCTAATCATTTGTATTTTCTGCATT CAGCATATTACCATTTGCAAATTATAAGAGTTTTGTGCCTTCTTTTCAAACCTTTTTAAGTATATTTCTTTTCTTC TTTATGACACTGGGAAGATCCTCAATTACAATTTTTAATAAGAGCAGTGAAAACTGCTGGACCACTCAAACAAAAA TTGAGCTGCCACTCCTGAGAACTGACTGTGTTGCTCTTATGGATCAGCCCTTTGGGACCCATCCTAATCCCAGGGA TTTACAGTGCCACATATGCACCCGCAGCCTTTAGATGTAGACTTTATCCACCTAGCCCTCAAAGGTCTCAGACACT GCCCAGAGCAGCCAACATCACCCAGGACAAAAGCAACCCTGCAGCTCAACTTGCTCTTCTAGATTTCTGCCTTCTC CTGGTTCCTGGCCTGGCAAATCTTTACTGCTTGGTTAGCCCCTTCATACTTTCCATCAGATTTTTCAAATATGTAC CCTTTTCCCACTTGTCCAGTAGTACTCAATGGGAGGGATGATCCAAATTACATAATTAATAATTGCTGAAAACTAA AGTACAATGTACAATTTTTATGTCAATGTCACATGCCAAGGGAGAAAATGCATAGGTATCAGTAGTGACTACTTAA GCATGTGTAACTTAGAGGTAATAAAAACAAAAATGTTAGGTAATATCTATCTATTCCAGATTAAAATCTACATCAA TAAATTCAAACTTCTAGGAAAAATATCTGCATATGTAATATATGACTGTGACTCCGATAGACGAACGTGGGAATAT AGTATGAAGATACTTCTCATCGTCTTCACTCTGTGAGGCAGTCAGTGTGAAATGAGAACCAGGGATTCAAAATGTG TTGCAAGACTATGAAAAGCACTAGAGTAAGTTCTACACAAATAAAGCAATCTCCTCATAAATTACACTGGGCTTAT CTGTGAGATGCATGTCCTTATCAAAATGGAGTTAATTCTAGGTAGGTGATCTTGTTTAAATAAAATGGACTCTGAC TCACTAGCTACTGGTCCACCATCGGTTTTTCCCTTTACTAAAAGGGAGGCCCCACACTGAGCCAGCATTTCCCAAG AGGAGGTGTCTTGCTGACATCAACTTCCAACAGGGTAAATTTTCATGGGAACCCAAAGAGAAGAGGAAGACCTCAA GAAAAAGGGCCTAAAGAAATGACAAGAATGATAACATTTTACACTTTTATTGTGCTATGTGTCAAATAGTGGTCTT CGCACTTTAAAAATGCCAATTCATTTTATTCTGACTACACATCCATGGCTTGTGCCTGTTATTTTTCCCTTTCATA GTTAATGCCATAGGAATGAAGATCACACAAAAGTAGGGATGGAGCCGGGTTTGCACCCAGACAATTCTGCCCCAGG GCCATGCTCACACCACTGCACTTTTCCAGAATGTGAGGGTGGGCGGAGAGTCCAGCTCAGGGAGAGAGATTGGAGT GAGAGAAGAAGGAGAGGGGGCCGACTGGATCACTGTGATGGTCTGGACCCACGATTCCAGGAGAGAAAGACAAGGA TTATGTCACTCAGGGAAAATATCCAAAGTCTCTGGTTTAAACTTAAGCATCTCCAGCTCCAGGACAGGTGGCTGGT GGGAAGACAAACTAAGCCAAAGCCACAGCTCTGAAGATTTCCCTCTCCTGAGAATTCTGCAGGGGTTTCCCTGACC TCATGGCCACCTCTCACCCTTGGCTCTTGTTTTTCCCCCAGGACTGATAAGGGCGTCCAGATGGGACGCCTTTATC AGTTGGTCTCGGGTTCTAGAGAAGCCATCAGAGTCAGTGGAGGATGAGCTTCATAAAGTGGGAGATCTCCAGGATC CTTCCTGGACTCCAAGATACCCAGAGAAGCCGGATCCTGTGTCCCGGAACCCCCTTCCTGTTCCTTTGTGGGCCCT GACCTTAGGGAGAACTGGGCTGGTGAGAAGATCAGGATGAACTGGGCTGGGGAGGCAAGAGGGAAAGGGCGGCTTG GAGGGCTTAGTAGCTCCTCTCGCGGCGCCTCCGTCCCGGGCTGGGATCTGCAGACTCCTCAGGTCACTTCTCCCAG AGCCGCCGCCCCAAGCCACCCTCCCCTGGTTCCCGTCCCTCTGTCCCCTCCCCAGCTCCCCCCACACAGTAAGAAG CTCCCAAGTGAGCGGCTCCGGTGCCGGGCGGGACGTGGGAGGGAGGCTGTGTCCCCGCGGGGAGGCAGGGCGACGG CGTCCAGGAGAGAGGGGAGCGGGGCGGTGTCCCAGGCACCCTGCGCCTCTCCCGCCCGCAATGTGCGGGTTCCCGG AGCCCAGGCCCGCACCCCGGGTACTTGAAGGCCGCCGGGCTCCGCCTTCACCACGTGGGCCCTGAGTTCCTCCGCG GCGCCTTCGTGGGCGACACGCGATTCCTGAGCTTCCACAGCCGCGGCGAGAATCAGAGCGTGAAGCGCGGGTGGAG AAGATGGCACAGGGCTGTGGGCGCCCTGAGGAAAGTTCTCGAAGACCGCAGGGAATGTGTTACTGAGGGGCCTGAG GTTCCTGGGCCCGCACCACCACCAGGGTCAGCCGGTGAGTGACCTCAGACTCCGGGCACAGGTGTGCCCCGCCCCG ACCCCAGAGTGACCAGCCCGGTTCTCCCAGGGATGGGGGGGCGGGGCCTCAGCTGATCCCTCTCAGGTGGGGAAGC GCTGGGGCCATTTTGCTCCAGGTTTCTCCTTCAATCTGGATCATGACTGACTTGTTCTGTGACCAATGACAGAGGG AGGAAGGAGCTGGGGTGGGCGGGGCGACCTCCCTCCCCTCCCTGGCCCCGCCTCCGGCTCACCCTGGGGCAGGTCC AGGGCACCGCACCTGCAGATGCTGCTGTCTGGCTGGGTGGTGGCTCCGGACAGGAGCTTCCTCGAAGGACACTTTA AGTCCGCCTACGACAAGGAGATTTCATGTCCCTGAACGAGGACCTGCAGACCTGGACAGCGGCTCAAAGAGCGGCT TGGAGGATCCATCACACCTGGGAGAGGTTCTGGACCGCGGAGGCCACAAGGGAAGCCCCGATGGGTCACTGCACTA GGTGGCTGCTCAGACACCTGGAGGATGGCAAGGAGATGATGCTGCCGGCAGGTACTGGGGTCCTCCAGGCCCCACG TCAGGACCTCTTGGAGCTGGAATTATGTTCCTTGGAGGCATCCATATTTGAGGAAAGAGGAGACCGAACAGTCTCC GTCTCCTCCTCCTCCTCCTTCTCCTCCTCCGTCGCCGCCTCCTCCTCCTCCTCCCTACTGCGGGGTTGGGGATTCT GGCCCAGGCTCCTGAGGCTCTCCCATGGGTGGGTGGGGAGGGAGGACAGAGAAGAAGGAGTGCAGGGAGGTAAATA GGAAAGGACAGTAGTTACCCTTGTCAACAGTGATGTACTTGGGTCTAGCTTCACCGGGAATCTTTTTCTTTCCTGG CCCTCTGTGCCCAACAATTACATATAATCTTTAACCCAACCAGAAGATAAAACACCAGGAAACGGAATCGGCAGAG ACACAGTAGATGAAAGTACCACGAAGGACTGCTAGGTTCTAATAGAAAGTAGCAGATGTGAGTATCAAAAGTTATA AACCTTTTTGCAAATCAGAAAAGAAACAGACTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGT CTCTCTCTGTCACCCAGGCTGGAGTGCAGTGGCGCGATCTCAGCTCACTGCAAGCTCCGCCTCCCAGGTTCACGCC ATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCGCCACTAAGCCCGGCTAATTTTTTGTATTTT TAGTAGAGACGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCGCCCGCCTCGGCCT CCCAGAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCGAAAAAGACATTTAAAGACTGAAAAGTGGTATC ACCAATGTTAGAACCAAAAAACTGGACCTGAGGGTGCATCACCCGAGGGGGTTAAGTTAAACTCTGTCCCTGTTCC TTCTAGAGCCCCGTGGAGATTCCTGCTGTGCAGCAAAGCCTGGGAGGGGCCCCTGGCTGTGGAAGGCAGGCTGAGA CGTCATAGGTGAGATAGGAGGAAGGGGACCTGCTGGACTCCCGGGGACCTGCTGGACTCCCGGAGGCCTGGTACCC AGGGAAGGCCAGTTCCTAGGGCTGCCTCTGGACTTCAGAACCTTGATGTTAAGTCATATTTTCCCGCTCCTCCATG AGCTTCCAGGAGCAGGGCCACATGGGGCTCAGAAAGTCCCACAGTGCCTAGGAAGTGGGTCTGTCTCTTGTGGGAC AAAAATTCTCAGGTCTTTCTCTTTCAGATTCTTAAATTTCTTAAAAGAGATTGAACTGGAATTACCCAGGCCCCAA ACTGAATCAAGGAATTGGGACTGTGTAATGTGCGTGTGTCTGTCTGTGCACATGTGGATGTATAAACAGGTATGGG CATCTATGTGTATGTGCGTGTTTATAAGTGCGTATATGTATGTATCTGTACATATTTATGTATATAAGCAGGTATG GGTATGTATGTGTGTATGTGTGTGTGTTACTCTGTGACTTCCTCATACTTGGCACCACCCTGGCCTTTTCCTGGTT GCCCCCCACACCATAGGTTGTAAGGGACAGAACAGCGCTCCACCTGCAGACATAGAACGGGGGTCAGGATAAGTGT TGGGGAGAGCTGGTTTCATCACACCTGGAATAAGGAAACAGGACCTAAATGGATGGGTCCCACTCTTTTACAGAAT TGTACCTTAAAAAAAGTGTCAGTCACGTTCCTAAGGGATTTACATGAATTAAATCATTTAAACCTCACAAGAGCCC TATGACCTAGAGACAGCTATCAGCCCCATTTTACAGACAAGGAAACTGAGGTCACTAGGAAGTTTAGTAACTGTCA GTGGGCTGACTCATGACTCTAAGGAGACAGTCTGACTGCTGAGCCCAAGTAACTGCTCTGTCATACTCACCCTCAC ACCCACCTACTACTGGCTCCCTGTGGGTCACCTCCTCCTGTGGGCTCTGACCAGCTTCCCTTTCTTCTCCAGGCAC AGAGACTGGACTGAAGTCTATTGCATTTGCCACAGTCCCGACTGGGGAGTCATGGGGTTGAAGTGACCCATAGGCT GATGGAGTGTGCTTGCTGGATGCGGGGGAAAGGGAGATTTATATCTGCCCTGGAGGGAGTCAATGGTGTTTGCATC ATGGCATATGAGGTGCACTATCTAGAATGCTGAAGGGTAAAGACCAGCAGGGGCCATGCAGAGTCTATTCATCACG GTTTTATTTCACAGCCTGCATGGGCCTGAGAGTGGTGGGGTGTTCACTCATCTCCATCCAATCCCTACTGGTTCCT GACCTCTCTTCTTCCAACTGGTAATACCTGCACTCAAGGTTGAACCATGAGGAGGAGTCTACCCACACCCCACACT TCCTCCTCTCTGCCTGCCACTCCCTAGTGGGGCCTCCTGGATGGTGTGAGAGGAGAGTGACGGAGATAGTAAGAGA ACTTGACATTCACACTGGTAAAGAGAAAGTGGGATGTCAACCTATGAGAAAGATAAGGGCTGCCACAGGGAAGGGG ATGAGATAAGTTCTAACTGGCCCCAAGGGTCGCTTAACTCAGTGAAAGCTGTGGGAGGTGTTTTCAGCTATCCATT GCTATGTAAGAAATTGCCACAAACTTAGCAGCTTACAACAACACACATGTATTATCCCACATTTCTATGGGTCAGG AATCCAGACACAGCTATGCAGCTTTCTCACATGATTTTCATCAGAGTGCCATGGCTGGGTCTTATCTGGAGGCTGA ACTGGGGAAGGATCCACTTCCAAGCTCAAGCAATTGTTGGCAGGATTCATTCCTCCATGCCTGTTAGACTGACAGC CTCAGTTCCTTACTGGCTGGTGGCCAGAGGCTGACTTCAGTTCCTTGCCACATGGGCCTTTCTGCTTCATCAAAAC TTGCAAACAAAGAAGGTAGAAGACAGAGTCATCTAGTAATACAGAAGTGCGGCTGTAATATGACCTCATTACGGAA GTGACATCATTTTTGTCACTTTCTATTGGTTAGAAGCAAGTTTAGGCCCCATCGGTTCTCAGCTGGATGAGATGCC AAGAGACAGGATCACCGGGCATCATCTTAGGGTCTCTATACACAGGCTGGACCATGACTGAACAAGATCATTACAA ACCCGGGTCCTGGACTGGGCCAGATGATCTGCAGAGCTGAGCTGTGTTTATGAAATCGAATCCCTGGAAACAAAAA TCAAGAGACGCCCACTGGAAAGGCTGGTCTTGCATTCTGTGTGAAAGCTAAGATGGCGTTCTCTCCAAATGTTTTT CTCTATTACTTTTCAAACCTCCTGCATCTGTAAAGAAGCAACACCACTAAGCCTATCTGGTTTTTTTTTCATTCGA GTGTCATACTGTTAGGCAAATCTTCTGCTTTCACTATTTCTTCAAGCTTGTTTTCATGCAGAATCCCACGAACTTC TGGTAATTACACTTTATTGATTTCTTTTCCTTCACTCAGTTTATTTTTTAGTGATTTTATTTCTCTTGTATGGATA AATTAGTCCATTTAATTAGGGAATTTGTGTCTTCTAAAGAAATATTTCTACTATTTTTTGGACCATATGGGCTAAG ATCCTCTTGCCAAGCCTCAGCTCACTTCCCACATGGACACGACAAAATTACTGGGGGTCCTGGAAAGTCGGGGATT GGCATAGTTCTTAAGCAGGATCAGACATGTAAGTCACAAAGATATGAGGCAGATACCTTTGATTTCCTTATGACCC TGATGACAGCATACCTGGCACTCAATACCTGTCTGTAGAGGTGAACTCAACTAAACTCCCTGATCACTCAATACCA TGTGAGCCCAAGGACCTCTTATGTCATGGGCCAAATTCCCTTGTTTTATGCCATTTTTCCAGATGGGGTGCTGTTC ACATGGGGACGTTTCTCCTTTTCCACCTCATTTTCCATGTGTGAAACACTGGGTCTTGATTACTCAGATCTCTCAG GGTCCTTTCTACCTTTTCCTCCATCCTAACATTCTCCCTACAGTTCCCGCCAGGGTTTCCCCGAACCTCTTCTTCT CCATGTATTCAGTCTAGCATCTCTCAGTTCATTCTTCACACTTCACCAAAGTGATATTCTGGAATGCAGATCTGAT CAAGGTTCTTCCTGACTTCAGTGCTGCCAGTGCTGCACATTGTCCTCGGATAAAAGCCAAAGGTTCTCCCCAACCC CACAAGCCTTAGTCATTGAATCTGCTCACTGCTCCAAGCTTGCTTTTTGCCCCTGTGCTCCTCTTTTTCTAATCTC TACCCTGAACTGCTGACAGTTCCCCTAGACTCCCTGTGTGTTCTTTCTTCTGAGCCTTTGTTTGTGATACTGATTC CCTAAAAGATTTCTCCTGCCATTCACCTGGATTAACTGTGTTCCTCATCCAGTTCTCTGTTTAGACATTGCATCCT CTTGGAAGCAGTTTTCCCGCACTAATTATAGTAGCCTGCATTTAGCTGTTTTTTTAGTCCCCTTGTGGAATCTTTG ATGTTTCACTCATTGAGGGCTAGGAGACCCTGACACATAGTAACTGCCTAATAAATGTTTGCTAAATAAATGTGGG GTTCACCATGAGATACCACGTTATACATGCAAGAATGGCATTAATTTGGCTGGGCGCGGTGGCTCAAGTCTGTAAT CCCAGCACTTTGGGAGGCCAAAGCAGGCAGATCACGAGATCAGGAGATCGAAACCATCCTGGCTAACACGGTGAAA CCCTGTCTCTACCAGAAATACAAAAAATTATCTGGGCGTGGTGGCATGCACCTGTAATCCCAGCTACTCGGGACGC TGAGGCAGGAGAATTGCTGGAACCTGGGAGGTGGAGGTTGCAGTGAACCAAGATCATACCACTGCACTCCAGCCTG GGAGACAGAGTGAGATTCTGTCTCAAAAAAAAAAATGGCATTAATTAAAAAGTCAAAAAACAATAGATGTTGGCAT GGATGGATTACACTGCTGGTTGTGAGAATGTAAATTAGTACAACTACTATGGAAAACAGTATGGAGATTCCTTAAA GAACTAAAACTAGATCTATCATTTGATCCAGCAATCCCACTACTGGGTATCTACCCAAAGGAAAATAAGTCATTAT ATGAAAAAGACACATGCACACGCATGTTTATAGCAACACAATTCATAATTGCAGGGATGTGGAACCAGCCTAAGTG CTCATTGACCAACCAGTGGCTAAAGAAAGTGTGGTGTATGTACACCATGGATTACTACTCAGCCATAAAAAGGAAT GAAATAATGCCTTATGTAGCAACTTAGATGGAGCTGGAGGCCATTATCCTAAGTGGAGTAACTCAGGAATGGAAAA ACCAAATACTGAATGTTCTCACTTATAAATGAGAGCTAAGCTATGAGGACACAAAAACATGCAAAATGACATAATG GACTCTAGGGGCTTCTTGGTGGAGGTTGGGAATAGGGTGAGGGATAAAAGTCAACACTGGGTAGAGTACACTGCTC GGGTGATGGTGCACCAAAATCTCAGAATTCACTACTAAAGAACTCACACACATAACCAAAAACTACCTGTCCCCCA AAAACTATTGAAATAAAAAAATTTTTTTAAATAAATGTGGGGTTGATTTGTAATTTAAAATTTATTTTGAATAGCT AATACAAGAACAATATTTAAAAGATTATAATAATAAAAATGTGTATAGTGTGCAACGCAAATTTCCTTCTCCACCC CATCCACAATTCTTCCAAATTCCTTGCCTGGATGCAACCACTGTTACCAGTTTCAGCAAGAAATTAAGACAGAAAT TAAAGTTCTGCTCCTCATAATAATCACGATCAATTATCCCTGCTTATACAGTAACCCCTCCTTTTCCCAACAGCCT CCTAGCATGAGGAACCCAAATTGAACAGGTAACAAACATACCCCTAAACGTAATGTAACTTGTACTCTGTTCCATG GTAGGAACTTCCTTCTCTGGGATCCCAAACTCCTAGACCAGCTGAGTACGTTGAGGGGATGGGAAGCACCAACACC CCACGCAGGTTACCGGAAGTGCTGGTGAGTATAGTCATTCCTTCTTCCAGCACTGGTGGTTAGAGACTTACTCTAC CTGTTGGAGACTTGGCACCATATAACAGCTGCTGGCGTAACCTTAGTGTATGCTTCATCCTGAAGGACATTACCCA TCCTGATAGGATGTGATCTTCAAGATAAAACCCAGCTGCACCCTCAAGAGACCATTCCACTGCTCTATCAGCTCGC AGAGTGTGTGATGCAGTATGGGGTAGAACCAGGAGATCTCATGGTCATGTGCCCACTACCAGACATCCTTCGCTAT AAAGTAGGTCCCTTAGTCTGGGGCAATGATATGTGGGTCCCCTATTAGAAGATCATACATATGTGAGCCCTTAGAT AATGTTTCTGAGTGTGGCACTGTGGGAAGAAAGAACAAACTCATACCGCTAATACAAGGCAACCTAAATCTGACAG AACCCCTGCCTTTTTCATTGTGAAAAAGTAAGAATAGAATCAATTTGCCATCAAATTGCTCATTGGCTTCCATAAG CGAAGGTAATCTGTTGGAGTTTATTTATCGCTGGAAAGTAGATTGTGACAATAACCACGTCAGCCATGCTGAAGGC AGCCCAAGCCTTGGGACCCACCCACAGTGCATCTCTTCCACCATAGATAACTGCTTTCAAGAGCCTGTTTCATGAG CACTGGGATGGTTAAGGACAGAGGCTGGCTGATGTGTACCGAATGATTCATCCTGGACACCTGGTTGTTTAGACTA CTTGTATAGAGGGTAATTTTTGCTGAGTAGTAACATCTGATACAAAAGATCCAAGCACTTTGTGTCTACTGTATGC CTCTTTCCAGATATTCCTGTTCCTGATCTTCCAATCTTGCTCCTTCCAGGCCCCTGACCTGCTATTTAAGCCACTT GCTGTTGCCTATAAGTCTGTGCATATTCTCACCTCAGGCCACTTCTGTCTACACAAAGTGGGTGAATCAGAGCCCC ACCTGCCTATTGGCAGGACCCTCTTCAATGCTGTCTCTACTCATTCCTGAGTTGCCCACACTGCAGACACACTCTA CTGCTGCCTCACACCAACACACTAAGCTGGCATGTTTATGAAGAAGCTCAGAATTTTCCTCTTAAGTCAGCTGGTC ATAGAAACTACCCATAAGGTCATTGGTGAGAGTCGAGGTCAAGGCAAAGGTCCAGCAGTGCGAGGTGACATGGGGT CTGAGCAAGGTCTTTACGTAATTAACACCAGTACTCAGAACATACGTACTTTAACCCAGGGGTCAGCCAATGGTTT CAATAAAGGCCCAGATGGTTTCCCTTTGCTGTGTGTGTGTTCATTCCCCTCTCCGAAGCTATGTGTAACCCCATAG AGATCACAGGGGTTCCCATCAACCACAGCCAGTTACATCCACAAAAACCTTGATCCTTGTTAGCAGATGGGAGAGG GTGGCTTGGAGGATTGAAATCCCTACTTCATGGGACTCTGGATACTTACACAGTTGCTTCCTTCTGTGTGTCTACA TGAATCTCAGCACTGTGTTTGGGACACCATCTACACTCTTATTCTTCATGCAATTCTGTTTGCTCCTCAGATGGCC GCTTTTCCTTTGAAGCTCAACAGTAGCCATCACGTACTTGGGCTGAGGGTTACTGATTAACTCTGTGGGATTCTGG GATCAGTTCCTTCCCTTTCTTAGCCATCCCTGTGCTTTACAAAACTTAGCTTCACAATTATACTCATCTCTCCCTG TGTGCACCTCTAAGAAATTACTGATAAAACACGAGTTTTTTTGAAATTACAAAAATATATGCAAGAAAATGTTTAT GGGGCCAATTGATCAGCACGGAAAAGCATAAACTTTCCTGTTTTCTGCCTCTCATTAGAATTTAATCCCCCAAAAT TGAACTCATTCCAAACTTCTGGCTTAACTAGGAGTTGCTGTAGCCAGCCTATTCTAGACAGCATCCTGTAAGCCCC TGGGATTGGCAGACACAAGACACTTTTTCCATTCATATATGTGGTTCTGTTCTGGCCAGATCAGTGGACTTCCAGT GCCCTTCTTGAGTCATACTGAGGTAAATTACTCAGACCACGAACTCACATTTTTAAATAAATAAAATAGCAGCATA GTTAAGAATTTATTTATCCCATTACTGGGTATATATGCAAAGGATTATAAATCATTCTACTATAAAGACACATGCA CACATATGTTCACTGCAGCACTATTTACAATAGCAAAGACTTGGAACCAATCCAAATGCCCATCAATGATAGACTG GACAAAGAAAATGTGGCACATACACACCATGGAATGTTATGCAGCCATAAAAAAGAATGAGTTAATGTCCTTTGCA GAGACATGGATGAAGCTGGAAACAATCGTTCTCAGCAAACTAACACAGAAACAGAAAACCAAACACCGCATGTTCT CACTTATAAGCAGGAGTTGAACAATGAGAACATGTGGACACAGGGAGGGAAACATCACATACCGGGGTCTGTCAGG GGATGGGGGCAAGGGGTGGGATAGCATTAGGAGAAATACCCAATGCATGCGGGGCTTAAAACCTAGATGACGGGTT GATGGATGCAGCAAACCACCATGGCACATGTGTACCTATGTAATGAACCTGTACATTCTGCACATATATCCCAGAA CTTAAAAGTATAATTTAAAAAAAAGAATTTATTTCATTTGTATAGTCCATGAAATTTTTTGGACATTTTTTAAACC TGCACTTTTCATAGTTTTTGATACATCCTTGCTCCAATAAATAATTTGCTAAAATTACTAAATCTCATAGATATAC CAATGGTTTGCATCAGCTAATGGCATATTTGCTTGTCAAACTGAGGTCAGCCAGTCCCCCTTCATTCACTGTTAGT AACTCATGTGTTGCATTGTTAAAAACCCAGTATCACCTCATCTCCCCTCTAGCATCTTCTCTGCAGAGGAGAAGCC AGGCACTATATCTCCCAGGATCCCCTTCCCTGGATAGTTCCAGTTTACATTTTCCAGTGAGAGAGACTTGCATAAG AAATGGGGCCCTGGAGAGATGGCGGGACAGACCTGTACCCATCAGTGGTGGCTGCAGGTGGAGGAGCAGGCAGATG TCAGGTTCTCAGTGGCTTCCCTGCTAGGCTAGAGACCCACCTGCTTTGCTTGTGCGGACTAAGATGAGTGATAAGA GCTTCCTCATAGGTTCTGGAGAATATAGCAATCTCGCAGCAGGATTCTGAGAACCTCCCATCCATGCTTCAAGCTG AAGTCTTCAGTATATGCTTCCCTGACCTCCCTACTGCAGCTTCCAGGAGCTCCAATGGTGACTGGTATTATTATAG TATCCCACTGCTGCTATAACAAACTACCACAACTATGTGGCTTAAAACAACACCAATGTATTCTCTTATAGTTCTG GAGGTAAGAAGTCAAAAATGGGTCACTATGGGCTAAAATTAACATGTCGTCAGAGCTGCATTTCTTCTGAGGCTCT AAAGGAAAATCTGTTTCCTCGCCCTTTCTAGCTTCTTGGGGCTGCCCGCATTCTTTGGCTTGTGGTCTCTTCTTCC ATCTTCCAAGTCAGCAGTCACATCACTTTGACCTCTGATTCTGTTATCACAGCTCTAACTCTGATGCTGCTTTCTA CTCCTTTCACTTATAAGGACTATTGTGATTACATCGAACCTGCCCAGATAATCCAGGATAATCTTCCCATCTCAAG AGCCTCAGCTTAATCACATCTGAAAATTTCCTTTTGCCCTATTAGGAGACATTTTTATAAGTTCCAGGGATTAGGA CACAGACATATTTAGGAGACCGTTATTCTGCCTGTCACATGACTTCACCAATATTTGCTACCCGTGGTTTCCAAAC ATTAGTGTATGCTCTTATTTCTATTTATTCCTGAAATACCAGAGTGAGTCTGTTTTTCTGAAAACAGCTCACTAAT GCCCAGAGGAGCTCAAAAATTTTCTGTCTGTTGTCTCAAAGTCTCCAAATTGTACTGATTCTTCAATGTGCATGGC TGTAAATTAGGCAATAATCTTGCTGGGGTGTTGGAAGGAGAAGAAAGGGAATGATTAGACAGCCCTTCTGATTCGG GACAGAATCTGATTCGGGACACTGTCCCTGATGGCTGGCCATCTTGGGCTGTAATCCAGTTTCCCTCCCACGTAGA CCCGGTCATTTCTGACTCCCCAAGAGGTTTTCACAGTATTCATGTCCACTTCCTTCATCAGTCATCTTCTTGTCTT ATATCTCCATGTTTACATTTTTCTTCTCTTCTACCACTGCAGTTCTGCCTTGATTCTTCAGCCATTGCCTTCCTTT TGCATGCATGTGCTTCAGCCAGTTCTCTAGGAAGACATTCCAGACAGCTCATTATCACTTGTTACTATGTTTATTT GACTGCAGAGCTTTCAAGATTTGTAACTTTCTATTTTTTAAATTTTAGTGTAAAAATAATTCTTGCTCACAGTAGG AAATGAAACAATCAAAATATGCATAAATATACTTTTAAATCTCTCCTTTCACTAAATCCAAACCCACTTAACTAAG GTGATTACTATTGTATCAGCCTACTCTCTGCATGTCTACTTTCTTCACTTGCACGCAAACCATAGTGAGTGTTTTT ATCTGGTAGCTTTTGTTGAGCTGTAATGACTATAAGTTTTATATGTAATTTAATCATTTTCAGGGCAACTTGAGAT ATAATTTAAATAGTATAAAATCCGCACATTCAAAATATACAATTCAGTGGCTTTTAGAATATTCACAGTTGTGCCT CCATTACCACAATCAATTACAGATCCTTTTATCTCCTCCCAGCCCTGCAGAAAAATCCATATCCAAACCCCAGCCC TAAGAAACTACCAACCTATGTTTTAACTCTACAGATTTACCTATTCTGAACATTTTATGTAATGAAATTATACAAC ATGTGGCTTTTTGTGTCTGTCTTCTTTTACTTACCAGAACATTTTCAAAGTTTGTGTGGGTCGTAGCTTGTATCAG TACTTCACATCTTTTTCATCGCTGAATTACATTCCATTGTATGGATATATCACAATTTATTTATTAGTTGGTGACA TTTTGGTCCTTCTCATTTGGATTGTGATTAATAATGCTGCTATAAACATGGCATATAGGTTTTTATGTGAACTCAT GTTTTCATTTCTCTTGGGTATACTGTATCATAGGAGGGGATTGCTGGGTCATGTAATAACTTAATGTTCACAAATT TGAGCTACTGCTAGCCTGCTTTCTAAAGGGGCTATGTCTCTTAAATCCCCACCAGCAAAGTGTGAGTATTCTAGTA TCTCCACATTCTCATCAACACTAATTATTATCTTTTTAATTATAGCCATTCTAGTGGGTGGGAAATAGTATCTCAT TTTTGGGTTGATGTGCATTTCCCTGATGGTTAATGATGTTGAACATGTTTCTATGTGCTTATGGGCCTTTTGTATA TTATTTGTCTTATTATTATTATTATTATTATTATTATTATTTATTGTTTATTATTATCTTATTATTAATATTATTA TATTGAGTTACAACCATTCTTTATATATTCTAGATACAAGTCCTTTCCTTGCCAGATATAAGATTTGCAAAACTTT TCTCCCATTCAATGAGTTTCTTTTCACTTTCTTGATGGTTTCCTTAGACTCACACATTTTTAATTTTGATGATGTT CAATTTATCTTTTATTTCCTCTTTTTGCTTGTGCCTTTGGTATCATTTAAGATCAGGTATTTTTACCTAATCCAAA GTCATGAAGATTTATGCTTATGTTTTCTTCTAAGAGTTCTCTAATATTAAGTCTCACATTTAGGTCTTTGATACAC TGAGGTAATTTTTATATGTGGTGTGAAGTAGGGATCCAGCTTTATTCTTTTGCATAGGGATAGACTGTTGTTTCTG CACTGTTTGATGAAAAGATAATTTCTTCCCCTCACTGAATTATATTAGCACTGTTTTATAAAACCAATTAACCATA TAAGTGAAGAGTATTGCTGGGCCCTCAATTTTCTTCTGACTTCATTCTTTTTAATGCTGTTGTAAGTTGGATTTTT AAATAACATTTGTATTAATGCATTGATACTCTATAGAAGCACACTCAATTTTTGTATTTTGATCTTGTAGCCTACC AATGTGCTAAACTAATTTAGTATTAGTGGTTTAGTAGTTGCTAAGCTTGTTTTTAGTGAATTCTTTCGTATTTCTA TATAAGATTTTATCATCTGCAATTGAGATAGTTTTACCTCTTGCTTTTTAATCTAGATGACTTTTATTTCATCTTA TTGCTCATTGTAGCTTTTGAAAAATTACATTGTATTCACAGTGCCCTACCATTTGATATTTTTATTTCTATTATAT CATGAACATCCTTTGAATTTCACAGAAAAAATGGTTTAACTCATCATTTTAATGCTGTTCCATAGTATGTTATATG CACCTACTCCCCTGGGGTAAATATTTAGGTGGTTTCATTTATTTGTCACCCACTCTACAGATGTCTATATGCACAT ATTCTCCCAGCCATCCCAGAGTTTTCTGATTTCCCATAACGTCAGTGATTAAACTCCTGATCTGTCTGACTAGCTA GACATGCTGACTGACTGACAGTTCCATTGCTACTTTGCATAATTTAAGATCAACAGCTACATTTGGATCTCAGATC ATCTAGGCCCAGCTGCAGTTAGTCTTTCCTAGTCTCAGAGATTCCCTCTCTGCCTGTTAATTTCTCTATCCCTGAA ACTGCCCTTGTACTCCAGCCCAAGCAGCTTCCTAGCCCAGTAGTCCTGGATCTGCCACTTGCTAACTAGAAGGTGT CATCTGCAGAAGGTAAGTAAGGCATTTATCTCCATTCACTTTATATTTAGTTATCAAATCTCCATGTAGCTCAGGT AGATCGAGCTGAAAACATTCTTGTGTTTAGTAATATAGCCATTGAGCACACCATCATTGCTCTTTTCATACCTTAG TCCTACTCAAAGATTAAAGTGACAGCTTCCCAGTTATGATAAAAAAGTATAAAACATTCTGAGGGACCTGTAAACT ATAAAGCTAAAATATCAGCTTCTGCATGCAACATATATGTCAAATTCTATGTCCAATACTCTTCTCATTTTTAGAA TTAATTCTGCAAACTTGAAGATTGAGCTTTTTATGAACTGATTGGCATCTGCTATGCTCACCAGATTATTCCCACT TGACTGAGAGGATGGTGGTAGCAAGAGCTCCTTCCTTTCAGAGGCTTTTAAAAATACTTATTGGGAAGAATGTACC ACATAAGGCATTTAACTAATGAAACCACAGATATAACCACTGGCAAAAAAATCAAACAAACATTTCTTTAACTGCC CTGTACTTGGTACATTCTCTTCCTCCTGCTAGGGAAGTATCTCCTCTCCCTTCACTTCACAGACTGGAATTTTCCA AATTCCTAGTCTCAACAAGACAAACTGTATTTTGAAATCACTGTTTTCCCAGAATACCCGGAGTGTTACCATGACT CCAGAAGATGCCTTCAACCAAGACTCATAATCTGACTGTAAGAAACCTTCAGATAAGGTATTGGGAACTTCTGTAA AATTGTAGCTGGGCTGTGATTAGAGAATTTTCACAATATCAACGAATCTTACAAAAGAGCTGCTGATCCAACAGGT CCTCAGAGATCCTGTGTGGGAACCAGAAGGTATTCTGTGAAAAACGACAATAAGAATAACCATAATAACAATAATG GCTGCATTTAAAAGGCTCTTGCTATATTTCAGGCACTGGTTTTTGTACCTACATGGATTATTTTGTTCAATATTTA TCACAACCATATGAGAAGGATGTTATTATCCACAATAAATAAATGAAATCTGTAAACTGTAACTTGTTCAAGAAAA TTAGGTACAGAGATGTTAAGTTACTTGCCCAAAGTTCCATAATTTTGAAGATATGAGGCTAGAATTCAGTTCCAGG CCATTTTACACTAGATCTACTAATTTAGCCACTGTATGATTGTACCAAGACTGACCTAAAGCTACCTCCCCTTCCC CAACAGGTTCTTTTATGACAGTGAGTATAAAATACAGGGCTAATGACGTATTGGGTGCAGAGAGGGGTTGGAAAGA ATGTGGTATTTCAGACTATGCTTACTATGCTTAAAAATCACAATTCCGTGGTGACTAGAGTTTATCTTAAACTTTC CTCCCTGGCATTCCATTGCATCCAGTTGAGAGAGCACTCTAGCTCCCTACATCCCAGAACATGTAGATCTGTCCGT GGTTCTGAAAGACACACTGGCAGGTCCCGCCAACTACATGAATGGCATTCATATTGTGGAAAACTGCCCACTAGTA AAAATGTACAGTTGAATTTGTACATTCGTTACTTACAAGGTTGGAGAACGTGAAGTACTGGACAATCCAACAATAG CTTGGAAAGATACCATAAAAAGACCCGCAGAATATTCTTTTATATGCATTATTCTGAAATGTACAAAACAAAACCA GAATGGGACACATTATGAGTGAGAAGTTTATCTTGAAATTTTAATCAGAATATGAAGAAAAGAAATCCAACATTAG ACCTGGAAAAAGATAAAATAATTTGTATTTCATTTAACAATATTTATAGATTCTCAATATATACACTATCCTTTTA AACCTCAATTTATATTTAACCATCCATTTACCTTTATTTTTTGTTTGTTTTTTTCTTTCACCTCATACTTTCTACC TGGGATATCTTTTTGTGACTAAAGTACATTCTTTAGAACTTCTTGTACTTTACTAGGTGTGTTTGTGTTAAATTGT TTGTCTTCAAAATTCATTGAGATTTAAATTTTATTATTATATTTTCATGCTTAAGTGTTATGTGTTTGTCTCTTCA AATTTTTCTGAAGATTATTTATAGTTTTATAGTCACTAAATGTATTTAACAATCTGTTCTTTAATCATAGCCCATT TAGCAATTTTATATCCTATACAATTATTCTGATTTCTCAGTTATATGATTGTATGATTCTGCTGTCTGTTGTATTT TCTTGTTCTTTCACGGTGCTTTGTCTCTTATGAACATTGTTCTCTGTTGTTGTTCTTAACTGTTAAGTGCTCCTTT TGCTGGTGTAATGATTTTTTGGAATTTTCAGAGTGCCAATGACAGTAGAAATTTTCCAGAGAAGTTTTGCTTGATT TTCCAAGGTTCCTTGGAGTCTGCACTACTTTAAAATAAATTCATGGCTTGATGATTTTCAGACCACCCAGGGAGTG TGAACTCGGGCTGCAAATCCACTTCTCTTTAATCTCAGCAGAAGGTTTTGCCCCTCTCCACTCAGCACCAAGGTGA CTTTCTAGGGAGACCTTCAAGCAAGGATGTTTTCCTTATACTGAGGAGCTGGCTTTGGGATCCTGGTGAAATGAGG AGAACACTCTATTAAATTTCTCACTCTGAGTGCTACCTGAACTCTGTCTTCTATTCCAAATGCCTTAGGAGGCCAT GAAAACTAAACCTTAATTATCCTACATTAAGTAAATAAGCTCAGCAAAAAAAGTAAATGCACAATTCCGTGATTTA GGATTTGACAATTTTTATTAAAGTTTAAGCCTCTCAATGCTTCTACATTGTGTTTTATTTTTTCACCATCCATTTT TGTTAGCATGAGGGTAGGTATGTTTACCTAAATGTGCCATGTGAGTGGTTCAAATCTCCTCCCCAACGCTCCTTAT CACAAACCTTACCATCTTATTCCTTTAAAGTCACTGACTATCTAAGCAAACTACTAGCTACTGCTGTGCATTGATT AGGACCCAACAGTAAGACGTTTCTCCTTTTGGTAAACTGCACTTCCAGATGGTCTAATTGAACATCTTCTCACTGG AAGTATTTTTATTTCCATTACTCTTAATGATGATTCCTGAAAGAGACTCTAATGCCCTGACAGTTAACTCTGGGGT ATCCAAGCATACTCAAATTTTTTTCCTTCTACAGTCAATTGTCCTTAGGGAACTCCTCAAGACCTCAATAATGAGA CAAGGGAGAGTGGACTCTCCAGTGGTAATAAGAACATTAGGAGTATAGTACAAATTATTAGGCAACTTACCTGGCC TTATGGAACCTGCTAAAGTCTGATGCTGTGTATACCATTTCCCCTTGCAGACTGAGGGCTGGTGAGCATGAGTGAC CTGATAAAACTCAGGTCATAATGGGCATCTCAAGTCACTTGGTCATTTTCTGTATCATGATCATAGAATTCAGAAT CTACCAGGGCCCAGTAGTAAGCCAGAAGCTATTACTCAAATTCAGAAAAAGAATGGAACTTTTTCCCCAAACCCTG AAACTTGGGCAATGAGTCCTATGACTGCCACACACAAACACACACACACACACACACACACACACACACACACACA CATACACTCAACAATATCCAAATAAGCATTTAGGGCCAAATGGCAGATATGCTTGACTTTTGCCTGGATCAAAATG ACATTTCCATTTATTATGGAATGTTTCTGTACTTGTACTAGCTCATAGGATTTTGGATTAGAGAAATACCCTTGCA GGATATGAAGTCATACTTTTTCATTGGTGAAATCATCTGTTCTCATTAGAGTTTAATAATATCATGCAGTTATTTC TCAAAGAGCTTGTACTCCTTAGATTTGCTGGAATTCCTCAAGTTAAAAAGACCAGGGCCTCAATAATGGGAGGTCT CATTGCCAATAGCTACAACTGGCTGTAGAATTTATTAAAAACATGTGAGTGCATTGTTTGGGGAAAGAATCAAGAA CAAAAGCAGTGCTTGTTTTGTACTTCACTGAACTACTTCCATGGCCTCCATTCAACTTTAGCTGCAGTTTTGGTGA CTTGATTCACAGACTGTCGGAAAGTTATGAGCTATGGAATGTGCTCTCTCCAATACTAAAGAGGCCAGTCATATAT ATGTAGGGTGTCCTTCTTTATCATTGTAGGTTGTATGAAGTCAGTGATTCCCATAGAACCTTGGGGTCACAGATGC CAGGCCTAATCTTCTTTTATTATTCATTCAATCTTTATTTTTTCAAACAATGGTCTCACTCTCTTGCCCAGGCTGG AGTCCAATGGTGCGAACACAACTCACTGCAGCCTCGACCGCCCCAGGCTTAGGTGATCCTCCCACCTCAGCCTTCC AAGTAGCCGGGACTACAGCTGTGTGCCACCGCACCTGGCTAATTTTTGTGTTTTTTGTAGAGATGGGTTTTTGTCA TGTTACCCAGGCTTGTCTTGAACTCCTGGGCTCAAGCAATCCACCCACCTTGGCCTCCCAAAGTTGTGGGATTACA GACATGAGCCACTGCACCCAGCTCTAATCTTATTTTAATTTTAGAAATCTAACTTGACAGTTTCTGGTGCCTGGAT CCATATTTGTCTCAGAAGATTGAATTGTGGACTGTGACCTTCTCTCCCAAAAGTCTCTTTCAGGGTAGAACTTCTG GTTATGGCAACATGAAGAGATAGACCAGCAAGTTTTCCTCCAACAGCAACATGAAAACTGTACTAAATACTAAAAA CAAACATTTGAAGTCACTGGAAAATTAACAAAGGCAAGCAATATGTGATAAGAGCTTTCTTGTTTAAGACTCCTTC TGTCTTAGGTAAGGACTGCAAGTTGGTGGCCTTTCCTTCTTACCTATGAGTGCTCTTCAGCCTCCCAGCAGATAAC TGCAGCCCTAGTGGCTCAATATGGGCAGTTTATAGAGTTCAGAGCCCAAATCAGCTAGAAATGTAAATGAGAATGT TGAAAGAGAGCTGCAGAAGAGTTGAGATCAACAATGTGAATGCAAATTATGCTCATCCCTAGTTGAACACTAAACT CTGCATGGGTGTGGGCCACTTGGGAATCTGGTGAAAAACCAGAAAGAAACTAGAGGGAGGTCTACCCTCCAAAGAG ATAAATGATCCTGGTGAGGTCTGCAAGTCTTCAGTAACATGGACTGAGTGCATTTGCCAACCTGCACAGAGCTCAG TAGAAGAAAGCAAAAATCTTACTGGCTTGAGAGGTGAAAAGGCAGGATTTGAGGCTAACAAAACAATTGGAAATTC AAAGAGAATTCCAGAAACAAAGCAACCACAATGAAGTTGAATCACAAAATCTGAGTATAAATGACCCAAATACTTG GTCAACCTCTAAATTACACAGATGCAGGACACACACCCAGAAACCCCTGCTGAAACCACGTAAGATACTAAGTGGA AATTCTCAAACAGAAAAAAAAGAAAATGAAAGTATTCTGGAAGAGGTCCACAGAAGTTTTGAGATGGCAGAATAAA GAACAAGCCTGTGCCTTTGAATATAAATCTCCAGAATGTGCTCAATTCTAAAATCCAAAACACAGATTGAAATAAG ATTAAAGAAAAAAATGAAGAGAACGTCATGAACCCATCAGAGAATATAAAGCAGGTGACCAGATATGCAAGTGGAT CCTCGAAAGAAGACACAGGATCAGAAAAAAATATTTGAGAAAATAATAGTTGAAAGTTTCCCACATTTGGTGGGGG ATTTTAGCTCATATCTAAGGTGTTCAATAAATGAAAGCAAAATAACTGCAGAGAAAATTACAAATAGGGTGACCAA GGCCTTGGCCTGGCCTGAGGCAACTTAGCTAGCCCCAGGGATGTGTGTTCTGGTGTGGAGTAAGATCAGGGAGCTA CCAGTGCAATCTCTGCCTCTACATCAGCGGGACTGATCATTTTAATTTTGATTGCAGTTACTGCTGGTATCTGAAT CAAAGTGGTGATGCTTCCTGAGGAAATTTCTGAAGCCATTAGTCAATTAGAACATTATAAGCCATGCCTCCCGTGA AGAGGAGCATCTAATCCCAGCATTTGCACCAGGGAACTCTGCCTGAAGGGATTACCAGTGACTTGAAAGTGTAACC AACAACAATCTTGTCACTATTACGCACCAGCTAAGCAATCTGAACATACATGCTGAAGACATATTTGGTGAGCTAT TTAAGGAGGCTAACTACTTCCACATTAGATCAAATTCTCTTAGAATTTGTTGCCTCATGGTCAAAGTCACTCAGCT GGATTCAGCAGTGGAAGAGGTGTCACCACAGGACATCAACATGGAAAAAGCCCTCAAAAGTTCCCCAGCCCAAGAC CAGCAAGCAGTTTCAAAGAGCAGCATTCCTACTCCTGCTGCTGACATTTACAATCAGAGTGATTGACCACCTCCCC TGAATAGCATGAGAGCACATGGAGATGATAAAGACAGGCTGAAGTTCTATACTGATCCTTCCCATTTATTTGACCT CTGGAAAGAAGAAGTGCTGCAGGACACAGAAGACAAAAGGAAAGACAGAAGGCATCAAAAGTAGCAAAACCACATA GATGGCACCACTTATGATGTGAAAAGGATTACAAAAGCCAGAAACAAGCACCATGAGTGGAATATGATGGCATATG ACAAAGAGCTTAGACCCAGCAACAGGTTGTCTCAGTGTGTACCATGGAGCATCCTGCAAGAACCCCTGTCCCTAGA CAGCAGGTCCCATACAATGGATGTTAGGGATGCTCTTATCGAGCTACTCCAAACCATTCTCACGACCCTTCCTAGG CAGCTGAAGATGCATGTCCACATGGGCCCACAAACCAGGCCCCTGAGCTTGAGTGCCACCCCTCCTCTGCCTCAGT GAGGCACATGGCCCTAAATGGACCTCAAGAGCGGCCCCCACTTCCCTGCCTTACCCCAGCTGTGTTCCAATCCTGT GCACTTATGGCTCCAGGAGACTACAGGATGCTCCCAGCACAGGTGCTTGCATATTACAACCCGTCAAGACCTCCTT CTCTTCCCCCTTTTACAGTACAAACTGCCTTTGTTGCCTTCTGCAAATCCTCCTGCCGCCTCCTTCCTCATATCAG CTGGCTCCACACACCCTCCTCCTCACCCTCCCTCCACTGGCCCCTGGGTCCAGCATTCCCTCCTCCAGCCACACAC TTTCCCCACCAGGCCTCTTGGCTCAGTTCTTCTTTTTTGTCTTCCCCATGCATTCGCCCCCACACTGCCACCAGTA GCTGAGGCAAAGTGTCAAGAACCTGCACAGCCACCAAAAAGTGATACGAGAAGTGATCTCCTTGCTGCTACTGGAA TGGGGATTTGACTGGAAAAGGTGCAGGATCTGTGTGAGCAAGAGGCCAAGAGTGAGCCCCTTGGGAAGGACAAGGT CACAACCCTGTCAATACATTGCAGTGGAGAAGTACAGGGATTCTGAGGGAGACTTAGAGTTTGACAAAAACAACTG GCCCAACCAAGGCAGTGCTGGGGCTAGCTCTATGCAACAGGTGGGTAGCTGGTACCAGGCTGGGTGACAGCCAGGA GACCATATGCTAAGAATGTACTTAAGATTTCAAGTGGTCTCAGCACTCAATGGTATTATAATCCCGCAGCTGAGCA CCTTTTGTATTAATGATGTGATATTGCTTCTGCACATCCAAAAATTCTGGGCTTTCTCAGTATTTACTGTGTAACA TTTAAATGCCATTAAGCATAGAATATCATGCTGCACATGAAGAAATAGGATGTAACTATTACATCGTCCTGAAAAG AGCGTTTTTTTTTTTCCTGTAGGCCATGAAAGTATTTAGTGTATTTTGGGTTTACTCTTATTGATCATTACAATTC TGCAGATGTGCTGTGTGAAGCTGCCTGGTGCTAGGCCTTTGAAGATTAATAACTGGGTTTCAGGTGGATATCTTCA GATGAGTAATTGATATTGTTTTACTGTTTTGGGGTGTTTTATGAGTTTGAAAAGCTGTTGGTTCTAGAGGGAAAGG TTTAACAAATAAGGAGAATCCAATATTTCTGCTTTCATTTTCTTGGCGTGGTATCCTCTGTGTGAATTTGAATGCT CAGTTGAATAGTTTTATTGCCTTAGTACACACTTGTCAAATGTAAAGTTGGAAGGACCCTTTTCAGGAAGGGTTTC CTGTGAACATTCACTTAGTAAATGCTTGTGGATGATTCTTGTAAGAGGTCTCAGTGCTTAGAAGTAATGAAAATGA AGAACAAGATCCTTTCACCTTCAGGGGACTTTGGGACCAATACTCAAAATATTTGCCAGCCCTTACAGCTTGGGCA CCAGCCAGCAGGAGCAGAGGTGAGTGGTCCAGGAGCTGGGCAGCTCTGGGCAGAGCAGCTGCATGTGGGCCCTGGG TGCTAAAGCAGGCCTGCTCATTGTGTGTCCTGGAAGAGCTGTGTTCTAAAGGAGGCCACAGGAGTTCTTAGCTCCT TAGTGTGTGACAGACAGTGCTTCAGAGGGCACTGTGCTCCACTTGGTCTTAATTTTGAAAGTTTACATTGAGGTGA AAGTAGATATTGACAGCTGTTCACTCTTCATGTGCTGTGTTCAGATTACGGATGAATCCATGAGCAGGGCCTTTGC CTTATCCTAGAAACACGTGGTTATCTTCCCTCATGTTGTTGCTGGCACATCACATGTTGATAAGTACCTCTCAAGA TTACCTTGATAGACCCGTAGCTGTAGAAGAGCACTTAGTTCTCACCTCTGCCCTTCCCCTTATTCTTGCACCGTGG TCATGCTAGAGACCCATGGGGTTTATTTTCCTGGCTAAGGCAAACTGTTGGGAAATGCAAGAATGAGAGCTTCTAT TGTGTAATTCTGGATGAAGAATAACTGCTTGTTTAGAACAAATAAATGTCCCAGGCTTTGATTATAGTTATGACTT CAAAAATATGCTAAGACCATTTACTTACTGAGGAAATCTTACCTACTTATAGTATTTCAAATTGATTGCAGTCATT AGTGACTTTCAGTTACGATGAAGGGAAGAATCTTGAGCTAAACGCAGGGTTGTCTGAGGTGATGATAGGAGTGGAA ACAGGATGGTAACTAATGGATTTAGGTTAATGAGTTCTGAGAAAATCAACCAGCCCCTGCAAGTCACAGCTCTGTG TCTCTAAGTGGACACCTGTCTGTCTTGAGGCAGTCATCATATAATACGCATCACATAGATTTTAGTCATATGGATT TTGAAACTCTGGAAACCATATGTCTGCAGCTCCCTTTCATGACCATGCTTGTGCTGGTTTATCTGATCTCCTCAGC TGTACCAGCTGCTGTGGCATGAGCTTCTTGAGCTTCTCTTTTTAGAGCTGATCATTATCTGGCGGCTGTCGCTATA ATTTTCTTGAATACAAGTAAACATTATTTATAAACTTTTAAATTTCTCTGTTTAATTTTTCTCTCTCTTTTTTTTT TAATGTAGAGGCCTACTTTGCTGGCATCTTTGGGTCCTACTCAGTCATAAACCACCCTCCCCACCCTAGAGTAGCC ACTCTTGATTTCTAATACAGATGAGTTCTGCCAGGTCTAGTTGAATGGCATTATACAGTCACCATCATGACCCTGG GTCTCATCATCTCGCTGTGTGTGGTCGTAGCCTGTTCACTCCCATAGCTGTCCAATGTTCCACTTTATAAATAACT CACATTTCTTGTCCTTTCACTGTTGATAGACAATTTTGTTGTATACAGATTTTACAAATCGTGCTGCTATGAATAA TATTTTCATATAGTTTGGCACACACATACATGCATTTCTATTGGTTTAGAACTAAGAGTGCTATTGCTGGATCATA GGTGAGTAGATGATTGGCTTAGTCTCTCAAAAACCAAGTTTCTAGTAGTAAACAAACAGTAGAGGAGGGTGAATCT CTTACTTAGAAATTATTCAGATAATAAATGAAGAAGGAATGAGAGACTGAGACTATAATAACTCTTTTGCAACCCA TCATGAATTAACAGATTTAGCCATTGAATAGCAATGGCAATTAACAACACAATAAAAGAAAAAACTAATGTGAGGT TCTTCCTCTTGATGGAAGAACACAATACAGCACCATCAAACAAGTCCAAGTGAAAAAGAAACCAAGCCTGAATAGA AGCTGATCTCCATAGCCAATTACCAATTTAGAGGCAATACAGATAATAGAAATACATATTAAACTATGCCTTGGGG AGCAATCAGCAAAATGCACACTATGGGAAGCTCTACCACACAATATAAATTTCAAGGAAGAATCTATAGAATAAAG ACAACAAAAGCATATTTCTAAAGGTAAAACTAAATCATAATATTGGATGATAAAAATAAAAATAAAACAAAGAAGT GATGATCGTAAAAGTCAGGTTGTGTTTTTATTTGAGGGAAGAAAGAGTTTATTGCTGGGCTGGAGCAAATGATGGG GCTTCTGGTTTGCCCCACAAACATCTATCCCTGGTGATTAATGGGTGTTTACTTTGTATTAAAGGACACAAATTTT AGACATTTTTTTCTTTTGGAGTCCTATATTTTATTTTATGACACAAAGGCTAATGAAAAAATAATTTATAGAGTAT GGTTACTGTTTTGCACAAAGCCTCCTCCCCATCTTCTTTTCTGGACACTGAGCACCCAGAACAACCAGCAGCCCCA GGACCCCCAGCAGGGGTGACCTCACTTCTAGGTGTGCATGCAGCTTACATCACCAGAGGTAACATGCAGGTCTACT CCTTGACTCCTGGAAGAACCTGATAGGACACAGCTGAAGGGAAGCCTTCTCCGCCATCTGTAGGCTCTTGGCCATC AGTGTAGAGGGAGCGGGTCCTCACTTCTCCACAGGCGTCTTCATGGCCATAGCCTCCTCTCTGCATGGGGAGTAAG GCCTGGCCCTTCGCCTGAACACGGTGACAGGGATCTCGCCAAAGGTGGAGATCACACCATTCCTCCTTTAGCAACC TCACGCTTCTTTTGCTTTACAGGAAAGTTGACTCAGGCTGGTGTCCAGTAAAGAAATCCCAAGGAGAGGCCGGGTG CGGTGGCTCACGCCTGTAATCCCAGGACTTTGGGAGGTCGAGGCGGGCGGATCACGAGGTCAGGAGATTGAGACCA TCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAAATACAAAACATTAGCAGGGCGTGGTGGCGGGCACCTGT AGTCCCAGCTACTCGGAAGGCTGAGCCAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGCTCCTGCTCCCAG GAGGCGGATGCCCAGGATGAACTTTAAGGTGGAGAGAGGAATGTCATTGCTCATCCTCCAGGTTCCAAGTAAGAAC CTTCCTGCCCAGCCCATCTCGATCTCCCTGAATCCTCAACGCTAATAAGGACTGTCTCCTTCTCACCTCCCTAGAC TGGGCTTTTTAACACTGGAGAGTGGATGTGATTTCTAGTTTCAGCATGTCCTGGTTTATTGTGCTGCCAGTAAAAT AAAATCAAAATACACATTGAATAAATAATAAATAACCCATAGTGAGCAAAGGCTTACAATGTATTTTTTTGAGTCA AGACCTCACTCTGGCCTGGGCTGGAGCCCAGTGGTGGGATCGTAGCTCAATGCAGCCTTGTATTTATGAGCTCAAG GGATCTTCCCACCTCAGCCTCCACAATACCTGGAAATACAAGCGCCCACCACCAGGCCCAGCTGTTTACTTATTTT TATTTTTTTAGAGACGAGGGTCTCACTATGTTGTCCAAGCTGGTCTCTAATTCCTGATCTCAAGCAATCCTCTTGC CTTAGCATCCTGAATTGCTGGGATTACAGGCATGAGCTGTCATGCCCAGCTTGTAATGTACTGACACTATCAAGGT TTCTTTCTCCAAGTGTGGACACAGCAGCAGACACCCCTTGTCTCTTGGGTCAGGACACTGGGTAGAGTGGAAGAGC AGGGCAACAAAGTCACTGCAGAAAGCACCCACGTGGAAGAGGTCCAGCAGGGAGAGCCACCTGTTCCAGGGACACC ATATTTAGGGATAACTCCTCTTTCTGGGCAGGACTGTTCTTTGATTACTTTTGTATTCACAATAGTTCTGAAATCG TAGGATGATGAGACTCAAGACTGGCTAGGGTTTTATTTTGGTTTAGTTTTTATTTTGTTTTGTTTTGTTTTTTTCA AAAAACCATCATGAGATTTGTTAATCTTTTGAATGGTTTTTGTGTCTCAATTTCCTTCAGAACTTAACTCTTCTTA ACATTTCACAGTCCACTTTCAGTTAAAAATGTACTAGTACCCATAAATAGAGAAATCTTGCAACCATTTATCCTCT ATAAAATGTCCATCTTTATGGTACAGATATTATATGTAATATATCTATATAGGTTATAAGTCCCACAAGAAAAAAA CTTCTTCTTATCTTTAAACAGTTCTATGTATATAAATTAGAGTAAATGAGGGGAACAAGATAGCCTTTTGCACTTA GCTCAGTATTTACCATTTTTGATCATCTTCATCTTTTCTGATAACCTCATTTCCCACCTGGTATCATTTGCCTTTA GCCTGAAGAATTTTCTTTACCAATTGTTATTGTGCAGATCTGCTGGTGACAAATTCTCTTAATTTTCTTTTACCTG AAACATCTCCTTATTTTGCCTGTCCTTGAAGGACATCTGTGCTGGATATAGAATTCTTAGTTGTCCTTTTTTTCTT CCAGCACTTTAAAGGTGTTATTCTACTTTCTTTTGTTTCTATGGTTTCTAATAAGAAGTCATTGGTCAGGACAAGA GGAACAGAGAAACCAAAACTGAGGAAATAACATGGTAGACCTAAAACTTATCAATAATGAAAAAAAAACCTATATG AATCAACACTCCAATGAAGGGCAGAGATTGTGTGAATTGGTTAAAAAAAAAAACAAAACACAGAACCCAACCATAT GCTCTTTCCAGATATGCAGTTTCTTTGTTTCTTTTTTTTTTAATTTAACTTTTATTTTTAGTTAAGGAGTACATGT ACAGGTTTGTTATATAGGTAAACTTGTGTCATGCGGTTTTATTGTACAGATTATTTCTGTACCCATTAGTACCCAC CCAAGTATTAAGCCTTAGTACCCATTAGCTATTTTTCCTGATCCTCTCCCTCCTCCTCTACCCTCAAGTGGACCCC AGTGTGTGTTGTTCCCTTCTGCGTGTCCATGTGTTCTCATCATATAACTCCTACTTATAAGTGAGAACATGTGGTA ATTGGTTTTCTGTTCCTGCCTCAGTTTGCTAAGGATAATGGCCTCCAACTCCATCCATGTTCCTGCAAAGGACATG ATCTCATTCTTTTTTATGGCTGCATGGTATTCTGTGGTGTATATGTGCCACATTTTCTTTTTCTTTTTTTTTTAAT GGAAAATAACTTTTATTGAGATCCCACCAGTTGCAATATCTGTTCCCAGCATTAAGCTCCTTCTTCCTTTGCAATT CGGTCTTTCTTGAGTGGTCCCATGAATGCTTTCTTCTCCTCCGTGGTCTGGAAGCGGCCATGGCCAAACTTGGAGG GGGTGTCAATGAACTTAAGGTCAATCTTCTCCAGAGCCCGCTGCTTTGTCTGCACCAGCAAGGACTTGTGGAGGGT GAGCACCCACTTCTTGGTTCCCACCACACAGCCTTTCAGCATGACAAAGTCATTGGTCACTTCACCATAGTGGACG AAGCCACCCAAAGGGTTGATGCTCTTGTCAGACAGGTCATAGTCAGTGGAGGCATTGTTCTTGATCAGCTTGCCAT CCTTGATAAGGTAGCCCTAGCCAATCCTATAGATCTTGTTGATCTCAGTGCGGTGATGGTAGCCTTTCTGCCCACC ACGTACCACAGAGAAGCCCACACGAGCAGGATGCCATGCCCCAATACAGGCCACCTTGCACAGGCCTTGGTGGGTC TTGCGGGGCAGCTTCTTGGTGTGCCAACGACTGGTGACCCTTTTGTAGCCTTTGCCCTTGGTCACCCTGATGACGT CGATCATCTCATCCTGCCCAAACACTTGGTTCACAGGTACCTGGTGCTTGAGCCTCTCGCCAGCCCAGTCCAGCTT CTCAGCCACAGTGCCTCCATTCACCTGGATCTCCATCAGGTGGGCCTTCTTCTGGCACAGAGGAAGCAGGTGCATC TGGGTGTGGGCAATGACGCAGATGACTTGGCAGTACTTCTTCATGCTGCTGAAGTCCTTCTCCAGCTGCTTCTTGC CATCCTCATCCTGCCATTTCTTGCAGTACTTGGTAAAGGCCTTCTTCTTAGATTTATGCCAGTTCTTATAGAAACG CCTCTTGCATTCATCACTGATGTGCTCAGCGAAGACAGTCTTGCAAGTCCGGAAGCCTTGAGGGGTTTCCACGCAG CCCACAATGCCCACTGGTGGCCTCTCCACAATGGTCACAGCCTCCACCACCTCCTTCTTGTTCACCTTGGATCCTG GCCTGTCGACTTCCCGCACGATGTGGGTCATGCCAGCCTTGTATCCCAGGAAGGCTGTGAGGTGGACCGGCTTGGA TGGGTCATCCTTAGGGAAGCTCTTCACCTTCCCACGATGCCTGCTGCTGCGCTTCCAAGGCAGGAAGCCGAGGGAC CCATGTCTGGGAGTGGAGAACTTTCTGTGAGACATCACGCCATCAAATCCTGCCGGTAGAGCATATTTGCCACATT TTCTTTATCCAGTCTACCACTGATGGACATTTAGGTTGATTCCATGTCTTTGCTATTGTGAATAGTGCTGCAATGA ACATATGCATACGTGTAAGACATGGGCTTTCTTTTTTTAATTTGCTTTGTTTTATTTTACTTTAGGTTCCAGGATA CATGTGCAGAACCTGCAGGTTTGTTACATACGTATAGTCTGCCATGGTGGTTTGCTGCACCTATTGACCCATCCTC TAAGTTCCCGTCCCTTGCCCCCCACACTCCCCAAAAGGCCCTGATATGTGTTGTTCCCCTCCCTGTGTCCATGTGT TGTCATTGTTCAACTCTCACTTAGGAATGAGAACATGAGGTGCTTTGTTTTCTGTTCCCGTGTTAGTTTGCTGAGG ATGATGACTTCCAGCTTCATCCATGTCCCTGCAAAGGACATGAACTCATTCCTTTTTCTGGCTGTGTACTATTCCA TGGTGGTATGCACCACATTTTCTTTATCCATCTATCACTGATGGACATTTGGGTTGGTTCCAAGTCTTTGCTATTG TAAATAGTGCTGCAGTAAACATACGTGTGCATGTGTCTTTATAGTAGAATGATTTATATTCCTTTGGGTAGATACC CAAAGCGTCAAATAGTATTTCTGGTTCTCGATCTCTGAGGAATGGCCACACTGTCTTCCACAATGGTTGAACTAGT TTACATTCCCAACAACAGTGTAAAAGTGTTCCTATTTCTCCACAGCCTCACCAGCATCTATTGTTTCTTGACTTTT TAATAATTACCATTCTGACTGGCGGGAGATGGTATCTCATTGTGGCTTTGATTTACATTTCTCTAATGAGCAGTGA TATTGAGCTTTTTTAATTTTTCTCATTAAGATTTTAATGTCTCATTTTAAAAAATTAAAGGAAGTTTCCATTTATT TTTTAAGATAAAGATTTAGCGCACCCAAATGCCCCCAAAGCCAACAGAAAAATAGCTTTGCCCTGTCATTTCCCTA AGAAAGCACTGCAGTTACTCAAAATATGCTCAAAGAAAAAAATGCAATCCTCTGAGTTCTAAGTTTCACGAAAGGA CCACATGTTAAACTATGTATATCGATTTGATGTGTAAGTATGCAATAAATATGTACACATACATTCCTATCTGCTT CACATCATTCTAGAGTATTCATAGTATATGAAGATGGGATTTAGAAATGTGAAAAGGCTGTAACAGTGAAAAGGAA AAAAAGGGTACAATGGTTTTTAGACCAGTAGAATAATAATGCTTAGCTAGTTAATTATTTTAACTTTGGAGCAGAC TAAAAAAGTTGTTTTGAAATAAATGGTACCTGTAAGTGATGCTTACTGCAATACTTGTTAAGTGTTATTTGTCACC ACTGACAGGAATTATATAGTGCTAGTAACACAGCTCCCACTGTCCTAGAATTCCTCTAAATGGCCAGCTATTGCTA CCATTATCTTGATAAGCATTTCAAGAATTGTGTTGCTGAGCCTTTTAAAAGATAACTAGTTTATAACCTATGTCTC CTTATGTGCCTACATCAGTTACTCATGGTCCCAAAGAAGTATAAAAGAGGATATAAGCTGCTGAAGATTTCACAGA AGAAACAGAGATATCAGAAACTTCATGATCATCAAACTTAAACCACCGCTGTTTTGCTGCATTTTTACAGTAGGCT GTGTAATGGCCTCCATCCAGCCCACCGCAGTGATCTGAAACAGAAAACAAATTATATTTCTTCAAATTGTTCTTTG GACCAATAACATACTGTGACAAGGCAAGATTTTCTAACAGGAAGTCCACAGATGTCTGTAATTTTTGTTTCCACCT GCCATTGTAGGAAAAATGTTTCAGATGCACTAAAAGCACAGGTGGTAACTTCCAGATTTCTTTTTTAAGAATCCCG TCGAGCTCTGCAAAGATTGCAGTAAAATCTGTTATTATCTATGAGTTTTTCTTCTTTAGAAAATAATCTAAGGCAA TCCTATAATGTACATTTACTTGTGGATGCTATCAGTAGAGACAAATACATGAAGGCCTCAAGTGTCCTAGACTTTT TGTGACGGGTGAGGCACTGTACTGTAGATTTGAATTGACCCTGAAAAAGTGCAACAATAATAGACTCATAGAGCCG CTTGTGTTTCTGCCAGGCATGTTCTGCAGCTTTAAAGTCATTGAGATGATCATTATTTTCTTCTTTATATGTCTTC CGATTATCAGTTTTATTTAGATCTTCATGGAGACCATCCATTAGGAACAGAAGAAATTCTTGTGAATCTTGACTGT ATCCTGCAAACTGGTAATTGATCTTCCCAATGGTGACTTTAAGGTCTTTTGGACTGATATATCTATACTGTCCTGT CCACGGGGCTTTCATGATTATACCAAATTCTTCTGCCACTTCACCTTTATGCCCCTAACAAATTTGACTTGTTAAT ATCATCCTGATAACAGTTTCGGTTGAAATAATCAGCCAAATGTGGAGCATTACATAGGCACTGCAATATTGAGTTC ATATAACAAGTATTTCCTAAGTTACGAAGTCCAGTAAGAGCTGGTCCAGAACCTCCAAAAACAGGATTGAGTTTCC AAATCTGAGAAGCAGAAAGCCTTGAGATCTCAGCTTTAGGGTAGCATGTTGGCTTGTCTTCCTGATTAACTGTTGG AGTTACTGCTGGCTTCCTCTTGAATAGCCTGGGTTATATCTGGGGAGGAGTAAGAGCATTTCAGTTTGGAAGGTTC CCTATCCTGCTTAGCAGGAATCTGTGGCTTGCCTTTATGAGTTGGAGGGGTGGAAGGAGGTGCAGATGAAGGAGCC ATTTCCAGTGGGTACATATGAACAGTGTTAGTGGTGAATGATAATAATGAAACGTTCCAGTGATTGGATCAAGAAA CTTGGCCCAGCCTGAAGGCAGTCCTGGTACCATCCTCCCCATTTCTTCACTTCGTGCTATTATCGAAGGTTCTCGT TGAGTTTTATTTCTTTCAGTATCATCTGTATCCTCTCTAAAAGTTTCTGTCCTTAGAATTCCAGTTTCTGGTTGTC CTTTAATCTTAAAAGGCTTGCCTGAACCTGAATCCCCTGTCGCAGATGTATGGGACACATCTCTTGTTGACTTTTT CTGTACTTCTGGGGTTGAACATCTTCTCCCCCTGTCCTCTACAGACTTCTCGGCACCAGAGGTTTCATGATCACTT TTACTTTGTCTTTTTACTCTTGTTATTTCTTTGCCCTTCTTTGCTGAGATTTCTTTATCCTCTTTCTTGGCCTGTT CACGTTCTTTCTTCTCCATTTCTTCTTTTGCTTTTTGTTGCTTCTGTGTAATTTCATTTTCTTCAGCTTCTTGTTT CTTTTTGGCTTTTTGCTCGTGTTCTTCCCTCCTCAGTTTCTTTCTGTTTCCCTTGCTGTCTTTCCTGAAGTTCTTT TTCTTGTTTGTTTTTCTCCATTAGAAGAGCAGTTTCTGCATGAATATGAGCCTTTTCTTCATCTGTTAACATGAGA GTTGGAGAGGAAACTACTGGCTTGGCGGAACAATCAGGAATAACTTTTTCATTCTGAGGAGACTGTTGCTCATGAT TTGTACTTTCAGATTTGATTATATGCTCTTCAGGCAATTTGACTGCCAGTTTTTTAGTATGATCAATCTGTGGAAC ATTCTTTATGCTAGGCACTGGCTGAATGATGGGTGAAACATCAGATTTAGAAGCAGCAACTGATTCAACTGGAATT GATATATTCAGTGGTCCTGTCCTCTCATTTTGATCATTATCACTTATTTGATCACTTATCAATTCTATGTCTTCAT CCACTTCTATAGGTGGAGGTGGCATCTCGGCAGCAGGTTTAGAAGGAATTGATTCTTCCAATGAGGGATAAGTAAA ATCCAATGAGATAGACAACTCTTCATTCTGGTGTTGTGGGGGTGGAGTGACCTTAGCATTTGTTGTATACTGGGAA TAGCAAAGGAACCAGTTTTTATAGCCTCCCTCTAAAACCAAAGGCCCAAGGCCCATTGCACAGGACAGTTTTACTT TCCCACTTGAAAAGTGCATCTTTCAGATGCCAGAGTGTTGTTCCAATCTGTAAATCTTTTGCAGAACTAAACCAGT CAAGAAGTACCATATACTCCACATTCCCCCTCTTCTTCCATGTATCTATAGAATCATCTGGGAGGTGTGCTTCAAT CCAGCTAGCAGTGACTCCTGGACTGATGGCTTTTCCAGGAACACTGAGAGAATGTAAAATACAGGAATCCTGATAA TCCTGCATTCTTTGAGCATCCATTATAATCAAGCTGATGTTTTTATCCATCATCATTGTGTATAGTTCCTTTGCTG TGATTGCTCCTTTCTCTTTGGTCTCACATTTTTCATTCTTTTCACCATTGCTCTTTTGGGTTTTGTCTTTGGAATC CAATACAATCTCCAAAGAATCTTTAGCCAACGTGCTGCCATCCTCTCTTCCTGTTTCCTGCCTTTTTTGTTGTAGC CACTGTGCTTCCCCCTGCCTGTCCTTTTCCTCAAGTTTTTTCCAGATTTCAACTTCTTCATATCTTAGTTTAAGGC TTTCAGAGAGTCGTTCAGTTTCTCCAGTGGCTTTTTTGATGTTTGCAGGTCCAAGTATTGAATGGAAGTAATACTG CTGTTGCTTGAAATCAGTTCTTTTTTGGATAGGATTATAAACAGTCATGTTTCATATACATGTGTGAGCTTTTTTT CATATGTTTCTTGGCCACGTAAATGTCTTCCTCTGAGAAGTGTCTGTTTATATCCTTTGCCCACTTTTTGATGGGG ATGGGTTTTTTTCTTGTAAATTTGTTTAAGTTCCTTGTAAACAAACATGTGAGCTCTCATCATTCTTGTTTAAACA CCTAACAGTCATCCTAACCAGTGCAACAAGGACCAGGCATGGTGGCTCATGCCTGTAATCCCTGCATTTTGGGAGG CTGAGGTGGGAGGATCACTTGAGATCAGGAGTTTGAGACCAGCCTGATAAGTGAGACCTCATCTCTACCAAATAAA AATAATTTTAAAAGAAAATAGATCAATGGATAAGAAAGGAAGAAATGAAAGTCTTTCTTTGTCACCAGCTTCATTG TATATGTAGAAAACACTAGGGAATTCTGAAAAAGTCTCTGGAATTAATCATTGAATTTGCAAAATAGTTCATAAAA TATATGTAATAAGTCGCTTAGATGAACATGAAAAGATAGCAAACAATACTAGTCATCAAAGAAGTGCAAGTTAAAA CCACAATGAGAAACCATCACACATCACCTAGAGCAGGTAAAGTTAAAAAGACATATGATAAGTCTTAACACTGGCA AGAATATGGAAAAAATAGGAATGTCTGATATTGCTGGTAGGAATGCAAAAAATGTGGCAGCCAATTTGTAAAGTGG TATGGCAGTTTCTTATACAGTTACCCATCTATTACCACATGGCCCAGCAATTCCACAAATACGTATTTATCCAAAA GAAATAAAAATGTAAGTCCACACTTGTAAGCAGTTATTTATAGTGGCTTCATTAATAACAAGCCCTAACTGGAGGA ATCCACATGTCTATCAACTGGAGACACAGAAACCAATGAATAAACTGGGATTCCAGCAATACTCGGCAGCTGCTCA GCAACAAAAATGAATGAATGGCATCATCTCAAACATCGTTATGCTAAGGGAGAGACCAAACAAAAGACTACATAAC ATATGATTGCATGTCCATGAAATTCTAGAAATGTCACTATTGCAGTGACAGAAAGCACAGCAGTGGTTGAATGAAG GGAAGGGGGTGAGGGTGGGAGGCAAGGATTAAATAGAAAGGGGCATAAAGAAAGTTTTTAGGGAAAAGAAACTGTC CTCTACAGCGCCACAACTCAGGAGTGACTGGGAGGGGGAAGTAAGGGGAGAAGAAGGTCTGAGGGATAAGGGGCAG AGAGAAGGGCTGGGGAAGCAGGAGGAGAGGACGAGGAGCAGGGGAAAGGACTCTAAAGCAGTGGAGGGGCCTAGTA GGAGGATCTTTGCATTTGGTGTTTCTCTACTGGGCAGTGTGGTAGTTACACTATAAATAATTACCAATATCCACCA AAAAGTGCAGCTAAAACTGGTGAATTTTTTTACACGTAAACGCCCTGATAAGCAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAGGGGGGGGGGGAGGAAAGAAGGCAAAAATAAAGACATTGTTAGATCATCAAACCCATAAA ATTCATTTCCTAGGGGTCCTGTACTACATGTAATTTTAAAGGACGTTCTACAGGCTGAAGGGAAATGATACTAGAT GGTGACCCAGATACACAGAAAGGAACAATTAACAACAGAAATGATGCACATACACATATCACATACACACCCATTT TCTTAATTTCCTGAAGATACGTGACTGCTTGTCTAAAACAAAAAGTATTACACTGTATTGTTGAGTTTATAACGTA TATTGATGTAACATATACAATAATAATAGCATAATGATAGTTTAAATGAAACTACACCATTTGAAGTGTCCTTTAT TTTGCTGGATGCAGCTTAATATTACCTGAATTTCACTGTGAAAAGTCAAGGAATTGGGTTTCAATTCTTACAACAA TAAAAAATTAATGTAAAGAAATATAGCTAAAAGCCACTAGGAGAATTAAAACCATAAGCTAAAAAATGTTTACTTG AAACATAAGAAAGTAGCAAAGGAGGAACAGAAACAAAAAGATATGAGACAAATTGAAAACGTATAGCAAAATGGTA GACCAAAATCCAACCATTATAAGTGAAGAAATGACACGACCTGAGTCACATTAGCAGGACTGCTGAGCACTATGGG GAGAACAGACATGGGCAGGAAGTGAGGGACAGTGTTAGTGCCACAATTCAGGAGTGACAGGGTGGCGGGGACTAAA GGGGAAAGAGGGTGTGAGGGATGAGAGGGGCAGACAGAAGGGCTGGAGAGGCAGGAGGTGAGGAAAAGGAGCAGAG GAAAGAATTCTAAAGCAGTAGAAGAGCCTGGCAGGGGGTTCTTTGCATTCGGTATTTAATACATTTTGTGTGACTG CCTTAAAACTAATGGGCTCCTTATGATTTTTTTTTAAAAAGGGGTTACAAAAATATCAAGTGTCCAAATAAAATAT GCACACTGCTTAGATGTGCATAGTTCCGGAAAACGGGCAGTGCTGGAGCGCTGGTGAAGAGCATTGGGACTGCATG GAGCCCTCACAACTTTGAGGTGATGACTACAGGCTCCCGGTTGCAATAGACAGTAACAAACCCTGCTTCTTTGTAT TCAGGAGATGTTCTGGACTCACACAGGGAAACTCTGGCTAGAGAATGAGGATAACTTTAAATGCAACAACCCAGAG TCACAGATCCATAGTCTGCGAAAGTAAAACAGGAGCTTTGAGAATTTAATTGTAATGCAGTTTTGACACAGGTCTT TCACAGATTGGAATTCTAATCATTCAGGGATTACCAATATTGTGCTACCTACTGTATCAATAAACAAAAAGGAAAC TGGTCTCTATGAGAATCTCTACCTGGTGCTTTCAGACAAAACTTCACCAGGTTTAAAGAGAAAACTCCTGACTCTA CACGTCCATTCACAGGGCGAGCTCACTGTCTGGCATCAAGTTCCCCATGGTGAGTTTCCCTGTACAAGAGTCCAAG GGGAGAGGTAAGTGTCCTTTATTTTGCTGGATGTAGTTTAATATTACCTGAGGTAAGGTAAGGCAAAGAGTGGGAG GCAGGGAGTCCAGTTCAGGGACGGGGATTCCAGGAGAAGTGAAGGGGAAGGGGCTGGGCGCAGCCTGGGGGTCTCT CCCTGGTTTCCACAGACAGATCCTTGGCCAGGACTCAGGCACACAGTGTGACAAAGATGCTTGGTGTAGGAGAAGA GGAATCAGGACGAAGTCCCAGGTCCCGGGCGGGGCTCTCAGGGTCTCAGGCTCCAAGGGCCGTGTCTGCAATGGGG AGGCGCCGCGTTGAGGATTCTCCACTCCCCTGAGTTTCACTTCTTCTCTCCCAACCTGCGTCGGGTCCTTCTTCCT GAATACTCATGACGCGTCCCCAATTCCCACTCCCATTGGGTGTCGGATTCTAGAGAAGCCAATCAGCGTCTCCGCA GTCCCGGTTCTGAAGTCCCCAGTCACCCACCCGGACTCAGATTCTCCCCAGACGCCGAGATGCGGGTCATGGCGCC CCGAACCCTCATCCTGCTGCTCTCGGGAGCCCTGGCCCTGACCGAGACCTGGGCCGGTGAGTGCGGGGTTGGGAGG GAATCGGCCTCTGCGGAGAGGAGCGAGGGGCCCGCCCGGCGAGGGCGCAGGACCCGGGGAGCAGCGCAGGGAGGAG GGTCGGGCGGGTCTCAGCCCCTCCTCGCCCCCAGGCTCCCACTCCATGAGGTATTTCTACACCGCTGTGTCCCGGC CCGGCCGCGGGGAGCCCCACTTCATCGCAGTGGGCTACGTGGACGACACGCAGTTCGTGCGGTTCGACAGCGACGC CGCGAGTCCGAGAGGGGAGCCGCGGGCGCCGTGGGTGGAGCAGGAGGGGCCGGAGTATTGGGACCGGGAGACACAG AAGTACAAGCGCCAGGCACAGACTGACCGAGTGAGCCTGCGGAACCTGCGCGGCTACTACAACCAGAGCGAGGCCA GTGAGTGACCCCGGCCCGGGGCGCAGGTCACGACCCCTCCTCATCCCCCACGGACGGCCCGGGTCGCCCCAAGTCT CCCGGTCTGAGATCCACCCCGAGGCTGCGGAACCCGCCCAGACCCTCGACCGGAGAGAGCCCCAGTCACCTTTACC CGGTTTCATTTTCAGTTTAGGCCAAAATCCCCGCGGGTTGGTCGGGGCGGGGCGGGGCTCGGGGGACGGGGCTGAC CGCGGGGGCGGGGCCAGGGTCTCACATCATCCAGAGGATGTATGGCTGCGACGTGGGGCCCGACGGGCGCCTCCTC CGCGGGTATGACCAGTCCGCCTACGACGGCAAGGATTACATCGCCCTGAACGAGGATCTGCGCTCCTGGACCGCCG CGGACACGGCGGCTCAGATCACCCAGCGCAAGTGGGAGGCGGCCCGTGAGGCGGAGCAGCTGAGAGCCTACCTGGA GGGCCTGTGCGTGGAGTGGCTCCGCAGATACCTGAAGAATGGGAAGGAGACGCTGCAGCGCGCGGGTACCAGGGGC AGTGGGGAGCCTTCCCCATCTCCTGTAGATCTCCCGGGATGGCCTCCCACGAGGAGGGGAGGAAAATGGGATCAGC GCTAGAATATCGCCCTCCCTTGAATGGAGAATGGGATGAGTTTTCCTGAGTTTCCTCTGAGGGCCCCCTCTGCTCT CTAGGACAATTAAGGGATGAAGTCCTTGAGGAAATGGAGGGGAAGACAGTCCCTAGAATACTGATCAGGGGTCCCC TTTGACCACTTTGACCACTGCAGCAGCTGTGGTCAGGCTGCTGACCTTTCTCTCAGGCCTTGTTCTCTGCCTCACG CTCAATGTGTTTGAAGGTTTGATTCCAGCTTTTCTGAGTCCTTCGGCCTCCACTCAGGTCAGGACCAGAAGTCGCT GTTCCTCCCTCAGAGACTAGAACTTTCCAATGAATAGGAGATTATCCCAGGTGCCTGTGTCCAGGCTGGCGTCTGG GTTCTGTGCCCCCTTCCCCACCCCAGGTGTCCTGTCCGTTCTCAGGATGGTCACATGGGCGCTGTTGGAGTGTCGC AAGAGAGATACAAAGTGTCTGAATTTTCTGACTCTTCCCGTCAGAACACCCAAAGACACACGTGACCCACCATCCC GTCTCTGACCATGAGGCCACCCTGAGGTGCTGGGCCCTGGGCTTCTACCCTGCGGAGATCACACTGACCTGGCAGT GGGATGGGGAGGACCAAACTCAGGACACTGAGCTTGTGGAGACCAGGCCAGCAGGAGATGGAACCTTCCAGAAGTG GGCAGCTGTGGTGGTGCCTTCTGGAGAAGAGCAGAGATACACGTGCCATGTGCAGCACGAGGGGCTGCCGGAGCCC CTCACCCTGAGATGGGGTAAGGAGGGGGATGAGGGGTGATGTGTCTTCTCAGGGAAAGCAGAAGTCCTGGAGCCCT TCAGCCAGGTCAGGGCTGAGGCTTGGGGGTCAGGGCCCCTCACCTTCCCCTCCTTTCCCAGAGCCGTCTTCCCAGC CCACCATCCCCATCGTGGGCATCGTTGCTGGCCTGGCTGTCCTGGCTGTCCTAGCTGTCCTAGGAGCTGTGGTGGC TGTTGTGATGTGTAGGAGGAAGAGCTCAGGTAGGGAAGGGGTGAGGAGTGGGGTCTGGGTTTTCTTGTTCCACTGG GAGTTTCAAGCCCCAGGTAGAAGTGTGCCCCACCTCGTTACTGGAAGCACCATCCACACATGGGCCATCCCAGCCT GGGACCCTGTGTGCCAGCACTTACTCTGTTGTGAAGCACATGACAATGAAGGACAGATGTATCACCTTGATGATTA TGGTGTTGGGGTCCTTGATTCCAGCATTCATGAGTCAGGGGAAGGTCCCTGCTAAGGACAGACCTTAGGAGGGCAG TTGCTCCAGAACCCACAGCTGCTTTCCCCGTGTTTCCTGATCCTGCCCTGGGTCTGCAGTCATAGTTCTGGAAACT TCTCTTGGGTCCAAGACTAGGAGGTTCCCCTAAGATCGCATGGCCCTGACTCCTCCCTGTCCCCTCACAGGGCATT TTCTTCCCACAGGTGGAAAAGGAGGGAGCTGCTCTCAGGCTGCGTGTAAGTGATGGCGGTGGGCGTGTGGAGGAGC TCACCCACCCCATAATTCCTCTTGTCCCACATCTCCTGCGGGCTCTGACCAGGTCTTTTTTTTTGTTCTACCCCAG CCAGCAACAGTGCCCAGGGCTCTGATGAGTCTCTCATCGCTTGTAAAGGTGAGATTCTGGGGAGCTGAAGTGGTCG GGGGTGGGGCAGAGGGAAAAGGCCTAGGTAATGGGGATCCTTTGATTGGGACGTTTCGAATGTGTGGTGAGCTGTT CAGAGTGTGATCACTTACCATGACTGACCTGAATTTGTTCATGACTATTGTGTTCTGTAGCCTGAGACAGCTGCCT GTGTGGGACTGAGATGCAGGATTTCTTCACACCTCTCCTTTGTGACTTCAAGAGCCTCTGGCATCTCTTTCTGCAA AGGCATCTGAATGTGTCTGCGTTCCTGTTAGCATAATGTGAGGAGGTGGACAGACAGCCCACCCCCGTGTCCACCG TGACCCCTGTCCCCACACTGACCTGTGTTCCCTCCCCGATCATCTTTCCTGTTCCAGAGAAGTGGGCTGGATGTCT CCATCTCTGTCTCAACTTCATGGTGCGCTGAGCTGCAACTTCTTACTTCCCTAATGAAGTTAGGAACCTGAATATA AATTTGTTTTCTCAAATATTTGCTATGAAGGGTTGATGGATTAATTAAATAAGTCAATTCCTGGAAGTTGAGAGAG CAAATAAAGACCTGAGAACTTTCCAGAATCCGCATGTTCTCTGTGCTGAGTCTGTTGCAGGTGGGGGTGGGGAAGG CTGTGAGGAGCCGAGTGTGGACGGGGGCCTGTGCCTAGTTGCTGTTCAGTTCTTCATGGGCTTTATGTAGTCAGTC CTTAGCTGGGTCACCTTCACTGCTCCATTGTCCTTGTCCCTTCAGTGGAAACTTGTCCAGCAGGAGCTGTGACCAC AGAGGCTCACACATCGCCCAGGGCAGCCCCTGCACACGGGAGTCCCTGTGCTTTCTGAGACAAATTTTCAGACCCA TTCAGCTCCTGCCCTCCTTATAGGGCTCCTCTTCTGCTTTGGTCTCCTGCCCTCTCTCCCTTCCCTGATTCCAGTG ATCTTCGTGCTGACTCCAATCCCAACTCATGAATCTAAAGCAGAGCCTAATTTAGATTTGTATTTGTTTGTAAAAT TGGGTCCATAGTCTAGAATTGTTCCTTCCTGAAGAGAGAAACCTGATCGTGTGCTGCAGCGTGCAGGGCGGTTGGT GTGGGAGGAGGGATAGGGGAGGGAGGACACACAAGCAGCCCTGCTGAGAAAAGTACAGGCGGCCTCGGTGTCAGTG TGAGGGGACCTTGTGCTGCAGCTGCCACAAAACAGCACTTGGCCTGAGGCTATGTTAATAAAGATACTGGCTTTAG AATAGGAGGTGCTCTACACTGATCATTCAACTGACCTTTGTTGTCAGCCAGACACAGGACAGAAAAGTTCTGCATC TGGGGAACACCATTGAAGTAAAATCAGAAAAATATCTGAGCATATGCTCCAGTGGTAAGAGGCAGACGATACATAC ACTATAACCACAGTAAGAAAAGAAAGTGATGGAAGGTGGTAAGTGCCATGAGGCAGGTGATCCGGGTATGGGCAGT GGGGACAGGGAAGGTGGCTGTTGGACAGGAGTTGTCAATGTGTGCCTTGTTGCAAAGATGACCTTTGAGGAAAGAT TTGAGGGACATGAGGATGTCTGGGGAAGTTCTTTCTAGGCAAGGAAACACAACTTCGTATAGAAAGGTATATACGA AGTTGT (LANDING PAD) SEQ ID NO: 2 GAAGTTCCTATACTCTAGAAAGAATAGGAACTTCGTCGACCCAGACATGATAAGATACATTGATGAGTTTGGACAA ACCACAACTAGAATGCAGTGAAAAAAATGCTTTATTTGTGAAATTTGTGATGCTATTGCTTTATTTGTAACCATTA TAAGCTGCAATAAACAAGTTAACAACAACAATTGCATTCATTTTATGTTTCAGGTTCAGGGGGAGGTGTGGGAGGT TTTTTAAAGCAAGTAAAACCTCTACAAATGTGGTATGGCTGATTATGATCTTAGTCCCCATCCTCGAGCAGCCTCA CCATGGCCCCAGTCTCAGAGTCCAGGTTTCTGATGTAGTTCATCACAATGTTCACATTGGTCCAGCCACCAGCCTG CATGATTTCAGGGATGGACACACCAGCCCTGGCCATGTCCCTGGCAGCACCCACTCTGGCAGAGTGGCCAGACCAG GCCAGGTATCTCTGCCCAGAGTCATCCTTGGCACCATAGATCAGGCGGTGGGTGGCCTCAAAGATCCCTTCCAGGG CCCGGGTGGACAGTTGGGAGGTGGCAGAAGGGGCAGCCACACCATTCTTTCTGACCCGGCAGAACAGGTAGTTGTT GGGGTCATCAGCCACACCAGACACAGAGATCCATCTCTCCACCAGCTTGGTAACCCCCAGGGACAGGGCCTTCTCC ACACCAGCTGTGGACACCAGGGTCTTGGTCCTGCCAATGTGGATCAGCATTCTCCCACCATCGGTGCGGGAGATGT CCTTCACTCTGATTCTGGCAATTTCGGCAATGCGCAGCAGGGTGTTGTAGGCAATGCCCAGGAAGGCCAGGTTCCT GATGTCCTGGCATCTGTCAGAGTTCTCCATCAGGGATCTGACTTGGTCAAAGTCAGTGCGTTCAAAGGCCAGGGCC TGCTTGGCTCTCTCCCCAGCATCCACATTCTCCTTTCTGATTCTCCTCATCACCAGGGACACAGCATTGGAGTCAG AAGGGCGAGGCAGGCCAGATCTCCTGTGCAGCATGTTGAGCTGGCCCAGGTGCTGTTGGATGGTCTTCACAGCCAG GCCTCTGGCTTGCAGGTACAGGAGGTAGTCCCTCACATCCTCAGGTTCAGCAGGGAACCATTTCCTGTTGTTCAGC TTGCACCAGGCAGCCCAGGATCTGCACACAGACAGGAGCATCTTCCAGGTGTGTTCAGAGAAGGCCTGCCTGTCCC TGAACATGTCCATCAGGTTCTTCCTGACTTCATCAGAGGTGGCATCCACAGGGAGGGCAGGCAGGTTTTGGTGCAC AGTCAGCAGGTTGGAGACTTTCCTCTTCTTCTTGGGCACCATGGTGGCGAATTCTTTACGAGGGTAGGAAGTGGTA CGGAAAGTTGGTATAAGACAAAAGTGTTGTGGAATTGAAGTTTACTCAAAAAATCAGCACTCTTTTATAGGCGCCC TGGTTTACATAAGCAAAGCTTATACGTTCTCTATCACTGATAGGGAGTAAACTGGATATACGTTCTCTATCACTGA TAGGGAGTAAACTGTAGATACGTTCTCTATCACTGATAGGGAGTAAACTGGTCATACGTTCTCTATCACTGATAGG GAGTAAACTCCTTATACGTTCTCTATCACTGATAGGGAGTAAAGTCTGCATACGTTCTCTATCACTGATAGGGAGT AAACTCTTCATACGTTCTCTATCACTGATAGGGAGTAAACTCGAGGGGATCCTGAAATTAACGCCGACGGGAGGGG CTTAATCCGCAGCCTGGAGATCCAGCCCCCTCAACCCGGGAGGTGGTCCCTGCAGTTACGCCAATGATAACCCCCG CCAGAAAAATCTTAGTAGCCTTCCCTTTTTGTTTTCCGTGCCCCAACTCGGCGGATTGACTCGGCCCCTTCCGGAA ACACCCGAATCAACTTCTAGTCAAATTATTGTTCACGCCGCAATGACCCACCCCTGGCCCGCGTCTGTGGAACTGA CCCCTGGTGTACAGGAGAGTTCGCTGCTGAAAGTGGTCCCAAAGGGGTACTAGTTTTTAAGCTCCCAACTCCCCCT CCCCCAGCGTCTGGAGGATTCCACACCCTCGCACCGCAGGGGCGAGGAAGTGGGCGGAGTCCGGTTTTGGCGCCAG CCGCTGAGGCTGCCAAGCAGAAAAGCCACCGCTGAGGAGACTCCGGTCACTGTCCTCGCCCCGCCTCCCCCTTCCC TCCCCTTGGGGACCACCGGGCGCCACGCCGCGAACGGTAAGTGCCGCGGTCGTCGGCGCCTCCGCCCTCCCCCTAG GGCCCCAATTCCCAGCGGGCGCGGCGCGCGGCCCCTCCCCCCGCCGGGCGCGCGCCCGCTGCCCCGCCCTTCGTGG CCGCCCGGCGTGGGCGGTGCCACCCCTCCCCCCGGCGGCCCCGCGCGCAGCTCCCGGCTCCCTCCCCCTTCGGATG TGGCTTGAGCTGTAGGCGCGGAGGGCCGGAGACGCTGCAGACCCGCGACCCGGAGCAGCTCGGAGGCGGTGAAGTC GGTGGCTTTCCTTCTCTCTAGCTCTCGCTCGCTGGTGGTGCTTCAGATGCCACACGCGTCCCGGGGGCCCGGTTCT CCGCTCCCCTCGGCTCCGGTGCCCGTCAGTGGGCAGAGCGCACATCGCCCACAGTCCCCGAGAAGTTGGGGGGAGG GGTCGGCAATTGAACCGGTGCCTAGAGAAGGTGGCGCGGGGTAAACTGGGAAAGTGATGTCGTGTACTGGCTCCGC CTTTTTCCCGAGGGTGGGGGAGAACCGTATATAAGTGCAGTAGTCGCCGTGAACGTTCTTTTTCGCAACGGGTTTG CCGCCAGAACACAGGTAAGTGCCGTGTGTGGTTCCCGCGGGCCTGGCCTCTTTACGGGTTATGGCCCTTGCGTGCC TTGAATTACTTCCACCTGGCTGCAGTACGTGATTCTTGATCCCGAGCTTCGGGTTGGAAGTGGGTGGGAGAGTTCG AGGCCTTGCGCTTAAGGAGCCCCTTCGCCTCGTGCATGAGTTGAGGCCTGGCCTGGGCGCTGGGGCCGCCGCGTGC GAATCTGGTGGCACCTTCGCGCCTGTCTCGCTGCTTTCGATAAGTCTCTAGCCATTTAAAATTTTTGATGACCTGC TGCGACGCTTTTTTTCTGGCAAGATAGTCTTGTAAATGCGGGCCAAGATCTGCACACTGGTATTTCGGTTTTTGGG GCCGCGGGCGGCGACGGGGCCCGTGCGTCCCAGCGCACATGTTCGGCGAGGCGGGGCCTGCGAGCGCGGCCACCGA GAATCGGACGGGGGTAGTCTCAAGCTGGCCGGCCTGCTCTGGTGCCTGGCCTCGCGCCGCCGTGTATCGCCCCGCC CTGGGCGGCAAGGCTGGCCCGGTCGGCACCAGTTGCGTGAGCGGAAAGATGGCCGCTTCCCGGCCCTGCTGCAGGG AGCTCAAAATGGAGGACGCGGCGCTCGGGAGAGCGGGCGGGTGAGTCACCCACACAAAGGAAAAGGGCCTTTCCGT CCTCAGCCGTCGCTTCATGTGACTCCACGGAGTACCGGGCGCCGTCCAGGCACCTCGATTAGTTCTCGAGCTTTTG GAGTACGTCGTCTTTAGGTTGGGGGGAGGGGTTTTATGCGATGGAGTTTCCCCACACTGAGTGGGTGGAGACTGAA GTTAGGCCAGCTTGGCACTTGATGTAATTCTCCTTGGAATTTGCCCTTTTTGAGTTTGGATCTTGGTTCATTCTCA AGCCTCAGACAGTGGTTCAAAGTTTTTTTCTTCCATTTCAGGTGTCGTGAGCCACCATGGGATCTAGACTGGACAA GAGCAAAGTCATAAACTCTGCTCTGGAATTACTCAATGGAGTCGGTATCGAAGGCCTGACGACAAGGAAACTCGCT CAAAAGCTGGGAGTTGAGCAGCCTACCCTGTACTGGCACGTGAAGAACAAGCGGGCCCTGCTCGATGCCCTGCCAA TCGAGATGCTGGACAGGCATCATACCCACTCCTGCCCCCTGGAAGGCGAGTCATGGCAAGACTTTCTGCGGAACAA CGCCAAGTCATACCGCTGTGCTCTCCTCTCACATCGCGACGGGGCTAAAGTGCATCTCGGCACCCGCCCAACAGAG AAACAGTACGAAACCCTGGAAAATCAGCTCGCGTTCCTGTGTCAGCAAGGCTTCTCCCTGGAGAACGCACTGTACG CTCTGTCCGCCGTGGGCCACTTTACACTGGGCTGCGTATTGGAGGAACAGGAGCATCAAGTAGCAAAAGAGGAAAG AGAGACACCTACCACCGATTCTATGCCCCCACTTCTGAAACAAGCAATTGAGCTGTTCGACCGGCAGGGAGCCGAA CCTGCCTTCCTTTTCGGCCTGGAACTAATCATATGTGGCCTGGAGAAACAGCTAAAGTGCGAAAGCGGCGGGCCGA CCGACGCCCTTGACGATTTTGACTTAGACATGCTCCCAGCCGATGCCCTTGACGACTTTGACCTTGATATGCTGCC TGCTGACGCTCTTGACGATTTTGACCTTGACATGCTCCCCGGGGGCTCAGGCGCCACCAACTTTAGCCTGCTGAAG CAGGCAGGCGACGTCGAGGAGAACCCCGGCCCTATAACTTCGTATAGCATACATTATACGAAGTTATCCAAAACAT TTAACATTTCTCAACAAGATCTAGAATTAGTAGAAGTAGCGACAGAGAAGATTACAATGCTTTATGAGGATAATAA ACATCATGTGGGAGCGGCAATTCGTACGAAAACAGGAGAAATCATTTCGGCAGTACATATTGAAGCGTATATAGGA CGAGTAACTGTTTGTGCAGAAGCCATTGCGATTGGTAGTGCAGTTTCGAATGGACAAAAGGATTTTGACACGATTG TAGCTGTTAGACACCCTTATTCTGACGAAGTAGATAGAAGTATTCGAGTGGTAAGTCCTTGTGGTATGTGTAGGGA GTTGATTTCAGACTATGCACCAGATTGTTTTGTGTTAATAGAAATGAATGGCAAGTTAGTCAAAACTACGATTGAA GAACTCATTCCACTCAAATATACCCGAAATGGCAGTGGAGAGGGCAGAGGAAGTCTGCTAACATGCGGTGACGTCG AGGAGAATCCTGGCCCAGTGAGCAAGGGCGAGGCAGTGATCAAGGAGTTCATGCGGTTCAAGGTGCACATGGAGGG CTCCATGAACGGCCACGAGTTCGAGATCGAGGGCGAGGGCGAGGGCCGCCCCTACGAGGGCACCCAGACCGCCAAG CTGAAGGTGACCAAGGGTGGCCCCCTGCCCTTCTCCTGGGACATCCTGTCCCCTCAGTTCATGTACGGCTCCAGGG CCTTCACCAAGCACCCCGCCGACATCCCCGACTACTATAAGCAGTCCTTCCCCGAGGGCTTCAAGTGGGAGCGCGT GATGAACTTCGAGGACGGCGGCGCCGTGACCGTGACCCAGGACACCTCCCTGGAGGACGGCACCCTGATCTACAAG GTGAAGCTCCGCGGCACCAACTTCCCTCCTGACGGCCCCGTAATGCAGAAGAAAACAATGGGCTGGGAAGCGTCCA CCGAGCGGTTGTACCCCGAGGACGGCGTGCTGAAGGGCGACATTAAGATGGCCCTGCGCCTGAAGGACGGCGGCCG CTACCTGGCGGACTTCAAGACCACCTACAAGGCCAAGAAGCCCGTGCAGATGCCCGGCGCCTACAACGTTGACCGC AAGTTGGACATCACCTCCCACAACGAGGACTACACCGTGGTGGAACAGTACGAACGCTCCGAGGGCCGCCACTCCA CCGGCGGCATGGACGAGCTGTACAAGTGACCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCC CCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATT GTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAG CAGGCATGCTGGGGATGCGGTGGGCTCTATGGCATGCACAACTTCGTATAGAAAGGTATATACGAAGTTGT SSODN (HLA-A SsODN) SEQ ID NO: 3 T*A*TAATTTTGCTTTTAACATATATTCAAATCCTTTGATACTGTTCCTTTCATATGGGCTTTAGAATAGGGAGGT GCTCTACAGTGATCATTCA*T*T *represents a phosphorothioate bond. (HLA-B/C ssODN) SEQ ID NO: 4 G*A*TGCACATACACATGTCACATTCACACTCATTTTCTTAATTTCCTGAAGGGCAAGGAAACTCCAGTCCAAATG CACAATGGCAGGAAGGTGTCTGTG*T*T *represents a phosphorothioate bond. (LANDING PAD) SEQ ID NO: 5      1 TTATTATCAT GACATTAACC TATAAAAATA GGCGTATCAC GAGGCCCTTT GTCACAGCTT     61 GTCTGTAAGC GGATGCCGGG AGCAGACAAG CCCGTCAGGG CGCGTCAGCG GGTGTTGGCG    121 GGTGTCGGGG CTGGCTTAAC TATGCGGCAT CAGAGCAGAT TGTACTGAGA GTGCACCATA    181 CCACAGCTTT TCAATTCAAT TCATCATTTT TTTTTTATTC TTTTTTTTGA TTTCGGTTTC    241 TTTGAAATTT TTTTGATTCG GTAATCTCCG AACAGAAGGA AGAACGAAGG AAGGAGCACA    301 GACTTAGATT GGTATATATA CGCATATGTA GTGTTGAAGA AACATGAAAT TGCCCAGTAT    361 TCTTAACCCA ACTGCACAGA ACAAAAACCT GCAGGAAACG AAGATAAATC ATGTCGAAAG    421 CTACATATAA GGAACGTGCT GCTACTCATC CTAGTCCTGT TGCTGCCAAG CTATTTAATA    481 TCATGCACGA AAAGCAAACA AACTTGTGTG CTTCATTGGA TGTTCGTACC ACCAAGGAAT    541 TACTGGAGTT AGTTGAAGCA TTAGGTCCCA AAATTTGTTT ACTAAAAACA CATGTGGATA    601 TCTTGACTGA TTTTTCCATG GAGGGCACAG TTAAGCCGCT AAAGGCATTA TCCGCCAAGT    661 ACAATTTTTT ACTCTTCGAA GACAGAAAAT TTGCTGACAT TGGTAATACA GTCAAATTGC    721 AGTACTCTGC GGGTGTATAC AGAATAGCAG AATGGGCAGA CATTACGAAT GCACACGGTG    781 TGGTGGGCCC AGGTATTGTT AGCGGTTTGA AGCAGGCGGC AGAAGAAGTA ACAAAGGAAC    841 CTAGAGGCCT TTTGATGTTA GCAGAATTGT CATGCAAGGG CTCCCTATCT ACTGGAGAAT    901 ATACTAAGGG TACTGTTGAC ATTGCGAAGA GCGACAAAGA TTTTGTTATC GGCTTTATTG    961 CTCAAAGAGA CATGGGTGGA AGAGATGAAG GTTACGATTG GTTGATTATG ACACCCGGTG   1021 TGGGTTTAGA TGACAAGGGA GATGCATTGG GTCAACAGTA TAGAACCGTG GATGATGTGG   1081 TGTCTACAGG ATCTGACATT ATTATTGTTG GAAGAGGACT ATTTGCAAAG GGAAGGGATG   1141 CTAAGGTAGA GGGTGAACGT TACAGAAAAG CAGGCTGGGA AGCATATTTG AGAAGATGCG   1201 GCCAGCAAAA CTAAAAAACT GTATTATAAG TAAATGCATG TATACTAAAC TCACAAATTA   1261 GAGCTTCAAT TTAATTATAT CAGTTATTAC CCTATGCGGT GTGAAATACC GCACAGATGC   1321 GTAAGGAGAA AATACCGCAT CAGGAAATTG TAAACGTTAA TATTTTGTTA AAATTCGCGT   1381 TAAATTTTTG TTAAATCAGC TCATTTTTTA ACCAATAGGC CGAAATCGGC AAAATCCCTT   1441 ATAAATCAAA AGAATAGACC GAGATAGGGT TGAGTGTTGT TCCAGTTTGG AACAAGAGTC   1501 CACTATTAAA GAACGTGGAC TCCAACGTCA AAGGGCGAAA AACCGTCTAT CAGGGCGATG   1561 GCCCACTACG TGAACCATCA CCCTAATCAA GTTTTTTGGG GTCGAGGTGC CGTAAAGCAC   1621 TAAATCGGAA CCCTAAAGGG AGCCCCCGAT TTAGAGCTTG ACGGGGAAAG CCGGCGAACG   1681 TGGCGAGAAA GGAAGGGAAG AAAGCGAAAG GAGCGGGCGC TAGGGCGCTG GCAAGTGTAG   1741 CGGTCACGCT GCGCGTAACC ACCACACCCG CCGCGCTTAA TGCGCCGCTA CAGGGCGCGT   1801 CGCGCCATTC GCCATTCAGG CTGCGCAACT GTTGGGAAGG GCGATCGGTG CGGGCCTCTT   1861 CGCTATTACG CCAGCTGGCG AAAGGGGGAT GTGCTGCAAG GCGATTAAGT TGGGTAACGC   1921 CAGGGTTTTC CCAGTCACGA CGTTGTAAAA CGACGGCCAG TGAGCGCGCG TAATACGACT   1981 CACTATAGGG CGAATTGGGT ACCGCGAGAC CTTCCTGGTC TCAGAAGTTC CTATACTCTA   2041 GAAAGAATAG GAACTTCGTC GACCCAGACA TGATAAGATA CATTGATGAG TTTGGACAAA   2101 CCACAACTAG AATGCAGTGA AAAAAATGCT TTATTTGTGA AATTTGTGAT GCTATTGCTT   2161 TATTTGTAAC CATTATAAGC TGCAATAAAC AAGTTAACAA CAACAATTGC ATTCATTTTA   2221 TGTTTCAGGT TCAGGGGGAG GTGTGGGAGG TTTTTTAAAG CAAGTAAAAC CTCTACAAAT   2281 GTGGTATGGC TGATTATGAT CTTAGTCCCC ATCCTCGAGC AGCCTCACCA TGGCCCCAGT   2341 CTCAGAGTCC AGGTTTCTGA TGTAGTTCAT CACAATGTTC ACATTGGTCC AGCCACCAGC   2401 CTGCATGATT TCAGGGATGG ACACACCAGC CCTGGCCATG TCCCTGGCAG CACCCACTCT   2461 GGCAGAGTGG CCAGACCAGG CCAGGTATCT CTGCCCAGAG TCATCCTTGG CACCATAGAT   2521 CAGGCGGTGG GTGGCCTCAA AGATCCCTTC CAGGGCCCGG GTGGACAGTT GGGAGGTGGC   2581 AGAAGGGGCA GCCACACCAT TCTTTCTGAC CCGGCAGAAC AGGTAGTTGT TGGGGTCATC   2641 AGCCACACCA GACACAGAGA TCCATCTCTC CACCAGCTTG GTAACCCCCA GGGACAGGGC   2701 CTTCTCCACA CCAGCTGTGG ACACCAGGGT CTTGGTCCTG CCAATGTGGA TCAGCATTCT   2761 CCCACCATCG GTGCGGGAGA TGTCCTTCAC TCTGATTCTG GCAATTTCGG CAATGCGCAG   2821 CAGGGTGTTG TAGGCAATGC CCAGGAAGGC CAGGTTCCTG ATGTCCTGGC ATCTGTCAGA   2881 GTTCTCCATC AGGGATCTGA CTTGGTCAAA GTCAGTGCGT TCAAAGGCCA GGGCCTGCTT   2941 GGCTCTCTCC CCAGCATCCA CATTCTCCTT TCTGATTCTC CTCATCACCA GGGACACAGC   3001 ATTGGAGTCA GAAGGGCGAG GCAGGCCAGA TCTCCTGTGC AGCATGTTGA GCTGGCCCAG   3061 GTGCTGTTGG ATGGTCTTCA CAGCCAGGCC TCTGGCTTGC AGGTACAGGA GGTAGTCCCT   3121 CACATCCTCA GGTTCAGCAG GGAACCATTT CCTGTTGTTC AGCTTGCACC AGGCAGCCCA   3181 GGATCTGCAC ACAGACAGGA GCATCTTCCA GGTGTGTTCA GAGAAGGCCT GCCTGTCCCT   3241 GAACATGTCC ATCAGGTTCT TCCTGACTTC ATCAGAGGTG GCATCCACAG GGAGGGCAGG   3301 CAGGTTTTGG TGCACAGTCA GCAGGTTGGA GACTTTCCTC TTCTTCTTGG GCACCATGGT   3361 GGCGAATTCT TTACGAGGGT AGGAAGTGGT ACGGAAAGTT GGTATAAGAC AAAAGTGTTG   3421 TGGAATTGAA GTTTACTCAA AAAATCAGCA CTCTTTTATA GGCGCCCTGG TTTACATAAG   3481 CAAAGCTTAT ACGTTCTCTA TCACTGATAG GGAGTAAACT GGATATACGT TCTCTATCAC   3541 TGATAGGGAG TAAACTGTAG ATACGTTCTC TATCACTGAT AGGGAGTAAA CTGGTCATAC   3601 GTTCTCTATC ACTGATAGGG AGTAAACTCC TTATACGTTC TCTATCACTG ATAGGGAGTA   3661 AAGTCTGCAT ACGTTCTCTA TCACTGATAG GGAGTAAACT CTTCATACGT TCTCTATCAC   3721 TGATAGGGAG TAAACTCGAG GGGATCCTGA AATTAACGCC GACGGGAGGG GOTTAATCCG   3781 CAGCCTGGAG ATCCAGCCCC CTCAACCCGG GAGGTGGTCC CTGCAGTTAC GCCAATGATA   3841 ACCCCCGCCA GAAAAATCTT AGTAGCCTTC CCTTTTTGTT TTCCGTGCCC CAACTCGGCG   3901 GATTGACTCG GCCCCTTCCG GAAACACCCG AATCAACTTC TAGTCAAATT ATTGTTCACG   3961 CCGCAATGAC CCACCCCTGG CCCGCGTCTG TGGAACTGAC CCCTGGTGTA CAGGAGAGTT   4021 CGCTGCTGAA AGTGGTCCCA AAGGGGTACT AGTTTTTAAG CTCCCAACTC CCCCTCCCCC   4081 AGCGTCTGGA GGATTCCACA CCCTCGCACC GCAGGGGCGA GGAAGTGGGC GGAGTCCGGT   4141 TTTGGCGCCA GCCGCTGAGG CTGCCAAGCA GAAAAGCCAC CGCTGAGGAG ACTCCGGTCA   4201 CTGTCCTCGC CCCGCCTCCC CCTTCCCTCC CCTTGGGGAC CACCGGGCGC CACGCCGCGA   4261 ACGGTAAGTG CCGCGGTCGT CGGCGCCTCC GCCCTCCCCC TAGGGCCCCA ATTCCCAGCG   4321 GGCGCGGCGC GCGGCCCCTC CCCCCGCCGG GCGCGCGCCC GCTGCCCCGC CCTTCGTGGC   4381 CGCCCGGCGT GGGCGGTGCC ACCCCTCCCC CCGGCGGCCC CGCGCGCAGC TCCCGGCTCC   4441 CTCCCCCTTC GGATGTGGCT TGAGCTGTAG GCGCGGAGGG CCGGAGACGC TGCAGACCCG   4501 CGACCCGGAG CAGCTCGGAG GCGGTGAAGT CGGTGGCTTT CCTTCTCTCT AGCTCTCGCT   4561 CGCTGGTGGT GCTTCAGATG CCACACGCGT CCCGGGGGCC CGGTTCTCCG CTCCCCTCGG   4621 CTCCGGTGCC CGTCAGTGGG CAGAGCGCAC ATCGCCCACA GTCCCCGAGA AGTTGGGGGG   4681 AGGGGTCGGC AATTGAACCG GTGCCTAGAG AAGGTGGCGC GGGGTAAACT GGGAAAGTGA   4741 TGTCGTGTAC TGGCTCCGCC TTTTTCCCGA GGGTGGGGGA GAACCGTATA TAAGTGCAGT   4801 AGTCGCCGTG AACGTTCTTT TTCGCAACGG GTTTGCCGCC AGAACACAGG TAAGTGCCGT   4861 GTGTGGTTCC CGCGGGCCTG GCCTCTTTAC GGGTTATGGC CCTTGCGTGC CTTGAATTAC   4921 TTCCACCTGG CTGCAGTACG TGATTCTTGA TCCCGAGCTT CGGGTTGGAA GTGGGTGGGA   4981 GAGTTCGAGG CCTTGCGCTT AAGGAGCCCC TTCGCCTCGT GCATGAGTTG AGGCCTGGCC   5041 TGGGCGCTGG GGCCGCCGCG TGCGAATCTG GTGGCACCTT CGCGCCTGTC TCGCTGCTTT   5101 CGATAAGTCT CTAGCCATTT AAAATTTTTG ATGACCTGCT GCGACGCTTT TTTTCTGGCA   5161 AGATAGTCTT GTAAATGCGG GCCAAGATCT GCACACTGGT ATTTCGGTTT TTGGGGCCGC   5221 GGGCGGCGAC GGGGCCCGTG CGTCCCAGCG CACATGTTCG GCGAGGCGGG GCCTGCGAGC   5281 GCGGCCACCG AGAATCGGAC GGGGGTAGTC TCAAGCTGGC CGGCCTGCTC TGGTGCCTGG   5341 CCTCGCGCCG CCGTGTATCG CCCCGCCCTG GGCGGCAAGG CTGGCCCGGT CGGCACCAGT   5401 TGCGTGAGCG GAAAGATGGC CGCTTCCCGG CCCTGCTGCA GGGAGCTCAA AATGGAGGAC   5461 GCGGCGCTCG GGAGAGCGGG CGGGTGAGTC ACCCACACAA AGGAAAAGGG CCTTTCCGTC   5521 CTCAGCCGTC GCTTCATGTG ACTCCACGGA GTACCGGGCG CCGTCCAGGC ACCTCGATTA   5581 GTTCTCGAGC TTTTGGAGTA CGTCGTCTTT AGGTTGGGGG GAGGGGTTTT ATGCGATGGA   5641 GTTTCCCCAC ACTGAGTGGG TGGAGACTGA AGTTAGGCCA GCTTGGCACT TGATGTAATT   5701 CTCCTTGGAA TTTGCCCTTT TTGAGTTTGG ATCTTGGTTC ATTCTCAAGC CTCAGACAGT   5761 GGTTCAAAGT TTTTTTCTTC CATTTCAGGT GTCGTGAGCC ACCATGGGAT CTAGACTGGA   5821 CAAGAGCAAA GTCATAAACT CTGCTCTGGA ATTACTCAAT GGAGTCGGTA TCGAAGGCCT   5881 GACGACAAGG AAACTCGCTC AAAAGCTGGG AGTTGAGCAG CCTACCCTGT ACTGGCACGT   5941 GAAGAACAAG CGGGCCCTGC TCGATGCCCT GCCAATCGAG ATGCTGGACA GGCATCATAC   6001 CCACTCCTGC CCCCTGGAAG GCGAGTCATG GCAAGACTTT CTGCGGAACA ACGCCAAGTC   6061 ATACCGCTGT GCTCTCCTCT CACATCGCGA CGGGGCTAAA GTGCATCTCG GCACCCGCCC   6121 AACAGAGAAA CAGTACGAAA CCCTGGAAAA TCAGCTCGCG TTCCTGTGTC AGCAAGGCTT   6181 CTCCCTGGAG AACGCACTGT ACGCTCTGTC CGCCGTGGGC CACTTTACAC TGGGCTGCGT   6241 ATTGGAGGAA CAGGAGCATC AAGTAGCAAA AGAGGAAAGA GAGACACCTA CCACCGATTC   6301 TATGCCCCCA CTTCTGAAAC AAGCAATTGA GCTGTTCGAC CGGCAGGGAG CCGAACCTGC   6361 CTTCCTTTTC GGCCTGGAAC TAATCATATG TGGCCTGGAG AAACAGCTAA AGTGCGAAAG   6421 CGGCGGGCCG ACCGACGCCC TTGACGATTT TGACTTAGAC ATGCTCCCAG CCGATGCCCT   6481 TGACGACTTT GACCTTGATA TGCTGCCTGC TGACGCTCTT GACGATTTTG ACCTTGACAT   6541 GCTCCCCGGG GGCTCAGGCG CCACCAACTT TAGCCTGCTG AAGCAGGCAG GCGACGTCGA   6601 GGAGAACCCC GGCCCTATAA CTTCGTATAG CATACATTAT ACGAAGTTAT CCAAAACATT   6661 TAACATTTCT CAACAAGATC TAGAATTAGT AGAAGTAGCG ACAGAGAAGA TTACAATGCT   6721 TTATGAGGAT AATAAACATC ATGTGGGAGC GGCAATTCGT ACGAAAACAG GAGAAATCAT   6781 TTCGGCAGTA CATATTGAAG CGTATATAGG ACGAGTAACT GTTTGTGCAG AAGCCATTGC   6841 GATTGGTAGT GCAGTTTCGA ATGGACAAAA GGATTTTGAC ACGATTGTAG CTGTTAGACA   6901 CCCTTATTCT GACGAAGTAG ATAGAAGTAT TCGAGTGGTA AGTCCTTGTG GTATGTGTAG   6961 GGAGTTGATT TCAGACTATG CACCAGATTG TTTTGTGTTA ATAGAAATGA ATGGCAAGTT   7021 AGTCAAAACT ACGATTGAAG AACTCATTCC ACTCAAATAT ACCCGAAATG GCAGTGGAGA   7081 GGGCAGAGGA AGTCTGCTAA CATGCGGTGA CGTCGAGGAG AATCCTGGCC CAGTGAGCAA   7141 GGGCGAGGCA GTGATCAAGG AGTTCATGCG GTTCAAGGTG CACATGGAGG GCTCCATGAA   7201 CGGCCACGAG TTCGAGATCG AGGGCGAGGG CGAGGGCCGC CCCTACGAGG GCACCCAGAC   7261 CGCCAAGCTG AAGGTGACCA AGGGTGGCCC CCTGCCCTTC TCCTGGGACA TCCTGTCCCC   7321 TCAGTTCATG TACGGCTCCA GGGCCTTCAC CAAGCACCCC GCCGACATCC CCGACTACTA   7381 TAAGCAGTCC TTCCCCGAGG GCTTCAAGTG GGAGCGCGTG ATGAACTTCG AGGACGGCGG   7441 CGCCGTGACC GTGACCCAGG ACACCTCCCT GGAGGACGGC ACCCTGATCT ACAAGGTGAA   7501 GCTCCGCGGC ACCAACTTCC CTCCTGACGG CCCCGTAATG CAGAAGAAAA CAATGGGCTG   7561 GGAAGCGTCC ACCGAGCGGT TGTACCCCGA GGACGGCGTG CTGAAGGGCG ACATTAAGAT   7621 GGCCCTGCGC CTGAAGGACG GCGGCCGCTA CCTGGCGGAC TTCAAGACCA CCTACAAGGC   7681 CAAGAAGCCC GTGCAGATGC CCGGCGCCTA CAACGTTGAC CGCAAGTTGG ACATCACCTC   7741 CCACAACGAG GACTACACCG TGGTGGAACA GTACGAACGC TCCGAGGGCC GCCACTCCAC   7801 CGGCGGCATG GACGAGCTGT ACAAGTGACC TCGACTGTGC CTTCTAGTTG CCAGCCATCT   7861 GTTGTTTGCC CCTCCCCCGT GCCTTCCTTG ACCCTGGAAG GTGCCACTCC CACTGTCCTT   7921 TCCTAATAAA ATGAGGAAAT TGCATCGCAT TGTCTGAGTA GGTGTCATTC TATTCTGGGG   7981 GGTGGGGTGG GGCAGGACAG CAAGGGGGAG GATTGGGAAG ACAATAGCAG GCATGCTGGG   8041 GATGCGGTGG GCTCTATGGC ATGCACAACT TCGTATAGAA AGGTATATAC GAAGTTGTAG   8101 AGACCAACCT GGTCTCAGCT AGCTCCCTTT AGTGAGGGTT AATTGCGCGC TTGGCGTAAT   8161 CATGGTCATA GCTGTTTCCT GTGTGAAATT GTTATCCGCT CACAATTCCA CACAACATAG   8221 GAGCCGGAAG CATAAAGTGT AAAGCCTGGG GTGCCTAATG AGTGAGGTAA CTCACATTAA   8281 TTGCGTTGCG CTCACTGCCC GCTTTCCAGT CGGGAAACCT GTCGTGCCAG CTGCATTAAT   8341 GAATCGGCCA ACGCGCGGGG AGAGGCGGTT TGCGTATTGG GCGCTCTTCC GCTTCCTCGC   8401 TCACTGACTC GCTGCGCTCG GTCGTTCGGC TGCGGCGAGC GGTATCAGCT CACTCAAAGG   8461 CGGTAATACG GTTATCCACA GAATCAGGGG ATAACGCAGG AAAGAACATG TGAGCAAAAG   8521 GCCAGCAAAA GGCCAGGAAC CGTAAAAAGG CCGCGTTGCT GGCGTTTTTC CATAGGCTCC   8581 GCCCCCCTGA CGAGCATCAC AAAAATCGAC GCTCAAGTCA GAGGTGGCGA AACCCGACAG   8641 GACTATAAAG ATACCAGGCG TTTCCCCCTG GAAGCTCCCT CGTGCGCTCT CCTGTTCCGA   8701 CCCTGCCGCT TACCGGATAC CTGTCCGCCT TTCTCCCTTC GGGAAGCGTG GCGCTTTCTC   8761 ATAGCTCACG CTGTAGGTAT CTCAGTTCGG TGTAGGTCGT TCGCTCCAAG CTGGGCTGTG   8821 TGCACGAACC CCCCGTTCAG CCCGACCGCT GCGCCTTATC CGGTAACTAT CGTCTTGAGT   8881 CCAACCCGGT AAGACACGAC TTATCGCCAC TGGCAGCAGC CACTGGTAAC AGGATTAGCA   8941 GAGCGAGGTA TGTAGGCGGT GCTACAGAGT TCTTGAAGTG GTGGCCTAAC TACGGCTACA   9001 CTAGAAGGAC AGTATTTGGT ATCTGCGCTC TGCTGAAGCC AGTTACCTTC GGAAAAAGAG   9061 TTGGTAGCTC TTGATCCGGC AAACAAACCA CCGCTGGTAG CGGTGGTTTT TTTGTTTGCA   9121 AGCAGCAGAT TACGCGCAGA AAAAAAGGAT CTCAAGAAGA TCCTTTGATC TTTTCTACGG   9181 GGTCTGACGC TCAGTGGAAC GAAAACTCAC GTTAAGGGAT TTTGGTCATG AGATTATCAA   9241 AAAGGATOTT CACCTAGATC CTTTTAAATT AAAAATGAAG TTTTAAATCA ATCTAAAGTA   9301 TATATGAGTA AACTTGGTCT GACAGTTACC AATGOTTAAT CAGTGAGGCA CCTATCTCAG   9361 CGATCTGTCT ATTTCGTTCA TCCATAGTTG CCTGACTCCC CGTCGTGTAG ATAACTACGA   9421 TACGGGAGGG CTTACCATCT GGCCCCAGTG CTGCAATGAT ACCGCGAGAT CCACGCTCAC   9481 CGGCTCCAGA TTTATCAGCA ATAAACCAGC CAGCCGGAAG GGCCGAGCGC AGAAGTGGTC   9541 CTGCAACTTT ATCCGCCTCC ATCCAGTCTA TTAATTGTTG CCGGGAAGCT AGAGTAAGTA   9601 GTTCGCCAGT TAATAGTTTG CGCAACGTTG TTGCCATTGC TACAGGCATC GTGGTGTCAC   9661 GCTCGTCGTT TGGTATGGCT TCATTCAGCT CCGGTTCCCA ACGATCAAGG CGAGTTACAT   9721 GATCCCCCAT GTTGTGCAAA AAAGCGGTTA GCTCCTTCGG TCCTCCGATC GTTGTCAGAA   9781 GTAAGTTGGC CGCAGTGTTA TCACTCATGG TTATGGCAGC ACTGCATAAT TCTCTTACTG   9841 TCATGCCATC CGTAAGATGC TTTTCTGTGA CTGGTGAGTA CTCAACCAAG TCATTCTGAG   9901 AATAGTGTAT GCGGCGACCG AGTTGCTCTT GCCCGGCGTC AATACGGGAT AATACCGCGC   9961 CACATAGCAG AACTTTAAAA GTGCTCATCA TTGGAAAACG TTCTTCGGGG CGAAAACTCT  10021 CAAGGATOTT ACCGCTGTTG AGATCCAGTT CGATGTAACC CACTCGTGCA CCCAACTGAT  10081 CTTCAGCATC TTTTACTTTC ACCAGCGTTT CTGGGTGAGC AAAAACAGGA AGGCAAAATG  10141 CCGCAAAAAA GGGAATAAGG GCGACACGGA AATGTTGAAT ACTCATACTC TTCCTTTTTC  10201 AATATTATTG AAGCATTTAT CAGGGTTATT GTCTCATGAG CGGATACATA TTTGAATGTA  10261 TTTAGAAAAA TAAACAAATA GGGGTTCCGC GCACATTTCC CCGAAAAGTG CCACCTGGGT  10321 CCTTTTCATC ACGTGCTATA AAAATAATTA TAATTTAAAT TTTTTAATAT AAATATATAA  10381 ATTAAAAATA GAAAGTAAAA AAAGAAATTA AAGAAAAAAT AGTTTTTGTT TTCCGAAGAT  10441 GTAAAAGACT CTAGGGGGAT CGCCAACAAA TACTACCTTT TATCTTGCTC TTCCTGCTCT  10501 CAGGTATTAA TGCCGAATTG TTTCATCTTG TCTGTGTAGA AGACCACACA CGAAAATCCT  10561 GTGATTTTAC ATTTTACTTA TCGTTAATCG AATGTATATC TATTTAATCT GCTTTTCTTG  10621 TCTAATAAAT ATATATGTAA AGTACGCTTT TTGTTGAAAT TTTTTAAACC TTTGTTTATT  10681 TTTTTTTCTT CATTCCGTAA CTCTTCTACC TTCTTTATTT ACTTTCTAAA ATCCAAATAC  10741 AAAACATAAA AATAAATAAA CACAGAGTAA ATTCCCAAAT TATTCCATCA TTAAAAGATA  10801 CGAGGCGCGT GTAAGTTACA GGCAAGCGAT CCGTCCTAAG AAACCA (LANDING PAD_noCre) SEQ ID NO: 6      1 TTATTATCAT GACATTAACC TATAAAAATA GGCGTATCAC GAGGCCCTTT GTCACAGCTT     61 GTCTGTAAGC GGATGCCGGG AGCAGACAAG CCCGTCAGGG CGCGTCAGCG GGTGTTGGCG    121 GGTGTCGGGG CTGGCTTAAC TATGCGGCAT CAGAGCAGAT TGTACTGAGA GTGCACCATA    181 CCACAGCTTT TCAATTCAAT TCATCATTTT TTTTTTATTC TTTTTTTTGA TTTCGGTTTC    241 TTTGAAATTT TTTTGATTCG GTAATCTCCG AACAGAAGGA AGAACGAAGG AAGGAGCACA    301 GACTTAGATT GGTATATATA CGCATATGTA GTGTTGAAGA AACATGAAAT TGCCCAGTAT    361 TCTTAACCCA ACTGCACAGA ACAAAAACCT GCAGGAAACG AAGATAAATC ATGTCGAAAG    421 CTACATATAA GGAACGTGCT GCTACTCATC CTAGTCCTGT TGCTGCCAAG CTATTTAATA    481 TCATGCACGA AAAGCAAACA AACTTGTGTG CTTCATTGGA TGTTCGTACC ACCAAGGAAT    541 TACTGGAGTT AGTTGAAGCA TTAGGTCCCA AAATTTGTTT ACTAAAAACA CATGTGGATA    601 TCTTGACTGA TTTTTCCATG GAGGGCACAG TTAAGCCGCT AAAGGCATTA TCCGCCAAGT    661 ACAATTTTTT ACTCTTCGAA GACAGAAAAT TTGCTGACAT TGGTAATACA GTCAAATTGC    721 AGTACTCTGC GGGTGTATAC AGAATAGCAG AATGGGCAGA CATTACGAAT GCACACGGTG    781 TGGTGGGCCC AGGTATTGTT AGCGGTTTGA AGCAGGCGGC AGAAGAAGTA ACAAAGGAAC    841 CTAGAGGCCT TTTGATGTTA GCAGAATTGT CATGCAAGGG CTCCCTATCT ACTGGAGAAT    901 ATACTAAGGG TACTGTTGAC ATTGCGAAGA GCGACAAAGA TTTTGTTATC GGCTTTATTG    961 CTCAAAGAGA CATGGGTGGA AGAGATGAAG GTTACGATTG GTTGATTATG ACACCCGGTG   1021 TGGGTTTAGA TGACAAGGGA GATGCATTGG GTCAACAGTA TAGAACCGTG GATGATGTGG   1081 TGTCTACAGG ATCTGACATT ATTATTGTTG GAAGAGGACT ATTTGCAAAG GGAAGGGATG   1141 CTAAGGTAGA GGGTGAACGT TACAGAAAAG CAGGCTGGGA AGCATATTTG AGAAGATGCG   1201 GCCAGCAAAA CTAAAAAACT GTATTATAAG TAAATGCATG TATACTAAAC TCACAAATTA   1261 GAGCTTCAAT TTAATTATAT CAGTTATTAC CCTATGCGGT GTGAAATACC GCACAGATGC   1321 GTAAGGAGAA AATACCGCAT CAGGAAATTG TAAACGTTAA TATTTTGTTA AAATTCGCGT   1381 TAAATTTTTG TTAAATCAGC TCATTTTTTA ACCAATAGGC CGAAATCGGC AAAATCCCTT   1441 ATAAATCAAA AGAATAGACC GAGATAGGGT TGAGTGTTGT TCCAGTTTGG AACAAGAGTC   1501 CACTATTAAA GAACGTGGAC TCCAACGTCA AAGGGCGAAA AACCGTCTAT CAGGGCGATG   1561 GCCCACTACG TGAACCATCA CCCTAATCAA GTTTTTTGGG GTCGAGGTGC CGTAAAGCAC   1621 TAAATCGGAA CCCTAAAGGG AGCCCCCGAT TTAGAGCTTG ACGGGGAAAG CCGGCGAACG   1681 TGGCGAGAAA GGAAGGGAAG AAAGCGAAAG GAGCGGGCGC TAGGGCGCTG GCAAGTGTAG   1741 CGGTCACGCT GCGCGTAACC ACCACACCCG CCGCGCTTAA TGCGCCGCTA CAGGGCGCGT   1801 CGCGCCATTC GCCATTCAGG CTGCGCAACT GTTGGGAAGG GCGATCGGTG CGGGCCTCTT   1861 CGCTATTACG CCAGCTGGCG AAAGGGGGAT GTGCTGCAAG GCGATTAAGT TGGGTAACGC   1921 CAGGGTTTTC CCAGTCACGA CGTTGTAAAA CGACGGCCAG TGAGCGCGCG TAATACGACT   1981 CACTATAGGG CGAATTGGGT ACCGCGAGAC CTTCCGGGTC TCAGAAGTTC CTATACTCTA   2041 GAAAGAATAG GAACTTCGTC GACCCAGACA TGATAAGATA CATTGATGAG TTTGGACAAA   2101 CCACAACTAG AATGCAGTGA AAAAAATGCT TTATTTGTGA AATTTGTGAT GCTATTGCTT   2161 TATTTGTAAC CATTATAAGC TGCAATAAAC AAGTTAACAA CAACAATTGC ATTCATTTTA   2221 TGTTTCAGGT TCAGGGGGAG GTGTGGGAGG TTTTTTAAAG CAAGTAAAAC CTCTACAAAT   2281 GTGGTATGGC TGATTATGAT CTTAGTCCCC ATCCTCGAGC AGCCTCACCA TGGCCCCAGT   2341 CTCAGAGTCC AGGTTTCTGA TGTAGTTCAT CACAATGTTC ACATTGGTCC AGCCACCAGC   2401 CTGCATGATT TCAGGGATGG ACACACCAGC CCTGGCCATG TCCCTGGCAG CACCCACTCT   2461 GGCAGAGTGG CCAGACCAGG CCAGGTATCT CTGCCCAGAG TCATCCTTGG CACCATAGAT   2521 CAGGCGGTGG GTGGCCTCAA AGATCCCTTC CAGGGCCCGG GTGGACAGTT GGGAGGTGGC   2581 AGAAGGGGCA GCCACACCAT TCTTTCTGAC CCGGCAGAAC AGGTAGTTGT TGGGGTCATC   2641 AGCCACACCA GACACAGAGA TCCATCTCTC CACCAGCTTG GTAACCCCCA GGGACAGGGC   2701 CTTCTCCACA CCAGCTGTGG ACACCAGGGT CTTGGTCCTG CCAATGTGGA TCAGCATTCT   2761 CCCACCATCG GTGCGGGAGA TGTCCTTCAC TCTGATTCTG GCAATTTCGG CAATGCGCAG   2821 CAGGGTGTTG TAGGCAATGC CCAGGAAGGC CAGGTTCCTG ATGTCCTGGC ATCTGTCAGA   2881 GTTCTCCATC AGGGATCTGA CTTGGTCAAA GTCAGTGCGT TCAAAGGCCA GGGCCTGCTT   2941 GGCTCTCTCC CCAGCATCCA CATTCTCCTT TCTGATTCTC CTCATCACCA GGGACACAGC   3001 ATTGGAGTCA GAAGGGCGAG GCAGGCCAGA TCTCCTGTGC AGCATGTTGA GCTGGCCCAG   3061 GTGCTGTTGG ATGGTCTTCA CAGCCAGGCC TCTGGCTTGC AGGTACAGGA GGTAGTCCCT   3121 CACATCCTCA GGTTCAGCAG GGAACCATTT CCTGTTGTTC AGCTTGCACC AGGCAGCCCA   3181 GGATCTGCAC ACAGACAGGA GCATCTTCCA GGTGTGTTCA GAGAAGGCCT GCCTGTCCCT   3241 GAACATGTCC ATCAGGTTCT TCCTGACTTC ATCAGAGGTG GCATCCACAG GGAGGGCAGG   3301 CAGGTTTTGG TGCACAGTCA GCAGGTTGGA GACTTTCCTC TTCTTCTTGG GCACCATGGT   3361 GGCGAATTCT TTACGAGGGT AGGAAGTGGT ACGGAAAGTT GGTATAAGAC AAAAGTGTTG   3421 TGGAATTGAA GTTTACTCAA AAAATCAGCA CTCTTTTATA GGCGCCCTGG TTTACATAAG   3481 CAAAGCTTAT ACGTTCTCTA TCACTGATAG GGAGTAAACT GGATATACGT TCTCTATCAC   3541 TGATAGGGAG TAAACTGTAG ATACGTTCTC TATCACTGAT AGGGAGTAAA CTGGTCATAC   3601 GTTCTCTATC ACTGATAGGG AGTAAACTCC TTATACGTTC TCTATCACTG ATAGGGAGTA   3661 AAGTCTGCAT ACGTTCTCTA TCACTGATAG GGAGTAAACT CTTCATACGT TCTCTATCAC   3721 TGATAGGGAG TAAACTCGAG GGGATCCTGA AATTAACGCC GACGGGAGGG GOTTAATCCG   3781 CAGCCTGGAG ATCCAGCCCC CTCAACCCGG GAGGTGGTCC CTGCAGTTAC GCCAATGATA   3841 ACCCCCGCCA GAAAAATCTT AGTAGCCTTC CCTTTTTGTT TTCCGTGCCC CAACTCGGCG   3901 GATTGACTCG GCCCCTTCCG GAAACACCCG AATCAACTTC TAGTCAAATT ATTGTTCACG   3961 CCGCAATGAC CCACCCCTGG CCCGCGTCTG TGGAACTGAC CCCTGGTGTA CAGGAGAGTT   4021 CGCTGCTGAA AGTGGTCCCA AAGGGGTACT AGTTTTTAAG CTCCCAACTC CCCCTCCCCC   4081 AGCGTCTGGA GGATTCCACA CCCTCGCACC GCAGGGGCGA GGAAGTGGGC GGAGTCCGGT   4141 TTTGGCGCCA GCCGCTGAGG CTGCCAAGCA GAAAAGCCAC CGCTGAGGAG ACTCCGGTCA   4201 CTGTCCTCGC CCCGCCTCCC CCTTCCCTCC CCTTGGGGAC CACCGGGCGC CACGCCGCGA   4261 ACGGTAAGTG CCGCGGTCGT CGGCGCCTCC GCCCTCCCCC TAGGGCCCCA ATTCCCAGCG   4321 GGCGCGGCGC GCGGCCCCTC CCCCCGCCGG GCGCGCGCCC GCTGCCCCGC CCTTCGTGGC   4381 CGCCCGGCGT GGGCGGTGCC ACCCCTCCCC CCGGCGGCCC CGCGCGCAGC TCCCGGCTCC   4441 CTCCCCCTTC GGATGTGGCT TGAGCTGTAG GCGCGGAGGG CCGGAGACGC TGCAGACCCG   4501 CGACCCGGAG CAGCTCGGAG GCGGTGAAGT CGGTGGCTTT CCTTCTCTCT AGCTCTCGCT   4561 CGCTGGTGGT GCTTCAGATG CCACACGCGT CCCGGGGGCC CGGTTCTCCG CTCCCCTCGG   4621 CTCCGGTGCC CGTCAGTGGG CAGAGCGCAC ATCGCCCACA GTCCCCGAGA AGTTGGGGGG   4681 AGGGGTCGGC AATTGAACCG GTGCCTAGAG AAGGTGGCGC GGGGTAAACT GGGAAAGTGA   4741 TGTCGTGTAC TGGCTCCGCC TTTTTCCCGA GGGTGGGGGA GAACCGTATA TAAGTGCAGT   4801 AGTCGCCGTG AACGTTCTTT TTCGCAACGG GTTTGCCGCC AGAACACAGG TAAGTGCCGT   4861 GTGTGGTTCC CGCGGGCCTG GCCTCTTTAC GGGTTATGGC CCTTGCGTGC CTTGAATTAC   4921 TTCCACCTGG CTGCAGTACG TGATTCTTGA TCCCGAGCTT CGGGTTGGAA GTGGGTGGGA   4981 GAGTTCGAGG CCTTGCGCTT AAGGAGCCCC TTCGCCTCGT GCATGAGTTG AGGCCTGGCC   5041 TGGGCGCTGG GGCCGCCGCG TGCGAATCTG GTGGCACCTT CGCGCCTGTC TCGCTGCTTT   5101 CGATAAGTCT CTAGCCATTT AAAATTTTTG ATGACCTGCT GCGACGCTTT TTTTCTGGCA   5161 AGATAGTCTT GTAAATGCGG GCCAAGATCT GCACACTGGT ATTTCGGTTT TTGGGGCCGC   5221 GGGCGGCGAC GGGGCCCGTG CGTCCCAGCG CACATGTTCG GCGAGGCGGG GCCTGCGAGC   5281 GCGGCCACCG AGAATCGGAC GGGGGTAGTC TCAAGCTGGC CGGCCTGCTC TGGTGCCTGG   5341 CCTCGCGCCG CCGTGTATCG CCCCGCCCTG GGCGGCAAGG CTGGCCCGGT CGGCACCAGT   5401 TGCGTGAGCG GAAAGATGGC CGCTTCCCGG CCCTGCTGCA GGGAGCTCAA AATGGAGGAC   5461 GCGGCGCTCG GGAGAGCGGG CGGGTGAGTC ACCCACACAA AGGAAAAGGG CCTTTCCGTC   5521 CTCAGCCGTC GCTTCATGTG ACTCCACGGA GTACCGGGCG CCGTCCAGGC ACCTCGATTA   5581 GTTCTCGAGC TTTTGGAGTA CGTCGTCTTT AGGTTGGGGG GAGGGGTTTT ATGCGATGGA   5641 GTTTCCCCAC ACTGAGTGGG TGGAGACTGA AGTTAGGCCA GCTTGGCACT TGATGTAATT   5701 CTCCTTGGAA TTTGCCCTTT TTGAGTTTGG ATCTTGGTTC ATTCTCAAGC CTCAGACAGT   5761 GGTTCAAAGT TTTTTTCTTC CATTTCAGGT GTCGTGAGCC ACCATGGGAT CTAGACTGGA   5821 CAAGAGCAAA GTCATAAACT CTGCTCTGGA ATTACTCAAT GGAGTCGGTA TCGAAGGCCT   5881 GACGACAAGG AAACTCGCTC AAAAGCTGGG AGTTGAGCAG CCTACCCTGT ACTGGCACGT   5941 GAAGAACAAG CGGGCCCTGC TCGATGCCCT GCCAATCGAG ATGCTGGACA GGCATCATAC   6001 CCACTCCTGC CCCCTGGAAG GCGAGTCATG GCAAGACTTT CTGCGGAACA ACGCCAAGTC   6061 ATACCGCTGT GCTCTCCTCT CACATCGCGA CGGGGCTAAA GTGCATCTCG GCACCCGCCC   6121 AACAGAGAAA CAGTACGAAA CCCTGGAAAA TCAGCTCGCG TTCCTGTGTC AGCAAGGCTT   6181 CTCCCTGGAG AACGCACTGT ACGCTCTGTC CGCCGTGGGC CACTTTACAC TGGGCTGCGT   6241 ATTGGAGGAA CAGGAGCATC AAGTAGCAAA AGAGGAAAGA GAGACACCTA CCACCGATTC   6301 TATGCCCCCA CTTCTGAAAC AAGCAATTGA GCTGTTCGAC CGGCAGGGAG CCGAACCTGC   6361 CTTCCTTTTC GGCCTGGAAC TAATCATATG TGGCCTGGAG AAACAGCTAA AGTGCGAAAG   6421 CGGCGGGCCG ACCGACGCCC TTGACGATTT TGACTTAGAC ATGCTCCCAG CCGATGCCCT   6481 TGACGACTTT GACCTTGATA TGCTGCCTGC TGACGCTCTT GACGATTTTG ACCTTGACAT   6541 GCTCCCCGGG GGCTCAGGCG CCACCAACTT TAGCCTGCTG AAGCAGGCAG GCGACGTCGA   6601 GGAGAACCCC GGCCCTATAA CTTCGTATAG CATACATTAT ACGAAGTTAT CCAAAACATT   6661 TAACATTTCT CAACAAGATC TAGAATTAGT AGAAGTAGCG ACAGAGAAGA TTACAATGCT   6721 TTATGAGGAT AATAAACATC ATGTGGGAGC GGCAATTCGT ACGAAAACAG GAGAAATCAT   6781 TTCGGCAGTA CATATTGAAG CGTATATAGG ACGAGTAACT GTTTGTGCAG AAGCCATTGC   6841 GATTGGTAGT GCAGTTTCGA ATGGACAAAA GGATTTTGAC ACGATTGTAG CTGTTAGACA   6901 CCCTTATTCT GACGAAGTAG ATAGAAGTAT TCGAGTGGTA AGTCCTTGTG GTATGTGTAG   6961 GGAGTTGATT TCAGACTATG CACCAGATTG TTTTGTGTTA ATAGAAATGA ATGGCAAGTT   7021 AGTCAAAACT ACGATTGAAG AACTCATTCC ACTCAAATAT ACCCGAAATG GCAGTGGAGA   7081 GGGCAGAGGA AGTCTGCTAA CATGCGGTGA CGTCGAGGAG AATCCTGGCC CAGTGAGCAA   7141 GGGCGAGGCA GTGATCAAGG AGTTCATGCG GTTCAAGGTG CACATGGAGG GCTCCATGAA   7201 CGGCCACGAG TTCGAGATCG AGGGCGAGGG CGAGGGCCGC CCCTACGAGG GCACCCAGAC   7261 CGCCAAGCTG AAGGTGACCA AGGGTGGCCC CCTGCCCTTC TCCTGGGACA TCCTGTCCCC   7321 TCAGTTCATG TACGGCTCCA GGGCCTTCAC CAAGCACCCC GCCGACATCC CCGACTACTA   7381 TAAGCAGTCC TTCCCCGAGG GCTTCAAGTG GGAGCGCGTG ATGAACTTCG AGGACGGCGG   7441 CGCCGTGACC GTGACCCAGG ACACCTCCCT GGAGGACGGC ACCCTGATCT ACAAGGTGAA   7501 GCTCCGCGGC ACCAACTTCC CTCCTGACGG CCCCGTAATG CAGAAGAAAA CAATGGGCTG   7561 GGAAGCGTCC ACCGAGCGGT TGTACCCCGA GGACGGCGTG CTGAAGGGCG ACATTAAGAT   7621 GGCCCTGCGC CTGAAGGACG GCGGCCGCTA CCTGGCGGAC TTCAAGACCA CCTACAAGGC   7681 CAAGAAGCCC GTGCAGATGC CCGGCGCCTA CAACGTTGAC CGCAAGTTGG ACATCACCTC   7741 CCACAACGAG GACTACACCG TGGTGGAACA GTACGAACGC TCCGAGGGCC GCCACTCCAC   7801 CGGCGGCATG GACGAGCTGT ACAAGTGACC TCGACTGTGC CTTCTAGTTG CCAGCCATCT   7861 GTTGTTTGCC CCTCCCCCGT GCCTTCCTTG ACCCTGGAAG GTGCCACTCC CACTGTCCTT   7921 TCCTAATAAA ATGAGGAAAT TGCATCGCAT TGTCTGAGTA GGTGTCATTC TATTCTGGGG   7981 GGTGGGGTGG GGCAGGACAG CAAGGGGGAG GATTGGGAAG ACAATAGCAG GCATGCTGGG   8041 GATGCGGTGG GCTCTATGGC ATGCACAACT TCGTATAGAA AGGTATATAC GAAGTTGTAG   8101 AGACCAACCG GGTCTCAGCT AGCTCCCTTT AGTGAGGGTT AATTGCGCGC TTGGCGTAAT   8161 CATGGTCATA GCTGTTTCCT GTGTGAAATT GTTATCCGCT CACAATTCCA CACAACATAG   8221 GAGCCGGAAG CATAAAGTGT AAAGCCTGGG GTGCCTAATG AGTGAGGTAA CTCACATTAA   8281 TTGCGTTGCG CTCACTGCCC GCTTTCCAGT CGGGAAACCT GTCGTGCCAG CTGCATTAAT   8341 GAATCGGCCA ACGCGCGGGG AGAGGCGGTT TGCGTATTGG GCGCTCTTCC GCTTCCTCGC   8401 TCACTGACTC GCTGCGCTCG GTCGTTCGGC TGCGGCGAGC GGTATCAGCT CACTCAAAGG   8461 CGGTAATACG GTTATCCACA GAATCAGGGG ATAACGCAGG AAAGAACATG TGAGCAAAAG   8521 GCCAGCAAAA GGCCAGGAAC CGTAAAAAGG CCGCGTTGCT GGCGTTTTTC CATAGGCTCC   8581 GCCCCCCTGA CGAGCATCAC AAAAATCGAC GCTCAAGTCA GAGGTGGCGA AACCCGACAG   8641 GACTATAAAG ATACCAGGCG TTTCCCCCTG GAAGCTCCCT CGTGCGCTCT CCTGTTCCGA   8701 CCCTGCCGCT TACCGGATAC CTGTCCGCCT TTCTCCCTTC GGGAAGCGTG GCGCTTTCTC   8761 ATAGCTCACG CTGTAGGTAT CTCAGTTCGG TGTAGGTCGT TCGCTCCAAG CTGGGCTGTG   8821 TGCACGAACC CCCCGTTCAG CCCGACCGCT GCGCCTTATC CGGTAACTAT CGTCTTGAGT   8881 CCAACCCGGT AAGACACGAC TTATCGCCAC TGGCAGCAGC CACTGGTAAC AGGATTAGCA   8941 GAGCGAGGTA TGTAGGCGGT GCTACAGAGT TOTTGAAGTG GTGGCCTAAC TACGGCTACA   9001 CTAGAAGGAC AGTATTTGGT ATCTGCGCTC TGCTGAAGCC AGTTACCTTC GGAAAAAGAG   9061 TTGGTAGCTC TTGATCCGGC AAACAAACCA CCGCTGGTAG CGGTGGTTTT TTTGTTTGCA   9121 AGCAGCAGAT TACGCGCAGA AAAAAAGGAT CTCAAGAAGA TCCTTTGATC TTTTCTACGG   9181 GGTCTGACGC TCAGTGGAAC GAAAACTCAC GTTAAGGGAT TTTGGTCATG AGATTATCAA   9241 AAAGGATOTT CACCTAGATC CTTTTAAATT AAAAATGAAG TTTTAAATCA ATCTAAAGTA   9301 TATATGAGTA AACTTGGTCT GACAGTTACC AATGOTTAAT CAGTGAGGCA CCTATCTCAG   9361 CGATCTGTCT ATTTCGTTCA TCCATAGTTG CCTGACTCCC CGTCGTGTAG ATAACTACGA   9421 TACGGGAGGG CTTACCATCT GGCCCCAGTG CTGCAATGAT ACCGCGAGAT CCACGCTCAC   9481 CGGCTCCAGA TTTATCAGCA ATAAACCAGC CAGCCGGAAG GGCCGAGCGC AGAAGTGGTC   9541 CTGCAACTTT ATCCGCCTCC ATCCAGTCTA TTAATTGTTG CCGGGAAGCT AGAGTAAGTA   9601 GTTCGCCAGT TAATAGTTTG CGCAACGTTG TTGCCATTGC TACAGGCATC GTGGTGTCAC   9661 GCTCGTCGTT TGGTATGGCT TCATTCAGCT CCGGTTCCCA ACGATCAAGG CGAGTTACAT   9721 GATCCCCCAT GTTGTGCAAA AAAGCGGTTA GCTCCTTCGG TCCTCCGATC GTTGTCAGAA   9781 GTAAGTTGGC CGCAGTGTTA TCACTCATGG TTATGGCAGC ACTGCATAAT TCTCTTACTG   9841 TCATGCCATC CGTAAGATGC TTTTCTGTGA CTGGTGAGTA CTCAACCAAG TCATTCTGAG   9901 AATAGTGTAT GCGGCGACCG AGTTGCTCTT GCCCGGCGTC AATACGGGAT AATACCGCGC   9961 CACATAGCAG AACTTTAAAA GTGCTCATCA TTGGAAAACG TTCTTCGGGG CGAAAACTCT  10021 CAAGGATOTT ACCGCTGTTG AGATCCAGTT CGATGTAACC CACTCGTGCA CCCAACTGAT  10081 CTTCAGCATC TTTTACTTTC ACCAGCGTTT CTGGGTGAGC AAAAACAGGA AGGCAAAATG  10141 CCGCAAAAAA GGGAATAAGG GCGACACGGA AATGTTGAAT ACTCATACTC TTCCTTTTTC  10201 AATATTATTG AAGCATTTAT CAGGGTTATT GTCTCATGAG CGGATACATA TTTGAATGTA  10261 TTTAGAAAAA TAAACAAATA GGGGTTCCGC GCACATTTCC CCGAAAAGTG CCACCTGGGT  10321 CCTTTTCATC ACGTGCTATA AAAATAATTA TAATTTAAAT TTTTTAATAT AAATATATAA  10381 ATTAAAAATA GAAAGTAAAA AAAGAAATTA AAGAAAAAAT AGTTTTTGTT TTCCGAAGAT  10441 GTAAAAGACT CTAGGGGGAT CGCCAACAAA TACTACCTTT TATCTTGCTC TTCCTGCTCT  10501 CAGGTATTAA TGCCGAATTG TTTCATCTTG TCTGTGTAGA AGACCACACA CGAAAATCCT  10561 GTGATTTTAC ATTTTACTTA TCGTTAATCG AATGTATATC TATTTAATCT GCTTTTCTTG  10621 TCTAATAAAT ATATATGTAA AGTACGCTTT TTGTTGAAAT TTTTTAAACC TTTGTTTATT  10681 TTTTTTTCTT CATTCCGTAA CTCTTCTACC TTCTTTATTT ACTTTCTAAA ATCCAAATAC  10741 AAAACATAAA AATAAATAAA CACAGAGTAA ATTCCCAAAT TATTCCATCA TTAAAAGATA  10801 CGAGGCGCGT GTAAGTTACA GGCAAGCGAT CCGTCCTAAG AAACCA (LANDING PAD_noCreTet) SEQ ID NO: 7      1 TTATTATCAT GACATTAACC TATAAAAATA GGCGTATCAC GAGGCCCTTT GTCACAGCTT     61 GTCTGTAAGC GGATGCCGGG AGCAGACAAG CCCGTCAGGG CGCGTCAGCG GGTGTTGGCG    121 GGTGTCGGGG CTGGCTTAAC TATGCGGCAT CAGAGCAGAT TGTACTGAGA GTGCACCATA    181 CCACAGCTTT TCAATTCAAT TCATCATTTT TTTTTTATTC TTTTTTTTGA TTTCGGTTTC    241 TTTGAAATTT TTTTGATTCG GTAATCTCCG AACAGAAGGA AGAACGAAGG AAGGAGCACA    301 GACTTAGATT GGTATATATA CGCATATGTA GTGTTGAAGA AACATGAAAT TGCCCAGTAT    361 TCTTAACCCA ACTGCACAGA ACAAAAACCT GCAGGAAACG AAGATAAATC ATGTCGAAAG    421 CTACATATAA GGAACGTGCT GCTACTCATC CTAGTCCTGT TGCTGCCAAG CTATTTAATA    481 TCATGCACGA AAAGCAAACA AACTTGTGTG CTTCATTGGA TGTTCGTACC ACCAAGGAAT    541 TACTGGAGTT AGTTGAAGCA TTAGGTCCCA AAATTTGTTT ACTAAAAACA CATGTGGATA    601 TCTTGACTGA TTTTTCCATG GAGGGCACAG TTAAGCCGCT AAAGGCATTA TCCGCCAAGT    661 ACAATTTTTT ACTCTTCGAA GACAGAAAAT TTGCTGACAT TGGTAATACA GTCAAATTGC    721 AGTACTCTGC GGGTGTATAC AGAATAGCAG AATGGGCAGA CATTACGAAT GCACACGGTG    781 TGGTGGGCCC AGGTATTGTT AGCGGTTTGA AGCAGGCGGC AGAAGAAGTA ACAAAGGAAC    841 CTAGAGGCCT TTTGATGTTA GCAGAATTGT CATGCAAGGG CTCCCTATCT ACTGGAGAAT    901 ATACTAAGGG TACTGTTGAC ATTGCGAAGA GCGACAAAGA TTTTGTTATC GGCTTTATTG    961 CTCAAAGAGA CATGGGTGGA AGAGATGAAG GTTACGATTG GTTGATTATG ACACCCGGTG   1021 TGGGTTTAGA TGACAAGGGA GATGCATTGG GTCAACAGTA TAGAACCGTG GATGATGTGG   1081 TGTCTACAGG ATCTGACATT ATTATTGTTG GAAGAGGACT ATTTGCAAAG GGAAGGGATG   1141 CTAAGGTAGA GGGTGAACGT TACAGAAAAG CAGGCTGGGA AGCATATTTG AGAAGATGCG   1201 GCCAGCAAAA CTAAAAAACT GTATTATAAG TAAATGCATG TATACTAAAC TCACAAATTA   1261 GAGCTTCAAT TTAATTATAT CAGTTATTAC CCTATGCGGT GTGAAATACC GCACAGATGC   1321 GTAAGGAGAA AATACCGCAT CAGGAAATTG TAAACGTTAA TATTTTGTTA AAATTCGCGT   1381 TAAATTTTTG TTAAATCAGC TCATTTTTTA ACCAATAGGC CGAAATCGGC AAAATCCCTT   1441 ATAAATCAAA AGAATAGACC GAGATAGGGT TGAGTGTTGT TCCAGTTTGG AACAAGAGTC   1501 CACTATTAAA GAACGTGGAC TCCAACGTCA AAGGGCGAAA AACCGTCTAT CAGGGCGATG   1561 GCCCACTACG TGAACCATCA CCCTAATCAA GTTTTTTGGG GTCGAGGTGC CGTAAAGCAC   1621 TAAATCGGAA CCCTAAAGGG AGCCCCCGAT TTAGAGCTTG ACGGGGAAAG CCGGCGAACG   1681 TGGCGAGAAA GGAAGGGAAG AAAGCGAAAG GAGCGGGCGC TAGGGCGCTG GCAAGTGTAG   1741 CGGTCACGCT GCGCGTAACC ACCACACCCG CCGCGCTTAA TGCGCCGCTA CAGGGCGCGT   1801 CGCGCCATTC GCCATTCAGG CTGCGCAACT GTTGGGAAGG GCGATCGGTG CGGGCCTCTT   1861 CGCTATTACG CCAGCTGGCG AAAGGGGGAT GTGCTGCAAG GCGATTAAGT TGGGTAACGC   1921 CAGGGTTTTC CCAGTCACGA CGTTGTAAAA CGACGGCCAG TGAGCGCGCG TAATACGACT   1981 CACTATAGGG CGAATTGGGT ACCGCGAGAC CTTCCTGGTC TCAGAAGTTC CTATACTCTA   2041 GAAAGAATAG GAACTTCGTC GACCCAGACA TGATAAGATA CATTGATGAG TTTGGACAAA   2101 CCACAACTAG AATGCAGTGA AAAAAATGCT TTATTTGTGA AATTTGTGAT GCTATTGCTT   2161 TATTTGTAAC CATTATAAGC TGCAATAAAC AAGTTAACAA CAACAATTGC ATTCATTTTA   2221 TGTTTCAGGT TCAGGGGGAG GTGGTCCCTG CAGTTACGCC AATGATAACC CCCGCCAGAA   2281 AAATCTTAGT AGCCTTCCCT TTTTGTTTTC CGTGCCCCAA CTCGGCGGAT TGACTCGGCC   2341 CCTTCCGGAA ACACCCGAAT CAACTTCTAG TCAAATTATT GTTCACGCCG CAATGACCCA   2401 CCCCTGGCCC GCGTCTGTGG AACTGACCCC TGGTGTACAG GAGAGTTCGC TGCTGAAAGT   2461 GGTCCCAAAG GGGTACTAGT TTTTAAGCTC CCAACTCCCC CTCCCCCAGC GTCTGGAGGA   2521 TTCCACACCC TCGCACCGCA GGGGCGAGGA AGTGGGCGGA GTCCGGTTTT GGCGCCAGCC   2581 GCTGAGGCTG CCAAGCAGAA AAGCCACCGC TGAGGAGACT CCGGTCACTG TCCTCGCCCC   2641 GCCTCCCCCT TCCCTCCCCT TGGGGACCAC CGGGCGCCAC GCCGCGAACG GTAAGTGCCG   2701 CGGTCGTCGG CGCCTCCGCC CTCCCCCTAG GGCCCCAATT CCCAGCGGGC GCGGCGCGCG   2761 GCCCCTCCCC CCGCCGGGCG CGCGCCCGCT GCCCCGCCCT TCGTGGCCGC CCGGCGTGGG   2821 CGGTGCCACC CCTCCCCCCG GCGGCCCCGC GCGCAGCTCC CGGCTCCCTC CCCCTTCGGA   2881 TGTGGCTTGA GCTGTAGGCG CGGAGGGCCG GAGACGCTGC AGACCCGCGA CCCGGAGCAG   2941 CTCGGAGGCG GTGAAGTCGG TGGCTTTCCT TCTCTCTAGC TCTCGCTCGC TGGTGGTGCT   3001 TCAGATGCCA CACGCGTCCC GGGGGCCCGG TTCTCCGCTC CCCTCGGCTC CGGTGCCCGT   3061 CAGTGGGCAG AGCGCACATC GCCCACAGTC CCCGAGAAGT TGGGGGGAGG GGTCGGCAAT   3121 TGAACCGGTG CCTAGAGAAG GTGGCGCGGG GTAAACTGGG AAAGTGATGT CGTGTACTGG   3181 CTCCGCCTTT TTCCCGAGGG TGGGGGAGAA CCGTATATAA GTGCAGTAGT CGCCGTGAAC   3241 GTTCTTTTTC GCAACGGGTT TGCCGCCAGA ACACAGGTAA GTGCCGTGTG TGGTTCCCGC   3301 GGGCCTGGCC TCTTTACGGG TTATGGCCCT TGCGTGCCTT GAATTACTTC CACCTGGCTG   3361 CAGTACGTGA TTCTTGATCC CGAGCTTCGG GTTGGAAGTG GGTGGGAGAG TTCGAGGCCT   3421 TGCGCTTAAG GAGCCCCTTC GCCTCGTGCA TGAGTTGAGG CCTGGCCTGG GCGCTGGGGC   3481 CGCCGCGTGC GAATCTGGTG GCACCTTCGC GCCTGTCTCG CTGCTTTCGA TAAGTCTCTA   3541 GCCATTTAAA ATTTTTGATG ACCTGCTGCG ACGCTTTTTT TCTGGCAAGA TAGTCTTGTA   3601 AATGCGGGCC AAGATCTGCA CACTGGTATT TCGGTTTTTG GGGCCGCGGG CGGCGACGGG   3661 GCCCGTGCGT CCCAGCGCAC ATGTTCGGCG AGGCGGGGCC TGCGAGCGCG GCCACCGAGA   3721 ATCGGACGGG GGTAGTCTCA AGCTGGCCGG CCTGCTCTGG TGCCTGGCCT CGCGCCGCCG   3781 TGTATCGCCC CGCCCTGGGC GGCAAGGCTG GCCCGGTCGG CACCAGTTGC GTGAGCGGAA   3841 AGATGGCCGC TTCCCGGCCC TGCTGCAGGG AGCTCAAAAT GGAGGACGCG GCGCTCGGGA   3901 GAGCGGGCGG GTGAGTCACC CACACAAAGG AAAAGGGCCT TTCCGTCCTC AGCCGTCGCT   3961 TCATGTGACT CCACGGAGTA CCGGGCGCCG TCCAGGCACC TCGATTAGTT CTCGAGCTTT   4021 TGGAGTACGT CGTCTTTAGG TTGGGGGGAG GGGTTTTATG CGATGGAGTT TCCCCACACT   4081 GAGTGGGTGG AGACTGAAGT TAGGCCAGCT TGGCACTTGA TGTAATTCTC CTTGGAATTT   4141 GCCCTTTTTG AGTTTGGATC TTGGTTCATT CTCAAGCCTC AGACAGTGGT TCAAAGTTTT   4201 TTTCTTCCAT TTCAGGTGTC GTGAGCCACC ATGATAACTT CGTATAGCAT ACATTATACG   4261 AAGTTATCCA AAACATTTAA CATTTCTCAA CAAGATCTAG AATTAGTAGA AGTAGCGACA   4321 GAGAAGATTA CAATGCTTTA TGAGGATAAT AAACATCATG TGGGAGCGGC AATTCGTACG   4381 AAAACAGGAG AAATCATTTC GGCAGTACAT ATTGAAGCGT ATATAGGACG AGTAACTGTT   4441 TGTGCAGAAG CCATTGCGAT TGGTAGTGCA GTTTCGAATG GACAAAAGGA TTTTGACACG   4501 ATTGTAGCTG TTAGACACCC TTATTCTGAC GAAGTAGATA GAAGTATTCG AGTGGTAAGT   4561 CCTTGTGGTA TGTGTAGGGA GTTGATTTCA GACTATGCAC CAGATTGTTT TGTGTTAATA   4621 GAAATGAATG GCAAGTTAGT CAAAACTACG ATTGAAGAAC TCATTCCACT CAAATATACC   4681 CGAAATGGCA GTGGAGAGGG CAGAGGAAGT CTGCTAACAT GCGGTGACGT CGAGGAGAAT   4741 CCTGGCCCAG TGAGCAAGGG CGAGGCAGTG ATCAAGGAGT TCATGCGGTT CAAGGTGCAC   4801 ATGGAGGGCT CCATGAACGG CCACGAGTTC GAGATCGAGG GCGAGGGCGA GGGCCGCCCC   4861 TACGAGGGCA CCCAGACCGC CAAGCTGAAG GTGACCAAGG GTGGCCCCCT GCCCTTCTCC   4921 TGGGACATCC TGTCCCCTCA GTTCATGTAC GGCTCCAGGG CCTTCACCAA GCACCCCGCC   4981 GACATCCCCG ACTACTATAA GCAGTCCTTC CCCGAGGGCT TCAAGTGGGA GCGCGTGATG   5041 AACTTCGAGG ACGGCGGCGC CGTGACCGTG ACCCAGGACA CCTCCCTGGA GGACGGCACC   5101 CTGATCTACA AGGTGAAGCT CCGCGGCACC AACTTCCCTC CTGACGGCCC CGTAATGCAG   5161 AAGAAAACAA TGGGCTGGGA AGCGTCCACC GAGCGGTTGT ACCCCGAGGA CGGCGTGCTG   5221 AAGGGCGACA TTAAGATGGC CCTGCGCCTG AAGGACGGCG GCCGCTACCT GGCGGACTTC   5281 AAGACCACCT ACAAGGCCAA GAAGCCCGTG CAGATGCCCG GCGCCTACAA CGTTGACCGC   5341 AAGTTGGACA TCACCTCCCA CAACGAGGAC TACACCGTGG TGGAACAGTA CGAACGCTCC   5401 GAGGGCCGCC ACTCCACCGG CGGCATGGAC GAGCTGTACA AGTGACCTCG ACTGTGCCTT   5461 CTAGTTGCCA GCCATCTGTT GTTTGCCCCT CCCCCGTGCC TTCCTTGACC CTGGAAGGTG   5521 CCACTCCCAC TGTCCTTTCC TAATAAAATG AGGAAATTGC ATCGCATTGT CTGAGTAGGT   5581 GTCATTCTAT TCTGGGGGGT GGGGTGGGGC AGGACAGCAA GGGGGAGGAT TGGGAAGACA   5641 ATAGCAGGCA TGCTGGGGAT GCGGTGGGCT CTATGGCATG CACAACTTCG TATAGAAAGG   5701 TATATACGAA GTTGTAGAGA CCAACCTGGT CTCAGCTAGC TCCCTTTAGT GAGGGTTAAT   5761 TGCGCGCTTG GCGTAATCAT GGTCATAGCT GTTTCCTGTG TGAAATTGTT ATCCGCTCAC   5821 AATTCCACAC AACATAGGAG CCGGAAGCAT AAAGTGTAAA GCCTGGGGTG CCTAATGAGT   5881 GAGGTAACTC ACATTAATTG CGTTGCGCTC ACTGCCCGCT TTCCAGTCGG GAAACCTGTC   5941 GTGCCAGCTG CATTAATGAA TCGGCCAACG CGCGGGGAGA GGCGGTTTGC GTATTGGGCG   6001 CTCTTCCGCT TCCTCGCTCA CTGACTCGCT GCGCTCGGTC GTTCGGCTGC GGCGAGCGGT   6061 ATCAGCTCAC TCAAAGGCGG TAATACGGTT ATCCACAGAA TCAGGGGATA ACGCAGGAAA   6121 GAACATGTGA GCAAAAGGCC AGCAAAAGGC CAGGAACCGT AAAAAGGCCG CGTTGCTGGC   6181 GTTTTTCCAT AGGCTCCGCC CCCCTGACGA GCATCACAAA AATCGACGCT CAAGTCAGAG   6241 GTGGCGAAAC CCGACAGGAC TATAAAGATA CCAGGCGTTT CCCCCTGGAA GCTCCCTCGT   6301 GCGCTCTCCT GTTCCGACCC TGCCGCTTAC CGGATACCTG TCCGCCTTTC TCCCTTCGGG   6361 AAGCGTGGCG CTTTCTCATA GCTCACGCTG TAGGTATCTC AGTTCGGTGT AGGTCGTTCG   6421 CTCCAAGCTG GGCTGTGTGC ACGAACCCCC CGTTCAGCCC GACCGCTGCG CCTTATCCGG   6481 TAACTATCGT CTTGAGTCCA ACCCGGTAAG ACACGACTTA TCGCCACTGG CAGCAGCCAC   6541 TGGTAACAGG ATTAGCAGAG CGAGGTATGT AGGCGGTGCT ACAGAGTTCT TGAAGTGGTG   6601 GCCTAACTAC GGCTACACTA GAAGGACAGT ATTTGGTATC TGCGCTCTGC TGAAGCCAGT   6661 TACCTTCGGA AAAAGAGTTG GTAGCTCTTG ATCCGGCAAA CAAACCACCG CTGGTAGCGG   6721 TGGTTTTTTT GTTTGCAAGC AGCAGATTAC GCGCAGAAAA AAAGGATCTC AAGAAGATCC   6781 TTTGATCTTT TCTACGGGGT CTGACGCTCA GTGGAACGAA AACTCACGTT AAGGGATTTT   6841 GGTCATGAGA TTATCAAAAA GGATCTTCAC CTAGATCCTT TTAAATTAAA AATGAAGTTT   6901 TAAATCAATC TAAAGTATAT ATGAGTAAAC TTGGTCTGAC AGTTACCAAT GOTTAATCAG   6961 TGAGGCACCT ATCTCAGCGA TCTGTCTATT TCGTTCATCC ATAGTTGCCT GACTCCCCGT   7021 CGTGTAGATA ACTACGATAC GGGAGGGCTT ACCATCTGGC CCCAGTGCTG CAATGATACC   7081 GCGAGATCCA CGCTCACCGG CTCCAGATTT ATCAGCAATA AACCAGCCAG CCGGAAGGGC   7141 CGAGCGCAGA AGTGGTCCTG CAACTTTATC CGCCTCCATC CAGTCTATTA ATTGTTGCCG   7201 GGAAGCTAGA GTAAGTAGTT CGCCAGTTAA TAGTTTGCGC AACGTTGTTG CCATTGCTAC   7261 AGGCATCGTG GTGTCACGCT CGTCGTTTGG TATGGCTTCA TTCAGCTCCG GTTCCCAACG   7321 ATCAAGGCGA GTTACATGAT CCCCCATGTT GTGCAAAAAA GCGGTTAGCT CCTTCGGTCC   7381 TCCGATCGTT GTCAGAAGTA AGTTGGCCGC AGTGTTATCA CTCATGGTTA TGGCAGCACT   7441 GCATAATTCT CTTACTGTCA TGCCATCCGT AAGATGOTTT TCTGTGACTG GTGAGTACTC   7501 AACCAAGTCA TTCTGAGAAT AGTGTATGCG GCGACCGAGT TGCTCTTGCC CGGCGTCAAT   7561 ACGGGATAAT ACCGCGCCAC ATAGCAGAAC TTTAAAAGTG CTCATCATTG GAAAACGTTC   7621 TTCGGGGCGA AAACTCTCAA GGATCTTACC GCTGTTGAGA TCCAGTTCGA TGTAACCCAC   7681 TCGTGCACCC AACTGATCTT CAGCATCTTT TACTTTCACC AGCGTTTCTG GGTGAGCAAA   7741 AACAGGAAGG CAAAATGCCG CAAAAAAGGG AATAAGGGCG ACACGGAAAT GTTGAATACT   7801 CATACTCTTC CTTTTTCAAT ATTATTGAAG CATTTATCAG GGTTATTGTC TCATGAGCGG   7861 ATACATATTT GAATGTATTT AGAAAAATAA ACAAATAGGG GTTCCGCGCA CATTTCCCCG   7921 AAAAGTGCCA CCTGGGTCCT TTTCATCACG TGCTATAAAA ATAATTATAA TTTAAATTTT   7981 TTAATATAAA TATATAAATT AAAAATAGAA AGTAAAAAAA GAAATTAAAG AAAAAATAGT   8041 TTTTGTTTTC CGAAGATGTA AAAGACTCTA GGGGGATCGC CAACAAATAC TACCTTTTAT   8101 CTTGCTCTTC CTGCTCTCAG GTATTAATGC CGAATTGTTT CATCTTGTCT GTGTAGAAGA   8161 CCACACACGA AAATCCTGTG ATTTTACATT TTACTTATCG TTAATCGAAT GTATATCTAT   8221 TTAATCTGCT TTTCTTGTCT AATAAATATA TATGTAAAGT ACGCTTTTTG TTGAAATTTT   8281 TTAAACCTTT GTTTATTTTT TTTTCTTCAT TCCGTAACTC TTCTACCTTC TTTATTTACT   8281 TTAAACCTTT GTTTATTTTT TTTTCTTCAT TCCGTAACTC TTCTACCTTC TTTATTTACT   8341 TTCTAAAATC CAAATACAAA ACATAAAAAT AAATAAACAC AGAGTAAATT CCCAAATTAT   8401 TCCATCATTA AAAGATACGA GGCGCGTGTA AGTTACAGGC AAGCGATCCG TCCTAAGAAA   8461 CCA (mini_Syn_HLA) SEQ ID NO: 8      1 GGGTCCTTTT CATCACGTGC TATAAAAATA ATTATAATTT AAATTTTTTA ATATAAATAT     61 ATAAATTAAA AATAGAAAGT AAAAAAAGAA ATTAAAGAAA AAATAGTTTT TGTTTTCCGA    121 AGATGTAAAA GACTCTAGGG GGATCGCCAA CAAATACTAC CTTTTATCTT GCTCTTCCTG    181 CTCTCAGGTA TTAATGCCGA ATTGTTTCAT CTTGTCTGTG TAGAAGACCA CACACGAAAA    241 TCCTGTGATT TTACATTTTA CTTATCGTTA ATCGAATGTA TATCTATTTA ATCTGCTTTT    301 CTTGTCTAAT AAATATATAT GTAAAGTACG CTTTTTGTTG AAATTTTTTA AACCTTTGTT    361 TATTTTTTTT TCTTCATTCC GTAACTCTTC TACCTTCTTT ATTTACTTTC TAAAATCCAA    421 ATACAAAACA TAAAAATAAA TAAACACAGA GTAAATTCCC AAATTATTCC ATCATTAAAA    481 GATACGAGGC GCGTGTAAGT TACAGGCAAG CGATCCGTCC TAAGAAACCA TTATTATCAT    541 GACATTAACC TATAAAAATA GGCGTATCAC GAGGCCCTTT CGTCTCGCGC GTTTCGGTGA    601 TGACGGTGAA AACCTCTGAC ACATGCAGCT CCCGGAGACG GTCACAGCTT GTCTGTAAGC    661 GGATGCCGGG AGCAGACAAG CCCGTCAGGG CGCGTCAGCG GGTGTTGGCG GGTGTCGGGG    721 CTGGCTTAAC TATGCGGCAT CAGAGCAGAT TGTACTGAGA GTGCACCATA AATTCCCGTT    781 TTAAGAGOTT GGTGAGCGCT AGGAGTCACT GCCAGGTATC GTTTGAACAC GGCATTAGTC    841 AGGGAAGTCA TAACACAGTC CTTTCCCGCA ATTTTCTTTT TCTATTACTC TTGGCCTCCT    901 CTAGTACACT CTATATTTTT TTATGCCTCG GTAATGATTT TCATTTTTTT TTTTCCACCT    961 AGCGGATGAC TCTTTTTTTT TCTTAGCGAT TGGCATTATC ACATAATGAA TTATACATTA   1021 TATAAAGTAA TGTGATTTCT TCGAAGAATA TACTAAAAAA TGAGCAGGCA AGATAAACGA   1081 AGGCAAAGAT GACAGAGCAG AAAGCCCTAG TAAAGCGTAT TACAAATGAA ACCAAGATTC   1141 AGATTGCGAT CTCTTTAAAG GGTGGTCCCC TAGCGATAGA GCACTCGATC TTCCCAGAAA   1201 AAGAGGCAGA AGCAGTAGCA GAACAGGCCA CACAATCGCA AGTGATTAAC GTCCACACAG   1261 GTATAGGGTT TCTGGACCAT ATGATACATG CTCTGGCCAA GCATTCCGGC TGGTCGCTAA   1321 TCGTTGAGTG CATTGGTGAC TTACACATAG ACGACCATCA CACCACTGAA GACTGCGGGA   1381 TTGCTCTCGG TCAAGCTTTT AAAGAGGCCC TAGGGGCCGT GCGTGGAGTA AAAAGGTTTG   1441 GATCAGGATT TGCGCCTTTG GATGAGGCAC TTTCCAGAGC GGTGGTAGAT CTTTCGAACA   1501 GGCCGTACGC AGTTGTCGAA CTTGGTTTGC AAAGGGAGAA AGTAGGAGAT CTCTCTTGCG   1561 AGATGATCCC GCATTTTCTT GAAAGCTTTG CAGAGGCTAG CAGAATTACC CTCCACGTTG   1621 ATTGTCTGCG AGGCAAGAAT GATCATCACC GTAGTGAGAG TGCGTTCAAG GCTCTTGCGG   1681 TTGCCATAAG AGAAGCCACC TCGCCCAATG GTACCAACGA TGTTCCCTCC ACCAAAGGTG   1741 TTCTTATGTA GTGACACCGA TTATTTAAAG CTGCAGCATA CGATATATAT ACATGTGTAT   1801 ATATGTATAC CTATGAATGT CAGTAAGTAT GTATACGAAC AGTATGATAC TGAAGATGAC   1861 AAGGTAATGC ATCATTCTAT ACGTGTCATT CTGAACGAGG CGCGCTTTCC TTTTTTCTTT   1921 TTGCTTTTTC TTTTTTTTTC TCTTGAACTC GACGGATCTA TGCGGTGTGA AATACCGCAC   1981 AGATGCGTCC TAGGGCGGCC GCATAACTTC GTATAGCATA CATTATACGA AGTTATCCGG   2041 AACCGAGTAC AAGCCCACGG TGCGCCTCGC CACCCGCGAC GACGTCCCCA GGGCCGTCCG   2101 CACCCTCGCC GCCGCGTTCG CCGACTACCC CGCCACGCGC CACACCGTCG ATCCGGACCG   2161 CCACATCGAG CGCGTGACCG AGCTGCAAGA ACTCTTCCTC ACGCGCGTCG GGCTCGACAT   2221 CGGCAAGGTG TGGGTCGCGG ACGACGGAGC CGCTGTGGCG GTCTGGACCA CGCCGGAGAG   2281 CGTCGAAGCG GGGGCGGTGT TCGCCGAGAT CGGCCCGCGC ATGGCCGAGT TGAGCGGTTC   2341 CCGGCTGGCC GCGCAGCAAC AGATGGAGGG CCTCCTGGCT CCGCACCGGC CCAAGGAGCC   2401 CGCGTGGTTC CTGGCCACCG TCGGAGTCTC GCCCGACCAC CAGGGCAAGG GTCTGGGCAG   2461 CGCCGTCGTG CTCCCCGGAG TGGAGGCGGC CGAGCGCGCC GGGGTGCCCG CCTTCCTGGA   2521 AACCTCCGCG CCCCGCAACC TCCCCTTCTA CGAGCGGCTC GGCTTCACCG TCACCGCCGA   2581 CGTCGAGGTG CCCGAAGGAC CGCGCACCTG GTGCATGACC CGCAAGCCCG GTGCCGCATG   2641 CCCCACGCTA CTGCGGGTTT ATATAGACGG TCCCCACGGG ATGGGGAAAA CCACCACCAC   2701 GCAACTGCTG GTGGCCCTGG GTTCGCGCGA CGATATCGTC TATGTACCCG AGCCGATGAC   2761 TTACTGGCGG GTGCTGGGGG CTTCCGAGAC AATCGCGAAC ATCTACACCA CACAACACCG   2821 CCTCGACCAG GGTGAGATAT CGGCCGGGGA CGCGGCGGTG GTAATGACAA GCGCCCAGAT   2881 AACAATGGGT ATGCCTTATG CCGTGACCGA CGCCGTTCTG GCTCCTCATA TCGGGGGGGA   2941 GGCTGGTAGC TCACATGCCC CGCCCCCGGC CCTCACCCTC ATCTTCGACC GCCATCCCAT   3001 CGCCGCCCTC CTGTGCTACC CGGCCGCGCG GTACCTTATG GGCAGCATGA CCCCCCAGGC   3061 CGTGCTGGCG TTCGTGGCCC TCATCCCGCC GACCTTGCCC GGCACCAACA TCGTGCTTGG   3121 GGCCCTGCCG GAGGACAGAC ACATCGACCG CCTGGCCAAA CGCCAGCGCC CCGGCGAGCG   3181 GCTGGACCTG GCTATGCTGG CTGCGATTCG CCGCGTTTAC GGGCTACTTG CCAATACGGT   3241 GCGGTATCTG CAGTGCGGCG GGTCGTGGCG GGAGGACTGG GGACAGCTTT CGGGGACGGC   3301 CGTGCCGCCC CAGGGTGCCG AGCCCCAGAG CAACGCGGGC CCACGACCCC ATATCGGGGA   3361 CACGTTATTT ACCCTGTTTC GGGCCCCCGA GTTGCTGGCC CCCAACGGCG ACCTGTATAA   3421 CGTGTTTGCC TGGGCCTTGG ACGTCTTGGC CAAACGCCTC CGTTCCATGC ACGTCTTTAT   3481 CCTGGATTAC GACCAATCGC CCGCCGGCTG CCGGGACGCC CTGCTGCAAC TTACCTCCGG   3541 GATGGTCCAG ACCCACGTCA CCACCCCCGG CTCCATACCG ACGATATGCG ACCTGGCGCG   3601 CACGTTTGCC CGCGAGATGG GGGAGGCTAA CGAGCTCGGC AGTGGAGAGG GCAGAGGAAG   3661 TCTGCTAACA TGCGGTGACG TCGAGGAGAA TCCTGGCCCA AGCCAGTTCG ACATCCTGTG   3721 CAAGACCCCC CCCAAGGTGC TGGTGCGGCA GTTCGTGGAG AGATTCGAGA GGCCCAGCGG   3781 CGAGAAGATC GCCAGCTGTG CCGCCGAGCT GACCTACCTG TGCTGGATGA TCACCCACAA   3841 CGGCACCGCC ATCAAGAGGG CCACCTTCAT GAGCTACAAC ACCATCATCA GCAACAGCCT   3901 GAGCTTCGAC ATCGTGAACA AGAGCCTGCA GTTCAAGTAC AAGACCCAGA AGGCCACCAT   3961 CCTGGAGGCC AGCCTGAAGA AGCTGATCCC CGCCTGGGAG TTCACCATCA TCCCTTACAA   4021 CGGCCAGAAG CACCAGAGCG ACATCACCGA CATCGTGTCC AGCCTGCAGC TGCAGTTCGA   4081 GAGCAGCGAG GAGGCCGACA AGGGCAACAG CCACAGCAAG AAGATGCTGA AGGCCCTGCT   4141 GTCCGAGGGC GAGAGCATCT GGGAGATCAC CGAGAAGATC CTGAACAGCT TCGAGTACAC   4201 CAGCAGGTTC ACCAAGACCA AGACCCTGTA CCAGTTCCTG TTCCTGGCCA CATTCATCAA   4261 CTGCGGCAGG TTCAGCGACA TCAAGAACGT GGACCCCAAG AGCTTCAAGC TGGTGCAGAA   4321 CAAGTACCTG GGCGTGATCA TTCAGTGCCT GGTGACAGAA ACCAAGACAA GCGTGTCCAG   4381 GCACATCTAC TTTTTCAGCG CCAGAGGCAG GATCGACCCC CTGGTGTACC TGGACGAGTT   4441 TCTGAGGAAC AGCGAGCCCG TGCTGAAGAG AGTGAACAGG ACCGGCAACA GCAGCAGCAA   4501 CAAGCAGGAG TACCAGCTGC TGAAGGACAA CCTGGTGCGC AGCTACAACA AGGCCCTGAA   4561 GAAGAACGCC CCCTACCCCA TCTTCGCTAT CAAGAACGGC CCTAAGAGCC ACATCGGCAG   4621 GCACCTGATG ACCAGCTTTC TGAGCATGAA GGGCCTGACC GAGCTGACAA ACGTGGTGGG   4681 CAACTGGAGC GACAAGAGGG CCTCCGCCGT GGCCAGGACC ACCTACACCC ACCAGATCAC   4741 CGCCATCCCC GACCACTACT TCGCCCTGGT GTCCAGGTAC TACGCCTACG ACCCCATCAG   4801 CAAGGAGATG ATCGCCCTGA AGGACGAAAC CAACCCCATC GAGGAGTGGC AGCACATCGA   4861 GCAGCTGAAG GGCAGCGCCG AGGGCAGCAT CAGATACCCC GCCTGGAACG GCATCATCAG   4921 CCAGGAGGTG CTGGACTACC TGAGCAGCTA CATCAACAGG CGGATCACCG GTTGCGTACG   4981 CGGATCCTCT GCTGGAGACA TGAGAGOTGC CAACCTTTGG CCAAGCCCGC TCATGATCAA   5041 ACGCTCTAAG AAGAACAGCC TGGCCTTGTC CCTGACGGCC GACCAGATGG TCAGTGCCTT   5101 GTTGGATGCT GAGCCCCCCA TACTCTATTC CGAGTATGAT CCTACCAGAC CCTTCAGTGA   5161 AGCTTCGATG ATGGGCTTAC TGACCAACCT GGCAGACAGG GAGCTGGTTC ACATGATCAA   5221 CTGGGCGAAG AGGGTGCCAG GCTTTGTGGA TTTGACCCTC CATGATCAGG TCCACCTTCT   5281 AGAATGTGCC TGGCTAGAGA TCCTGATGAT TGGTCTCGTC TGGCGCTCCA TGGAGCACCC   5341 AGTGAAGCTA CTGTTTGCTC CTAACTTGCT CTTGGACAGG AACCAGGGAA AATGTGTAGA   5401 GGGCATGGTG GAGATOTTCG ACATGCTGCT GGCTACATCA TCTCGGTTCC GCATGATGAA   5461 TCTGCAGGGA GAGGAGTTTG TGTGCCTCAA ATCTATTATT TTGCTTAATT CTGGAGTGTA   5521 CACATTTCTG TCCAGCACCC TGAAGTCTCT GGAAGAGAAG GACCATATCC ACCGAGTCCT   5581 GGACAAGATC ACAGACACTT TGATCCACCT GATGGCCAAG GCAGGCCTGA CCCTGCAGCA   5641 GCAGCACCAG CGGCTGGCCC AGCTCCTCCT CATCCTCTCC CACATCAGGC ACATGAGTAA   5701 CAAAGGCATG GAGCATCTGT ACAGCATGAA GTGCAAGAAC GTGGTGCCCC TCTATGACCT   5761 GCTGCTGGAG GCGGCGGACG CCCACCGCCT ACATGCGCCC ACTAGCCGTG GAGGGGCATC   5821 CGTGGAGGAG ACGGACCAAA GCCACTTGGC CACTGCGGGC TCTACTTCAT CGCATTCCTT   5881 GCAAAAGTAT TACATCACGG GGGAGGCAGA GGGTTTCCCT GCCACAGCTG GCTCCGGCGA   5941 GGGCAGGGGA AGTCTTCTAA CATGCGGGGA CGTGGAGGAA AATCCCGGCC CAGTGAGCAA   6001 GGGTGAGGAG GATAACATGG CCTCTCTCCC AGCGACACAT GAGTTACACA TCTTTGGCTC   6061 CATCAACGGT GTGGACTTTG ACATGGTGGG TCAGGGCACC GGCAATCCAA ATGATGGTTA   6121 TGAGGAGTTA AACCTGAAGT CCACCAAGGG CGACCTCCAG TTCTCCCCCT GGATTCTGGT   6181 CCCTCATATC GGGTATGGCT TCCATCAGTA CCTGCCCTAC CCTGACGGGA TGTCGCCTTT   6241 CCAGGCCGCC ATGGTAGATG GCTCTGGATA CCAAGTCCAT CGCACAATGC AGTTTGAAGA   6301 TGGTGCCTCC CTTACTGTGA ACTACCGCTA CACCTACGAG GGAAGCCACA TCAAAGGAGA   6361 GGCCCAGGTG AAGGGGACTG GTTTCCCTGC TGACGGTCCT GTGATGACCA ACTCGCTGAC   6421 CGCTGCGGAC TGGTGCAGGT CGAAGAAGAC TTACCCCAAC GACAAAACCA TCATCAGTAC   6481 CTTTAAGTGG AGTTACACCA CTGGAAATGG CAAGCGCTAC CGGAGCACTG CGCGGACCAC   6541 CTACACCTTT GCCAAGCCAA TGGCGGCTAA CTATCTGAAG AACCAGCCGA TGTACGTGTT   6601 CCGTAAGACG GAACTCAAGC ACTCCAAGAC CGAGCTGAAC TTCAAGGAGT GGCAAAAGGC   6661 GTTTACCGAT GTGATGGGCA TGGACGAGCT GTACAAGTGA ATTCGATCAT AATCAGCCAT   6721 ACCACATTTG TAGAGGTTTT ACTTGCTTTA AAAAACCTCC CACACCTCCC CCTGAACCTG   6781 AAACATAAAA TGAATGCAAT TGTTGTTGTT AACTTGTTTA TTGCAGCTTA TAATGGTTAC   6841 AAATAAAGCA ATAGCATCAC AAATTTCACA AATAAAGCAT TTTTTTCACT GCATTCTAGT   6901 TGTGGTTTGT CCAAACTCAT CAATGTATCT TATCATGTCT GGCTCGAGGG AAGTTCCTAT   6961 ACTCTAGAAA GAATAGGAAC TTCAAAGGAA GTGCTTCAGG GTGAAGGAAA ATGATACTAG   7021 ATGGTGACCC AGATATACAG AAAGGAACAA TTAACAACAG AAATGATGCA CATACACATG   7081 TCACATTCAC ACTCATTTTC TTAATTTCCT GAAGACATAT GGCTACTTGT TTAAAACAAA   7141 AAGTATTACA CTGTATCATT GAGCTTATAA TATAGGTTGA TGTAATATAT ACAACAATAA   7201 TAGCACAATG GTAGGTTACA AGAAACTACA CTGTTAGAAG TGTCCTTTAT TTTCTGGATG   7261 CAGOTTAATA TAACCTGAAC TTCACTGTGA AAAGTCAAGG AATCGGGTTT CCATTCTTTG   7321 CTATTGTGTA AAGAAATATA GCCAAAAGCC ACTAGGAGAA TTAAAACCAT AAACTAAAAA   7381 ATGTTTATTT GACACATAAG AAAGTAGTAA AGGAGGAACA GAAACAAAAA GATATGAGAC   7441 AAATTGAAAA CGTATAGCAA AATTGTAGAC CAAAACCCAA CCATTGCAAG TGAAGAAATG   7501 ACATGACCTG AGTCACATTA GCAGGACTGC TGAGCACTGT GGGGAGAACA GATATGGGCA   7561 GGAGGTGAGG GACAGTGTTA GTGCCACAAT TCAGGAGGGA AAGGGTGGCA GGGACTAACG   7621 GGGGTGGTGT GAAGGATGAG AAGGGCAGAC AGAAGGGCTG GAGAGGCAGG AGGAGAGGAA   7681 AAGGAGCAGG AGAAAGAATT CTAAAGCAGT GGAAGAGCCT GGCAGAGGGT TCTTTGCATT   7741 CGGTATTTAA TACATTTTGT TGGACTTCCT AAAAACTAAT TGGCTCCTTA TGATTAAAAA   7801 AAAAAGAGTT ACAAAAATAC CAAGTGTTCA GATAAAATAT GCACACTGCT TGGATGTGCA   7861 GAGTTCAGGA AAACAGGCAG TGCTTGAGCG CTGGTGAAGA GCATTGGGAC TGCATGGAGC   7921 CCTCGCAACT TTGAGGTGAT GACTACAGGT TCCCGGTTGC AATAGACAGT AACAAACCCT   7981 GCTTCTTTAT ATTCAGGAGA TGTTCTGGAC TCACACAGGG AAACTCAGGG TGGGGAATGA   8041 AGATAATTTT AAATGCAACA ACCCAGAGTC ACAGATCCAT AGTCTGGGAA AGTAAAACTT   8101 AGGAGCTTTG AGAGTTTAAT TGTAATGCTG TTTTGACACA GGTCTTTTGC AGATTGGAAT   8161 TCTAATCATT CAGGGATTAC CAATATTGTG CTACCTACTG TATTAATAAA CAAAAAGGAA   8221 ACTGGTCTCT ATGAGAATCT CTGTGTGGTG GCTTCAGACA AAACTTCGCC AGGTTTAGAG   8281 AGAAAACCCC TGTCTCTACA CCTCCATTCC CAGGGCGAGC TCACTCTCTG GCATCAAGTT   8341 CTCCGTGATC AGTTTCCCTA CACAAGANTC CAAGAGGAGA GGTAAGGAGT GAGAGGCAGG   8401 GAGTCCAGTT CAGGGACAGG GATTCCAGGA GGAGAAGTGA AGGGGAAGCG GGTGGGCGCA   8461 GCCTGGGGGT CTCTCCCTGG TTTCCACAGA CAGATCCTTG TGCAGGACTC AGGCAGACAG   8521 TGTGACAAAG AGGCTTGGTG TAGGAGAAGA GGGATCAGGA CGAAGTCCCA TGTCCCGGAC   8581 GGGGCTCTCA GGGTCTCAGG CTCCGAGGGC CGCGTCTGCA TTGGGGAGGC GCAGCGTTGG   8641 GGATTCCCCA CTCCCACGAG TTTCACTTCT TCTCCCAACC TATGTCGGGT CCTTCTTCCA   8701 GGATACTCGT GACGCGTCCC CATTTCCCAC TCCCATTGGG TGTCGGGTGT CTAGAGAAGC   8761 CAATCAGTGT CGCCGGGGTC CCAGTTCTAA AGTCCCCACG CACCCACCCG GACTCAGAGT   8821 CTCCTCAGAC ACCGAGATGC GGGTCACGGC ACCCCGAACC CTCCTCCTGC TGCTCTGGGG   8881 GGCCCTGGCC CTGACCGAGA CCTGGGCGTG AGTGGCTTAA TGGAAAGGTG GTTTGGGCCT   8941 CTGTGGGGAG GAGCGAGGGG ACCGCAGGCG GGGGCGCAGG ACCCGGGGAG CCGCGCCGGG   9001 AGGAGGGTCT GGCGGGTCTC AGCCCCTCCT CGCCCCCAGG CTCCCACTCC ATGAGGTATT   9061 TCTACACCGC CATGTCCCGG CCCGGCCGCG GGGAGCCCCG CTTCATCGCA GTGGGCTACG   9121 TGGACGACAC GCAGTTCGTG AGGTTCGACA GCGACGCCGC GAGTCCGAGA GAGGAGCCGC   9181 GGGCGCCGTG GATAGAGCAG GAGGGGCCGG AGTATTGGGA CCGGAACACA CAGATCTACA   9241 AGGCCCAGGC ACAGACTGAC CGAGAGAGCC TGCGGAACCT GCGCGGCTAC TACAACCAGA   9301 GCGAGGCCGG TGAGTGACCC CGGCCCGGGG CGCAGGTCAC GACTCCCCAT CCCCCACGTA   9361 CGGCCCGGGT CGCCCCGAGT CTCCGGGTCC GAGATCCGCC TCCCTGAGGC CACGGGACCC   9421 GCCCAGACCC TCGACCGGCG AGAGCCCCAG GCGCGTTTAC CCGGTTTCAT TTTCAGTTGA   9481 GGCCAAAATC CCCGCGGGTT GGTCGGGGCG GGGCGGGGCT CGGGGGACGG GGCTGACCGC   9541 GGGGCCGGGG CCAGGGTCTC ACACTTGGCA GACGATGTAT GGCTGCGACC TGGGGCCGGA   9601 CGGGCGCCTC CTCCGCGGGC ATAACCAGTT AGCCTACGAC GGCAAGGATT ACATCGCCCT   9661 GAACGAGGAC CTGAGCTCCT GGACCGCGGC GGACACCGCG GCTCAGATCA CCCAGCGCAA   9721 GTGGGAGGCG GCCCGTGAGG CGGAGCAGCT GAGAGCCTAC CTGGAGGGCA CGTGCGTGGA   9781 GTGGCTCCGC AGATACCTGG AGAACGGGAA GGAGACGCTG CAGCGCGCGG GTACCAGGGG   9841 CAGTGGGGAG CCTTCCCCAT CTCCTATAGG TCGCCGGGGA TGGCCTCCCA CGAGAAGAGG   9901 AGGAAAATGG GATCAGCGCT AGAATGTCGC CCTCCCTTGA ATGGAGAATG GCATGAGTTT   9961 TCCTGAGTTT CCTCTGAGGG CCCCCTCTTC TCTCTAGGAC AATTAAGGGA TGACGTCTCT  10021 GAGGAAATGG AGGGGAAGAC AGTCCCTAGA ATACTGATCA GGGGTCCTCT TTGACCCCTG  10081 CAGCAGCCTT GGGAACTGCT ACAAAAGGCC AGAGCTTGTT CTCTGCCTCA CACTCAGTGT  10141 GTTTGGGGCT CTGATTCCAG CACTTCTGAG TCACTTTACC TCCACTCAGA TCAGGAGCAG  10201 AAGTCCCTGT TCCCCGCTCA GAGACTCGAA CTTTCCAATG AATAGGAGAT TATCCCAGGT  10261 GCCTGCGTCC AGGCTGGTGT CTGGGTTCTG TGCCCCTTCC CCACCCCAGG TGTCCTGTCC  10321 ATTCTCAGGC TGGTCACATG GGTGGTCCTA GGGTGTCCTA TGAGAGATGC AAAGCGCCTG  10381 AATTTTCTGA CTCTTCCCAT CAGACCCCCC AAAGACACAC GTGACCCACC ACCCCATCTC  10441 TGACCATGAG GCCACCCTGA GGTGCTGGGC CCTGGGCTTC TACCCTGCGG AGATCACACT  10501 GACCTGGCAG CGGGATGGCG AGGACCAAAC TCAGGACACT GAGCTTGTGG AGACCAGACC  10561 AGCAGGAGAT AGAACCTTCC AGAAGTGGGC AGCTGTGGTG GTGCCTTCTG GAGAAGAGCA  10621 GAGATACACA TGCCATGTAC AGCATGAGGG GCTGCCGAAG CCCCTCACCC TGAGATGGGG  10681 TAAGGAGGGG GATGAGGGGT CATATCTCTT CTCAGGGAAA GCAGGAGCCC TTCTGGAGCC  10741 CTTCAGCAGG GTCAGGGCCC CTCGTCTTCC CCTCCTTTCC CAGAGCCATC TTCCCAGTCC  10801 ACCATCCCCA TCGTGGGCAT TGTTGCTGGC CTGGCTGTCC TAGCAGTTGT GGTCATCGGA  10861 GCTGTGGTCG CTACTGTGAT GTGTAGGAGG AAGAGCTCAG GTAGGGAAGG GGTGAGGGGT  10921 GGGGTCTGGG TTTTCTTGTC CCACTGGGGG TTTCAAGCCC CAGGTAGAAG TGTTCCCTGC  10981 CTCATTACTG GGAAGCAGCA TCCACACAGG GGCTAATGCA GCCTGGGACC CTGTGTGCCA  11041 GCACTTACTC TCTTGTGCAG CACATGTGAC AATGAAGGAC GGATGTATCA CCTTGATGGT  11101 TGTGGTGTTG GGGTCCTGAT TTCAGCATTC ATGAGTCAGG GGAAGGTCCC TGCTAAGGAC  11161 AGACCTTAGG AGGGCAGTTG GTCCAGGACC CACACTTGCT TTCCTCGTGT TTCCTGATCC  11221 TGCCTTGGGT CTGTAGTCAT ACTTCTGGAA ATTCCTTTTG GGTCCAAGAC GAGGAGGTTC  11281 CTCTAAGATC TCATGGCCCT GCTTCCTCCC AGTCCCCTCA CAGGACATTT TCTTCCCACA  11341 GGTGGAAAAG GAGGGAGCTA CTCTCAGGCT GCGTGTAAGT GGTGGGGGTG GGAGTGTGGA  11401 GGAGCTCACC CACCCCATAA TTCCTCCTGT CCCACGTCTC CTGCGGGCTC TGACCAGGTC  11461 CTGTTTTTGT TCTACTCCAG CCAGCGACAG TGCCCAGGGC TCTGATGTGT CTCTCACAGC  11521 TTGAAAAGGT GAGATTCTTG GGGTCTAGAG TGGGCGGGGG GGTGGCGGGG GGTGGGGAGG  11581 GGGCAGAGGG GAAAGGCCTG GGTAATGGAG ATTCTTTGAT TGGGATGTTT CGCGTGTGTG  11641 GTGGGCTGTT TAGAGTGTCA TCACTTACCA TGACTAACCA GAATTTGTTC ATGACTGTTG  11701 TTTTCTGTAG CCTGAGACAG CTGTCTTGTG AGGGACTGAG ATGCAGGATT TCTTCACTCC  11761 TCCCCTTTGT GACTTCAAGA GCCTCTGGCA TCTCTTTCTG CAAAGGCACC TGAATGTGTC  11821 TGCGTCCCTG TTAGCATAAT GTGAGGAGGT GGAGAGACAG CCCACCCCCG TGTCCACTGT  11881 GACCCCTGTT CCCATGCTTG CTTCTAGAGC TCCTTTTCTC ACACATCGCC CAGGGTGGCC  11941 CCTGCACACG GGGGTCTCTG TGCATTCTGA GACAAATTTT CAGAGCCATT CACCTCCTGC  12001 CCTGCTTCTA GAGCTCCTTT TCTGCTCTGC TCTCCTGCCC TCTCTCCCTG CCCTGGTTCT  12061 AGTGATCTTG GTGCTGAATC CAATCCCAAC TCCTGAATCT GTAAAGCAGA GTCTAATTTA  12121 GACTTACATT TGTCTGTGAA ATTGGACCCA TCATCAAGGA CTGTTCTTTC CTGAAGGGAG  12181 AACCTGATTG TGTGCTGCAG TGTGCTGGGG CAGGGGGTGC GGGGAGGGGG TTGCTGTAGA  12241 AAGAGGGATG GGGAGGGAAA GGAAGTGCTT CAGGGTGGCC TGAGGCTATG TTAATAAAGA  12301 TACTGCCTTC AAAATAGGGA GGTGCTCTAC AGTGATCATT CATTCAACTG ACCTTTGTCA  12361 TTGGCCAGAC ATAGGACAGA ATGGTTCTGC ATCTGGGGAA CACCACTGAA GTAAAATCAG  12421 AAAAATCTCT GGCCTTTTGT AGCAGGCGCG CCGAAGCTTG CTCCTCAATT CCACATGCTT  12481 ATCATAGATA TCAAGCAGTG CCCTTGCTGT CTGCCCATCT TTTCTGACCC TGGGACACCA  12541 CCCTTTATTT ACTTTCCCCA CAACTCCTTG AAGGTCAAGC CCCCTTGGCT GATACTCTGG  12601 GTTATCATAG TAAATGTGCC CTCTATCTTT TGCAGGTCAC TGGAAAGGAG GGTTCCTAAA  12661 GCATTCACTC CTGACCCTGA GGGAGGTGGG TGCACTCACT CCAGGACTCA GGTTCACCAC  12721 AGATAAGCAA AAAAGTCCTC ACATTCAAAA TTGTCCTGGG CCACATGCAG CCCACGAGCC  12781 GCGGGTTGGA CAAGCCTGCA TCTAGAACGT ATGCACCATA ACCCCAGACA TTTTTCTGTT  12841 TTTACTTTAA GGATGCTTTC TAAATGCAAA AGCAGTCATA TCCCTAGCAG ACAACAAATG  12901 TCAGTTGAAT GAATGATCAC TGTAGAGCAC CTCCCTATTC TAAAGCCCAT ATCTTTATTA  12961 ATGTAGCCAC AGGGCAAATG CTGTTTTGTG GCAGCTAAAG AACATAAGTT CACGTGGACA  13021 TCCATGCCGC CAGTGCTTTT CTCACCAGGG CTGCTTGTGT GTCCTCCCTC CTCCCACACC  13081 AACCCTCCTG CACACTTCAG CACAAAACTA TATATTTCTC TTCAGGAACA ATAACCCTAG  13141 CCTTATGGGT ACAATTTTCC AACCACATAT GAATCTAAAT TAGACTCTGC TTTATAAATC  13201 TATGAGTTTG GATTGGAGCC AGCACTAGGA TTACTACAAC TCAGAGCAGG AAGAAGAGTA  13261 GGAGGGCAGA AGAGGAGTTC CAACAGAAAG TTAACCATGA TGAGAAACTA TGGGACCCCT  13321 CCTCTCTGCA AATGTCACAA TCTGGTTCCT TTAAAAAGAT TGGAGAAAAA TCGAAAATAC  13381 CATTAAGGAA AAAGCCCTGG GAGGAAGGCA AGACCTGGAC AGGTCTGAAA ATTTGTCTCT  13441 TGATACCACA AGGAGATTTG TATGCAGGGA CCACCCTAGG TGACATCCAA CTCCCTGTGA  13501 TCACAGGTCT TGGTGGGACA AGGTTCTACT GAAGGGCCAA GGACAATGGA GCAGCAAAGA  13561 TGACCCAGGT GAGCTGTGAC CACATAAAGC CCATGGTGGC CAGAACAGAA ACTGGGCACA  13621 GCCCCATCTA CTCTCCTCCC CTGCAACAAA TCAGCACAAG AAACACGTGG ACTCTGGAAG  13681 GTTCTCATGT CTTCCATTTA TTTTGTCTCT CAAATTTTAG GAATCTTCTC CTTTAATTAA  13741 CTCATCAACC TCTCATGGCA AGAATTTGAG AAAGTAAATT TATACTCAGG TTCTAATTTT  13801 AATAGGGAAG GAAGAAGTTA CAGCTCAGTG CACCATGAAG TTGAGACAGA GATGGAGACA  13861 CCTCAGCCCC ACCTCTCTGG AACAGGAAAG ATGATTGGGG AGGGAGCACA GGTCAGCGTG  13921 GGAAGAGGGT CATGGTGGAC ATGGGGGTGG GGTGGTCTCC CCACCTCCTC ACATTATGCC  13981 TACACGAACA CAGACACATG CAGGTGCCTT TGCAGAAACA AAGTCAGGGT TCTTCAAGTC  14041 ACAAAGGGAA GGGCAGGAAC AACTCTTGCC TCTCAGTCCC ACACAAGGCA GCTGTCTCAC  14101 ACTATAGAAA AAAATATTCA TGAACAAATT CATATCCATC ACAGTGAGGG GTCACACCTT  14161 AAACAGCCCA TCGCATGCTC AATACATCCA ATGCAAAGAA ACCCCATAGC ACAGCTGTGT  14221 CCACTGTTCC GCCCAACACC CAACACACAT TAGGTCCTCC AAGCTCTCAC CTTTACAAGC  14281 TGTGAGAGAC ACATCAGAGC CCTGGGCACT GTCACTGCCT GGGGTAGAAC AAAAACAGAA  14341 CCTGGTCAGA TCCCACAGAA GATGTGGCTA GAGGAGGAAT TGTGGGGTGG GTGAGCTCCC  14401 CCATGGGCTC CCAAACACAA TATCCCAAGG ACCTCAGGCA TCAGCCTCCT TCATACTTAC  14461 TTGCAGCCTG AGTGTAACTC CCTCCTTTTC TATCTGTGAG AAGAAAATGT CCTGTGAGAT  14521 ACCAGAAAGG AGCCAGGGCC TTAAGGTCCT AGAGGAACCT CCTAGTCTTG GACCCCAGAG  14581 AAGTTTCCAG AAATGTGTGA CTGCAGACCC AGGGCGGGAT CAGGAAACAT GAAGAAAGCA  14641 GGTGTGGGTC CTGGACCAAT AGCCCTCCTG AGGTCTGTCC TCAGGGACCT TCCCCTGTGA  14701 CTTGTGACTG CTGGGATCAG GTCCCATCAC CGCCGTAATC AAGGTGATAA ATCTGTCCTT  14761 CATTTTAACA GGTGCTTTAC AAAAGAGTAA GTGCTGGCAC ACAGGGCCCA GGCTGGGTAG  14821 GCCCATGATT GTGGATGGTG CTTCCCAGTA ATGAGACAGG GCACATTTCT AGCTGGGGCT  14881 TGGAACCCTC AGTGAGACAA GAAATCTCAG ACCCCACCCT TCACCCCTTC TCCACCTGAG  14941 CTCTTCCTCC TCCACATCAC GGCAGCGACC ACAGCTCCAG TGATCACAGC TCCAAGGAGA  15001 ACCAGGCCAG CAATGATGCC CACGATGGGG ATGGTGGGCT GGGAAGACAG CTCTGGGAAA  15061 AGAGGGGAAG GTGAGGGGCC CTGACCCTGC TAAAGGTCTC CAGAGAGGCT CCTGCTTTCC  15121 CTAAGAGACA TGACACCCCC ATCTCCCTCC TTACCCCATC TCAGGGTGAG GGGCTTGGGC  15181 AGACCCTCAT GCTGCACATG GCAGGTGTAT CTCTGCTCCT CTCCAGAAGG CACCACCACA  15241 GCCGCCCACT TCTGGAAGGT TCCATCCCCT GCAGGCCTGG TCTCCACGAG CTCCGTGTCC  15301 TGGGTCTGGT CCTCCCCATC CCGCTGCCAG GTCAGTGTGA TCTCCGCAGG GTAGAAGCCC  15361 AGGGCCCAGC ACCTCAGGGT GGCCTCATGG TCAGAGATGG GGTGGTGGGT CATATGTGTC  15421 TTGGGGGGGT CTGACGGGAA GAGTCAGAAA ATTCAGGCAT TTTGCATCTG TCATGGGACA  15481 CTCCACCAGC ACGCATGTGG CCATCTTGAG AATGGACAGG ACACCCGGGA TGGGGAAGAG  15541 AGCACAGAAC CCAGACACCA GCCTGGACAC AGGCACCTGG GATAATCTTC TATTCCCTGA  15601 GAAGGGAACA GCGACTTCTG GTCCTGACCT GAGTGGAGGC TGAGGGACTC AGAAGTGCTG  15661 GACTCAGACC CCCACACACA TTGAGTGTGA AGCAGAGAAC AAGGCCTGAG AGGAAAAGTC  15721 ACGGGCCCAA GGCTGCTGCC GGTGTCAAAG GGAACCACTC ATCAGTATTC GAGGGATCGT  15781 CTTCCCGTCA CTCCTTCAGA GATTTTATCC CTTAATTGTG TCAGAGAGCA GGGCGGAACC  15841 TCAGAGTCAC TCTCTGGTAC AGGATCTGGA ACCCAGGAGG ATTCCTCTCC CTCAGGACCA  15901 GAGGGAGGGT GATATTCTAG TGTTGGTCCC AATTGTCTCC CCTCCTTGTG GGAGGCCAGC  15961 CCGGGAGATC TACAGGCGAT CAGGAAGGCG CCCCGTGGCC CCTGGTACCC GTGCGCTGCA  16021 GCGTCTCCTT CCCGTTCTCC AGGTATCTGC GGAGCCACTC CACGCACGTG CCCTCCAGGT  16081 AGGCTCTCAA CTGCTCCGCC CAACGGGCCG CCTCCCACTT GCGCTGGGTG ATCTGAGCCG  16141 CCATGTCCGC CGCGGTCCAA GAGCGCAGGT CCTCGTTCAG GGCGATGTAA TCCTTGCCGT  16201 CGTAGGCGTG CTGTTCATAC CCGCGGAGGA AGCGCCCGTC CGACCCCACG TCGCAGCCAT  16261 ACATTATCTG GATGGTGTGA GAACCTGGCC CCGACCCCGC GGTCAGCCCA GTCCCCCGAG  16321 CCCCGCCCAG CCCCGACCAA CCCGGGGGAA TTTTTGGCCT AAACTGAAAA TGAAACCGGG  16381 TAAAGGCGCC TGGGCCTCTC CCGGGTCAAG GGTCTCGGGG TCCCGCGGCT TCGGGGTGGA  16441 TCTCGGACCC GGAGACTGTG GGCGACCTGG CCCGTCCGTG GGGGATGAGG GGTCGTGACC  16501 TGCGCCCCCG GCCGGGGTCA CTCACCGGCC TCGCTCTGGT TGTAGTAGCC GCGCAGGGTC  16561 CCCAGGTCCA CTCGGTCAGT CTGTGACTGG GCCTTCACAT TCCGTGTCTC CTGGTCCCAA  16621 TACTCAGGCC TCTCCTGCTC TATCCACGGC GCCCGCGGCT CCATCCTCTG GCTCGCGGCG  16681 TCGCTGTCGA ACCGCACGAA CTGCGTGTCG TCCACGTAGC CCACTGCGAT GAAGCGGGGC  16741 TCTCCACTGC CGGGCCGGGA CACGGATGTG GAGAAATACC TCATGGAGTG GGAGCCTGGG  16801 GGCGAGCAGT GGCTGAGACC TGACCGACCC TCCTCCCGGC GCGGCTCCCC CGGTCCTGCG  16861 CCCCCGCCAG GAGGGCCCCT TGCTTCTCCC CGCAGAGGCG GTTTCCCTCC CGACCCCGCA  16921 CTCACCCGCC CAGGTCTGGG TCAGGGCCAG GGCCCCCGAG AGTAGCAGGA GGAGGGTTCG  16981 GGGCGCCATG ACGGCCATCC TCGGCGTCTG GGGAGAATCT GAGTCCCGGT GGGTGCGTGC  17041 GGGCTTTAGA ACAGCGACCG CGACGACACT GATTGGCTTC TCTGGAAACC CGACACCCAA  17101 TGGGAGTGAG AACTGGGTCC GCGTCGTGAG TATCCAGGAT GAAGGACCCT ACGTAGGTTG  17161 GGAGAGGGAG AAAAGAAACT GCGGAGTTGG GGAATCCCCA AGGCTGTGAC TCCCCAATCC  17221 ATACACCGCC TTCGGGGCCT GAGACCCTGA GAGCCACGCC TGGGGCCCTG GGACTTCGCC  17281 CTGACCCCTC TGCTCCTGTG CGAAGCGCTC TGTCTCAATG TCTCCCTGAG TCTTGGCCCA  17341 AGAGCTGTCT GAGAAACAAG GGAGAAACCC TCGGTTCACT TTTCATCCCA TTATCTCTGT  17401 CCCTGAACTG GACTCCCTGA CTCCCACTCC TTACCTGTCC ACCTGGACTC TTCTAGAAGA  17461 AAAATCACCC CATGGAGTTT GGTGCCAGAG AGTAAGCTTG CTCTGGGAAT GGAGGTGTAG  17521 ATTTTTGTTG TTGTTGTTTT TTTTTTAAT CCGGAAAAGT TGTGCCTGAG TGCATGAGAC  17581 AGAATAGAGA CCAATTTGCT CTTTGTTTAT TAACTACAGT GGGTAGCAGA ATCTTGGTAA  17641 CCCCTGAATG ATCAGGAATC TAATAGGTAA AAAATGTGAC TTTGGCCCCT TAATGTATAA  17701 ATGTGTCCAA AAGCATTACA ACAGGACTCA CAAAGCTACT AAGTTGCACT TTCCCAGACA  17761 ATGTATCTGT GACTCCTGCT TGTCTTACTT TAAATTTGCC ATCATTCCTT AGCTCTGAGT  17821 TTCTGTGTGA GTCCACGACA TCTCCTCAAT ACAAAGTAGC CACTGTGTTC CTATATGTTG  17881 CAACCAGAAG CCATTACAGG CTTTATTCAC CTCAAAGTTG CAACTGTTCA AGGCAGTCAC  17941 AATGCCCCTC ACTAGTGCTC ATGCACTGCC TGTTTTTAGG AAGTATCCAC TTCTAAGTGT  18001 TGTGTATATT TTATAGGAAC ACTTAGTAAT TTTTAAACCT GATTAACATA AAAAATAGTT  18061 TTTAGGCAGA CCCACATGAG GTATTAAAAG ACAACTGCCA AGGACACCCT GCTAGGCTCT  18121 GTAGATTGAT GTATTAAAAT CCATAAAACA ATGTCTTTAA ACCTAAGAAT TCTGCTGCTT  18181 TCAAATTCTT TCCTCTGCTC CTTTTCCTCA CCTCCTGCTT CTCCAGCCCT TCCCTCCATC  18241 CTTCTCATCC TTCAGGCCCT CCTCTCCCCT TAGTCCCCAC CACACTGTCA CTCATGAATT  18301 GTGACACTAG CACTGTCCCA TGACCTGCTA CGTAACTGTT CTTTTCACAG TGGCCCTGCT  18361 CCTGTGAGTC GGAGTGTGTC ATTTCTCCAC TTAAAACACT CCAGTGTCTC CACCTCGGTC  18421 TTGTGAAGCT TCTGGAGTGT CAGGCACTTG AGCATATGAG GGGATACCTC GTTCATTGTA  18481 GGGACTAAGT TAATTTTTGT TGACTTAATG AATGAAATAT GAGTGTATTA AATTGCATCA  18541 CAGATAATTA TAAACTGTAA AACACTGAAA AAGTTCAGAA AGATTTTATT TTATGCAACT  18601 AGTGTGTATA TCAATTCATC AATTCATTCG CACACTACCA TGCCTGGCAA AACAACACAC  18661 ATTTATCTGC TTATAGTTCC TTGGTCAGAA ATCTGGGCAA GATGTGGATA GAATCTCCAT  18721 TCTGGGCTTC CAAAAGCTGT GTTTTCATTT TGAATCCTCC TTCGGGTTTA TACAGAGGTG  18781 GCAGAATGCA GTTTCTTGCA GTTGTAAGAC TGAGGTCCCT GTTCCTGGCT AGCTGTCAAT  18841 GTAGAGAACT GGGAGGGGCT CAATTCCCGG TGCTCACCAG CGTTCTTTCC TACACAGCCC  18901 CTTAATTTTT CTTTTTTTTT TTTTTTTTGA GACGGAGTCT GGCTCTGTAG CCCAGGCTGG  18961 GGTACAGTGG CCCAATGATC TCTGCTCACT ACAAGTTCTG CCTCCTGGGT TCACACCATT  19021 CTCCTGTCTC AGTCCCAAGT AGCTGGGACT ACAGGCGCCC ACCACTATGC TCTAATTTTT  19081 TTTTTCTTAG TAGAGACAGG GTTTCACCTT GTTAGCCAGG ATTGTCTCGA CCTCCTGACC  19141 TCATGATCCG CCCGCCTCGG CCTCCCAAAG TGTCGGGATT ACAGGCGTGA GCCACCGCGC  19201 CCGGCCCATA GCCCCTTCCT TTTCAAAGCC CATGGTGGAG GAAACCCCTC ATGCTGAGTC  19261 CCTTTCACAC TGTAAGTCTC TATGCTCATG AAGAACCCAG TCCTTTCAAG GGCTCACCTG  19321 ATTAGGACAG TCCAAGCAGG ATAAACCCAG CATAAAGTCA ACTAATTGAG ACCCTTAATT  19381 ATATCTGCTA AATCCCTTCA CAGCAGCACC TACATTAGAG TTGGTTGAAT AACTGGAGGA  19441 AGGTGAATGA CCAGGAGCTG CTTGTTGAGG CCATCATAGA ATCAGCCTAG CAAGGGTTGG  19501 ATCTTCCTTT TGTGTTTAAT TGGGACACAG TTGGAAAGTG AAGTTCAAGT AACGTGATCA  19561 TTGTGAATGG TCATAAAATA CATCCTCTTC AGCCATGGAA ATTGTCCTTA CTTTTTAAAA  19621 CTAAGTTACA TGTTTAATAT CTTATAATTA ATTTAGGCCA GGTGTGGTGG CTCACATCTG  19681 TCATCCTAGC ACTGTGGAAG GCAGAGGAAT GGAGATTTGT TGACTCCAGA AGTTCAAGAT  19741 CAGCCTGGGC AAAACCTCCA TCTATACAAA AAATTAGAAA ATTAGCCAGG CATGGTAGTT  19801 CATGATGGTA GTCGCAGCTA CTCAGGAGGC TGAGGTCAGA GAGTCCCTTG ACCCCAGGAG  19861 TTCGACACTG CAGTGCATGG TGATCATGCC ACTGCATTCC AGCCTGGGTG ACAGAGCAAG  19921 ACCCTGTCTC AAAAATAATA ATGATGATGA TGACACATTT AGAGCAAATG CAATTTGATG  19981 TGTAATAATA CATCCTCTCT TGTGAAAATA TATTATTTAC TGTTGCATAA CAAATTACGT  20041 AAAACTTAGC TCGAAACAAC AAATGTTTCT CATCTCCCAC AGTTTCCAAT CGTCAGGAAT  20101 CCAGGAGAGG TTTCCCTGAG TGCTTCCTGC TCAGGGCCTC TCACAAGGTT GCACTCCAGT  20161 TGTCAGCCAG GGGCCGCAGC ATCTGAGGGC TTCGCTGGGG CTGGGAATTC ACAAGAAACA  20221 TGGATCAGTC ACATGGCTGT TGGAAAAGGC CTGGTTCCTT GTTGTCTGTT CCCAGAAGGC  20281 CTCAGTTCTC AGTCATGTGG ACCTTCCTGC AGGGCTGCTT ATGGCACAGC GGCTGGCTTC  20341 CCCAAGAGCT CATGATCCCA GATTCAGAGA GAGAGAAGGT GGAAGCCGCA GTTAGTTTTA  20401 TGTTCTACAC CCAGAGTCAC AAACTGTTAT GTTGGCACTA TTCTATAAGT TAGAAGTTGT  20461 ATTAGTCCAT TCTCACACTG CTATAAAGAA ATACCTGAGA CTGGGTAATT TATAAAGGAA  20521 AGAGETTTAA TTGACCCACA GTTCTGCATG ACTGAGGAGG CTGCCCCAGG AAACTTACAG  20581 TCATGGCAGA AGTGGAAGCA AACCCGTCCT TCTTCATGTG GTGACAGGAG AGAGAAATGC  20641 ACAATGAAGC AGGGAAAAGC CCCTTATAAA ACCATCAGAT CTCATGAGTA TTCCCTCAGC  20701 ATCAGGAGAA CAGCATGGGG GCACCGTCCC CATGATCCAA TCAACTCCCA TGAGGTCCCT  20761 CCCCCAATAG GTAGGGATTA CAATTTGCAT AACAACTCAA GATGACATTT GGGTGGGAAC  20821 ACAGAACCAG GCCATTTCAG AAGTGCCTCA TTAAGTCCAA GCCACACTCA AGAGAGGGAA  20881 TTAAGCTGCA CCTCCAGAAA GGAACAGTAT CAAAGGATTT GAATATATGT TAAAAGCAAA  20941 ATTATAACTA TTGTTTCAGG TTTCTGAAAA TCAAAGTCTT CTTGTATCTA ATTATTTTTC  21001 ATTAACTCTT TAAGCTTGTC TTTTAATTTA ATTTTTTTTT AAGTTCCAGG GTACATGTGT  21061 AGGATGTGCA GGTTTGTTAC ATAGGTAAAT GTGTGCCATG TTGGTTTGCT GCACCTGTCA  21121 ACTCATCACC TAGGTATTAA CCCTGGCATG CATTAGCTAT TTTTGCTAAT GATCCTCTCA  21181 TCACCACCCT CCCCCAACAG GCCCCAGTAT GTGTTGTTCC TCTCCCTGTG TCCATCTGTT  21241 CTCATTGCTC AGTTCCCAGT TATATATGAG AACATGTGGT GTTTGGTTTT CTGTTCCTGT  21301 GTGAGTTTGC TGAGGATAAT GGCTTCCACC TTCATCCATA TCCCTGCAAA GGACTTGATC  21361 TCCTTCCTTT TTATGGCTGC ATAATATTCC ATGGTGTATA TGTACCATAT TTTCTTTATC  21421 CAGACCATCA TTGATGGGCA TTTGGGTTGA TTCCATGTCT TTGCTATTGT GAATAGTGCT  21481 GCCATGAATG TAAACATGCA TATGTCTTTA TAATAGAATG ATTTATATTC CTTTGGGTAT  21541 ATACCCTGCA ATGGGATTGC TGGGTCAAAT GGTATTTCTG GTTCTAAATC TTTGAGGAAT  21601 CGCCACACTG TCACTGTCTT CCACAATGGA TTAACCATTT ACTTTTCCAC CAACAGTGTA  21661 AAAGCATTCC TATTTCTCCG CAACCTTGCC AGCATCTGTT GTTTCTTGAC TATTTAATAA  21721 TTGCCATTCT GACTGGCATA AAATGGTATC TCATTTGTCG TTTTGATTTG CATTTCTCTA  21781 ATGATCAGTG ATGGGAGCTT TCTTTTTCAT ATTTTTGTTG GCCACATGTA TGTCTTCTTT  21841 AGAAGTGTCT GTTCATGTTC TTTGTCCACT TTTTAATGAA GTTTTTTTTC ATGTAAATTT  21901 GCTTAAGTTC TTTGTGGATT CTGAATACTA GACTTTTGTC AGATGAACAG ATGGCAAAAT  21961 TTTTCTCCCA TTCTGTAGCA TGTCTGTTCA CTCTGATTGA TGATAGTTTC TTTTGCTGTG  22021 CAGAAAAAAA TTGCCTAATC TGATTGCTTT TCATTTACAA AAATGAGAAT CTCATACTTC  22081 AGTTAACACA TCTAGCTTAG CATGATGCCA ATAATTTTGG CTTGATGCTG TAGCCCGAAA  22141 TGGTTAGCTC GAATTGAGAG ACAAGTTATT TTCAAAAACT GGCTATCCGA TGGGCATTCT  22201 ATAACACACT TAACATCTTT TGTTGTGGTA TTGAATGAGA TGTGATAGAA GTGATTTGGA  22261 CACCACTATG ATTCTAAATA GCACTGCTAT TATGTGCTTC TGAATTTTTT TTCTTTTTAG  22321 CAGTCCTATT CTGTTTCCAT TCATATTTGC TATTCCATCA CTGGGTATTC CTTCCTACTC  22381 TTTTCATGTT TCATTTATTT TGATCAGTGA TGTGCATTTC CAATTCTGTA AAAGTTTAAT  22441 TCAGTTGTAT GTGTGGTAAA ATGTAACATA GAATCTTTGC AAGATGAAAT TACCTTGCAC  22501 AGCATATTGA ACATTGTATT ATTGAAAATC TAGAGAGATG CCAGTGAGCC AAGGATCGAA  22561 TGACCTATAT GTAGCCAAGG CCGTTTTCAT GGCATCCTGG TCCTCTCTGT CACATAGCTC  22621 CTTACAATTC TCTGTGGTTT TCTTCCAATG TAAGTAGTTC TTGTTAAGAA TCTTTGCAAT  22681 GAACTTTGAA ATTCTTTTCT TTTTCATTGC TATAAAAAAC AGGTATATTT TAATTTGGAA  22741 AACTCTGTTT AAGGAATTAT AATCAAGTAA CTACCAGGGG GCCCAGCACT GGTGTAAAAC  22801 ACAAAACTGT AAAACTACCC TGGGCTGCTA CCCAGTACTC CCATTGCACA GGACAGTTTT  22861 ACTTTCCCAC TTGAAAAGTG CATCTTTCAG ATGCCAGAGT GTTGTTCCAA TCTGTAAATC  22921 TTTTGCAGAA CTAAACCAGT CAAGAAGTAC CATATACTCC ACATTCCCCC TCTTCTTCCA  22981 TGTATCTATA GAATCATCTG GGAGGTGTGC TTCAATCCAG CTAGCAGTGA CTCCTGGACT  23041 GATGGCTTTT CCAGGAACAC TGAGAGAATG TAAAATACAG GAATCCTGAT AATCCTGCAT  23101 TCTTTGAGCA TCCATTATAA TCAAGCTGAT GTTTTTATCC ATCATCATTG TGTATAGTTC  23161 CTTTGCTGTG ATTGCTCCTT TCTCTTTGGT CTCACATTTT TCATTCTTTT CACCATTGCT  23221 CTTTTGGGTT TTGTCTTTGG AATCCAATAC AATCTCCAAA GAATCTTTAG CCAACGTGCT  23281 GCCATCCTCT CTTCCTGTTT CCTGCCTTTT TTGTTGTAGC CACTGTGCTT CCCCCTGCCT  23341 GTCCTTTTCC TCAAGTTTTT TCCAGATTTC AACTTCTTCA TATCTTAGTT TAAGGCTTTC  23401 AGAGAGTCGT TCAGTTTCTC CAGTGGCTTT TTTGATGTTT GCAGGTCCAA GTATTGAATG  23461 GAAGTAATAC TGCTGTTGCT TGAAATCAGT TCTTTTTTGG ATAGGATTAT AAACAGTCAT  23521 GTTTCATATA CATGTGTGAG CTTTTTTTCA TATGTTTCTT GGCCACGTAA ATGTCTTCCT  23581 CTGAGAAGTG TCTGTTTATA TCCTTTGCCC ACTTTTTGAT GGGGATGGGT TTTTTTCTTG  23641 TAAATTTGTT TAAGTTCCTT GTAAACAAAC ATGTGAGCTC TCATCATTCT TGTTTAAACA  23701 CCTAACAGTC ATCCTAACCA GTGCAACAAG GACCAGGCAT GGTGGCTCAT GCCTGTAATC  23761 CCTGCATTTT GGGAGGCTGA GGTGGGAGGA TCACTTGAGA TCAGGAGTTT GAGACCAGCC  23821 TGATAAGTGA GACCTCATCT CTACCAAATA AAAATAATTT TAAAAGAAAA TAGATCAATG  23881 GATAAGAAAG GAAGAAATGA AAGTCTTTCT TTGTCACCAG CTTCATTGTA TATGTAGAAA  23941 ACACTAGGGA ATTCTGAAAA AGTCTCTGGA ATTAATCATT GAATTTGCAA AATAGTTCAT  24001 AAAATATATG TAATAAGTCG CTTAGATGAA CATGAAAAGA TAGCAAACAA TACTAGTCAT  24061 CAAAGAAGTG CAAGTTAAAA CCACAATGAG AAACCATCAC ACATCACCTA GAGCAGGTAA  24121 AGTTAAAAAG ACATATGATA AGTCTTAACA CTGGCAAGAA TATGGAAAAA ATAGGAATGT  24181 CTGATATTGC TGGTAGGAAT GCAAAAAATG TGGCAGCCAA TTTGTAAAGT GGTATGGCAG  24241 TTTCTTATAC AGTTACCCAT CTATTACCAC ATGGCCCAGC AATTCCACAA ATACGTATTT  24301 ATCCAAAAGA AATAAAAATG TAAGTCCACA CTTGTAAGCA GTTATTTATA GTGGCTTCAT  24361 TAATAACAAG CCCTAACTGG AGGAATCCAC ATGTCTATCA ACTGGAGACA CAGAAACCAA  24421 TGAATAAACT GGGATTCCAG CAATACTCGG CAGCTGCTCA GCAACAAAAA TGAATGAATG  24481 GCATCATCTC AAACATCGTT ATGCTAAGGG AGAGACCAAA CAAAAGACTA CATAACATAT  24541 GATTGCATGT CCATGAAATT CTAGAAATGT CACTATTGCA GTGACAGAAA GCACAGCAGT  24601 GGTTGAATGA AGGGAAGGGG GTGAGGGTGG GAGGCAAGGA TTAAATAGAA AGGGGCATAA  24661 AGAAAGTTTT TAGGGAAAAG AAACTGTCCT CTACAGCGCC ACAACTCAGG AGTGACTGGG  24721 AGGGGGAAGT AAGGGGAGAA GAAGGTCTGA GGGATAAGGG GCAGAGAGAA GGGCTGGGGA  24781 AGCAGGAGGA GAGGACGAGG AGCAGGGGAA AGGACTCTAA AGCAGTGGAG GGGCCTAGTA  24841 GGAGGATCTT TGCATTTGGT GTTTCTCTAC TGGGCAGTGT GGTAGTTACA CTATAAATAA  24901 TTACCAATAT CCACCAAAAA GTGCAGCTAA AACTGGTGAA TTTTTTTACA CGTAAACGCC  24961 CTGATAAGCA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAGG GGGGGGGGGA  25021 GGAAAGAAGG CAAAAATAAA GACATTGTTA GATCATCAAA CCCATAAAAT TCATTTCCTA  25081 GGGGTCCTGT ACTACATGTA ATTTTAAAGG ACGTTCTACA GGCTGAAGGG AAATGATACT  25141 AGATGGTGAC CCAGATACAC AGAAAGGAAC AATTAACAAC AGAAATGATG CACATACACA  25201 TATCACATAC ACACCCATTT TOTTAATTTC CTGAAGATAC GTGACTGCTT GTCTAAAACA  25261 AAAAGTATTA CACTGTATTG TTGAGTTTAT AACGTATATT GATGTAACAT ATACAATAAT  25321 AATAGCATAA TGATAGTTTA AATGAAACTA CACCATTTGA AGTGTCCTTT ATTTTGCTGG  25381 ATGCAGOTTA ATATTACCTG AATTTCACTG TGAAAAGTCA AGGAATTGGG TTTCAATTCT  25441 TACAACAATA AAAAATTAAT GTAAAGAAAT ATAGCTAAAA GCCACTAGGA GAATTAAAAC  25501 CATAAGCTAA AAAATGTTTA CTTGAAACAT AAGAAAGTAG CAAAGGAGGA ACAGAAACAA  25561 AAAGATATGA GACAAATTGA AAACGTATAG CAAAATGGTA GACCAAAATC CAACCATTAT  25621 AAGTGAAGAA ATGACACGAC CTGAGTCACA TTAGCAGGAC TGCTGAGCAC TATGGGGAGA  25681 ACAGACATGG GCAGGAAGTG AGGGACAGTG TTAGTGCCAC AATTCAGGAG TGACAGGGTG  25741 GCGGGGACTA AAGGGGAAAG AGGGTGTGAG GGATGAGAGG GGCAGACAGA AGGGCTGGAG  25801 AGGCAGGAGG TGAGGAAAAG GAGCAGAGGA AAGAATTCTA AAGCAGTAGA AGAGCCTGGC  25861 AGGGGGTTCT TTGCATTCGG TATTTAATAC ATTTTGTGTG ACTGCCTTAA AACTAATGGG  25921 CTCCTTATGA TTTTTTTTTA AAAAGGGGTT ACAAAAATAT CAAGTGTCCA AATAAAATAT  25981 GCACACTGCT TAGATGTGCA TAGTTCCGGA AAACGGGCAG TGCTGGAGCG CTGGTGAAGA  26041 GCATTGGGAC TGCATGGAGC CCTCACAACT TTGAGGTGAT GACTACAGGC TCCCGGTTGC  26101 AATAGACAGT AACAAACCCT GCTTCTTTGT ATTCAGGAGA TGTTCTGGAC TCACACAGGG  26161 AAACTCTGGC TAGAGAATGA GGATAACTTT AAATGCAACA ACCCAGAGTC ACAGATCCAT  26221 AGTCTGCGAA AGTAAAACAG GAGCTTTGAG AATTTAATTG TAATGCAGTT TTGACACAGG  26281 TCTTTCACAG ATTGGAATTC TAATCATTCA GGGATTACCA ATATTGTGCT ACCTACTGTA  26341 TCAATAAACA AAAAGGAAAC TGGTCTCTAT GAGAATCTCT ACCTGGTGCT TTCAGACAAA  26401 ACTTCACCAG GTTTAAAGAG AAAACTCCTG ACTCTACACG TCCATTCACA GGGCGAGCTC  26461 ACTGTCTGGC ATCAAGTTCC CCATGGTGAG TTTCCCTGTA CAAGAGTCCA AGGGGAGAGG  26521 TAAGTGTCCT TTATTTTGCT GGATGTAGTT TAATATTACC TGAGGTAAGG TAAGGTAAGG  26581 CAAAGAGTGG GAGGCAGGGA GTCCAGTTCA GGGACGGGGA TTCCAGGAGG AGAAGTGAAG  26641 GGGAAGGGGC TGGGCGCAGC CTGGGGGTCT CTCCCTGGTT TCCACAGACA GATCCTTGGC  26701 CAGGACTCAG GCACACAGTG TGACAAAGAT GCTTGGTGTA GGAGAAGAGG AATCAGGACG  26761 AAGTCCCAGG TCCCGGGCGG GGCTCTCAGG GTCTCAGGCT CCAAGGGCCG TGTCTGCACT  26821 GGGGAGGCGC CGCGTTGAGG ATTCTCCACT CCCCTGAGTT TCACTTCTCC CAACCTGCGT  26881 CGGGTCCTTC TTCCTGAATA CTCATGACGC GTCCCCAATT CCCACTCCCA TTGGGTGTCG  26941 GATTCTAGAG AAGCCAATCA GCGTCTCCGC AGTCCCGGTT CTGAAGTCCC CAGTCACCCA  27001 CCCGGACTCA GATTCTCCCC AGACGCCGAG ATGCGGGTCA TGGCGCCCCG AACCCTCATC  27061 CTGCTGCTCT CGGGAGCCCT GGCCCTGACC GAGACCTGGG CCGGTGAGTG CGGGGTTGGG  27121 AGGGAATCGG CCTCTGCGGA GAGGAGCGAG GGGCCCGCCC GGCGAGGGCG CAGGACCCGG  27181 GGAGCCGCGC AGGGAGGAGG GTCGGGCGGG TCTCAGCCCC TCCTCGCCCC CAGGCTCCCA  27241 CTCCATGAGG TATTTCTACA CCGCTGTGTC CCGGCCCGGC CGCGGGGAGC CCCACTTCAT  27301 CGCAGTGGGC TACGTGGACG ACACGCAGTT CGTGCGGTTC GACAGCGACG CCGCGAGTCC  27361 GAGAGGGGAG CCGCGGGCGC CGTGGGTGGA GCAGGAGGGG CCGGAGTATT GGGACCGGGA  27421 GACACAGAAG TACAAGCGCC AGGCACAGAC TGACCGAGTG AGCCTGCGGA ACCTGCGCGG  27481 CTACTACAAC CAGAGCGAGG CCAGTGAGTG ACCCCGGCCC GGGGCGCAGG TCACGACCCC  27541 TCCTCATCCC CCACGGACGG CCCGGGTCGC CCCAAGTCTC CCGGTCTGAG ATCCACCCCG  27601 AGGCTGNGCT GCGGAACCCG CCCAGACCCT CGACCGGAGA GAGCCCCAGT CACCTTTACC  27661 CGGTTTCATT TTCAGTTTAG GCCAAAATCC CCGCGGGTTG GTCGGGGCGG GGCGGGGCTC  27721 GGGGGACGGG GCTGACCGCG GGGGCGGGGC CAGGGTCTCA CATCATCCAG AGGATGTATG  27781 GCTGCGACGT GGGGCCCGAC GGGCGCCTCC TCCGCGGGTA TGACCAGTAC GCCTACGACG  27841 GCAAGGATTA CATCGCCCTG AACGAGGATC TGCGCTCCTG GACCGCCGCG GACACGGCGG  27901 CTCAGATCAC CCAGCGCAAG TGGGAGGCGG CCCGTGAGGC GGAGCAGCTG AGAGCCTACC  27961 TGGAGGGCCT GTGCGTGGAG TGGCTCCGCA GATACCTGAA GAATGGGAAG GAGACGCTGC  28021 AGCGCGCGGG TACCAGGGGC AGTGGGGAGC CTTCCCCATC TCCTGTAGAT CTCCCGGGAT  28081 GGCCTCCCAC GAGGAGGGGA GGAAAATGGG ATCAGCGCTA GAATATCGCC CTCCCTTGAA  28141 TGGAGAATGG GATGAGTTTT CCTGAGTTTC CTCTGAGGGC CCCCTCTGCT CTCTAGGACA  28201 ATTAAGGGAT GAAGTCCTTG AGGAAATGGA GGGGAAGACA GTCCCTAGAA TACTGATCAG  28261 GGGTCCCCTT TGACCACTTT GACCACTGCA GCAGCTGTGG TCAGGCTGCT GACCTTTCTC  28321 TCAGGCCTTG TTCTCTGCCT CACGCTCAAT GTGTTTGAAG GTTTGATTCC AGCTTTTCTG  28381 AGTCCTTCGG CCTCCACTCA GGTCAGGACC AGAAGTCGCT GTTCCTCCCT CAGAGACTAG  28441 AACTTTCCAA TGAATAGGAG ATTATCCCAG GTGCCTGTGT CCAGGCTGGC GTCTGGGTTC  28501 TGTGCCCCCT TCCCCACCCC AGGTGTCCTG TCCGTTCTCA GGATGGTCAC ATGGGCGCTG  28561 TTGGAGTGTC GCAAGAGAGA TACAAAGTGT CTGAATTTTC TGACTCTTCC CGTCAGAACA  28621 CCCAAAGACA CACGTGACCC ACCATCCCGT CTCTGACCAT GAGGCCACCC TGAGGTGCTG  28681 GGCCCTGGGC TTCTACCCTG CGGAGATCAC ACTGACCTGG CAGTGGGATG GGGAGGACCA  28741 AACTCAGGAC ACTGAGCTTG TGGAGACCAG GCCAGCAGGA GATGGAACCT TCCAGAAGTG  28801 GGCAGCTGTG GTGGTGCCTT CTGGAGAAGA GCAGAGATAC ACGTGCCATG TGCAGCACGA  28861 GGGGCTGCCG GAGCCCCTCA CCCTGAGATG GGGTAAGGAG GGGGGGTGAG TCCTGNATGT  28921 CTTCTCAGGG AAAGCAGAAG TCCTCCTGGA GCCCTTCAGC CAGGTCAGGG CTGAGGCTTG  28981 GGGGTCAGGG CCCCTCACCT TCCCCTCCTT TCCCAGAGCC GTCTTCCCAG CCCACCATCC  29041 CCATCGTGGG CATCGTTGCT GGCCTGGCTG TCCTGGCTGT CCTAGCTGTC CTAGGAGCTG  29101 TGGTGGCTGT TGTGATGTGT AGGAGGAAGA GCTCAGGTAG GGAAGGGGTG AGGAGTGGGG  29161 TCTGGGTTTT CTTGTTCCAC TGGGAGTTTC AAGCCCCAGG TAGAAGTGTG CCCCACCTCG  29221 TTACTGGAAG CACCATCCAC ACATGGGCCA TCCCAGCCTG GGACCCTGTG TGCCAGCACT  29281 TACTCTGTTG TGAAGCACAT GTGACAATGA AGGACAGATG TATCACCTTG ATGATTATGG  29341 TGTTGGGGTC CTGATTCCAG CATTCATGAG TCAGGGGAAG GTCCCTGCTA AGGACAGACC  29401 TTAGGAGGGC AGTTGCTCCA GAACCCACAG CTGCTTTCCC CGTGTTTCCT GATCCTGCCC  29461 TGGGTCTGCA GTCATAGTTC TGGAAACTTC TCTTGGGTCC AAGACTAGGA GGTTCCCCTA  29521 AGATCGCATG GCCCTGACTC CTCCCTGTCC CCTCACAGGG CATTTTCTTC CCACAGGTGG  29581 AAAAGGAGGG AGCTGCTCTC AGGCTGCGTG GTAAGTGATG GCGGTGGGCG TGTGGAGGAG  29641 CTCACCCACC CCATAATTCC TCTTGTCCCA CATCTCCTGC GGGCTCTGAC CAGGTCTTTT  29701 TTTTTGTTCT ACCCCAGCCA GCAACAGTGC CCAGGGCTCT GATGAGTCTC TCATCGCTTG  29761 TAAAGGTGAG ATTCTGGGGA GCTGAAGTGG TCGGGGGTGG GGCAGAGGGA AAAGGCCTAG  29821 GTAATGGGGA TCCTTTGATT GGGACGTTTC GAATGTGTGG TGAGCTGTTC AGAGTGTGAT  29881 CACTTACCAT GACTGACCTG AATTTGTTCA TGACTATTGT GTTCTGTAGC CTGAGACAGC  29941 TGCCTGTGTG GGACTGAGAT GCAGGATTTC TTCACACCTC TCCTTTGTGA CTTCAAGAGC  30001 CTCTGGCATC TCTTTCTGCA AAGGCATCTG AATGTGTCTG CGTTCCTGTT AGCATAATGT  30061 GAGGAGGTGG ACAGACAGCC CACCCCCGTG TCCACCGTGA CCCCTGTCCC CACACTGACC  30121 TGTGTTCCCT CCCCGATCAT CTTTCCTGTT CCAGAGAAGT GGGGCTGGAT GTCTCCATCT  30181 CTGTCTCAAC TTCATGGTGC GCTGAGCTGC AACTTCTTAC TTCCCTAATG AAGTTAGGAA  30241 CCTGAATATA AATTTGTTTT CTCAAATATT TGCTATGAAG GGTTGATGGA TTAATTAAAT  30301 AAGTCAATTC CTGGAAGTTG AGAGAGCAAA TAAAGACCTG AGAACTTTCC AGAATCCGCA  30361 TGTTCTCTGT GCTGAGTCTG TTGCAGGTGG GGGTGGGGAA GGCTGTGAGG AGCCGAGTGT  30421 GGACGGGGCC TGTGCCTAGT TGCTGTTCAG TTCTTCATGG GCTTTATGTA GTCAGTCCTT  30481 AGCTGGGTCA CCTTCACTGC TCCATTGTCC TTGTCCCTTC AGTGGAAACT TGTCCAGCAG  30541 GAGCTGTGAC CACAGAGGCT CACACATCGC CCAGGGCAGC CCCTGCACAC GGGAGTCCCT  30601 GTGCTTTCTG AGACAAATTT TCAGACCCAT TCAGCTCCTG CCCTCCTTAT AGGGCTCCTC  30661 TTCTGCTTTG GTCTCCTGCC CTCTCTCCCT TCCCTGATTC CAGTGATCTT CGTGCTGACT  30721 CCAATCCCAA CTCATGAATC TAAAGCAGAG CCTAATTTAG ATTTGTATTT GTTTGTAAAA  30781 TTGGGTCCAT AGTCTAGAAT TGTTCCTTCC TGAAGAGAGA AACCTGATCG TGTGCTGCAG  30841 CGTGCAGGGC GGTTGGTGTG GGAGGAGGGA TAGGGGAGGG AGGACACACA AGCAGCCCTG  30901 CTGAGAAAAG TACAGGCGGC CTCGGTGTCA GTGTGAGGGG NCCTTGTGCT GCAGCTGCCA  30961 CAAAACAGCA CTTGGCCTGA GGCTATGTTA ATAAAGATAC TGGCTTTAGA ATAGGAGGTG  31021 CTCTACACTG ATCATTCAAC TGACCTTTGT TGTCAGCCAG ACACAGGACA GAAAAGTTCT  31081 GCATCTGGGG AACACCATTG AAGTAAAATC AGAAAAATAT CTGAGCATAT GCTCCAGTGG  31141 TAAGAGGCAG ACGATACATA CACTATAACC ACAGTAAGAA AAGAAAGTGA TGGAAGGTGG  31201 TAAGTGCCAT GAGGCAGGTG ATCCGGGTAT GGGCAGTGGG GACAGGGAAG GTGGCTGTTG  31261 GACAGGAGTT GTCAATGTGT GCCTTGTTGC AAAGATGACC TTTGAGGAAA GATTTGAGGG  31321 ACATGAGGAT GTCTGGGGAA GTTCTTTCTA GGCAAGGAAA CACAACTTCG TATAGAAAGG  31381 TATATACGAA GTTGTGCGGC CGCGTCGACC AATTCTCATG TTTGACAGCT TATCATCGAA  31441 TTTCTGCCAT TCATCCGCTT ATTATCACTT ATTCAGGCGT AGCAACCAGG CGTTTAAGGG  31501 CACCAATAAC TGCCTTAAAA AAATTAGAAA AACTCATCGA GCATCAAATG AAACTGCAAT  31561 TTATTCATAT CAGGATTATC AATACCATAT TTTTGAAAAA GCCGTTTCTG TAATGAAGGA  31621 GAAAACTCAC CGAGGCAGTT CCATAGGATG GCAAGATCCT GGTATCGGTC TGCGATTCCG  31681 ACTCGTCCAA CATCAATACA ACCTATTAAT TTCCCCTCGT CAAAAATAAG GTTATCAAGT  31741 GAGAAATCAC CATGAGTGAC GACTGAATCC GGTGAGAATG GCAAAAGATT ATGCATTTCT  31801 TTCCAGACTT GTTCAACAGG CCAGCCATTA CGCTCGTCAT CAAAATCACT CGCATCAACC  31861 AAACCGTTAT TCATTCGTGA TTGCGCCTGA GCGAGACGAA ATACGCGATC GCTGTTAAAA  31921 GGACAATTAC AAACAGGAAT CGAATGCAAC CGGCGCAGGA ACACTGCCAG CGCATCAACA  31981 ATATTTTCAC CTGAATCAGG ATATTCTTCT AATACCTGGA ATGCTGTTTT TCCGGGGATC  32041 GCAGTGGTGA GTAACCATGC ATCATCAGGA GTACGGATAA AATGCTTGAT GGTCGGAAGA  32101 GGCATAAATT CCGTCAGCCA GTTTAGTCTG ACCATCTCAT CTGTAACATC ATTGGCAACG  32161 CTACCTTTGC CATGTTTCAG AAACAACTCT GGCGCATCGG GCTTCCCATA CAATCGATAG  32221 ATTGTCGCAC CTGATTGCCC GACATTATCG CGAGCCCATT TATACCCATA TAAATCAGCA  32281 TCCATGTTGG AATTTAATCG CGGCCTCGAG CAAGACGTTT CCCGTTGAAT ATGGCTCATT  32341 TTAGCTTCCT TAGCTCCTGA AAATCTCGAT AACTCAAAAA ATACGCCCGG TAGTGATCTT  32401 ATTTCATTAT GGTGAAAGTT GGAACCTCTT ACGTGCCGAT CAACGTCTCA TTTTCGCCAA  32461 AAGTTGGCCC AGGGCTTCCC GGTATCAACA GGGACACCAG GATTTATTTA TTCTGCGAAG  32521 TGATCTTCCG TCACAGGTAT TTATTCGCGA TAAGCTCATG GAGCGGCGTA ACCGTCGCAC  32581 AGGAAGGACA GAGAAAGCGC GGATCTGGGA AGTGACGGAC AGAACGGTCA GGACCTGGAT  32641 TGGGGAGGCG GTTGCCGCCG CTGCTGCTGA CGGTGTGACG TTCTCTGTTC CGGTCACACC  32701 ACATACGTTC CGCCATTCCT ATGCGATGCA CATGCTGTAT GCCGGTATAC CGCTGAAAGT  32761 TCTGCAAAGC CTGATGGGAC ATAAGTCCAT CAGTTCAACG GAAGTCTACA CGAAGGTTTT  32821 TGCGCTGGAT GTGGCTGCCC GGCACCGGGT GCAGTTTGCG ATGCCGGAGT CTGATGCGGT  32881 TGCGATGCTG AAACAATTAT CCTGAGAATA AATGCCTTGG CCTTTATATG GAAATGTGGA  32941 ACTGAGTGGA TATGCTGTTT TTGTCTGTTA AACAGAGAAG CTGGCTGTTA TCCACTGAGA  33001 AGCGAACGAA ACAGTCGGGA AAATCTCCCA TTATCGTAGA GATCCGCATT ATTAATCTCA  33061 GGAGCCTGTG TAGCGTTTAT AGGAAGTAGT GTTCTGTCAT GATGCCTGCA AGCGGTAACG  33121 AAAACGATTT GAATATGCCT TCAGGAACAA TAGAAATCTT CGTGCGGTGT TACGTTGAAG  33181 TGGAGCGGAT TATGTCAGCA ATGGACAGAA CAACCTAATG AACACAGAAC CATGATGTGG  33241 TCTGTCCTTT TACAGCCAGT AGTGCTCGCC GCAGTCGAGC GACAGGGCGA AGCCCTCGAG  33301 CTGGTTGCCC TCGCCGCTGG GCTGGCGGCC GTCTATGGCC CTGCAAACGC GCCAGAAACG  33361 CCGTCGAAGC CGTGTGCGAG ACACCGCGGC CGGCCGCCGG CGTTGTGGAT ACCTCGCGGA  33421 AAACTTGGCC CTCACTGACA GATGAGGGGC GGACGTTGAC ACTTGAGGGG CCGACTCACC  33481 CGGCGCGGCG TTGACAGATG AGGGGCAGGC TCGATTTCGG CCGGCGACGT GGAGCTGGCC  33541 AGCCTCGCAA ATCGGCGAAA ACGCCTGATT TTACGCGAGT TTCCCACAGA TGATGTGGAC  33601 AAGCCTGGGG ATAAGTGCCC TGCGGTATTG ACACTTGAGG GGCGCGACTA CTGACAGATG  33661 AGGGGCGCGA TCCTTGACAC TTGAGGGGCA GAGTGCTGAC AGATGAGGGG CGCACCTATT  33721 GACATTTGAG GGGCTGTCCA CAGGCAGAAA ATCCAGCATT TGCAAGGGTT TCCGCCCGTT  33781 TTTCGGCCAC CGCTAACCTG TCTTTTAACC TGCTTTTAAA CCAATATTTA TAAACCTTGT  33841 TTTTAACCAG GGCTGCGCCC TGTGCGCGTG ACCGCGCACG CCGAAGGGGG GTGCCCCCCC  33901 TTCTCGAACC CTCCCGGTCG AGTGAGCGAG GAAGCACCAG GGAACAGCAC TTATATATTC  33961 TGCTTACACA CGATGCCTGA AAAAACTTCC CTTGGGGTTA TCCACTTATC CACGGGGATA  34021 TTTTTATAAT TATTTTTTTT ATAGTTTTTA GATCTTCTTT TTTAGAGCGC CTTGTAGGCC  34081 TTTATCCATG CTGGTTCTAG AGAAGGTGTT GTGACAAATT GCCCTTTCAG TGTGACAAAT  34141 CACCCTCAAA TGACAGTCCT GTCTGTGACA AATTGCCCTT AACCCTGTGA CAAATTGCCC  34201 TCAGAAGAAG CTGTTTTTTC ACAAAGTTAT CCCTGCTTAT TGACTCTTTT TTATTTAGTG  34261 TGACAATCTA AAAACTTGTC ACACTTCACA TGGATCTGTC ATGGCGGAAA CAGCGGTTAT  34321 CAATCACAAG AAACGTTAAA ATAGCCCGCG AATCGTCCAG TCAAACGACC TCACTGAGGC  34381 GGCATATAGT CTCTCCCGGG ATCAAAAACG TATGCTGTAT CTGTTCGTTG ACCAGATCAG  34441 AAAATCTGAT GGCACCCTAC AGGAACATGA CGGTATCTGC GAGATCCATG TTGCTAAATA  34501 TGCTGAAATA TTCGGATTGA CCTCTGCGGA AGCCAGTAAG GATATACGGC AGGCATTGAA  34561 GAGTTTCGCG GGGAAGGAAG TGGTTTTTTA TCGCCCTGAA GAGGATGCCG GCGATGAAAA  34621 AGGCTATGAA TCTTTTCCTT GGTTTATCAA ACGTGCGCAC AGTCCATCCA GAGGGCTTTA  34681 CAGTGTACAT ATCAACCCAT ATCTCATTCC CTTCTTTATC GGGTTACAGA ACCGGTTTAC  34741 GCAGTTTCGG CTTAGTGAAA CAAAAGAAAT CACCAATCCG TATGCCATGC GTTTATACGA  34801 ATCCCTGTGT CAGTATCGTA AGCCGGATGG CTCAGGCATC GTCTCTCTGA AAATCGACTG  34861 GATCATAGAG CGTTACCAGC TGCCTCAAAG TTACCAGCGT ATGCCTGACT TCCGCCGCCG  34921 CTTCCTGCAG GTCTGTGTTA ATGAGATCAA CAGCAGAACT CCAATGCGCC TCTCATACAT  34981 TGAGAAAAAG AAAGGCCGCC AGACGACTCA TATCGTATTT TCCTTCCGCG ATATCACTTC  35041 CATGACGACA GGATAGTCTG AGGGTTATCT GTCACAGATT TGAGGGTGGT TCGTCACATT  35101 TGTTCTGACC TACTGAGGGT AATTTGTCAC AGTTTTGCTG TTTCCTTCAG CCTGCATGGA  35161 TTTTCTCATA CTTTTTGAAC TGTAATTTTT AAGGAAGCCA AATTTGAGGG CAGTTTGTCA  35221 CAGTTGATTT CCTTCTCTTT CCCTTCGTCA TGTGACCTGA TATCGGGGGT TAGTTCGTCA  35281 TCATTGATGA GGGTTGATTA TCACAGTTTA TTACTCTGAA TTGGCTATCC GCGTGTGTAC  35341 CTCTACCTGG AGTTTTTCCC ACGGTGGATA TTTCTTCTTG CGCTGAGCGT AAGAGCTATC  35401 TGACAGAACA GTTCTTCTTT GCTTCCTCGC CAGTTCGCTC GCTATGCTCG GTTACACGGC  35461 TGCGGCGAGC GCTAGTGATA ATAAGTGACT GAGGTATGTG CTCTTCTTAT CTCCTTTTGT  35521 AGTGTTGCTC TTATTTTAAA CAACTTTGCG GTTTTTTGAT GACTTTGCGA TTTTGTTGTT  35581 GCTTTGCAGT AAATTGCAAG ATTTAATAAA AAAACGCAAA GCAATGATTA AAGGATGTTC  35641 AGAATGAAAC TCATGGAAAC ACTTAACCAG TGCATAAACG CTGGTCATGA AATGACGAAG  35701 GCTATCGCCA TTGCACAGTT TAATGATGAC AGCCCGGAAG CGAGGAAAAT AACCCGGCGC  35761 TGGAGAATAG GTGAAGCAGC GGATTTAGTT GGGGTTTCTT CTCAGGCTAT CAGAGATGCC  35821 GAGAAAGCAG GGCGACTACC GCACCCGGAT ATGGAAATTC GAGGACGGGT TGAGCAACGT  35881 GTTGGTTATA CAATTGAACA AATTAATCAT ATGCGTGATG TGTTTGGTAC GCGATTGCGA  35941 CGTGCTGAAG ACGTATTTCC ACCGGTGATC GGGGTTGCTG CCCATAAAGG TGGCGTTTAC  36001 AAAACCTCAG TTTCTGTTCA TCTTGCTCAG GATCTGGCTC TGAAGGGGCT ACGTGTTTTG  36061 CTCGTGGAAG GTAACGACCC CCAGGGAACA GCCTCAATGT ATCACGGATG GGTACCAGAT  36121 CTTCATATTC ATGCAGAAGA CACTCTCCTG CCTTTCTATC TTGGGGAAAA GGACGATGTC  36181 ACTTATGCAA TAAAGCCCAC TTGCTGGCCG GGGCTTGACA TTATTCCTTC CTGTCTGGCT  36241 CTGCACCGTA TTGAAACTGA GTTAATGGGC AAATTTGATG AAGGTAAACT GCCCACCGAT  36301 CCACACCTGA TGCTCCGACT GGCCATTGAA ACTGTTGCTC ATGACTATGA TGTCATAGTT  36361 ATTGACAGCG CGCCTAACCT GGGTATCGGC ACGATTAATG TCGTATGTGC TGCTGATGTG  36421 CTGATTGTTC CCACGCCTGC TGAGTTGTTT GACTACACCT CCGCACTGCA GTTTTTCGAT  36481 ATGCTTCGTG ATCTGCTCAA GAACGTTGAT CTTAAAGGGT TCGAGCCTGA TGTACGTATT  36541 TTGCTTACCA AATACAGCAA TAGCAATGGC TCTCAGTCCC CGTGGATGGA GGAGCAAATT  36601 CGGGATGCCT GGGGAAGCAT GGTTCTAAAA AATGTTGTAC GTGAAACGGA TGAAGTTGGT  36661 AAAGGTCAGA TCCGGATGAG AACTGTTTTT GAACAGGCCA TTGATCAACG CTCTTCAACT  36721 GGTGCCTGGA GAAATGCTCT TTCTATTTGG GAACCTGTCT GCAATGAAAT TTTCGATCGT  36781 CTGATTAAAC CACGCTGGGA GATTAGATAA TGAAGCGTGC GCCTGTTATT CCAAAACATA  36841 CGCTCAATAC TCAACCGGTT GAAGATACTT CGTTATCGAC ACCAGCTGCC CCGATGGTGG  36901 ATTCGTTAAT TGCGCGCGTA GGAGTAATGG CTCGCGGTAA TGCCATTACT TTGCCTGTAT  36961 GTGGTCGGGA TGTGAAGTTT ACTCTTGAAG TGCTCCGGGG TGATAGTGTT GAGAAGACCT  37021 CTCGGGTATG GTCAGGTAAT GAACGTGACC AGGAGCTGCT TACTGAGGAC GCACTGGATG  37081 ATCTCATCCC TTCTTTTCTA CTGACTGGTC AACAGACACC GGCGTTCGGT CGAAGAGTAT  37141 CTGGTGTCAT AGAAATTGCC GATGGGAGTC GCCGTCGTAA AGCTGCTGCA CTTACCGAAA  37201 GTGATTATCG TGTTCTGGTT GGCGAGCTGG ATGATGAGCA GATGGCTGCA TTATCCAGAT  37261 TGGGTAACGA TTATCGCCCA ACAAGTGCTT ATGAACGTGG TCAGCGTTAT GCAAGCCGAT  37321 TGCAGAATGA ATTTGCTGGA AATATTTCTG CGCTGGCTGA TGCGGAAAAT ATTTCACGTA  37381 AGATTATTAC CCGCTGTATC AACACCGCCA AATTGCCTAA ATCAGTTGTT GCTCTTTTTT  37441 CTCACCCCGG TGAACTATCT GCCCGGTCAG GTGATGCACT TCAAAAAGCC TTTACAGATA  37501 AAGAGGAATT ACTTAAGCAG CAGGCATCTA ACCTTCATGA GCAGAAAAAA GCTGGGGTGA  37561 TATTTGAAGC TGAAGAAGTT ATCACTCTTT TAACTTCTGT GCTTAAAACG TCATCTGCAT  37621 CAAGAACTAG TTTAAGCTCA CGACATCAGT TTGCTCCTGG AGCGACAGTA TTGTATAAGG  37681 GCGATAAAAT GGTGCTTAAC CTGGACAGGT CTCGTGTTCC AACTGAGTGT ATAGAGAAAA  37741 TTGAGGCCAT TOTTAAGGAA CTTGAAAAGC CAGCACCCTG ATGCGACCTC GTTTTAGTCT  37801 ACGTTTATCT GTCTTTACTT AATGTCCTTT GTTACAGGCC AGAAAGCATA ACTGGCCTGA  37861 ATATTCTCTC TGGGCCCACT GTTCCACTTG TATCGTCGGT CTGATAATCA GACTGGGACC  37921 ACGGTCCCAC TCGTATCGTC GGTCTGATTA TTAGTCTGGG ACCACGGTCC CACTCGTATC  37981 GTCGGTCTGA TTATTAGTCT GGGACCACGG TCCCACTCGT ATCGTCGGTC TGATAATCAG  38041 ACTGGGACCA CGGTCCCACT CGTATCGTCG GTCTGATTAT TAGTCTGGGA CCATGGTCCC  38101 ACTCGTATCG TCGGTCTGAT TATTAGTCTG GGACCACGGT CCCACTCGTA TCGTCGGTCT  38161 GATTATTAGT CTGGAACCAC GGTCCCACTC GTATCGTCGG TCTGATTATT AGTCTGGGAC  38221 CACGGTCCCA CTCGTATCGT CGGTCTGATT ATTAGTCTGG GACCACGATC CCACTCGTGT  38281 TGTCGGTCTG ATTATCGGTC TGGGACCACG GTCCCACTTG TATTGTCGAT CAGACTATCA  38341 GCGTGAGACT ACGATTCCAT CAATGCCTGT CAAGGGCAAG TATTGACATG TCGTCGTAAC  38401 CTGTAGAACG GAGTAACCTC GGTGTGCGGT TGTATGCCTG CTGTGGATTG CTGCTGTGTC  38461 CTGCTTATCC ACAACATTTT GCGCACGGTT ATGTGGAC (Payload Vector 1) SEQ ID NO: 9      1 CCCCGAAAAG TGCCACCTGG GTCCTTTTCA TCACGTGCTA TAAAAATAAT TATAATTTAA     61 ATTTTTTAAT ATAAATATAT AAATTAAAAA TAGAAAGTAA AAAAAGAAAT TAAAGAAAAA    121 ATAGTTTTTG TTTTCCGAAG ATGTAAAAGA CTCTAGGGGG ATCGCCAACA AATACTACCT    181 TTTATCTTGC TCTTCCTGCT CTCAGGTATT AATGCCGAAT TGTTTCATCT TGTCTGTGTA    241 GAAGACCACA CACGAAAATC CTGTGATTTT ACATTTTACT TATCGTTAAT CGAATGTATA    301 TCTATTTAAT CTGCTTTTCT TGTCTAATAA ATATATATGT AAAGTACGCT TTTTGTTGAA    361 ATTTTTTAAA CCTTTGTTTA TTTTTTTTTC TTCATTCCGT AACTCTTCTA CCTTCTTTAT    421 TTACTTTCTA AAATCCAAAT ACAAAACATA AAAATAAATA AACACAGAGT AAATTCCCAA    481 ATTATTCCAT CATTAAAAGA TACGAGGCGC GTGTAAGTTA CAGGCAAGCG ATCCGTCCTA    541 AGAAACCATT ATTATCATGA CATTAACCTA TAAAAATAGG CGTATCACGA GGCCCTTTCG    601 TCTCGCGCGT TTCGGTGATG ACGGTGAAAA CCTCTGACAC ATGCAGCTCC CGGAGACGGT    661 CACAGOTTGT CTGTAAGCGG ATGCCGGGAG CAGACAAGCC CGTCAGGGCG CGTCAGCGCG    721 TGTTGGCGGG TGTCGGGGCT GGCTTAACTA TGCGGCATCA GAGCAGATTG TACTGAGAGT    781 GCACCATAAA TTCCCGTTTT AAGAGCTTGG TGAGCGCTAG GAGTCACTGC CAGGTATCGT    841 TTGAACACGG CATTAGTCAG GGAAGTCATA ACACAGTCCT TTCCCGCAAT TTTCTTTTTC    901 TATTACTCTT GGCCTCCTCT AGTACACTCT ATATTTTTTT ATGCCTCGGT AATGATTTTC    961 ATTTTTTTTT TTCCCCTAGC GGATGACTCT TTTTTTTTCT TAGCGATTGG CATTATCACA   1021 TAATGAATTA TACATTATAT AAAGTAATGT GATTTCTTCG AAGAATATAC TAAAAAATGA   1081 GCAGGCAAGA TAAACGAAGG CAAAGATGAC AGAGCAGAAA GCCCTAGTAA AGCGTATTAC   1141 AAATGAAACC AAGATTCAGA TTGCGATCTC TTTAAAGGGT GGTCCCCTAG CGATAGAGCA   1201 CTCGATCTTC CCAGAAAAAG AGGCAGAAGC AGTAGCAGAA CAGGCCACAC AATCGCAAGT   1261 GATTAACGTC CACACAGGTA TAGGGTTTCT GGACCATATG ATACATGCTC TGGCCAAGCA   1321 TTCCGGCTGG TCGCTAATCG TTGAGTGCAT TGGTGACTTA CACATAGACG ACCATCACAC   1381 CACTGAAGAC TGCGGGATTG CTCTCGGTCA AGCTTTTAAA GAGGCCCTAC TGGCGCGTGG   1441 AGTAAAAAGG TTTGGATCAG GATTTGCGCC TTTGGATGAG GCACTTTCCA GAGCGGTGGT   1501 AGATCTTTCG AACAGGCCGT ACGCAGTTGT CGAACTTGGT TTGCAAAGGG AGAAAGTAGG   1561 AGATCTCTCT TGCGAGATGA TCCCGCATTT TCTTGAAAGC TTTGCAGAGG CTAGCAGAAT   1621 TACCCTCCAC GTTGATTGTC TGCGAGGCAA GAATGATCAT CACCGTAGTG AGAGTGCGTT   1681 CAAGGCTCTT GCGGTTGCCA TAAGAGAAGC CACCTCGCCC AATGGTACCA ACGATGTTCC   1741 CTCCACCAAA GGTGTTCTTA TGTAGTGACA CCGATTATTT AAAGCTGCAG CATACGATAT   1801 ATATACATGT GTATATATGT ATACCTATGA ATGTCAGTAA GTATGTATAC GAACAGTATG   1861 ATACTGAAGA TGACAAGGTA ATGCATCATT CTATACGTGT CATTCTGAAC GAGGCGCGCT   1921 TTCCTTTTTT CTTTTTGCTT TTTCTTTTTT TTTCTCTTGA ACTCGACGGA TCTATGCGGT   1981 GTGAAATACC GCACAGATGC GTCCTAGGGC GGCCGCATAA CTTCGTATAG CATACATTAT   2041 ACGAAGTTAT CCGGAACCGA GTACAAGCCC ACGGTGCGCC TCGCCACCCG CGACGACGTC   2101 CCCAGGGCCG TCCGCACCCT CGCCGCCGCG TTCGCCGACT ACCCCGCCAC GCGCCACACC   2161 GTCGATCCGG ACCGCCACAT CGAGCGCGTG ACCGAGCTGC AAGAACTCTT CCTCACGCGC   2221 GTCGGGCTCG ACATCGGCAA GGTGTGGGTC GCGGACGACG GAGCCGCTGT GGCGGTCTGG   2281 ACCACGCCGG AGAGCGTCGA AGCGGGGGCG GTGTTCGCCG AGATCGGCCC GCGCATGGCC   2341 GAGTTGAGCG GTTCCCGGCT GGCCGCGCAG CAACAGATGG AGGGCCTCCT GGCTCCGCAC   2401 CGGCCCAAGG AGCCCGCGTG GTTCCTGGCC ACCGTCGGAG TCTCGCCCGA CCACCAGGGC   2461 AAGGGTCTGG GCAGCGCCGT CGTGCTCCCC GGAGTGGAGG CGGCCGAGCG CGCCGGGGTG   2521 CCCGCCTTCC TGGAAACCTC CGCGCCCCGC AACCTCCCCT TCTACGAGCG GCTCGGCTTC   2581 ACCGTCACCG CCGACGTCGA GGTGCCCGAA GGACCGCGCA CCTGGTGCAT GACCCGCAAG   2641 CCCGGTGCCG CATGCGGCAG TGGAGAGGGC AGAGGAAGTC TGCTAACATG CGGTGACGTC   2701 GAGGAGAATC CTGGCCCAGG CGCCGTGAGC AAGGGCGAGG AGGATAACAT GGCCTCTCTC   2761 CCAGCGACAC ATGAGTTACA CATCTTTGGC TCCATCAACG GTGTGGACTT TGACATGGTG   2821 GGTCAGGGCA CCGGCAATCC AAATGATGGT TATGAGGAGT TAAACCTGAA GTCCACCAAG   2881 GGCGACCTCC AGTTCTCCCC CTGGATTCTG GTCCCTCATA TCGGGTATGG CTTCCATCAG   2941 TACCTGCCCT ACCCTGACGG GATGTCGCCT TTCCAGGCCG CCATGGTAGA TGGCTCTGGA   3001 TACCAAGTCC ATCGCACAAT GCAGTTTGAA GATGGTGCCT CCCTTACTGT GAACTACCGC   3061 TACACCTACG AGGGAAGCCA CATCAAAGGA GAGGCCCAGG TGAAGGGGAC TGGTTTCCCT   3121 GCTGACGGTC CTGTGATGAC CAACTCGCTG ACCGCTGCGG ACTGGTGCAG GTCGAAGAAG   3181 ACTTACCCCA ACGACAAAAC CATCATCAGT ACCTTTAAGT GGAGTTACAC CACTGGAAAT   3241 GGCAAGCGCT ACCGGAGCAC TGCGCGGACC ACCTACACCT TTGCCAAGCC AATGGCGGCT   3301 AACTATCTGA AGAACCAGCC GATGTACGTG TTCCGTAAGA CGGAACTCAA GCACTCCAAG   3361 ACCGAGCTGA ACTTCAAGGA GTGGCAAAAG GCGTTTACCG ATGTGATGGG CATGGACGAG   3421 CTGTACAAGT GAATTCGATC ATAATCAGCC ATACCACATT TGTAGAGGTT TTACTTGCTT   3481 TAAAAAACCT CCCACACCTC CCCCTGAACC TGAAACATAA AATGAATGCA ATTGTTGTTG   3541 TTAACTTGTT TATTGCAGCT TATAATGGTT ACAAATAAAG CAATAGCATC ACAAATTTCA   3601 CAAATAAAGC ATTTTTTTCA CTGCATTCTA GTTGTGGTTT GTCCAAACTC ATCAATGTAT   3661 CTTATCATGT CTGGGAGCTC ATAACTTCGT ATAGTATAGT ATATACGAAT TATACGCGTA   3721 TCCATACTGG CGCGCCACAA CTTCGTATAG AAAGGTATAT ACGAAGTTGT GTCGACCAAT   3781 TCTCATGTTT GACAGOTTAT CATCGAATTT CTGCCATTCA TCCGCTTATT ATCACTTATT   3841 CAGGCGTAGC AACCAGGCGT TTAAGGGCAC CAATAACTGC CTTAAAAAAA TTAGAAAAAC   3901 TCATCGAGCA TCAAATGAAA CTGCAATTTA TTCATATCAG GATTATCAAT ACCATATTTT   3961 TGAAAAAGCC GTTTCTGTAA TGAAGGAGAA AACTCACCGA GGCAGTTCCA TAGGATGGCA   4021 AGATCCTGGT ATCGGTCTGC GATTCCGACT CGTCCAACAT CAATACAACC TATTAATTTC   4081 CCCTCGTCAA AAATAAGGTT ATCAAGTGAG AAATCACCAT GAGTGACGAC TGAATCCGGT   4141 GAGAATGGCA AAAGCTTATG CATTTCTTTC CAGACTTGTT CAACAGGCCA GCCATTACGC   4201 TCGTCATCAA AATCACTCGC ATCAACCAAA CCGTTATTCA TTCGTGATTG CGCCTGAGCG   4261 AGACGAAATA CGCGATCGCT GTTAAAAGGA CAATTACAAA CAGGAATCGA ATGCAACCGG   4321 CGCAGGAACA CTGCCAGCGC ATCAACAATA TTTTCACCTG AATCAGGATA TTCTTCTAAT   4381 ACCTGGAATG CTGTTTTCCC TGGGATCGCA GTGGTGAGTA ACCATGCATC ATCAGGAGTA   4441 CGGATAAAAT GCTTGATGGT CGGAAGAGGC ATAAATTCCG TCAGCCAGTT TAGTCTGACC   4501 ATCTCATCTG TAACATCATT GGCAACGCTA CCTTTGCCAT GTTTCAGAAA CAACTCTGGC   4561 GCATCGGGCT TCCCATACAA TCGATAGATT GTCGCACCTG ATTGCCCGAC ATTATCGCGA   4621 GCCCATTTAT ACCCATATAA ATCAGCATCC ATGTTGGAAT TTAATCGCGG CCTCGAGCAA   4681 GACGTTTCCC GTTGAATATG GCTCATTTTA GCTTCCTTAG CTCCTGAAAA TCTCGATAAC   4741 TCAAAAAATA CGCCCGGTAG TGATCTTATT TCATTATGGT GAAAGTTGGA ACCTCTTACG   4801 TGCCGATCAA CGTCTCATTT TCGCCAAAAG TTGGCCCAGG GCTTCCCGGT ATCAACAGGG   4861 ACACCAGGAT TTATTTATTC TGCGAAGTGA TCTTCCGTCA CAGGTATTTA TTCGCGATAA   4921 GCTCATGGAG CGGCGTAACC GTCGCACAGG AAGGACAGAG AAAGCGCGGA TCTGGGAAGT   4981 GACGGACAGA ACGGTCAGGA CCTGGATTGG GGAGGCGGTT GCCGCCGCTG CTGCTGACGG   5041 TGTGACGTTC TCTGTTCCGG TCACACCACA TACGTTCCGC CATTCCTATG CGATGCACAT   5101 GCTGTATGCC GGTATACCGC TGAAAGTTCT GCAAAGCCTG ATGGGACATA AGTCCATCAG   5161 TTCAACGGAA GTCTACACGA AGGTTTTTGC GCTGGATGTG GCTGCCCGGC ACCGGGTGCA   5221 GTTTGCGATG CCGGAGTCTG ATGCGGTTGC GATGCTGAAA CAATTATCCT GAGAATAAAT   5281 GCCTTGGCCT TTATATGGAA ATGTGGAACT GAGTGGATAT GCTGTTTTTG TCTGTTAAAC   5341 AGAGAAGCTG GCTGTTATCC ACTGAGAAGC GAACGAAACA GTCGGGAAAA TCTCCCATTA   5401 TCGTAGAGAT CCGCATTATT AATCTCAGGA GCCTGTGTAG CGTTTATAGG AAGTAGTGTT   5461 CTGTCATGAT GCCTGCAAGC GGTAACGAAA ACGATTTGAA TATGCCTTCA GGAACAATAG   5521 AAATCTTCGT GCGGTGTTAC GTTGAAGTGG AGCGGATTAT GTCAGCAATG GACAGAACAA   5581 CCTAATGAAC ACAGAACCAT GATGTGGTCT GTCCTTTTAC AGCCAGTAGT GCTCGCCGCA   5641 GTCGAGCGAC AGGGCGAAGC CCTCGAGCTG GTTGCCCTCG CCGCTGGGCT GGCGGCCGTC   5701 TATGGCCCTG CAAACGCGCC AGAAACGCCG TCGAAGCCGT GTGCGAGACA CCGCGGCCGG   5761 CCGCCGGCGT TGTGGATACC TCGCGGAAAA CTTGGCCCTC ACTGACAGAT GAGGGGCGGA   5821 CGTTGACACT TGAGGGGCCG ACTCACCCGG CGCGGCGTTG ACAGATGAGG GGCAGGCTCG   5881 ATTTCGGCCG GCGACGTGGA GCTGGCCAGC CTCGCAAATC GGCGAAAACG CCTGATTTTA   5941 CGCGAGTTTC CCACAGATGA TGTGGACAAG CCTGGGGATA AGTGCCCTGC GGTATTGACA   6001 CTTGAGGGGC GCGACTACTG ACAGATGAGG GGCGCGATCC TTGACACTTG AGGGGCAGAG   6061 TGCTGACAGA TGAGGGGCGC ACCTATTGAC ATTTGAGGGG CTGTCCACAG GCAGAAAATC   6121 CAGCATTTGC AAGGGTTTCC GCCCGTTTTT CGGCCACCGC TAACCTGTCT TTTAACCTGC   6181 TTTTAAACCA ATATTTATAA ACCTTGTTTT TAACCAGGGC TGCGCCCTGT GCGCGTGACC   6241 GCGCACGCCG AAGGGGGGTG CCCCCCCTTC TCGAACCCTC CCGGTCGAGT GAGCGAGGAA   6301 GCACCAGGGA ACAGCACTTA TATATTCTGC TTACACACGA TGCCTGAAAA AACTTCCCTT   6361 GGGGTTATCC ACTTATCCAC GGGGATATTT TTATAATTAT TTTTTTTATA GTTTTTAGAT   6421 CTTCTTTTTT AGAGCGCCTT GTAGGCCTTT ATCCATGCTG GTTCTAGAGA AGGTGTTGTG   6481 ACAAATTGCC CTTTCAGTGT GACAAATCAC CCTCAAATGA CAGTCCTGTC TGTGACAAAT   6541 TGCCCTTAAC CCTGTGACAA ATTGCCCTCA GAAGAAGCTG TTTTTTCACA AAGTTATCCC   6601 TGCTTATTGA CTCTTTTTTA TTTAGTGTGA CAATCTAAAA ACTTGTCACA CTTCACATGG   6661 ATCTGTCATG GCGGAAACAG CGGTTATCAA TCACAAGAAA CGTAAAAATA GCCCGCGAAT   6721 CGTCCAGTCA AACGACCTCA CTGAGGCGGC ATATAGTCTC TCCCGGGATC AAAAACGTAT   6781 GCTGTATCTG TTCGTTGACC AGATCAGAAA ATCTGATGGC ACCCTACAGG AACATGACGG   6841 TATCTGCGAG ATCCATGTTG CTAAATATGC TGAAATATTC GGATTGACCT CTGCGGAAGC   6901 CAGTAAGGAT ATACGGCAGG CATTGAAGAG TTTCGCGGGG AAGGAAGTGG TTTTTTATCG   6961 CCCTGAAGAG GATGCCGGCG ATGAAAAAGG CTATGAATCT TTTCCTTGGT TTATCAAACG   7021 TGCGCACAGT CCATCCAGAG GGCTTTACAG TGTACATATC AACCCATATC TCATTCCCTT   7081 CTTTATCGGG TTACAGAACC GGTTTACGCA GTTTCGGCTT AGTGAAACAA AAGAAATCAC   7141 CAATCCGTAT GCCATGCGTT TATACGAATC CCTGTGTCAG TATCGTAAGC CGGATGGCTC   7201 AGGCATCGTC TCTCTGAAAA TCGACTGGAT CATAGAGCGT TACCAGCTGC CTCAAAGTTA   7261 CCAGCGTATG CCTGACTTCC GCCGCCGCTT CCTGCAGGTC TGTGTTAATG AGATCAACAG   7321 CAGAACTCCA ATGCGCCTCT CATACATTGA GAAAAAGAAA GGCCGCCAGA CGACTCATAT   7381 CGTATTTTCC TTCCGCGATA TCACTTCCAT GACGACAGGA TAGTCTGAGG GTTATCTGTC   7441 ACAGATTTGA GGGTGGTTCG TCACATTTGT TCTGACCTAC TGAGGGTAAT TTGTCACAGT   7501 TTTGCTGTTT CCTTCAGCCT GCATGGATTT TCTCATACTT TTTGAACTGT AATTTTTAAG   7561 GAAGCCAAAT TTGAGGGCAG TTTGTCACAG TTGATTTCCT TCTCTTTCCC TTCGTCATGT   7621 GACCTGATAT CGGGGGTTAG TTCGTCATCA TTGATGAGGG TTGATTATCA CAGTTTATTA   7681 CTCTGAATTG GCTATCCGCG TGTGTACCTC TACCTGGAGT TTTTCCCACG GTGGATATTT   7741 CTTCTTGCGC TGAGCGTAAG AGCTATCTGA CAGAACAGTT CTTCTTTGCT TCCTCGCCAG   7801 TTCGCTCGCT ATGCTCGGTT ACACGGCTGC GGCGAGCGCT AGTGATAATA AGTGACTGAG   7861 GTATGTGCTC TTCTTATCTC CTTTTGTAGT GTTGCTCTTA TTTTAAACAA CTTTGCGGTT   7921 TTTTGATGAC TTTGCGATTT TGTTGTTGCT TTGCAGTAAA TTGCAAGATT TAATAAAAAA   7981 ACGCAAAGCA ATGATTAAAG GATGTTCAGA ATGAAACTCA TGGAAACACT TAACCAGTGC   8041 ATAAACGCTG GTCATGAAAT GACGAAGGCT ATCGCCATTG CACAGTTTAA TGATGACAGC   8101 CCGGAAGCGA GGAAAATAAC CCGGCGCTGG AGAATAGGTG AAGCAGCGGA TTTAGTTGGG   8161 GTTTCTTCTC AGGCTATCAG AGATGCCGAG AAAGCAGGGC GACTACCGCA CCCGGATATG   8221 GAAATTCGAG GACGGGTTGA GCAACGTGTT GGTTATACAA TTGAACAAAT TAATCATATG   8281 CGTGATGTGT TTGGTACGCG ATTGCGACGT GCTGAAGACG TATTTCCACC GGTGATCGGG   8341 GTTGCTGCCC ATAAAGGTGG CGTTTACAAA ACCTCAGTTT CTGTTCATCT TGCTCAGGAT   8401 CTGGCTCTGA AGGGGCTACG TGTTTTGCTC GTGGAAGGTA ACGACCCCCA GGGAACAGCC   8461 TCAATGTATC ACGGATGGGT ACCAGATOTT CATATTCATG CAGAAGACAC TCTCCTGCCT   8521 TTCTATCTTG GGGAAAAGGA CGATGTCACT TATGCAATAA AGCCCACTTG CTGGCCGGGG   8581 CTTGACATTA TTCCTTCCTG TCTGGCTCTG CACCGTATTG AAACTGAGTT AATGGGCAAA   8641 TTTGATGAAG GTAAACTGCC CACCGATCCA CACCTGATGC TCCGACTGGC CATTGAAACT   8701 GTTGCTCATG ACTATGATGT CATAGTTATT GACAGCGCGC CTAACCTGGG TATCGGCACG   8761 ATTAATGTCG TATGTGCTGC TGATGTGCTG ATTGTTCCCA CGCCTGCTGA GTTGTTTGAC   8821 TACACCTCCG CACTGCAGTT TTTCGATATG CTTCGTGATC TGCTCAAGAA CGTTGATCTT   8881 AAAGGGTTCG AGCCTGATGT ACGTATTTTG CTTACCAAAT ACAGCAATAG CAATGGCTCT   8941 CAGTCCCCGT GGATGGAGGA GCAAATTCGG GATGCCTGGG GAAGCATGGT TCTAAAAAAT   9001 GTTGTACGTG AAACGGATGA AGTTGGTAAA GGTCAGATCC GGATGAGAAC TGTTTTTGAA   9061 CAGGCCATTG ATCAACGCTC TTCAACTGGT GCCTGGAGAA ATGCTCTTTC TATTTGGGAA   9121 CCTGTCTGCA ATGAAATTTT CGATCGTCTG ATTAAACCAC GCTGGGAGAT TAGATAATGA   9181 AGCGTGCGCC TGTTATTCCA AAACATACGC TCAATACTCA ACCGGTTGAA GATACTTCGT   9241 TATCGACACC AGCTGCCCCG ATGGTGGATT CGTTAATTGC GCGCGTAGGA GTAATGGCTC   9301 GCGGTAATGC CATTACTTTG CCTGTATGTG GTCGGGATGT GAAGTTTACT CTTGAAGTGC   9361 TCCGGGGTGA TAGTGTTGAG AAGACCTCTC GGGTATGGTC AGGTAATGAA CGTGACCAGG   9421 AGCTGCTTAC TGAGGACGCA CTGGATGATC TCATCCCTTC TTTTCTACTG ACTGGTCAAC   9481 AGACACCGGC GTTCGGTCGA AGAGTATCTG GTGTCATAGA AATTGCCGAT GGGAGTCGCC   9541 GTCGTAAAGC TGCTGCACTT ACCGAAAGTG ATTATCGTGT TCTGGTTGGC GAGCTGGATG   9601 ATGAGCAGAT GGCTGCATTA TCCAGATTGG GTAACGATTA TCGCCCAACA AGTGCTTATG   9661 AACGTGGTCA GCGTTATGCA AGCCGATTGC AGAATGAATT TGCTGGAAAT ATTTCTGCGC   9721 TGGCTGATGC GGAAAATATT TCACGTAAGA TTATTACCCG CTGTATCAAC ACCGCCAAAT   9781 TGCCTAAATC AGTTGTTGCT CTTTTTTCTC ACCCCGGTGA ACTATCTGCC CGGTCAGGTG   9841 ATGCACTTCA AAAAGCCTTT ACAGATAAAG AGGAATTACT TAAGCAGCAG GCATCTAACC   9901 TTCATGAGCA GAAAAAAGCT GGGGTGATAT TTGAAGCTGA AGAAGTTATC ACTCTTTTAA   9961 CTTCTGTGCT TAAAACGTCA TCTGCATCAA GAACTAGTTT AAGCTCACGA CATCAGTTTG  10021 CTCCTGGAGC GACAGTATTG TATAAGGGCG ATAAAATGGT GCTTAACCTG GACAGGTCTC  10081 GTGTTCCAAC TGAGTGTATA GAGAAAATTG AGGCCATTCT TAAGGAACTT GAAAAGCCAG  10141 CACCCTGATG CGACCACGTT TTAGTCTACG TTTATCTGTC TTTACTTAAT GTCCTTTGTT  10201 ACAGGCCAGA AAGCATAACT GGCCTGAATA TTCTCTCTGG GCCCACTGTT CCACTTGTAT  10261 CGTCGGTCTG ATAATCAGAC TGGGACCACG GTCCCACTCG TATCGTCGGT CTGATTATTA  10321 GTCTGGGACC ACGGTCCCAC TCGTATCGTC GGTCTGATTA TTAGTCTGGG ACCACGGTCC  10381 CACTCGTATC GTCGGTCTGA TAATCAGACT GGGACCACGG TCCCACTCGT ATCGTCGGTC  10441 TGATTATTAG TCTGGGACCA TGGTCCCACT CGTATCGTCG GTCTGATTAT TAGTCTGGGA  10501 CCACGGTCCC ACTCGTATCG TCGGTCTGAT TATTAGTCTG GAACCACGGT CCCACTCGTA  10561 TCGTCGGTCT GATTATTAGT CTGGGACCAC GGTCCCACTC GTATCGTCGG TCTGATTATT  10621 AGTCTGGGAC CACGATCCCA CTCGTGTTGT CGGTCTGATT ATCGGTCTGG GACCACGGTC  10681 CCACTTGTAT TGTCGATCAG ACTATCAGCG TGAGACTACG ATTCCATCAA TGCCTGTCAA  10741 GGGCAAGTAT TGACATGTCG TCGTAACCTG TAGAACGGAG TAACCTCGGT GTGCGGTTGT  10801 ATGCCTGCTG TGGATTGCTG CTGTGTCCTG CTTATCCACA ACATTTTGCG CACGGTTATG  10861 TGGAC (Payload Vector 2) SEQ ID NO: 10      1 CCCCGAAAAG TGCCACCTGG GTCCTTTTCA TCACGTGCTA TAAAAATAAT TATAATTTAA     61 ATTTTTTAAT ATAAATATAT AAATTAAAAA TAGAAAGTAA AAAAAGAAAT TAAAGAAAAA    121 ATAGTTTTTG TTTTCCGAAG ATGTAAAAGA CTCTAGGGGG ATCGCCAACA AATACTACCT    181 TTTATCTTGC TCTTCCTGCT CTCAGGTATT AATGCCGAAT TGTTTCATCT TGTCTGTGTA    241 GAAGACCACA CACGAAAATC CTGTGATTTT ACATTTTACT TATCGTTAAT CGAATGTATA    301 TCTATTTAAT CTGCTTTTCT TGTCTAATAA ATATATATGT AAAGTACGCT TTTTGTTGAA    361 ATTTTTTAAA CCTTTGTTTA TTTTTTTTTC TTCATTCCGT AACTCTTCTA CCTTCTTTAT    421 TTACTTTCTA AAATCCAAAT ACAAAACATA AAAATAAATA AACACAGAGT AAATTCCCAA    481 ATTATTCCAT CATTAAAAGA TACGAGGCGC GTGTAAGTTA CAGGCAAGCG ATCCGTCCTA    541 AGAAACCATT ATTATCATGA CATTAACCTA TAAAAATAGG CGTATCACGA GGCCCTTTCG    601 TCTCGCGCGT TTCGGTGATG ACGGTGAAAA CCTCTGACAC ATGCAGCTCC CGGAGACGGT    661 CACAGOTTGT CTGTAAGCGG ATGCCGGGAG CAGACAAGCC CGTCAGGGCG CGTCAGCGCG    721 TGTTGGCGGG TGTCGGGGCT GGCTTAACTA TGCGGCATCA GAGCAGATTG TACTGAGAGT    781 GCACCATAAA TTCCCGTTTT AAGAGCTTGG TGAGCGCTAG GAGTCACTGC CAGGTATCGT    841 TTGAACACGG CATTAGTCAG GGAAGTCATA ACACAGTCCT TTCCCGCAAT TTTCTTTTTC    901 TATTACTCTT GGCCTCCTCT AGTACACTCT ATATTTTTTT ATGCCTCGGT AATGATTTTC    961 ATTTTTTTTT TTCCCCTAGC GGATGACTCT TTTTTTTTCT TAGCGATTGG CATTATCACA   1021 TAATGAATTA TACATTATAT AAAGTAATGT GATTTCTTCG AAGAATATAC TAAAAAATGA   1081 GCAGGCAAGA TAAACGAAGG CAAAGATGAC AGAGCAGAAA GCCCTAGTAA AGCGTATTAC   1141 AAATGAAACC AAGATTCAGA TTGCGATCTC TTTAAAGGGT GGTCCCCTAG CGATAGAGCA   1201 CTCGATCTTC CCAGAAAAAG AGGCAGAAGC AGTAGCAGAA CAGGCCACAC AATCGCAAGT   1261 GATTAACGTC CACACAGGTA TAGGGTTTCT GGACCATATG ATACATGCTC TGGCCAAGCA   1321 TTCCGGCTGG TCGCTAATCG TTGAGTGCAT TGGTGACTTA CACATAGACG ACCATCACAC   1381 CACTGAAGAC TGCGGGATTG CTCTCGGTCA AGCTTTTAAA GAGGCCCTAC TGGCGCGTGG   1441 AGTAAAAAGG TTTGGATCAG GATTTGCGCC TTTGGATGAG GCACTTTCCA GAGCGGTGGT   1501 AGATCTTTCG AACAGGCCGT ACGCAGTTGT CGAACTTGGT TTGCAAAGGG AGAAAGTAGG   1561 AGATCTCTCT TGCGAGATGA TCCCGCATTT TCTTGAAAGC TTTGCAGAGG CTAGCAGAAT   1621 TACCCTCCAC GTTGATTGTC TGCGAGGCAA GAATGATCAT CACCGTAGTG AGAGTGCGTT   1681 CAAGGCTCTT GCGGTTGCCA TAAGAGAAGC CACCTCGCCC AATGGTACCA ACGATGTTCC   1741 CTCCACCAAA GGTGTTCTTA TGTAGTGACA CCGATTATTT AAAGCTGCAG CATACGATAT   1801 ATATACATGT GTATATATGT ATACCTATGA ATGTCAGTAA GTATGTATAC GAACAGTATG   1861 ATACTGAAGA TGACAAGGTA ATGCATCATT CTATACGTGT CATTCTGAAC GAGGCGCGCT   1921 TTCCTTTTTT CTTTTTGCTT TTTCTTTTTT TTTCTCTTGA ACTCGACGGA TCTATGCGGT   1981 GTGAAATACC GCACAGATGC GTCCTAGGGC GGCCGCATAA CTTCGTATAG CATACATTAT   2041 ACGAAGTTAT CCGGAAAAAC ATTTAACATT TCTCAACAAG ATCTAGAATT AGTAGAAGTA   2101 GCGACAGAGA AGATTACAAT GCTTTATGAG GATAATAAAC ATCATGTGGG AGCGGCAATT   2161 CGTACGAAAA CAGGAGAAAT CATTTCGGCA GTACATATTG AAGCGTATAT AGGACGAGTA   2221 ACTGTTTGTG CAGAAGCCAT TGCGATTGGT AGTGCAGTTT CGAATGGACA AAAGGATTTT   2281 GACACGATTG TAGCTGTTAG ACACCCTTAT TCTGACGAAG TAGATAGAAG TATTCGAGTG   2341 GTAAGTCCTT GTGGTATGTG TAGGGAGTTG ATTTCAGACT ATGCACCAGA TTGTTTTGTG   2401 TTAATAGAAA TGAATGGCAA GTTAGTCAAA ACTACGATTG AAGAACTCAT TCCACTCAAA   2461 TATACCCGAA ATGGCAGTGG AGAGGGCAGA GGAAGTCTGC TAACATGCGG TGACGTCGAG   2521 GAGAATCCTG GCCCAGTGAG CAAGGGCGAG GCAGTGATCA AGGAGTTCAT GCGGTTCAAG   2581 GTGCACATGG AGGGCTCCAT GAACGGCCAC GAGTTCGAGA TCGAGGGCGA GGGCGAGGGC   2641 CGCCCCTACG AGGGCACCCA GACCGCCAAG CTGAAGGTGA CCAAGGGTGG CCCCCTGCCC   2701 TTCTCCTGGG ACATCCTGTC CCCTCAGTTC ATGTACGGCT CCAGGGCCTT CACCAAGCAC   2761 CCCGCCGACA TCCCCGACTA CTATAAGCAG TCCTTCCCCG AGGGCTTCAA GTGGGAGCGC   2821 GTGATGAACT TCGAGGACGG CGGCGCCGTG ACCGTGACCC AGGACACCTC CCTGGAGGAC   2881 GGCACCCTGA TCTACAAGGT GAAGCTCCGC GGCACCAACT TCCCTCCTGA CGGCCCCGTA   2941 ATGCAGAAGA AAACAATGGG CTGGGAAGCG TCCACCGAGC GGTTGTACCC CGAGGACGGC   3001 GTGCTGAAGG GCGACATTAA GATGGCCCTG CGCCTGAAGG ACGGCGGCCG CTACCTGGCG   3061 GACTTCAAGA CCACCTACAA GGCCAAGAAG CCCGTGCAGA TGCCCGGCGC CTACAACGTT   3121 GACCGCAAGT TGGACATCAC CTCCCACAAC GAGGACTACA CCGTGGTGGA ACAGTACGAA   3181 CGCTCCGAGG GCCGCCACTC CACCGGCGGC ATGGACGAGC TGTACAAGTG AATTCGATCA   3241 TAATCAGCCA TACCACATTT GTAGAGGTTT TACTTGCTTT AAAAAACCTC CCACACCTCC   3301 CCCTGAACCT GAAACATAAA ATGAATGCAA TTGTTGTTGT TAACTTGTTT ATTGCAGCTT   3361 ATAATGGTTA CAAATAAAGC AATAGCATCA CAAATTTCAC AAATAAAGCA TTTTTTTCAC   3421 TGCATTCTAG TTGTGGTTTG TCCAAACTCA TCAATGTATC TTATCATGTC TGGGAGCTCA   3481 TAACTTCGTA TAGCGTGCGT TATACGAAGT TATACGCGTA TCCATACTGG CGCGCCATAA   3541 CTTCGTATAG TATAGTATAT ACGAATTATG TCGACCAATT CTCATGTTTG ACAGCTTATC   3601 ATCGAATTTC TGCCATTCAT CCGCTTATTA TCACTTATTC AGGCGTAGCA ACCAGGCGTT   3661 TAAGGGCACC AATAACTGCC TTAAAAAAAT TAGAAAAACT CATCGAGCAT CAAATGAAAC   3721 TGCAATTTAT TCATATCAGG ATTATCAATA CCATATTTTT GAAAAAGCCG TTTCTGTAAT   3781 GAAGGAGAAA ACTCACCGAG GCAGTTCCAT AGGATGGCAA GATCCTGGTA TCGGTCTGCG   3841 ATTCCGACTC GTCCAACATC AATACAACCT ATTAATTTCC CCTCGTCAAA AATAAGGTTA   3901 TCAAGTGAGA AATCACCATG AGTGACGACT GAATCCGGTG AGAATGGCAA AAGCTTATGC   3961 ATTTCTTTCC AGACTTGTTC AACAGGCCAG CCATTACGCT CGTCATCAAA ATCACTCGCA   4021 TCAACCAAAC CGTTATTCAT TCGTGATTGC GCCTGAGCGA GACGAAATAC GCGATCGCTG   4081 TTAAAAGGAC AATTACAAAC AGGAATCGAA TGCAACCGGC GCAGGAACAC TGCCAGCGCA   4141 TCAACAATAT TTTCACCTGA ATCAGGATAT TCTTCTAATA CCTGGAATGC TGTTTTCCCT   4201 GGGATCGCAG TGGTGAGTAA CCATGCATCA TCAGGAGTAC GGATAAAATG CTTGATGGTC   4261 GGAAGAGGCA TAAATTCCGT CAGCCAGTTT AGTCTGACCA TCTCATCTGT AACATCATTG   4321 GCAACGCTAC CTTTGCCATG TTTCAGAAAC AACTCTGGCG CATCGGGCTT CCCATACAAT   4381 CGATAGATTG TCGCACCTGA TTGCCCGACA TTATCGCGAG CCCATTTATA CCCATATAAA   4441 TCAGCATCCA TGTTGGAATT TAATCGCGGC CTCGAGCAAG ACGTTTCCCG TTGAATATGG   4501 CTCATTTTAG CTTCCTTAGC TCCTGAAAAT CTCGATAACT CAAAAAATAC GCCCGGTAGT   4561 GATCTTATTT CATTATGGTG AAAGTTGGAA CCTCTTACGT GCCGATCAAC GTCTCATTTT   4621 CGCCAAAAGT TGGCCCAGGG CTTCCCGGTA TCAACAGGGA CACCAGGATT TATTTATTCT   4681 GCGAAGTGAT CTTCCGTCAC AGGTATTTAT TCGCGATAAG CTCATGGAGC GGCGTAACCG   4741 TCGCACAGGA AGGACAGAGA AAGCGCGGAT CTGGGAAGTG ACGGACAGAA CGGTCAGGAC   4801 CTGGATTGGG GAGGCGGTTG CCGCCGCTGC TGCTGACGGT GTGACGTTCT CTGTTCCGGT   4861 CACACCACAT ACGTTCCGCC ATTCCTATGC GATGCACATG CTGTATGCCG GTATACCGCT   4921 GAAAGTTCTG CAAAGCCTGA TGGGACATAA GTCCATCAGT TCAACGGAAG TCTACACGAA   4981 GGTTTTTGCG CTGGATGTGG CTGCCCGGCA CCGGGTGCAG TTTGCGATGC CGGAGTCTGA   5041 TGCGGTTGCG ATGCTGAAAC AATTATCCTG AGAATAAATG CCTTGGCCTT TATATGGAAA   5101 TGTGGAACTG AGTGGATATG CTGTTTTTGT CTGTTAAACA GAGAAGCTGG CTGTTATCCA   5161 CTGAGAAGCG AACGAAACAG TCGGGAAAAT CTCCCATTAT CGTAGAGATC CGCATTATTA   5221 ATCTCAGGAG CCTGTGTAGC GTTTATAGGA AGTAGTGTTC TGTCATGATG CCTGCAAGCG   5281 GTAACGAAAA CGATTTGAAT ATGCCTTCAG GAACAATAGA AATCTTCGTG CGGTGTTACG   5341 TTGAAGTGGA GCGGATTATG TCAGCAATGG ACAGAACAAC CTAATGAACA CAGAACCATG   5401 ATGTGGTCTG TCCTTTTACA GCCAGTAGTG CTCGCCGCAG TCGAGCGACA GGGCGAAGCC   5461 CTCGAGCTGG TTGCCCTCGC CGCTGGGCTG GCGGCCGTCT ATGGCCCTGC AAACGCGCCA   5521 GAAACGCCGT CGAAGCCGTG TGCGAGACAC CGCGGCCGGC CGCCGGCGTT GTGGATACCT   5581 CGCGGAAAAC TTGGCCCTCA CTGACAGATG AGGGGCGGAC GTTGACACTT GAGGGGCCGA   5641 CTCACCCGGC GCGGCGTTGA CAGATGAGGG GCAGGCTCGA TTTCGGCCGG CGACGTGGAG   5701 CTGGCCAGCC TCGCAAATCG GCGAAAACGC CTGATTTTAC GCGAGTTTCC CACAGATGAT   5761 GTGGACAAGC CTGGGGATAA GTGCCCTGCG GTATTGACAC TTGAGGGGCG CGACTACTGA   5821 CAGATGAGGG GCGCGATCCT TGACACTTGA GGGGCAGAGT GCTGACAGAT GAGGGGCGCA   5881 CCTATTGACA TTTGAGGGGC TGTCCACAGG CAGAAAATCC AGCATTTGCA AGGGTTTCCG   5941 CCCGTTTTTC GGCCACCGCT AACCTGTCTT TTAACCTGCT TTTAAACCAA TATTTATAAA   6001 CCTTGTTTTT AACCAGGGCT GCGCCCTGTG CGCGTGACCG CGCACGCCGA AGGGGGGTGC   6061 CCCCCCTTCT CGAACCCTCC CGGTCGAGTG AGCGAGGAAG CACCAGGGAA CAGCACTTAT   6121 ATATTCTGCT TACACACGAT GCCTGAAAAA ACTTCCCTTG GGGTTATCCA CTTATCCACG   6181 GGGATATTTT TATAATTATT TTTTTTATAG TTTTTAGATC TTCTTTTTTA GAGCGCCTTG   6241 TAGGCCTTTA TCCATGCTGG TTCTAGAGAA GGTGTTGTGA CAAATTGCCC TTTCAGTGTG   6301 ACAAATCACC CTCAAATGAC AGTCCTGTCT GTGACAAATT GCCCTTAACC CTGTGACAAA   6361 TTGCCCTCAG AAGAAGCTGT TTTTTCACAA AGTTATCCCT GCTTATTGAC TCTTTTTTAT   6421 TTAGTGTGAC AATCTAAAAA CTTGTCACAC TTCACATGGA TCTGTCATGG CGGAAACAGC   6481 GGTTATCAAT CACAAGAAAC GTAAAAATAG CCCGCGAATC GTCCAGTCAA ACGACCTCAC   6541 TGAGGCGGCA TATAGTCTCT CCCGGGATCA AAAACGTATG CTGTATCTGT TCGTTGACCA   6601 GATCAGAAAA TCTGATGGCA CCCTACAGGA ACATGACGGT ATCTGCGAGA TCCATGTTGC   6661 TAAATATGCT GAAATATTCG GATTGACCTC TGCGGAAGCC AGTAAGGATA TACGGCAGGC   6721 ATTGAAGAGT TTCGCGGGGA AGGAAGTGGT TTTTTATCGC CCTGAAGAGG ATGCCGGCGA   6781 TGAAAAAGGC TATGAATCTT TTCCTTGGTT TATCAAACGT GCGCACAGTC CATCCAGAGG   6841 GCTTTACAGT GTACATATCA ACCCATATCT CATTCCCTTC TTTATCGGGT TACAGAACCG   6901 GTTTACGCAG TTTCGGCTTA GTGAAACAAA AGAAATCACC AATCCGTATG CCATGCGTTT   6961 ATACGAATCC CTGTGTCAGT ATCGTAAGCC GGATGGCTCA GGCATCGTCT CTCTGAAAAT   7021 CGACTGGATC ATAGAGCGTT ACCAGCTGCC TCAAAGTTAC CAGCGTATGC CTGACTTCCG   7081 CCGCCGCTTC CTGCAGGTCT GTGTTAATGA GATCAACAGC AGAACTCCAA TGCGCCTCTC   7141 ATACATTGAG AAAAAGAAAG GCCGCCAGAC GACTCATATC GTATTTTCCT TCCGCGATAT   7201 CACTTCCATG ACGACAGGAT AGTCTGAGGG TTATCTGTCA CAGATTTGAG GGTGGTTCGT   7261 CACATTTGTT CTGACCTACT GAGGGTAATT TGTCACAGTT TTGCTGTTTC CTTCAGCCTG   7321 CATGGATTTT CTCATACTTT TTGAACTGTA ATTTTTAAGG AAGCCAAATT TGAGGGCAGT   7381 TTGTCACAGT TGATTTCCTT CTCTTTCCCT TCGTCATGTG ACCTGATATC GGGGGTTAGT   7441 TCGTCATCAT TGATGAGGGT TGATTATCAC AGTTTATTAC TCTGAATTGG CTATCCGCGT   7501 GTGTACCTCT ACCTGGAGTT TTTCCCACGG TGGATATTTC TTCTTGCGCT GAGCGTAAGA   7561 GCTATCTGAC AGAACAGTTC TTCTTTGCTT CCTCGCCAGT TCGCTCGCTA TGCTCGGTTA   7621 CACGGCTGCG GCGAGCGCTA GTGATAATAA GTGACTGAGG TATGTGCTCT TCTTATCTCC   7681 TTTTGTAGTG TTGCTCTTAT TTTAAACAAC TTTGCGGTTT TTTGATGACT TTGCGATTTT   7741 GTTGTTGCTT TGCAGTAAAT TGCAAGATTT AATAAAAAAA CGCAAAGCAA TGATTAAAGG   7801 ATGTTCAGAA TGAAACTCAT GGAAACACTT AACCAGTGCA TAAACGCTGG TCATGAAATG   7861 ACGAAGGCTA TCGCCATTGC ACAGTTTAAT GATGACAGCC CGGAAGCGAG GAAAATAACC   7921 CGGCGCTGGA GAATAGGTGA AGCAGCGGAT TTAGTTGGGG TTTCTTCTCA GGCTATCAGA   7981 GATGCCGAGA AAGCAGGGCG ACTACCGCAC CCGGATATGG AAATTCGAGG ACGGGTTGAG   8041 CAACGTGTTG GTTATACAAT TGAACAAATT AATCATATGC GTGATGTGTT TGGTACGCGA   8101 TTGCGACGTG CTGAAGACGT ATTTCCACCG GTGATCGGGG TTGCTGCCCA TAAAGGTGGC   8161 GTTTACAAAA CCTCAGTTTC TGTTCATCTT GCTCAGGATC TGGCTCTGAA GGGGCTACGT   8221 GTTTTGCTCG TGGAAGGTAA CGACCCCCAG GGAACAGCCT CAATGTATCA CGGATGGGTA   8281 CCAGATCTTC ATATTCATGC AGAAGACACT CTCCTGCCTT TCTATCTTGG GGAAAAGGAC   8341 GATGTCACTT ATGCAATAAA GCCCACTTGC TGGCCGGGGC TTGACATTAT TCCTTCCTGT   8401 CTGGCTCTGC ACCGTATTGA AACTGAGTTA ATGGGCAAAT TTGATGAAGG TAAACTGCCC   8461 ACCGATCCAC ACCTGATGCT CCGACTGGCC ATTGAAACTG TTGCTCATGA CTATGATGTC   8521 ATAGTTATTG ACAGCGCGCC TAACCTGGGT ATCGGCACGA TTAATGTCGT ATGTGCTGCT   8581 GATGTGCTGA TTGTTCCCAC GCCTGCTGAG TTGTTTGACT ACACCTCCGC ACTGCAGTTT   8641 TTCGATATGC TTCGTGATCT GCTCAAGAAC GTTGATCTTA AAGGGTTCGA GCCTGATGTA   8701 CGTATTTTGC TTACCAAATA CAGCAATAGC AATGGCTCTC AGTCCCCGTG GATGGAGGAG   8761 CAAATTCGGG ATGCCTGGGG AAGCATGGTT CTAAAAAATG TTGTACGTGA AACGGATGAA   8821 GTTGGTAAAG GTCAGATCCG GATGAGAACT GTTTTTGAAC AGGCCATTGA TCAACGCTCT   8881 TCAACTGGTG CCTGGAGAAA TGCTCTTTCT ATTTGGGAAC CTGTCTGCAA TGAAATTTTC   8941 GATCGTCTGA TTAAACCACG CTGGGAGATT AGATAATGAA GCGTGCGCCT GTTATTCCAA   9001 AACATACGCT CAATACTCAA CCGGTTGAAG ATACTTCGTT ATCGACACCA GCTGCCCCGA   9061 TGGTGGATTC GTTAATTGCG CGCGTAGGAG TAATGGCTCG CGGTAATGCC ATTACTTTGC   9121 CTGTATGTGG TCGGGATGTG AAGTTTACTC TTGAAGTGCT CCGGGGTGAT AGTGTTGAGA   9181 AGACCTCTCG GGTATGGTCA GGTAATGAAC GTGACCAGGA GCTGCTTACT GAGGACGCAC   9241 TGGATGATCT CATCCCTTCT TTTCTACTGA CTGGTCAACA GACACCGGCG TTCGGTCGAA   9301 GAGTATCTGG TGTCATAGAA ATTGCCGATG GGAGTCGCCG TCGTAAAGCT GCTGCACTTA   9361 CCGAAAGTGA TTATCGTGTT CTGGTTGGCG AGCTGGATGA TGAGCAGATG GCTGCATTAT   9421 CCAGATTGGG TAACGATTAT CGCCCAACAA GTGCTTATGA ACGTGGTCAG CGTTATGCAA   9481 GCCGATTGCA GAATGAATTT GCTGGAAATA TTTCTGCGCT GGCTGATGCG GAAAATATTT   9541 CACGTAAGAT TATTACCCGC TGTATCAACA CCGCCAAATT GCCTAAATCA GTTGTTGCTC   9601 TTTTTTCTCA CCCCGGTGAA CTATCTGCCC GGTCAGGTGA TGCACTTCAA AAAGCCTTTA   9661 CAGATAAAGA GGAATTACTT AAGCAGCAGG CATCTAACCT TCATGAGCAG AAAAAAGCTG   9721 GGGTGATATT TGAAGCTGAA GAAGTTATCA CTCTTTTAAC TTCTGTGCTT AAAACGTCAT   9781 CTGCATCAAG AACTAGTTTA AGCTCACGAC ATCAGTTTGC TCCTGGAGCG ACAGTATTGT   9841 ATAAGGGCGA TAAAATGGTG CTTAACCTGG ACAGGTCTCG TGTTCCAACT GAGTGTATAG   9901 AGAAAATTGA GGCCATTCTT AAGGAACTTG AAAAGCCAGC ACCCTGATGC GACCACGTTT   9961 TAGTCTACGT TTATCTGTCT TTACTTAATG TCCTTTGTTA CAGGCCAGAA AGCATAACTG  10021 GCCTGAATAT TCTCTCTGGG CCCACTGTTC CACTTGTATC GTCGGTCTGA TAATCAGACT  10081 GGGACCACGG TCCCACTCGT ATCGTCGGTC TGATTATTAG TCTGGGACCA CGGTCCCACT  10141 CGTATCGTCG GTCTGATTAT TAGTCTGGGA CCACGGTCCC ACTCGTATCG TCGGTCTGAT  10201 AATCAGACTG GGACCACGGT CCCACTCGTA TCGTCGGTCT GATTATTAGT CTGGGACCAT  10261 GGTCCCACTC GTATCGTCGG TCTGATTATT AGTCTGGGAC CACGGTCCCA CTCGTATCGT  10321 CGGTCTGATT ATTAGTCTGG AACCACGGTC CCACTCGTAT CGTCGGTCTG ATTATTAGTC  10381 TGGGACCACG GTCCCACTCG TATCGTCGGT CTGATTATTA GTCTGGGACC ACGATCCCAC  10441 TCGTGTTGTC GGTCTGATTA TCGGTCTGGG ACCACGGTCC CACTTGTATT GTCGATCAGA  10501 CTATCAGCGT GAGACTACGA TTCCATCAAT GCCTGTCAAG GGCAAGTATT GACATGTCGT  10561 CGTAACCTGT AGAACGGAGT AACCTCGGTG TGCGGTTGTA TGCCTGCTGT GGATTGCTGC  10621 TGTGTCCTGC TTATCCACAA CATTTTGCGC ACGGTTATGT GGAC (Payload Vector Exit1_FlpOUTneo) SEQ ID NO: 11      1 CCCCGAAAAG TGCCACCTGG GTCCTTTTCA TCACGTGCTA TAAAAATAAT TATAATTTAA     61 ATTTTTTAAT ATAAATATAT AAATTAAAAA TAGAAAGTAA AAAAAGAAAT TAAAGAAAAA    121 ATAGTTTTTG TTTTCCGAAG ATGTAAAAGA CTCTAGGGGG ATCGCCAACA AATACTACCT    181 TTTATCTTGC TCTTCCTGCT CTCAGGTATT AATGCCGAAT TGTTTCATCT TGTCTGTGTA    241 GAAGACCACA CACGAAAATC CTGTGATTTT ACATTTTACT TATCGTTAAT CGAATGTATA    301 TCTATTTAAT CTGCTTTTCT TGTCTAATAA ATATATATGT AAAGTACGCT TTTTGTTGAA    361 ATTTTTTAAA CCTTTGTTTA TTTTTTTTTC TTCATTCCGT AACTCTTCTA CCTTCTTTAT    421 TTACTTTCTA AAATCCAAAT ACAAAACATA AAAATAAATA AACACAGAGT AAATTCCCAA    481 ATTATTCCAT CATTAAAAGA TACGAGGCGC GTGTAAGTTA CAGGCAAGCG ATCCGTCCTA    541 AGAAACCATT ATTATCATGA CATTAACCTA TAAAAATAGG CGTATCACGA GGCCCTTTCG    601 TCTCGCGCGT TTCGGTGATG ACGGTGAAAA CCTCTGACAC ATGCAGCTCC CGGAGACGGT    661 CACAGOTTGT CTGTAAGCGG ATGCCGGGAG CAGACAAGCC CGTCAGGGCG CGTCAGCGCG    721 TGTTGGCGGG TGTCGGGGCT GGCTTAACTA TGCGGCATCA GAGCAGATTG TACTGAGAGT    781 GCACCATAAA TTCCCGTTTT AAGAGCTTGG TGAGCGCTAG GAGTCACTGC CAGGTATCGT    841 TTGAACACGG CATTAGTCAG GGAAGTCATA ACACAGTCCT TTCCCGCAAT TTTCTTTTTC    901 TATTACTCTT GGCCTCCTCT AGTACACTCT ATATTTTTTT ATGCCTCGGT AATGATTTTC    961 ATTTTTTTTT TTCCCCTAGC GGATGACTCT TTTTTTTTCT TAGCGATTGG CATTATCACA   1021 TAATGAATTA TACATTATAT AAAGTAATGT GATTTCTTCG AAGAATATAC TAAAAAATGA   1081 GCAGGCAAGA TAAACGAAGG CAAAGATGAC AGAGCAGAAA GCCCTAGTAA AGCGTATTAC   1141 AAATGAAACC AAGATTCAGA TTGCGATCTC TTTAAAGGGT GGTCCCCTAG CGATAGAGCA   1201 CTCGATCTTC CCAGAAAAAG AGGCAGAAGC AGTAGCAGAA CAGGCCACAC AATCGCAAGT   1261 GATTAACGTC CACACAGGTA TAGGGTTTCT GGACCATATG ATACATGCTC TGGCCAAGCA   1321 TTCCGGCTGG TCGCTAATCG TTGAGTGCAT TGGTGACTTA CACATAGACG ACCATCACAC   1381 CACTGAAGAC TGCGGGATTG CTCTCGGTCA AGCTTTTAAA GAGGCCCTAC TGGCGCGTGG   1441 AGTAAAAAGG TTTGGATCAG GATTTGCGCC TTTGGATGAG GCACTTTCCA GAGCGGTGGT   1501 AGATCTTTCG AACAGGCCGT ACGCAGTTGT CGAACTTGGT TTGCAAAGGG AGAAAGTAGG   1561 AGATCTCTCT TGCGAGATGA TCCCGCATTT TCTTGAAAGC TTTGCAGAGG CTAGCAGAAT   1621 TACCCTCCAC GTTGATTGTC TGCGAGGCAA GAATGATCAT CACCGTAGTG AGAGTGCGTT   1681 CAAGGCTCTT GCGGTTGCCA TAAGAGAAGC CACCTCGCCC AATGGTACCA ACGATGTTCC   1741 CTCCACCAAA GGTGTTCTTA TGTAGTGACA CCGATTATTT AAAGCTGCAG CATACGATAT   1801 ATATACATGT GTATATATGT ATACCTATGA ATGTCAGTAA GTATGTATAC GAACAGTATG   1861 ATACTGAAGA TGACAAGGTA ATGCATCATT CTATACGTGT CATTCTGAAC GAGGCGCGCT   1921 TTCCTTTTTT CTTTTTGCTT TTTCTTTTTT TTTCTCTTGA ACTCGACGGA TCTATGCGGT   1981 GTGAAATACC GCACAGATGC GTCCTAGGGC GGCCGCATAA CTTCGTATAG CATACATTAT   2041 ACGAAGTTAT CCGGAACCGA GTACAAGCCC ACGGTGCGCC TCGCCACCCG CGACGACGTC   2101 CCCAGGGCCG TCCGCACCCT CGCCGCCGCG TTCGCCGACT ACCCCGCCAC GCGCCACACC   2161 GTCGATCCGG ACCGCCACAT CGAGCGCGTG ACCGAGCTGC AAGAACTCTT CCTCACGCGC   2221 GTCGGGCTCG ACATCGGCAA GGTGTGGGTC GCGGACGACG GAGCCGCTGT GGCGGTCTGG   2281 ACCACGCCGG AGAGCGTCGA AGCGGGGGCG GTGTTCGCCG AGATCGGCCC GCGCATGGCC   2341 GAGTTGAGCG GTTCCCGGCT GGCCGCGCAG CAACAGATGG AGGGCCTCCT GGCTCCGCAC   2401 CGGCCCAAGG AGCCCGCGTG GTTCCTGGCC ACCGTCGGAG TCTCGCCCGA CCACCAGGGC   2461 AAGGGTCTGG GCAGCGCCGT CGTGCTCCCC GGAGTGGAGG CGGCCGAGCG CGCCGGGGTG   2521 CCCGCCTTCC TGGAAACCTC CGCGCCCCGC AACCTCCCCT TCTACGAGCG GCTCGGCTTC   2581 ACCGTCACCG CCGACGTCGA GGTGCCCGAA GGACCGCGCA CCTGGTGCAT GACCCGCAAG   2641 CCCGGTGCCG CATGCCCCAC GCTACTGCGG GTTTATATAG ACGGTCCCCA CGGGATGGGG   2701 AAAACCACCA CCACGCAACT GCTGGTGGCC CTGGGTTCGC GCGACGATAT CGTCTATGTA   2761 CCCGAGCCGA TGACTTACTG GCGGGTGCTG GGGGCTTCCG AGACAATCGC GAACATCTAC   2821 ACCACACAAC ACCGCCTCGA CCAGGGTGAG ATATCGGCCG GGGACGCGGC GGTGGTAATG   2881 ACAAGCGCCC AGATAACAAT GGGTATGCCT TATGCCGTGA CCGACGCCGT TCTGGCTCCT   2941 CATATCGGGG GGGAGGCTGG TAGCTCACAT GCCCCGCCCC CGGCCCTCAC CCTCATCTTC   3001 GACCGCCATC CCATCGCCGC CCTCCTGTGC TACCCGGCCG CGCGGTACCT TATGGGCAGC   3061 ATGACCCCCC AGGCCGTGCT GGCGTTCGTG GCCCTCATCC CGCCGACCTT GCCCGGCACC   3121 AACATCGTGC TTGGGGCCCT GCCGGAGGAC AGACACATCG ACCGCCTGGC CAAACGCCAG   3181 CGCCCCGGCG AGCGGCTGGA CCTGGCTATG CTGGCTGCGA TTCGCCGCGT TTACGGGCTA   3241 CTTGCCAATA CGGTGCGGTA TCTGCAGTGC GGCGGGTCGT GGCGGGAGGA CTGGGGACAG   3301 CTTTCGGGGA CGGCCGTGCC GCCCCAGGGT GCCGAGCCCC AGAGCAACGC GGGCCCACGA   3361 CCCCATATCG GGGACACGTT ATTTACCCTG TTTCGGGCCC CCGAGTTGCT GGCCCCCAAC   3421 GGCGACCTGT ATAACGTGTT TGCCTGGGCC TTGGACGTCT TGGCCAAACG CCTCCGTTCC   3481 ATGCACGTCT TTATCCTGGA TTACGACCAA TCGCCCGCCG GCTGCCGGGA CGCCCTGCTG   3541 CAACTTACCT CCGGGATGGT CCAGACCCAC GTCACCACCC CCGGCTCCAT ACCGACGATA   3601 TGCGACCTGG CGCGCACGTT TGCCCGCGAG ATGGGGGAGG CTAACGAGCT CGGCAGTGGA   3661 GAGGGCAGAG GAAGTCTGCT AACATGCGGT GACGTCGAGG AGAATCCTGG CCCAAGCCAG   3721 TTCGACATCC TGTGCAAGAC CCCCCCCAAG GTGCTGGTGC GGCAGTTCGT GGAGAGATTC   3781 GAGAGGCCCA GCGGCGAGAA GATCGCCAGC TGTGCCGCCG AGCTGACCTA CCTGTGCTGG   3841 ATGATCACCC ACAACGGCAC CGCCATCAAG AGGGCCACCT TCATGAGCTA CAACACCATC   3901 ATCAGCAACA GCCTGAGCTT CGACATCGTG AACAAGAGCC TGCAGTTCAA GTACAAGACC   3961 CAGAAGGCCA CCATCCTGGA GGCCAGCCTG AAGAAGCTGA TCCCCGCCTG GGAGTTCACC   4021 ATCATCCCTT ACAACGGCCA GAAGCACCAG AGCGACATCA CCGACATCGT GTCCAGCCTG   4081 CAGCTGCAGT TCGAGAGCAG CGAGGAGGCC GACAAGGGCA ACAGCCACAG CAAGAAGATG   4141 CTGAAGGCCC TGCTGTCCGA GGGCGAGAGC ATCTGGGAGA TCACCGAGAA GATCCTGAAC   4201 AGCTTCGAGT ACACCAGCAG GTTCACCAAG ACCAAGACCC TGTACCAGTT CCTGTTCCTG   4261 GCCACATTCA TCAACTGCGG CAGGTTCAGC GACATCAAGA ACGTGGACCC CAAGAGCTTC   4321 AAGCTGGTGC AGAACAAGTA CCTGGGCGTG ATCATTCAGT GCCTGGTGAC AGAAACCAAG   4381 ACAAGCGTGT CCAGGCACAT CTACTTTTTC AGCGCCAGAG GCAGGATCGA CCCCCTGGTG   4441 TACCTGGACG AGTTTCTGAG GAACAGCGAG CCCGTGCTGA AGAGAGTGAA CAGGACCGGC   4501 AACAGCAGCA GCAACAAGCA GGAGTACCAG CTGCTGAAGG ACAACCTGGT GCGCAGCTAC   4561 AACAAGGCCC TGAAGAAGAA CGCCCCCTAC CCCATCTTCG CTATCAAGAA CGGCCCTAAG   4621 AGCCACATCG GCAGGCACCT GATGACCAGC TTTCTGAGCA TGAAGGGCCT GACCGAGCTG   4681 ACAAACGTGG TGGGCAACTG GAGCGACAAG AGGGCCTCCG CCGTGGCCAG GACCACCTAC   4741 ACCCACCAGA TCACCGCCAT CCCCGACCAC TACTTCGCCC TGGTGTCCAG GTACTACGCC   4801 TACGACCCCA TCAGCAAGGA GATGATCGCC CTGAAGGACG AAACCAACCC CATCGAGGAG   4861 TGGCAGCACA TCGAGCAGCT GAAGGGCAGC GCCGAGGGCA GCATCAGATA CCCCGCCTGG   4921 AACGGCATCA TCAGCCAGGA GGTGCTGGAC TACCTGAGCA GCTACATCAA CAGGCGGATC   4981 ACCGGTTGCG TACGCGGATC CTCTGCTGGA GACATGAGAG CTGCCAACCT TTGGCCAAGC   5041 CCGCTCATGA TCAAACGCTC TAAGAAGAAC AGCCTGGCCT TGTCCCTGAC GGCCGACCAG   5101 ATGGTCAGTG CCTTGTTGGA TGCTGAGCCC CCCATACTCT ATTCCGAGTA TGATCCTACC   5161 AGACCCTTCA GTGAAGCTTC GATGATGGGC TTACTGACCA ACCTGGCAGA CAGGGAGCTG   5221 GTTCACATGA TCAACTGGGC GAAGAGGGTG CCAGGCTTTG TGGATTTGAC CCTCCATGAT   5281 CAGGTCCACC TTCTAGAATG TGCCTGGCTA GAGATCCTGA TGATTGGTCT CGTCTGGCGC   5341 TCCATGGAGC ACCCAGTGAA GCTACTGTTT GCTCCTAACT TGCTCTTGGA CAGGAACCAG   5401 GGAAAATGTG TAGAGGGCAT GGTGGAGATC TTCGACATGC TGCTGGCTAC ATCATCTCGG   5461 TTCCGCATGA TGAATCTGCA GGGAGAGGAG TTTGTGTGCC TCAAATCTAT TATTTTGCTT   5521 AATTCTGGAG TGTACACATT TCTGTCCAGC ACCCTGAAGT CTCTGGAAGA GAAGGACCAT   5581 ATCCACCGAG TCCTGGACAA GATCACAGAC ACTTTGATCC ACCTGATGGC CAAGGCAGGC   5641 CTGACCCTGC AGCAGCAGCA CCAGCGGCTG GCCCAGCTCC TCCTCATCCT CTCCCACATC   5701 AGGCACATGA GTAACAAAGG CATGGAGCAT CTGTACAGCA TGAAGTGCAA GAACGTGGTG   5761 CCCCTCTATG ACCTGCTGCT GGAGGCGGCG GACGCCCACC GCCTACATGC GCCCACTAGC   5821 CGTGGAGGGG CATCCGTGGA GGAGACGGAC CAAAGCCACT TGGCCACTGC GGGCTCTACT   5881 TCATCGCATT CCTTGCAAAA GTATTACATC ACGGGGGAGG CAGAGGGTTT CCCTGCCACA   5941 GCTGGCTCCG GCGAGGGCAG GGGAAGTCTT CTAACATGCG GGGACGTGGA GGAAAATCCC   6001 GGCCCAGTGA GCAAGGGTGA GGAGGATAAC ATGGCCTCTC TCCCAGCGAC ACATGAGTTA   6061 CACATCTTTG GCTCCATCAA CGGTGTGGAC TTTGACATGG TGGGTCAGGG CACCGGCAAT   6121 CCAAATGATG GTTATGAGGA GTTAAACCTG AAGTCCACCA AGGGCGACCT CCAGTTCTCC   6181 CCCTGGATTC TGGTCCCTCA TATCGGGTAT GGCTTCCATC AGTACCTGCC CTACCCTGAC   6241 GGGATGTCGC CTTTCCAGGC CGCCATGGTA GATGGCTCTG GATACCAAGT CCATCGCACA   6301 ATGCAGTTTG AAGATGGTGC CTCCCTTACT GTGAACTACC GCTACACCTA CGAGGGAAGC   6361 CACATCAAAG GAGAGGCCCA GGTGAAGGGG ACTGGTTTCC CTGCTGACGG TCCTGTGATG   6421 ACCAACTCGC TGACCGCTGC GGACTGGTGC AGGTCGAAGA AGACTTACCC CAACGACAAA   6481 ACCATCATCA GTACCTTTAA GTGGAGTTAC ACCACTGGAA ATGGCAAGCG CTACCGGAGC   6541 ACTGCGCGGA CCACCTACAC CTTTGCCAAG CCAATGGCGG CTAACTATCT GAAGAACCAG   6601 CCGATGTACG TGTTCCGTAA GACGGAACTC AAGCACTCCA AGACCGAGCT GAACTTCAAG   6661 GAGTGGCAAA AGGCGTTTAC CGATGTGATG GGCATGGACG AGCTGTACAA GTGAATTCGA   6721 TCATAATCAG CCATACCACA TTTGTAGAGG TTTTACTTGC TTTAAAAAAC CTCCCACACC   6781 TCCCCCTGAA CCTGAAACAT AAAATGAATG CAATTGTTGT TGTTAACTTG TTTATTGCAG   6841 CTTATAATGG TTACAAATAA AGCAATAGCA TCACAAATTT CACAAATAAA GCATTTTTTT   6901 CACTGCATTC TAGTTGTGGT TTGTCCAAAC TCATCAATGT ATCTTATCAT GTCTGGCTCG   6961 AGGGAAGTTC CTATACTCTA GAAAGAATAG GAACTTCGGC GGACGCGTAT AGATCAGGCG   7021 CGCCACAACT TCGTATAGAA AGGTATATAC GAAGTTGTGC GGCCGCGTCG ACCAATTCTC   7081 ATGTTTGACA GOTTATCATC GAATTTCTGC CATTCATCCG CTTATTATCA CTTATTCAGG   7141 CGTAGCAACC AGGCGTTTAA GGGCACCAAT AACTGCCTTA AAAAAATTAG AAAAACTCAT   7201 CGAGCATCAA ATGAAACTGC AATTTATTCA TATCAGGATT ATCAATACCA TATTTTTGAA   7261 AAAGCCGTTT CTGTAATGAA GGAGAAAACT CACCGAGGCA GTTCCATAGG ATGGCAAGAT   7321 CCTGGTATCG GTCTGCGATT CCGACTCGTC CAACATCAAT ACAACCTATT AATTTCCCCT   7381 CGTCAAAAAT AAGGTTATCA AGTGAGAAAT CACCATGAGT GACGACTGAA TCCGGTGAGA   7441 ATGGCAAAAG CTTATGCATT TCTTTCCAGA CTTGTTCAAC AGGCCAGCCA TTACGCTCGT   7501 CATCAAAATC ACTCGCATCA ACCAAACCGT TATTCATTCG TGATTGCGCC TGAGCGAGAC   7561 GAAATACGCG ATCGCTGTTA AAAGGACAAT TACAAACAGG AATCGAATGC AACCGGCGCA   7621 GGAACACTGC CAGCGCATCA ACAATATTTT CACCTGAATC AGGATATTCT TCTAATACCT   7681 GGAATGCTGT TTTCCCTGGG ATCGCAGTGG TGAGTAACCA TGCATCATCA GGAGTACGGA   7741 TAAAATGCTT GATGGTCGGA AGAGGCATAA ATTCCGTCAG CCAGTTTAGT CTGACCATCT   7801 CATCTGTAAC ATCATTGGCA ACGCTACCTT TGCCATGTTT CAGAAACAAC TCTGGCGCAT   7861 CGGGCTTCCC ATACAATCGA TAGATTGTCG CACCTGATTG CCCGACATTA TCGCGAGCCC   7921 ATTTATACCC ATATAAATCA GCATCCATGT TGGAATTTAA TCGCGGCCTC GAGCAAGACG   7981 TTTCCCGTTG AATATGGCTC ATTTTAGCTT CCTTAGCTCC TGAAAATCTC GATAACTCAA   8041 AAAATACGCC CGGTAGTGAT CTTATTTCAT TATGGTGAAA GTTGGAACCT CTTACGTGCC   8101 GATCAACGTC TCATTTTCGC CAAAAGTTGG CCCAGGGCTT CCCGGTATCA ACAGGGACAC   8161 CAGGATTTAT TTATTCTGCG AAGTGATCTT CCGTCACAGG TATTTATTCG CGATAAGCTC   8221 ATGGAGCGGC GTAACCGTCG CACAGGAAGG ACAGAGAAAG CGCGGATCTG GGAAGTGACG   8281 GACAGAACGG TCAGGACCTG GATTGGGGAG GCGGTTGCCG CCGCTGCTGC TGACGGTGTG   8341 ACGTTCTCTG TTCCGGTCAC ACCACATACG TTCCGCCATT CCTATGCGAT GCACATGCTG   8401 TATGCCGGTA TACCGCTGAA AGTTCTGCAA AGCCTGATGG GACATAAGTC CATCAGTTCA   8461 ACGGAAGTCT ACACGAAGGT TTTTGCGCTG GATGTGGCTG CCCGGCACCG GGTGCAGTTT   8521 GCGATGCCGG AGTCTGATGC GGTTGCGATG CTGAAACAAT TATCCTGAGA ATAAATGCCT   8581 TGGCCTTTAT ATGGAAATGT GGAACTGAGT GGATATGCTG TTTTTGTCTG TTAAACAGAG   8641 AAGCTGGCTG TTATCCACTG AGAAGCGAAC GAAACAGTCG GGAAAATCTC CCATTATCGT   8701 AGAGATCCGC ATTATTAATC TCAGGAGCCT GTGTAGCGTT TATAGGAAGT AGTGTTCTGT   8761 CATGATGCCT GCAAGCGGTA ACGAAAACGA TTTGAATATG CCTTCAGGAA CAATAGAAAT   8821 CTTCGTGCGG TGTTACGTTG AAGTGGAGCG GATTATGTCA GCAATGGACA GAACAACCTA   8881 ATGAACACAG AACCATGATG TGGTCTGTCC TTTTACAGCC AGTAGTGCTC GCCGCAGTCG   8941 AGCGACAGGG CGAAGCCCTC GAGCTGGTTG CCCTCGCCGC TGGGCTGGCG GCCGTCTATG   9001 GCCCTGCAAA CGCGCCAGAA ACGCCGTCGA AGCCGTGTGC GAGACACCGC GGCCGGCCGC   9061 CGGCGTTGTG GATACCTCGC GGAAAACTTG GCCCTCACTG ACAGATGAGG GGCGGACGTT   9121 GACACTTGAG GGGCCGACTC ACCCGGCGCG GCGTTGACAG ATGAGGGGCA GGCTCGATTT   9181 CGGCCGGCGA CGTGGAGCTG GCCAGCCTCG CAAATCGGCG AAAACGCCTG ATTTTACGCG   9241 AGTTTCCCAC AGATGATGTG GACAAGCCTG GGGATAAGTG CCCTGCGGTA TTGACACTTG   9301 AGGGGCGCGA CTACTGACAG ATGAGGGGCG CGATCCTTGA CACTTGAGGG GCAGAGTGCT   9361 GACAGATGAG GGGCGCACCT ATTGACATTT GAGGGGCTGT CCACAGGCAG AAAATCCAGC   9421 ATTTGCAAGG GTTTCCGCCC GTTTTTCGGC CACCGCTAAC CTGTCTTTTA ACCTGCTTTT   9481 AAACCAATAT TTATAAACCT TGTTTTTAAC CAGGGCTGCG CCCTGTGCGC GTGACCGCGC   9541 ACGCCGAAGG GGGGTGCCCC CCCTTCTCGA ACCCTCCCGG TCGAGTGAGC GAGGAAGCAC   9601 CAGGGAACAG CACTTATATA TTCTGCTTAC ACACGATGCC TGAAAAAACT TCCCTTGGGG   9661 TTATCCACTT ATCCACGGGG ATATTTTTAT AATTATTTTT TTTATAGTTT TTAGATCTTC   9721 TTTTTTAGAG CGCCTTGTAG GCCTTTATCC ATGCTGGTTC TAGAGAAGGT GTTGTGACAA   9781 ATTGCCCTTT CAGTGTGACA AATCACCCTC AAATGACAGT CCTGTCTGTG ACAAATTGCC   9841 CTTAACCCTG TGACAAATTG CCCTCAGAAG AAGCTGTTTT TTCACAAAGT TATCCCTGCT   9901 TATTGACTCT TTTTTATTTA GTGTGACAAT CTAAAAACTT GTCACACTTC ACATGGATCT   9961 GTCATGGCGG AAACAGCGGT TATCAATCAC AAGAAACGTA AAAATAGCCC GCGAATCGTC  10021 CAGTCAAACG ACCTCACTGA GGCGGCATAT AGTCTCTCCC GGGATCAAAA ACGTATGCTG  10081 TATCTGTTCG TTGACCAGAT CAGAAAATCT GATGGCACCC TACAGGAACA TGACGGTATC  10141 TGCGAGATCC ATGTTGCTAA ATATGCTGAA ATATTCGGAT TGACCTCTGC GGAAGCCAGT  10201 AAGGATATAC GGCAGGCATT GAAGAGTTTC GCGGGGAAGG AAGTGGTTTT TTATCGCCCT  10261 GAAGAGGATG CCGGCGATGA AAAAGGCTAT GAATCTTTTC CTTGGTTTAT CAAACGTGCG  10321 CACAGTCCAT CCAGAGGGCT TTACAGTGTA CATATCAACC CATATCTCAT TCCCTTCTTT  10381 ATCGGGTTAC AGAACCGGTT TACGCAGTTT CGGCTTAGTG AAACAAAAGA AATCACCAAT  10441 CCGTATGCCA TGCGTTTATA CGAATCCCTG TGTCAGTATC GTAAGCCGGA TGGCTCAGGC  10501 ATCGTCTCTC TGAAAATCGA CTGGATCATA GAGCGTTACC AGCTGCCTCA AAGTTACCAG  10561 CGTATGCCTG ACTTCCGCCG CCGCTTCCTG CAGGTCTGTG TTAATGAGAT CAACAGCAGA  10621 ACTCCAATGC GCCTCTCATA CATTGAGAAA AAGAAAGGCC GCCAGACGAC TCATATCGTA  10681 TTTTCCTTCC GCGATATCAC TTCCATGACG ACAGGATAGT CTGAGGGTTA TCTGTCACAG  10741 ATTTGAGGGT GGTTCGTCAC ATTTGTTCTG ACCTACTGAG GGTAATTTGT CACAGTTTTG  10801 CTGTTTCCTT CAGCCTGCAT GGATTTTCTC ATACTTTTTG AACTGTAATT TTTAAGGAAG  10861 CCAAATTTGA GGGCAGTTTG TCACAGTTGA TTTCCTTCTC TTTCCCTTCG TCATGTGACC  10921 TGATATCGGG GGTTAGTTCG TCATCATTGA TGAGGGTTGA TTATCACAGT TTATTACTCT  10981 GAATTGGCTA TCCGCGTGTG TACCTCTACC TGGAGTTTTT CCCACGGTGG ATATTTCTTC  11041 TTGCGCTGAG CGTAAGAGCT ATCTGACAGA ACAGTTCTTC TTTGCTTCCT CGCCAGTTCG  11101 CTCGCTATGC TCGGTTACAC GGCTGCGGCG AGCGCTAGTG ATAATAAGTG ACTGAGGTAT  11161 GTGCTCTTCT TATCTCCTTT TGTAGTGTTG CTCTTATTTT AAACAACTTT GCGGTTTTTT  11221 GATGACTTTG CGATTTTGTT GTTGCTTTGC AGTAAATTGC AAGATTTAAT AAAAAAACGC  11281 AAAGCAATGA TTAAAGGATG TTCAGAATGA AACTCATGGA AACACTTAAC CAGTGCATAA  11341 ACGCTGGTCA TGAAATGACG AAGGCTATCG CCATTGCACA GTTTAATGAT GACAGCCCGG  11401 AAGCGAGGAA AATAACCCGG CGCTGGAGAA TAGGTGAAGC AGCGGATTTA GTTGGGGTTT  11461 CTTCTCAGGC TATCAGAGAT GCCGAGAAAG CAGGGCGACT ACCGCACCCG GATATGGAAA  11521 TTCGAGGACG GGTTGAGCAA CGTGTTGGTT ATACAATTGA ACAAATTAAT CATATGCGTG  11581 ATGTGTTTGG TACGCGATTG CGACGTGCTG AAGACGTATT TCCACCGGTG ATCGGGGTTG  11641 CTGCCCATAA AGGTGGCGTT TACAAAACCT CAGTTTCTGT TCATCTTGCT CAGGATCTGG  11701 CTCTGAAGGG GCTACGTGTT TTGCTCGTGG AAGGTAACGA CCCCCAGGGA ACAGCCTCAA  11761 TGTATCACGG ATGGGTACCA GATCTTCATA TTCATGCAGA AGACACTCTC CTGCCTTTCT  11821 ATCTTGGGGA AAAGGACGAT GTCACTTATG CAATAAAGCC CACTTGCTGG CCGGGGCTTG  11881 ACATTATTCC TTCCTGTCTG GCTCTGCACC GTATTGAAAC TGAGTTAATG GGCAAATTTG  11941 ATGAAGGTAA ACTGCCCACC GATCCACACC TGATGCTCCG ACTGGCCATT GAAACTGTTG  12001 CTCATGACTA TGATGTCATA GTTATTGACA GCGCGCCTAA CCTGGGTATC GGCACGATTA  12061 ATGTCGTATG TGCTGCTGAT GTGCTGATTG TTCCCACGCC TGCTGAGTTG TTTGACTACA  12121 CCTCCGCACT GCAGTTTTTC GATATGCTTC GTGATCTGCT CAAGAACGTT GATCTTAAAG  12181 GGTTCGAGCC TGATGTACGT ATTTTGCTTA CCAAATACAG CAATAGCAAT GGCTCTCAGT  12241 CCCCGTGGAT GGAGGAGCAA ATTCGGGATG CCTGGGGAAG CATGGTTCTA AAAAATGTTG  12301 TACGTGAAAC GGATGAAGTT GGTAAAGGTC AGATCCGGAT GAGAACTGTT TTTGAACAGG  12361 CCATTGATCA ACGCTCTTCA ACTGGTGCCT GGAGAAATGC TOTTTCTATT TGGGAACCTG  12421 TCTGCAATGA AATTTTCGAT CGTCTGATTA AACCACGCTG GGAGATTAGA TAATGAAGCG  12481 TGCGCCTGTT ATTCCAAAAC ATACGCTCAA TACTCAACCG GTTGAAGATA CTTCGTTATC  12541 GACACCAGCT GCCCCGATGG TGGATTCGTT AATTGCGCGC GTAGGAGTAA TGGCTCGCGG  12601 TAATGCCATT ACTTTGCCTG TATGTGGTCG GGATGTGAAG TTTACTCTTG AAGTGCTCCG  12661 GGGTGATAGT GTTGAGAAGA CCTCTCGGGT ATGGTCAGGT AATGAACGTG ACCAGGAGCT  12721 GCTTACTGAG GACGCACTGG ATGATCTCAT CCCTTCTTTT CTACTGACTG GTCAACAGAC  12781 ACCGGCGTTC GGTCGAAGAG TATCTGGTGT CATAGAAATT GCCGATGGGA GTCGCCGTCG  12841 TAAAGCTGCT GCACTTACCG AAAGTGATTA TCGTGTTCTG GTTGGCGAGC TGGATGATGA  12901 GCAGATGGCT GCATTATCCA GATTGGGTAA CGATTATCGC CCAACAAGTG CTTATGAACG  12961 TGGTCAGCGT TATGCAAGCC GATTGCAGAA TGAATTTGCT GGAAATATTT CTGCGCTGGC  13021 TGATGCGGAA AATATTTCAC GTAAGATTAT TACCCGCTGT ATCAACACCG CCAAATTGCC  13081 TAAATCAGTT GTTGCTCTTT TTTCTCACCC CGGTGAACTA TCTGCCCGGT CAGGTGATGC  13141 ACTTCAAAAA GCCTTTACAG ATAAAGAGGA ATTACTTAAG CAGCAGGCAT CTAACCTTCA  13201 TGAGCAGAAA AAAGCTGGGG TGATATTTGA AGCTGAAGAA GTTATCACTC TTTTAACTTC  13261 TGTGCTTAAA ACGTCATCTG CATCAAGAAC TAGTTTAAGC TCACGACATC AGTTTGCTCC  13321 TGGAGCGACA GTATTGTATA AGGGCGATAA AATGGTGCTT AACCTGGACA GGTCTCGTGT  13381 TCCAACTGAG TGTATAGAGA AAATTGAGGC CATTCTTAAG GAACTTGAAA AGCCAGCACC  13441 CTGATGCGAC CACGTTTTAG TCTACGTTTA TCTGTCTTTA CTTAATGTCC TTTGTTACAG  13501 GCCAGAAAGC ATAACTGGCC TGAATATTCT CTCTGGGCCC ACTGTTCCAC TTGTATCGTC  13561 GGTCTGATAA TCAGACTGGG ACCACGGTCC CACTCGTATC GTCGGTCTGA TTATTAGTCT  13621 GGGACCACGG TCCCACTCGT ATCGTCGGTC TGATTATTAG TCTGGGACCA CGGTCCCACT  13681 CGTATCGTCG GTCTGATAAT CAGACTGGGA CCACGGTCCC ACTCGTATCG TCGGTCTGAT  13741 TATTAGTCTG GGACCATGGT CCCACTCGTA TCGTCGGTCT GATTATTAGT CTGGGACCAC  13801 GGTCCCACTC GTATCGTCGG TCTGATTATT AGTCTGGAAC CACGGTCCCA CTCGTATCGT  13861 CGGTCTGATT ATTAGTCTGG GACCACGGTC CCACTCGTAT CGTCGGTCTG ATTATTAGTC  13921 TGGGACCACG ATCCCACTCG TGTTGTCGGT CTGATTATCG GTCTGGGACC ACGGTCCCAC  13981 TTGTATTGTC GATCAGACTA TCAGCGTGAG ACTACGATTC CATCAATGCC TGTCAAGGGC  14041 AAGTATTGAC ATGTCGTCGT AACCTGTAGA ACGGAGTAAC CTCGGTGTGC GGTTGTATGC  14101 CTGCTGTGGA TTGCTGCTGT GTCCTGCTTA TCCACAACAT TTTGCGCACG GTTATGTGGA  14161 C (Payload Vector Exit2_FlpOUTneo) SEQ ID NO: 12      1 CCCCGAAAAG TGCCACCTGG GTCCTTTTCA TCACGTGCTA TAAAAATAAT TATAATTTAA     61 ATTTTTTAAT ATAAATATAT AAATTAAAAA TAGAAAGTAA AAAAAGAAAT TAAAGAAAAA    121 ATAGTTTTTG TTTTCCGAAG ATGTAAAAGA CTCTAGGGGG ATCGCCAACA AATACTACCT    181 TTTATCTTGC TCTTCCTGCT CTCAGGTATT AATGCCGAAT TGTTTCATCT TGTCTGTGTA    241 GAAGACCACA CACGAAAATC CTGTGATTTT ACATTTTACT TATCGTTAAT CGAATGTATA    301 TCTATTTAAT CTGCTTTTCT TGTCTAATAA ATATATATGT AAAGTACGCT TTTTGTTGAA    361 ATTTTTTAAA CCTTTGTTTA TTTTTTTTTC TTCATTCCGT AACTCTTCTA CCTTCTTTAT    421 TTACTTTCTA AAATCCAAAT ACAAAACATA AAAATAAATA AACACAGAGT AAATTCCCAA    481 ATTATTCCAT CATTAAAAGA TACGAGGCGC GTGTAAGTTA CAGGCAAGCG ATCCGTCCTA    541 AGAAACCATT ATTATCATGA CATTAACCTA TAAAAATAGG CGTATCACGA GGCCCTTTCG    601 TCTCGCGCGT TTCGGTGATG ACGGTGAAAA CCTCTGACAC ATGCAGCTCC CGGAGACGGT    661 CACAGOTTGT CTGTAAGCGG ATGCCGGGAG CAGACAAGCC CGTCAGGGCG CGTCAGCGCG    721 TGTTGGCGGG TGTCGGGGCT GGCTTAACTA TGCGGCATCA GAGCAGATTG TACTGAGAGT    781 GCACCATAAA TTCCCGTTTT AAGAGCTTGG TGAGCGCTAG GAGTCACTGC CAGGTATCGT    841 TTGAACACGG CATTAGTCAG GGAAGTCATA ACACAGTCCT TTCCCGCAAT TTTCTTTTTC    901 TATTACTCTT GGCCTCCTCT AGTACACTCT ATATTTTTTT ATGCCTCGGT AATGATTTTC    961 ATTTTTTTTT TTCCCCTAGC GGATGACTCT TTTTTTTTCT TAGCGATTGG CATTATCACA   1021 TAATGAATTA TACATTATAT AAAGTAATGT GATTTCTTCG AAGAATATAC TAAAAAATGA   1081 GCAGGCAAGA TAAACGAAGG CAAAGATGAC AGAGCAGAAA GCCCTAGTAA AGCGTATTAC   1141 AAATGAAACC AAGATTCAGA TTGCGATCTC TTTAAAGGGT GGTCCCCTAG CGATAGAGCA   1201 CTCGATCTTC CCAGAAAAAG AGGCAGAAGC AGTAGCAGAA CAGGCCACAC AATCGCAAGT   1261 GATTAACGTC CACACAGGTA TAGGGTTTCT GGACCATATG ATACATGCTC TGGCCAAGCA   1321 TTCCGGCTGG TCGCTAATCG TTGAGTGCAT TGGTGACTTA CACATAGACG ACCATCACAC   1381 CACTGAAGAC TGCGGGATTG CTCTCGGTCA AGCTTTTAAA GAGGCCCTAC TGGCGCGTGG   1441 AGTAAAAAGG TTTGGATCAG GATTTGCGCC TTTGGATGAG GCACTTTCCA GAGCGGTGGT   1501 AGATCTTTCG AACAGGCCGT ACGCAGTTGT CGAACTTGGT TTGCAAAGGG AGAAAGTAGG   1561 AGATCTCTCT TGCGAGATGA TCCCGCATTT TCTTGAAAGC TTTGCAGAGG CTAGCAGAAT   1621 TACCCTCCAC GTTGATTGTC TGCGAGGCAA GAATGATCAT CACCGTAGTG AGAGTGCGTT   1681 CAAGGCTCTT GCGGTTGCCA TAAGAGAAGC CACCTCGCCC AATGGTACCA ACGATGTTCC   1741 CTCCACCAAA GGTGTTCTTA TGTAGTGACA CCGATTATTT AAAGCTGCAG CATACGATAT   1801 ATATACATGT GTATATATGT ATACCTATGA ATGTCAGTAA GTATGTATAC GAACAGTATG   1861 ATACTGAAGA TGACAAGGTA ATGCATCATT CTATACGTGT CATTCTGAAC GAGGCGCGCT   1921 TTCCTTTTTT CTTTTTGCTT TTTCTTTTTT TTTCTCTTGA ACTCGACGGA TCTATGCGGT   1981 GTGAAATACC GCACAGATGC GTCCTAGGGC GGCCGCATAA CTTCGTATAG CATACATTAT   2041 ACGAAGTTAT CCGGAAAAAC ATTTAACATT TCTCAACAAG ATCTAGAATT AGTAGAAGTA   2101 GCGACAGAGA AGATTACAAT GOTTTATGAG GATAATAAAC ATCATGTGGG AGCGGCAATT   2161 CGTACGAAAA CAGGAGAAAT CATTTCGGCA GTACATATTG AAGCGTATAT AGGACGAGTA   2221 ACTGTTTGTG CAGAAGCCAT TGCGATTGGT AGTGCAGTTT CGAATGGACA AAAGGATTTT   2281 GACACGATTG TAGCTGTTAG ACACCCTTAT TCTGACGAAG TAGATAGAAG TATTCGAGTG   2341 GTAAGTCCTT GTGGTATGTG TAGGGAGTTG ATTTCAGACT ATGCACCAGA TTGTTTTGTG   2401 TTAATAGAAA TGAATGGCAA GTTAGTCAAA ACTACGATTG AAGAACTCAT TCCACTCAAA   2461 TATACCCGAA ATGCATGCCC CACGCTACTG CGGGTTTATA TAGACGGTCC CCACGGGATG   2521 GGGAAAACCA CCACCACGCA ACTGCTGGTG GCCCTGGGTT CGCGCGACGA TATCGTCTAT   2581 GTACCCGAGC CGATGACTTA CTGGCGGGTG CTGGGGGCTT CCGAGACAAT CGCGAACATC   2641 TACACCACAC AACACCGCCT CGACCAGGGT GAGATATCGG CCGGGGACGC GGCGGTGGTA   2701 ATGACAAGCG CCCAGATAAC AATGGGTATG CCTTATGCCG TGACCGACGC CGTTCTGGCT   2761 CCTCATATCG GGGGGGAGGC TGGTAGCTCA CATGCCCCGC CCCCGGCCCT CACCCTCATC   2821 TTCGACCGCC ATCCCATCGC CGCCCTCCTG TGCTACCCGG CCGCGCGGTA CCTTATGGGC   2881 AGCATGACCC CCCAGGCCGT GCTGGCGTTC GTGGCCCTCA TCCCGCCGAC CTTGCCCGGC   2941 ACCAACATCG TGCTTGGGGC CCTGCCGGAG GACAGACACA TCGACCGCCT GGCCAAACGC   3001 CAGCGCCCCG GCGAGCGGCT GGACCTGGCT ATGCTGGCTG CGATTCGCCG CGTTTACGGG   3061 CTACTTGCCA ATACGGTGCG GTATCTGCAG TGCGGCGGGT CGTGGCGGGA GGACTGGGGA   3121 CAGCTTTCGG GGACGGCCGT GCCGCCCCAG GGTGCCGAGC CCCAGAGCAA CGCGGGCCCA   3181 CGACCCCATA TCGGGGACAC GTTATTTACC CTGTTTCGGG CCCCCGAGTT GCTGGCCCCC   3241 AACGGCGACC TGTATAACGT GTTTGCCTGG GCCTTGGACG TCTTGGCCAA ACGCCTCCGT   3301 TCCATGCACG TCTTTATCCT GGATTACGAC CAATCGCCCG CCGGCTGCCG GGACGCCCTG   3361 CTGCAACTTA CCTCCGGGAT GGTCCAGACC CACGTCACCA CCCCCGGCTC CATACCGACG   3421 ATATGCGACC TGGCGCGCAC GTTTGCCCGC GAGATGGGGG AGGCTAACGA GCTCGGCAGT   3481 GGAGAGGGCA GAGGAAGTCT GCTAACATGC GGTGACGTCG AGGAGAATCC TGGCCCAAGC   3541 CAGTTCGACA TCCTGTGCAA GACCCCCCCC AAGGTGCTGG TGCGGCAGTT CGTGGAGAGA   3601 TTCGAGAGGC CCAGCGGCGA GAAGATCGCC AGCTGTGCCG CCGAGCTGAC CTACCTGTGC   3661 TGGATGATCA CCCACAACGG CACCGCCATC AAGAGGGCCA CCTTCATGAG CTACAACACC   3721 ATCATCAGCA ACAGCCTGAG CTTCGACATC GTGAACAAGA GCCTGCAGTT CAAGTACAAG   3781 ACCCAGAAGG CCACCATCCT GGAGGCCAGC CTGAAGAAGC TGATCCCCGC CTGGGAGTTC   3841 ACCATCATCC CTTACAACGG CCAGAAGCAC CAGAGCGACA TCACCGACAT CGTGTCCAGC   3901 CTGCAGCTGC AGTTCGAGAG CAGCGAGGAG GCCGACAAGG GCAACAGCCA CAGCAAGAAG   3961 ATGCTGAAGG CCCTGCTGTC CGAGGGCGAG AGCATCTGGG AGATCACCGA GAAGATCCTG   4021 AACAGCTTCG AGTACACCAG CAGGTTCACC AAGACCAAGA CCCTGTACCA GTTCCTGTTC   4081 CTGGCCACAT TCATCAACTG CGGCAGGTTC AGCGACATCA AGAACGTGGA CCCCAAGAGC   4141 TTCAAGCTGG TGCAGAACAA GTACCTGGGC GTGATCATTC AGTGCCTGGT GACAGAAACC   4201 AAGACAAGCG TGTCCAGGCA CATCTACTTT TTCAGCGCCA GAGGCAGGAT CGACCCCCTG   4261 GTGTACCTGG ACGAGTTTCT GAGGAACAGC GAGCCCGTGC TGAAGAGAGT GAACAGGACC   4321 GGCAACAGCA GCAGCAACAA GCAGGAGTAC CAGCTGCTGA AGGACAACCT GGTGCGCAGC   4381 TACAACAAGG CCCTGAAGAA GAACGCCCCC TACCCCATCT TCGCTATCAA GAACGGCCCT   4441 AAGAGCCACA TCGGCAGGCA CCTGATGACC AGCTTTCTGA GCATGAAGGG CCTGACCGAG   4501 CTGACAAACG TGGTGGGCAA CTGGAGCGAC AAGAGGGCCT CCGCCGTGGC CAGGACCACC   4561 TACACCCACC AGATCACCGC CATCCCCGAC CACTACTTCG CCCTGGTGTC CAGGTACTAC   4621 GCCTACGACC CCATCAGCAA GGAGATGATC GCCCTGAAGG ACGAAACCAA CCCCATCGAG   4681 GAGTGGCAGC ACATCGAGCA GCTGAAGGGC AGCGCCGAGG GCAGCATCAG ATACCCCGCC   4741 TGGAACGGCA TCATCAGCCA GGAGGTGCTG GACTACCTGA GCAGCTACAT CAACAGGCGG   4801 ATCACCGGTT GCGTACGCGG ATCCTCTGCT GGAGACATGA GAGCTGCCAA CCTTTGGCCA   4861 AGCCCGCTCA TGATCAAACG CTCTAAGAAG AACAGCCTGG CCTTGTCCCT GACGGCCGAC   4921 CAGATGGTCA GTGCCTTGTT GGATGCTGAG CCCCCCATAC TCTATTCCGA GTATGATCCT   4981 ACCAGACCCT TCAGTGAAGC TTCGATGATG GGCTTACTGA CCAACCTGGC AGACAGGGAG   5041 CTGGTTCACA TGATCAACTG GGCGAAGAGG GTGCCAGGCT TTGTGGATTT GACCCTCCAT   5101 GATCAGGTCC ACCTTCTAGA ATGTGCCTGG CTAGAGATCC TGATGATTGG TCTCGTCTGG   5161 CGCTCCATGG AGCACCCAGT GAAGCTACTG TTTGCTCCTA ACTTGCTCTT GGACAGGAAC   5221 CAGGGAAAAT GTGTAGAGGG CATGGTGGAG ATCTTCGACA TGCTGCTGGC TACATCATCT   5281 CGGTTCCGCA TGATGAATCT GCAGGGAGAG GAGTTTGTGT GCCTCAAATC TATTATTTTG   5341 CTTAATTCTG GAGTGTACAC ATTTCTGTCC AGCACCCTGA AGTCTCTGGA AGAGAAGGAC   5401 CATATCCACC GAGTCCTGGA CAAGATCACA GACACTTTGA TCCACCTGAT GGCCAAGGCA   5461 GGCCTGACCC TGCAGCAGCA GCACCAGCGG CTGGCCCAGC TCCTCCTCAT CCTCTCCCAC   5521 ATCAGGCACA TGAGTAACAA AGGCATGGAG CATCTGTACA GCATGAAGTG CAAGAACGTG   5581 GTGCCCCTCT ATGACCTGCT GCTGGAGGCG GCGGACGCCC ACCGCCTACA TGCGCCCACT   5641 AGCCGTGGAG GGGCATCCGT GGAGGAGACG GACCAAAGCC ACTTGGCCAC TGCGGGCTCT   5701 ACTTCATCGC ATTCCTTGCA AAAGTATTAC ATCACGGGGG AGGCAGAGGG TTTCCCTGCC   5761 ACAGCTGGCT CCGGCGAGGG CAGGGGAAGT CTTCTAACAT GCGGGGACGT GGAGGAAAAT   5821 CCCGGCCCAG TGAGCAAGGG CGAGGCAGTG ATCAAGGAGT TCATGCGGTT CAAGGTGCAC   5881 ATGGAGGGCT CCATGAACGG CCACGAGTTC GAGATCGAGG GCGAGGGCGA GGGCCGCCCC   5941 TACGAGGGCA CCCAGACCGC CAAGCTGAAG GTGACCAAGG GTGGCCCCCT GCCCTTCTCC   6001 TGGGACATCC TGTCCCCTCA GTTCATGTAC GGCTCCAGGG CCTTCACCAA GCACCCCGCC   6061 GACATCCCCG ACTACTATAA GCAGTCCTTC CCCGAGGGCT TCAAGTGGGA GCGCGTGATG   6121 AACTTCGAGG ACGGCGGCGC CGTGACCGTG ACCCAGGACA CCTCCCTGGA GGACGGCACC   6181 CTGATCTACA AGGTGAAGCT CCGCGGCACC AACTTCCCTC CTGACGGCCC CGTAATGCAG   6241 AAGAAAACAA TGGGCTGGGA AGCGTCCACC GAGCGGTTGT ACCCCGAGGA CGGCGTGCTG   6301 AAGGGCGACA TTAAGATGGC CCTGCGCCTG AAGGACGGCG GCCGCTACCT GGCGGACTTC   6361 AAGACCACCT ACAAGGCCAA GAAGCCCGTG CAGATGCCCG GCGCCTACAA CGTTGACCGC   6421 AAGTTGGACA TCACCTCCCA CAACGAGGAC TACACCGTGG TGGAACAGTA CGAACGCTCC   6481 GAGGGCCGCC ACTCCACCGG CGGCATGGAC GAGCTGTACA AGTGAATTCG ATCATAATCA   6541 GCCATACCAC ATTTGTAGAG GTTTTACTTG CTTTAAAAAA CCTCCCACAC CTCCCCCTGA   6601 ACCTGAAACA TAAAATGAAT GCAATTGTTG TTGTTAACTT GTTTATTGCA GCTTATAATG   6661 GTTACAAATA AAGCAATAGC ATCACAAATT TCACAAATAA AGCATTTTTT TCACTGCATT   6721 CTAGTTGTGG TTTGTCCAAA CTCATCAATG TATCTTATCA TGTCTGGCTC GAGGGAAGTT   6781 CCTATACTCT AGAAAGAATA GGAACTTCGG CGGACGCGTA TAGATCAGGC GCGCCATAAC   6841 TTCGTATAGT ATAGTATATA CGAATTATGC GGCCGCGTCG ACCAATTCTC ATGTTTGACA   6901 GOTTATCATC GAATTTCTGC CATTCATCCG CTTATTATCA CTTATTCAGG CGTAGCAACC   6961 AGGCGTTTAA GGGCACCAAT AACTGCCTTA AAAAAATTAG AAAAACTCAT CGAGCATCAA   7021 ATGAAACTGC AATTTATTCA TATCAGGATT ATCAATACCA TATTTTTGAA AAAGCCGTTT   7081 CTGTAATGAA GGAGAAAACT CACCGAGGCA GTTCCATAGG ATGGCAAGAT CCTGGTATCG   7141 GTCTGCGATT CCGACTCGTC CAACATCAAT ACAACCTATT AATTTCCCCT CGTCAAAAAT   7201 AAGGTTATCA AGTGAGAAAT CACCATGAGT GACGACTGAA TCCGGTGAGA ATGGCAAAAG   7261 CTTATGCATT TCTTTCCAGA CTTGTTCAAC AGGCCAGCCA TTACGCTCGT CATCAAAATC   7321 ACTCGCATCA ACCAAACCGT TATTCATTCG TGATTGCGCC TGAGCGAGAC GAAATACGCG   7381 ATCGCTGTTA AAAGGACAAT TACAAACAGG AATCGAATGC AACCGGCGCA GGAACACTGC   7441 CAGCGCATCA ACAATATTTT CACCTGAATC AGGATATTCT TCTAATACCT GGAATGCTGT   7501 TTTCCCTGGG ATCGCAGTGG TGAGTAACCA TGCATCATCA GGAGTACGGA TAAAATGCTT   7561 GATGGTCGGA AGAGGCATAA ATTCCGTCAG CCAGTTTAGT CTGACCATCT CATCTGTAAC   7621 ATCATTGGCA ACGCTACCTT TGCCATGTTT CAGAAACAAC TCTGGCGCAT CGGGCTTCCC   7681 ATACAATCGA TAGATTGTCG CACCTGATTG CCCGACATTA TCGCGAGCCC ATTTATACCC   7741 ATATAAATCA GCATCCATGT TGGAATTTAA TCGCGGCCTC GAGCAAGACG TTTCCCGTTG   7801 AATATGGCTC ATTTTAGCTT CCTTAGCTCC TGAAAATCTC GATAACTCAA AAAATACGCC   7861 CGGTAGTGAT CTTATTTCAT TATGGTGAAA GTTGGAACCT CTTACGTGCC GATCAACGTC   7921 TCATTTTCGC CAAAAGTTGG CCCAGGGCTT CCCGGTATCA ACAGGGACAC CAGGATTTAT   7981 TTATTCTGCG AAGTGATCTT CCGTCACAGG TATTTATTCG CGATAAGCTC ATGGAGCGGC   8041 GTAACCGTCG CACAGGAAGG ACAGAGAAAG CGCGGATCTG GGAAGTGACG GACAGAACGG   8101 TCAGGACCTG GATTGGGGAG GCGGTTGCCG CCGCTGCTGC TGACGGTGTG ACGTTCTCTG   8161 TTCCGGTCAC ACCACATACG TTCCGCCATT CCTATGCGAT GCACATGCTG TATGCCGGTA   8221 TACCGCTGAA AGTTCTGCAA AGCCTGATGG GACATAAGTC CATCAGTTCA ACGGAAGTCT   8281 ACACGAAGGT TTTTGCGCTG GATGTGGCTG CCCGGCACCG GGTGCAGTTT GCGATGCCGG   8341 AGTCTGATGC GGTTGCGATG CTGAAACAAT TATCCTGAGA ATAAATGCCT TGGCCTTTAT   8401 ATGGAAATGT GGAACTGAGT GGATATGCTG TTTTTGTCTG TTAAACAGAG AAGCTGGCTG   8461 TTATCCACTG AGAAGCGAAC GAAACAGTCG GGAAAATCTC CCATTATCGT AGAGATCCGC   8521 ATTATTAATC TCAGGAGCCT GTGTAGCGTT TATAGGAAGT AGTGTTCTGT CATGATGCCT   8581 GCAAGCGGTA ACGAAAACGA TTTGAATATG CCTTCAGGAA CAATAGAAAT CTTCGTGCGG   8641 TGTTACGTTG AAGTGGAGCG GATTATGTCA GCAATGGACA GAACAACCTA ATGAACACAG   8701 AACCATGATG TGGTCTGTCC TTTTACAGCC AGTAGTGCTC GCCGCAGTCG AGCGACAGGG   8761 CGAAGCCCTC GAGCTGGTTG CCCTCGCCGC TGGGCTGGCG GCCGTCTATG GCCCTGCAAA   8821 CGCGCCAGAA ACGCCGTCGA AGCCGTGTGC GAGACACCGC GGCCGGCCGC CGGCGTTGTG   8881 GATACCTCGC GGAAAACTTG GCCCTCACTG ACAGATGAGG GGCGGACGTT GACACTTGAG   8941 GGGCCGACTC ACCCGGCGCG GCGTTGACAG ATGAGGGGCA GGCTCGATTT CGGCCGGCGA   9001 CGTGGAGCTG GCCAGCCTCG CAAATCGGCG AAAACGCCTG ATTTTACGCG AGTTTCCCAC   9061 AGATGATGTG GACAAGCCTG GGGATAAGTG CCCTGCGGTA TTGACACTTG AGGGGCGCGA   9121 CTACTGACAG ATGAGGGGCG CGATCCTTGA CACTTGAGGG GCAGAGTGCT GACAGATGAG   9181 GGGCGCACCT ATTGACATTT GAGGGGCTGT CCACAGGCAG AAAATCCAGC ATTTGCAAGG   9241 GTTTCCGCCC GTTTTTCGGC CACCGCTAAC CTGTCTTTTA ACCTGCTTTT AAACCAATAT   9301 TTATAAACCT TGTTTTTAAC CAGGGCTGCG CCCTGTGCGC GTGACCGCGC ACGCCGAAGG   9361 GGGGTGCCCC CCCTTCTCGA ACCCTCCCGG TCGAGTGAGC GAGGAAGCAC CAGGGAACAG   9421 CACTTATATA TTCTGCTTAC ACACGATGCC TGAAAAAACT TCCCTTGGGG TTATCCACTT   9481 ATCCACGGGG ATATTTTTAT AATTATTTTT TTTATAGTTT TTAGATCTTC TTTTTTAGAG   9541 CGCCTTGTAG GCCTTTATCC ATGCTGGTTC TAGAGAAGGT GTTGTGACAA ATTGCCCTTT   9601 CAGTGTGACA AATCACCCTC AAATGACAGT CCTGTCTGTG ACAAATTGCC CTTAACCCTG   9661 TGACAAATTG CCCTCAGAAG AAGCTGTTTT TTCACAAAGT TATCCCTGCT TATTGACTCT   9721 TTTTTATTTA GTGTGACAAT CTAAAAACTT GTCACACTTC ACATGGATCT GTCATGGCGG   9781 AAACAGCGGT TATCAATCAC AAGAAACGTA AAAATAGCCC GCGAATCGTC CAGTCAAACG   9841 ACCTCACTGA GGCGGCATAT AGTCTCTCCC GGGATCAAAA ACGTATGCTG TATCTGTTCG   9901 TTGACCAGAT CAGAAAATCT GATGGCACCC TACAGGAACA TGACGGTATC TGCGAGATCC   9961 ATGTTGCTAA ATATGCTGAA ATATTCGGAT TGACCTCTGC GGAAGCCAGT AAGGATATAC  10021 GGCAGGCATT GAAGAGTTTC GCGGGGAAGG AAGTGGTTTT TTATCGCCCT GAAGAGGATG  10081 CCGGCGATGA AAAAGGCTAT GAATCTTTTC CTTGGTTTAT CAAACGTGCG CACAGTCCAT  10141 CCAGAGGGCT TTACAGTGTA CATATCAACC CATATCTCAT TCCCTTCTTT ATCGGGTTAC  10201 AGAACCGGTT TACGCAGTTT CGGCTTAGTG AAACAAAAGA AATCACCAAT CCGTATGCCA  10261 TGCGTTTATA CGAATCCCTG TGTCAGTATC GTAAGCCGGA TGGCTCAGGC ATCGTCTCTC  10321 TGAAAATCGA CTGGATCATA GAGCGTTACC AGCTGCCTCA AAGTTACCAG CGTATGCCTG  10381 ACTTCCGCCG CCGCTTCCTG CAGGTCTGTG TTAATGAGAT CAACAGCAGA ACTCCAATGC  10441 GCCTCTCATA CATTGAGAAA AAGAAAGGCC GCCAGACGAC TCATATCGTA TTTTCCTTCC  10501 GCGATATCAC TTCCATGACG ACAGGATAGT CTGAGGGTTA TCTGTCACAG ATTTGAGGGT  10561 GGTTCGTCAC ATTTGTTCTG ACCTACTGAG GGTAATTTGT CACAGTTTTG CTGTTTCCTT  10621 CAGCCTGCAT GGATTTTCTC ATACTTTTTG AACTGTAATT TTTAAGGAAG CCAAATTTGA  10681 GGGCAGTTTG TCACAGTTGA TTTCCTTCTC TTTCCCTTCG TCATGTGACC TGATATCGGG  10741 GGTTAGTTCG TCATCATTGA TGAGGGTTGA TTATCACAGT TTATTACTCT GAATTGGCTA  10801 TCCGCGTGTG TACCTCTACC TGGAGTTTTT CCCACGGTGG ATATTTCTTC TTGCGCTGAG  10861 CGTAAGAGCT ATCTGACAGA ACAGTTCTTC TTTGCTTCCT CGCCAGTTCG CTCGCTATGC  10921 TCGGTTACAC GGCTGCGGCG AGCGCTAGTG ATAATAAGTG ACTGAGGTAT GTGCTCTTCT  10981 TATCTCCTTT TGTAGTGTTG CTCTTATTTT AAACAACTTT GCGGTTTTTT GATGACTTTG  11041 CGATTTTGTT GTTGCTTTGC AGTAAATTGC AAGATTTAAT AAAAAAACGC AAAGCAATGA  11101 TTAAAGGATG TTCAGAATGA AACTCATGGA AACACTTAAC CAGTGCATAA ACGCTGGTCA  11161 TGAAATGACG AAGGCTATCG CCATTGCACA GTTTAATGAT GACAGCCCGG AAGCGAGGAA  11221 AATAACCCGG CGCTGGAGAA TAGGTGAAGC AGCGGATTTA GTTGGGGTTT CTTCTCAGGC  11281 TATCAGAGAT GCCGAGAAAG CAGGGCGACT ACCGCACCCG GATATGGAAA TTCGAGGACG  11341 GGTTGAGCAA CGTGTTGGTT ATACAATTGA ACAAATTAAT CATATGCGTG ATGTGTTTGG  11401 TACGCGATTG CGACGTGCTG AAGACGTATT TCCACCGGTG ATCGGGGTTG CTGCCCATAA  11461 AGGTGGCGTT TACAAAACCT CAGTTTCTGT TCATCTTGCT CAGGATCTGG CTCTGAAGGG  11521 GCTACGTGTT TTGCTCGTGG AAGGTAACGA CCCCCAGGGA ACAGCCTCAA TGTATCACGG  11581 ATGGGTACCA GATCTTCATA TTCATGCAGA AGACACTCTC CTGCCTTTCT ATCTTGGGGA  11641 AAAGGACGAT GTCACTTATG CAATAAAGCC CACTTGCTGG CCGGGGCTTG ACATTATTCC  11701 TTCCTGTCTG GCTCTGCACC GTATTGAAAC TGAGTTAATG GGCAAATTTG ATGAAGGTAA  11761 ACTGCCCACC GATCCACACC TGATGCTCCG ACTGGCCATT GAAACTGTTG CTCATGACTA  11821 TGATGTCATA GTTATTGACA GCGCGCCTAA CCTGGGTATC GGCACGATTA ATGTCGTATG  11881 TGCTGCTGAT GTGCTGATTG TTCCCACGCC TGCTGAGTTG TTTGACTACA CCTCCGCACT  11941 GCAGTTTTTC GATATGCTTC GTGATCTGCT CAAGAACGTT GATCTTAAAG GGTTCGAGCC  12001 TGATGTACGT ATTTTGCTTA CCAAATACAG CAATAGCAAT GGCTCTCAGT CCCCGTGGAT  12061 GGAGGAGCAA ATTCGGGATG CCTGGGGAAG CATGGTTCTA AAAAATGTTG TACGTGAAAC  12121 GGATGAAGTT GGTAAAGGTC AGATCCGGAT GAGAACTGTT TTTGAACAGG CCATTGATCA  12181 ACGCTCTTCA ACTGGTGCCT GGAGAAATGC TCTTTCTATT TGGGAACCTG TCTGCAATGA  12241 AATTTTCGAT CGTCTGATTA AACCACGCTG GGAGATTAGA TAATGAAGCG TGCGCCTGTT  12301 ATTCCAAAAC ATACGCTCAA TACTCAACCG GTTGAAGATA CTTCGTTATC GACACCAGCT  12361 GCCCCGATGG TGGATTCGTT AATTGCGCGC GTAGGAGTAA TGGCTCGCGG TAATGCCATT  12421 ACTTTGCCTG TATGTGGTCG GGATGTGAAG TTTACTCTTG AAGTGCTCCG GGGTGATAGT  12481 GTTGAGAAGA CCTCTCGGGT ATGGTCAGGT AATGAACGTG ACCAGGAGCT GCTTACTGAG  12541 GACGCACTGG ATGATCTCAT CCCTTCTTTT CTACTGACTG GTCAACAGAC ACCGGCGTTC  12601 GGTCGAAGAG TATCTGGTGT CATAGAAATT GCCGATGGGA GTCGCCGTCG TAAAGCTGCT  12661 GCACTTACCG AAAGTGATTA TCGTGTTCTG GTTGGCGAGC TGGATGATGA GCAGATGGCT  12721 GCATTATCCA GATTGGGTAA CGATTATCGC CCAACAAGTG CTTATGAACG TGGTCAGCGT  12781 TATGCAAGCC GATTGCAGAA TGAATTTGCT GGAAATATTT CTGCGCTGGC TGATGCGGAA  12841 AATATTTCAC GTAAGATTAT TACCCGCTGT ATCAACACCG CCAAATTGCC TAAATCAGTT  12901 GTTGCTCTTT TTTCTCACCC CGGTGAACTA TCTGCCCGGT CAGGTGATGC ACTTCAAAAA  12961 GCCTTTACAG ATAAAGAGGA ATTACTTAAG CAGCAGGCAT CTAACCTTCA TGAGCAGAAA  13021 AAAGCTGGGG TGATATTTGA AGCTGAAGAA GTTATCACTC TTTTAACTTC TGTGCTTAAA  13081 ACGTCATCTG CATCAAGAAC TAGTTTAAGC TCACGACATC AGTTTGCTCC TGGAGCGACA  13141 GTATTGTATA AGGGCGATAA AATGGTGCTT AACCTGGACA GGTCTCGTGT TCCAACTGAG  13201 TGTATAGAGA AAATTGAGGC CATTCTTAAG GAACTTGAAA AGCCAGCACC CTGATGCGAC  13261 CACGTTTTAG TCTACGTTTA TCTGTCTTTA CTTAATGTCC TTTGTTACAG GCCAGAAAGC  13321 ATAACTGGCC TGAATATTCT CTCTGGGCCC ACTGTTCCAC TTGTATCGTC GGTCTGATAA  13381 TCAGACTGGG ACCACGGTCC CACTCGTATC GTCGGTCTGA TTATTAGTCT GGGACCACGG  13441 TCCCACTCGT ATCGTCGGTC TGATTATTAG TCTGGGACCA CGGTCCCACT CGTATCGTCG  13501 GTCTGATAAT CAGACTGGGA CCACGGTCCC ACTCGTATCG TCGGTCTGAT TATTAGTCTG  13561 GGACCATGGT CCCACTCGTA TCGTCGGTCT GATTATTAGT CTGGGACCAC GGTCCCACTC  13621 GTATCGTCGG TCTGATTATT AGTCTGGAAC CACGGTCCCA CTCGTATCGT CGGTCTGATT  13681 ATTAGTCTGG GACCACGGTC CCACTCGTAT CGTCGGTCTG ATTATTAGTC TGGGACCACG  13741 ATCCCACTCG TGTTGTCGGT CTGATTATCG GTCTGGGACC ACGGTCCCAC TTGTATTGTC  13801 GATCAGACTA TCAGCGTGAG ACTACGATTC CATCAATGCC TGTCAAGGGC AAGTATTGAC  13861 ATGTCGTCGT AACCTGTAGA ACGGAGTAAC CTCGGTGTGC GGTTGTATGC CTGCTGTGGA  13921 TTGCTGCTGT GTCCTGCTTA TCCACAACAT TTTGCGCACG GTTATGTGGA C (pCAG-iCre) SEQ ID NO: 13      1 TTACCAATGC TTAATCAGTG AGGCACCTAT CTCAGCGATC TGTCTATTTC GTTCATCCAT     61 AGTTGCCTGA CTCCCCGTCG TGTAGATAAC TACGATACGG GAGGGCTTAC CATCTGGCCC    121 CAGTGCTGCA ATGATACCGC GAGACCCACG CTCACCGGCT CCAGATTTAT CAGCAATAAA    181 CCAGCCAGCC GGAAGGGCCG AGCGCAGAAG TGGTCCTGCA ACTTTATCCG CCTCCATCCA    241 GTCTATTAAT TGTTGCCGGG AAGCTAGAGT AAGTAGTTCG CCAGTTAATA GTTTGCGCAA    301 CGTTGTTGCC ATTGCTACAG GCATCGTGGT GTCACGCTCG TCGTTTGGTA TGGCTTCATT    361 CAGCTCCGGT TCCCAACGAT CAAGGCGAGT TACATGATCC CCCATGTTGT GCAAAAAAGC    421 GGTTAGCTCC TTCGGTCCTC CGATCGTTGT CAGAAGTAAG TTGGCCGCAG TGTTATCACT    481 CATGGTTATG GCAGCACTGC ATAATTCTCT TACTGTCATG CCATCCGTAA GATGCTTTTC    541 TGTGACTGGT GAGTACTCAA CCAAGTCATT CTGAGAATAG TGTATGCGGC GACCGAGTTG    601 CTCTTGCCCG GCGTCAATAC GGGATAATAC CGCGCCACAT AGCAGAACTT TAAAAGTGCT    661 CATCATTGGA AAACGTTCTT CGGGGCGAAA ACTCTCAAGG ATCTTACCGC TGTTGAGATC    721 CAGTTCGATG TAACCCACTC GTGCACCCAA CTGATCTTCA GCATCTTTTA CTTTCACCAG    781 CGTTTCTGGG TGAGCAAAAA CAGGAAGGCA AAATGCCGCA AAAAAGGGAA TAAGGGCGAC    841 ACGGAAATGT TGAATACTCA TACTCTTCCT TTTTCAATAT TATTGAAGCA TTTATCAGGG    901 TTATTGTCTC ATGAGCGGAT ACATATTTGA ATGTATTTAG AAAAATAAAC AAATAGGGGT    961 TCCGCGCACA TTTCCCCGAA AAGTGCCACC TGGGTCGACA TTGATTATTG ACTAGTTATT   1021 AATAGTAATC AATTACGGGG TCATTAGTTC ATAGCCCATA TATGGAGTTC CGCGTTACAT   1081 AACTTACGGT AAATGGCCCG CCTGGCTGAC CGCCCAACGA CCCCCGCCCA TTGACGTCAA   1141 TAATGACGTA TGTTCCCATA GTAACGCCAA TAGGGACTTT CCATTGACGT CAATGGGTGG   1201 AGTATTTACG GTAAACTGCC CACTTGGCAG TACATCAAGT GTATCATATG CCAAGTACGC   1261 CCCCTATTGA CGTCAATGAC GGTAAATGGC CCGCCTGGCA TTATGCCCAG TACATGACCT   1321 TATGGGACTT TCCTACTTGG CAGTACATCT ACGTATTAGT CATCGCTATT ACCATGGTCG   1381 AGGTGAGCCC CACGTTCTGC TTCACTCTCC CCATCTCCCC CCCCTCCCCA CCCCCAATTT   1441 TGTATTTATT TATTTTTTAA TTATTTTGTG CAGCGATGGG GGCGGGGGGG GGGGGGGCGC   1501 GCGCCAGGCG GGGCGGGGCG GGGCGAGGGG CGGGGCGGGG CGAGGCGGAA AGGTGCGGCG   1561 GCAGCCAATC AGAGCGGCGC GCTCCGAAAG TTTCCTTTTA TGGCGAGGCG GCGGCGGCGG   1621 CGGCCCTATA AAAAGCGAAG CGCGCGGCGG GCGGGAGTCG CTGCGTTGCC TTCGCCCCGT   1681 GCCCCGCTCC GCGCCGCCTC GCGCCGCCCG CCCCGGCTCT GACTGACCGC GTTACTCCCA   1741 CAGGTGAGCG GGCGGGACGG CCCTTCTCCT CCGGGCTGTA ATTAGCGCTT GGTTTAATGA   1801 CGGCTCGTTT CTTTTCTGTG GCTGCGTGAA AGCCTTAAAG GGCTCCGGGA GGGCCCTTTG   1861 TGCGGGGGGG AGCGGCTCGG GGGGTGCGTG CGTGTGTGTG TGCGTGGGGA GCGCCGCGTG   1921 CGGCTCCGCG CTGCCCGGCG GCTGTGAGCG CTGCGGGCGC GGCGCGGGGC TTTGTGCGCT   1981 CCGCAGTGTG CGCGAGGGGA GCGCGGCCGG GGGCGGTGCC CCGCGGTGCG GGGGGGGCTG   2041 CGAGGGGAAC AAAGGCTGCG TGCGGGGTGT GTGCGTGGGG GGGTGAGCAG GGGGTGTGGG   2101 CGCGGCGGTC GGGCTGTAAC CCCCCCCTGC ACCCCCCTCC CCGAGTTGCT GAGCACGGCC   2161 CGGCTTCGGG TGCGGGGCTC CGTACGGGGC GTGGCGCGGG GCTCGCCGTG CCGGGCGGGG   2221 GGTGGCGGCA GGTGGGGGTG CCGGGCGGGG CGGGGCCGCC TCGGGCCGGG GAGGGCTCGG   2281 GGGAGGGGCG CGGCGGCCCC CGGAGCGCCG GCGGCTGTCG AGGCGCGGCG AGCCGCAGCC   2341 ATTGCCTTTT ATGGTAATCG TGCGAGAGGG CGCAGGGACT TCCTTTGTCC CAAATCTGTG   2401 CGGAGCCGAA ATCTGGGAGG CGCCGCCGCA CCCCCTCTAG CGGGCGCGGG GCGAAGCGGT   2461 GCGGCGCCGG CAGGAAGGAA ATGGGCGGGG AGGGCCTTCG TGCGTCGCCG CGCCGCCGTC   2521 CCCTTCTCCC TCTCCAGCCT CGGGGCTGTC CGCGGGGGGA CGGCTGCCTT CGGGGGGGAC   2581 GGGGCAGGGC GGGGTTCGGC TTCTGGCGTG TGACCGGCGG CTCTAGAGCC TCTGCTAACC   2641 ATGTTCATGC CTTCTTCTTT TTCCTACAGC TCCTGGGCAA CGTGCTGGTT ATTGTGCTGT   2701 CTCATCATTT TGGCAAAGAA TTGATTAATT CGAGCGAACG CGTGCCGCCA CCATGGTGCC   2761 CAAGAAGAAG AGGAAAGTCT CCAACCTGCT GACTGTGCAC CAAAACCTGC CTGCCCTCCC   2821 TGTGGATGCC ACCTCTGATG AAGTCAGGAA GAACCTGATG GACATGTTCA GGGACAGGCA   2881 GGCCTTCTCT GAACACACCT GGAAGATGCT CCTGTCTGTG TGCAGATCCT GGGCTGCCTG   2941 GTGCAAGCTG AACAACAGGA AATGGTTCCC TGCTGAACCT GAGGATGTGA GGGACTACCT   3001 CCTGTACCTG CAAGCCAGAG GCCTGGCTGT GAAGACCATC CAACAGCACC TGGGCCAGCT   3061 CAACATGCTG CACAGGAGAT CTGGCCTGCC TCGCCCTTCT GACTCCAATG CTGTGTCCCT   3121 GGTGATGAGG AGAATCAGAA AGGAGAATGT GGATGCTGGG GAGAGAGCCA AGCAGGCCCT   3181 GGCCTTTGAA CGCACTGACT TTGACCAAGT CAGATCCCTG ATGGAGAACT CTGACAGATG   3241 CCAGGACATC AGGAACCTGG CCTTCCTGGG CATTGCCTAC AACACCCTGC TGCGCATTGC   3301 CGAAATTGCC AGAATCAGAG TGAAGGACAT CTCCCGCACC GATGGTGGGA GAATGCTGAT   3361 CCACATTGGC AGGACCAAGA CCCTGGTGTC CACAGCTGGT GTGGAGAAGG CCCTGTCCCT   3421 GGGGGTTACC AAGCTGGTGG AGAGATGGAT CTCTGTGTCT GGTGTGGCTG ATGACCCCAA   3481 CAACTACCTG TTCTGCCGGG TCAGAAAGAA TGGTGTGGCT GCCCCTTCTG CCACCTCCCA   3541 ACTGTCCACC CGGGCCCTGG AAGGGATOTT TGAGGCCACC CACCGCCTGA TCTATGGTGC   3601 CAAGGATGAC TCTGGGCAGA GATACCTGGC CTGGTCTGGC CACTCTGCCA GAGTGGGTGC   3661 TGCCAGGGAC ATGGCCAGGG CTGGTGTGTC CATCCCTGAA ATCATGCAGG CTGGTGGCTG   3721 GACCAATGTG AACATTGTGA TGAACTACAT CAGAAACCTG GACTCTGAGA CTGGGGCCAT   3781 GGTGAGGCTG CTCGAGGATG GGGACTGAGC GGCCGCACTC CTCAGGTGCA GGCTGCCTAT   3841 CAGAAGGTGG TGGCTGGTGT GGCCAATGCC CTGGCTCACA AATACCACTG AGATCTTTTT   3901 CCCTCTGCCA AAAATTATGG GGACATCATG AAGCCCCTTG AGCATCTGAC TTCTGGCTAA   3961 TAAAGGAAAT TTATTTTCAT TGCAATAGTG TGTTGGAATT TTTTGTGTCT CTCACTCGGA   4021 AGGACATATG GGAGGGCAAA TCATTTAAAA CATCAGAATG AGTATTTGGT TTAGAGTTTG   4081 GCAACATATG CCCATATGCT GGCTGCCATG AACAAAGGTT GGCTATAAAG AGGTCATCAG   4141 TATATGAAAC AGCCCCCTGC TGTCCATTCC TTATTCCATA GAAAAGCCTT GACTTGAGGT   4201 TAGATTTTTT TTATATTTTG TTTTGTGTTA TTTTTTTCTT TAACATCCCT AAAATTTTCC   4261 TTACATGTTT TACTAGCCAG ATTTTTCCTC CTCTCCTGAC TACTCCCAGT CATAGCTGTC   4321 CCTCTTCTCT TATGGAGATC CCTCGACCTG CAGCCCAAGC TTGGCGTAAT CATGGTCATA   4381 GCTGTTTCCT GTGTGAAATT GTTATCCGCT CACAATTCCA CACAACATAC GAGCCGGAAG   4441 CATAAAGTGT AAAGCCTGGG GTGCCTAATG AGTGAGCTAA CTCACATTAA TTGCGTTGCG   4501 CTCACTGCCC GCTTTCCAGT CGGGAAACCT GTCGTGCCAG CGGATCCGCA TCTCAATTAG   4561 TCAGCAACCA TAGTCCCGCC CCTAACTCCG CCCAGTTCCG CCCATTCTCC GCCCCATGGC   4621 TGACTAATTT TTTTTATTTA TGCAGAGGCC GAGGCCGCCT CGGCCTCTGA GCTATTCCAG   4681 AAGTAGTGAG GAGGCTTTTT TGGAGGCCTA GGCTTTTGCA AAAAGCTAAC TTGTTTATTG   4741 CAGCTTATAA TGGTTACAAA TAAAGCAATA GCATCACAAA TTTCACAAAT AAAGCATTTT   4801 TTTCACTGCA TTCTAGTTGT GGTTTGTCCA AACTCATCAA TGTATCTTAT CATGTCTGGA   4861 TCCGCTGCAT TAATGAATCG GCCAACGCGC GGGGAGAGGC GGTTTGCGTA TTGGGCGCTC   4921 TTCCGCTTCC TCGCTCACTG ACTCGCTGCG CTCGGTCGTT CGGCTGCGGC GAGCGGTATC   4981 AGCTCACTCA AAGGCGGTAA TACGGTTATC CACAGAATCA GGGGATAACG CAGGAAAGAA   5041 CATGTGAGCA AAAGGCCAGC AAAAGGCCAG GAACCGTAAA AAGGCCGCGT TGCTGGCGTT   5101 TTTCCATAGG CTCCGCCCCC CTGACGAGCA TCACAAAAAT CGACGCTCAA GTCAGAGGTG   5161 GCGAAACCCG ACAGGACTAT AAAGATACCA GGCGTTTCCC CCTGGAAGCT CCCTCGTGCG   5221 CTCTCCTGTT CCGACCCTGC CGCTTACCGG ATACCTGTCC GCCTTTCTCC CTTCGGGAAG   5281 CGTGGCGCTT TCTCATAGCT CACGCTGTAG GTATCTCAGT TCGGTGTAGG TCGTTCGCTC   5341 CAAGCTGGGC TGTGTGCACG AACCCCCCGT TCAGCCCGAC CGCTGCGCCT TATCCGGTAA   5401 CTATCGTCTT GAGTCCAACC CGGTAAGACA CGACTTATCG CCACTGGCAG CAGCCACTGG   5461 TAACAGGATT AGCAGAGCGA GGTATGTAGG CGGTGCTACA GAGTTCTTGA AGTGGTGGCC   5521 TAACTACGGC TACACTAGAA GAACAGTATT TGGTATCTGC GCTCTGCTGA AGCCAGTTAC   5581 CTTCGGAAAA AGAGTTGGTA GCTCTTGATC CGGCAAACAA ACCACCGCTG GTAGCGGTGG   5641 TTTTTTTGTT TGCAAGCAGC AGATTACGCG CAGAAAAAAA GGATCTCAAG AAGATCCTTT   5701 GATCTTTTCT ACGGGGTCTG ACGCTCAGTG GAACGAAAAC TCACGTTAAG GGATTTTGGT   5761 CATGAGATTA TCAAAAAGGA TCTTCACCTA GATCCTTTTA AATTAAAAAT GAAGTTTTAA   5821 ATCAATCTAA AGTATATATG AGTAAACTTG GTCTGACAG (SynHLA_FullClone) SEQ ID NO: 14      1 GGGTCCTTTT CATCACGTGC TATAAAAATA ATTATAATTT AAATTTTTTA ATATAAATAT     61 ATAAATTAAA AATAGAAAGT AAAAAAAGAA ATTAAAGAAA AAATAGTTTT TGTTTTCCGA    121 AGATGTAAAA GACTCTAGGG GGATCGCCAA CAAATACTAC CTTTTATCTT GCTCTTCCTG    181 CTCTCAGGTA TTAATGCCGA ATTGTTTCAT CTTGTCTGTG TAGAAGACCA CACACGAAAA    241 TCCTGTGATT TTACATTTTA CTTATCGTTA ATCGAATGTA TATCTATTTA ATCTGCTTTT    301 CTTGTCTAAT AAATATATAT GTAAAGTACG CTTTTTGTTG AAATTTTTTA AACCTTTGTT    361 TATTTTTTTT TCTTCATTCC GTAACTCTTC TACCTTCTTT ATTTACTTTC TAAAATCCAA    421 ATACAAAACA TAAAAATAAA TAAACACAGA GTAAATTCCC AAATTATTCC ATCATTAAAA    481 GATACGAGGC GCGTGTAAGT TACAGGCAAG CGATCCGTCC TAAGAAACCA TTATTATCAT    541 GACATTAACC TATAAAAATA GGCGTATCAC GAGGCCCTTT CGTCTCGCGC GTTTCGGTGA    601 TGACGGTGAA AACCTCTGAC ACATGCAGCT CCCGGAGACG GTCACAGCTT GTCTGTAAGC    661 GGATGCCGGG AGCAGACAAG CCCGTCAGGG CGCGTCAGCG GGTGTTGGCG GGTGTCGGGG    721 CTGGCTTAAC TATGCGGCAT CAGAGCAGAT TGTACTGAGA GTGCACCATA AATTCCCGTT    781 TTAAGAGCTT GGTGAGCGCT AGGAGTCACT GCCAGGTATC GTTTGAACAC GGCATTAGTC    841 AGGGAAGTCA TAACACAGTC CTTTCCCGCA ATTTTCTTTT TCTATTACTC TTGGCCTCCT    901 CTAGTACACT CTATATTTTT TTATGCCTCG GTAATGATTT TCATTTTTTT TTTTCCACCT    961 AGCGGATGAC TCTTTTTTTT TCTTAGCGAT TGGCATTATC ACATAATGAA TTATACATTA   1021 TATAAAGTAA TGTGATTTCT TCGAAGAATA TACTAAAAAA TGAGCAGGCA AGATAAACGA   1081 AGGCAAAGAT GACAGAGCAG AAAGCCCTAG TAAAGCGTAT TACAAATGAA ACCAAGATTC   1141 AGATTGCGAT CTCTTTAAAG GGTGGTCCCC TAGCGATAGA GCACTCGATC TTCCCAGAAA   1201 AAGAGGCAGA AGCAGTAGCA GAACAGGCCA CACAATCGCA AGTGATTAAC GTCCACACAG   1261 GTATAGGGTT TCTGGACCAT ATGATACATG CTCTGGCCAA GCATTCCGGC TGGTCGCTAA   1321 TCGTTGAGTG CATTGGTGAC TTACACATAG ACGACCATCA CACCACTGAA GACTGCGGGA   1381 TTGCTCTCGG TCAAGCTTTT AAAGAGGCCC TAGGGGCCGT GCGTGGAGTA AAAAGGTTTG   1441 GATCAGGATT TGCGCCTTTG GATGAGGCAC TTTCCAGAGC GGTGGTAGAT CTTTCGAACA   1501 GGCCGTACGC AGTTGTCGAA CTTGGTTTGC AAAGGGAGAA AGTAGGAGAT CTCTCTTGCG   1561 AGATGATCCC GCATTTTCTT GAAAGCTTTG CAGAGGCTAG CAGAATTACC CTCCACGTTG   1621 ATTGTCTGCG AGGCAAGAAT GATCATCACC GTAGTGAGAG TGCGTTCAAG GCTCTTGCGG   1681 TTGCCATAAG AGAAGCCACC TCGCCCAATG GTACCAACGA TGTTCCCTCC ACCAAAGGTG   1741 TTCTTATGTA GTGACACCGA TTATTTAAAG CTGCAGCATA CGATATATAT ACATGTGTAT   1801 ATATGTATAC CTATGAATGT CAGTAAGTAT GTATACGAAC AGTATGATAC TGAAGATGAC   1861 AAGGTAATGC ATCATTCTAT ACGTGTCATT CTGAACGAGG CGCGCTTTCC TTTTTTCTTT   1921 TTGCTTTTTC TTTTTTTTTC TCTTGAACTC GACGGATCTA TGCGGTGTGA AATACCGCAC   1981 AGATGCGTCC TAGGGCGGCC GCATAACTTC GTATAGCATA CATTATACGA AGTTATCCGG   2041 AACCGAGTAC AAGCCCACGG TGCGCCTCGC CACCCGCGAC GACGTCCCCA GGGCCGTCCG   2101 CACCCTCGCC GCCGCGTTCG CCGACTACCC CGCCACGCGC CACACCGTCG ATCCGGACCG   2161 CCACATCGAG CGCGTGACCG AGCTGCAAGA ACTCTTCCTC ACGCGCGTCG GGCTCGACAT   2221 CGGCAAGGTG TGGGTCGCGG ACGACGGAGC CGCTGTGGCG GTCTGGACCA CGCCGGAGAG   2281 CGTCGAAGCG GGGGCGGTGT TCGCCGAGAT CGGCCCGCGC ATGGCCGAGT TGAGCGGTTC   2341 CCGGCTGGCC GCGCAGCAAC AGATGGAGGG CCTCCTGGCT CCGCACCGGC CCAAGGAGCC   2401 CGCGTGGTTC CTGGCCACCG TCGGAGTCTC GCCCGACCAC CAGGGCAAGG GTCTGGGCAG   2461 CGCCGTCGTG CTCCCCGGAG TGGAGGCGGC CGAGCGCGCC GGGGTGCCCG CCTTCCTGGA   2521 AACCTCCGCG CCCCGCAACC TCCCCTTCTA CGAGCGGCTC GGCTTCACCG TCACCGCCGA   2581 CGTCGAGGTG CCCGAAGGAC CGCGCACCTG GTGCATGACC CGCAAGCCCG GTGCCGCATG   2641 CCCCACGCTA CTGCGGGTTT ATATAGACGG TCCCCACGGG ATGGGGAAAA CCACCACCAC   2701 GCAACTGCTG GTGGCCCTGG GTTCGCGCGA CGATATCGTC TATGTACCCG AGCCGATGAC   2761 TTACTGGCGG GTGCTGGGGG CTTCCGAGAC AATCGCGAAC ATCTACACCA CACAACACCG   2821 CCTCGACCAG GGTGAGATAT CGGCCGGGGA CGCGGCGGTG GTAATGACAA GCGCCCAGAT   2881 AACAATGGGT ATGCCTTATG CCGTGACCGA CGCCGTTCTG GCTCCTCATA TCGGGGGGGA   2941 GGCTGGTAGC TCACATGCCC CGCCCCCGGC CCTCACCCTC ATCTTCGACC GCCATCCCAT   3001 CGCCGCCCTC CTGTGCTACC CGGCCGCGCG GTACCTTATG GGCAGCATGA CCCCCCAGGC   3061 CGTGCTGGCG TTCGTGGCCC TCATCCCGCC GACCTTGCCC GGCACCAACA TCGTGCTTGG   3121 GGCCCTGCCG GAGGACAGAC ACATCGACCG CCTGGCCAAA CGCCAGCGCC CCGGCGAGCG   3181 GCTGGACCTG GCTATGCTGG CTGCGATTCG CCGCGTTTAC GGGCTACTTG CCAATACGGT   3241 GCGGTATCTG CAGTGCGGCG GGTCGTGGCG GGAGGACTGG GGACAGCTTT CGGGGACGGC   3301 CGTGCCGCCC CAGGGTGCCG AGCCCCAGAG CAACGCGGGC CCACGACCCC ATATCGGGGA   3361 CACGTTATTT ACCCTGTTTC GGGCCCCCGA GTTGCTGGCC CCCAACGGCG ACCTGTATAA   3421 CGTGTTTGCC TGGGCCTTGG ACGTCTTGGC CAAACGCCTC CGTTCCATGC ACGTCTTTAT   3481 CCTGGATTAC GACCAATCGC CCGCCGGCTG CCGGGACGCC CTGCTGCAAC TTACCTCCGG   3541 GATGGTCCAG ACCCACGTCA CCACCCCCGG CTCCATACCG ACGATATGCG ACCTGGCGCG   3601 CACGTTTGCC CGCGAGATGG GGGAGGCTAA CGAGCTCGGC AGTGGAGAGG GCAGAGGAAG   3661 TCTGCTAACA TGCGGTGACG TCGAGGAGAA TCCTGGCCCA AGCCAGTTCG ACATCCTGTG   3721 CAAGACCCCC CCCAAGGTGC TGGTGCGGCA GTTCGTGGAG AGATTCGAGA GGCCCAGCGG   3781 CGAGAAGATC GCCAGCTGTG CCGCCGAGCT GACCTACCTG TGCTGGATGA TCACCCACAA   3841 CGGCACCGCC ATCAAGAGGG CCACCTTCAT GAGCTACAAC ACCATCATCA GCAACAGCCT   3901 GAGCTTCGAC ATCGTGAACA AGAGCCTGCA GTTCAAGTAC AAGACCCAGA AGGCCACCAT   3961 CCTGGAGGCC AGCCTGAAGA AGCTGATCCC CGCCTGGGAG TTCACCATCA TCCCTTACAA   4021 CGGCCAGAAG CACCAGAGCG ACATCACCGA CATCGTGTCC AGCCTGCAGC TGCAGTTCGA   4081 GAGCAGCGAG GAGGCCGACA AGGGCAACAG CCACAGCAAG AAGATGCTGA AGGCCCTGCT   4141 GTCCGAGGGC GAGAGCATCT GGGAGATCAC CGAGAAGATC CTGAACAGCT TCGAGTACAC   4201 CAGCAGGTTC ACCAAGACCA AGACCCTGTA CCAGTTCCTG TTCCTGGCCA CATTCATCAA   4261 CTGCGGCAGG TTCAGCGACA TCAAGAACGT GGACCCCAAG AGCTTCAAGC TGGTGCAGAA   4321 CAAGTACCTG GGCGTGATCA TTCAGTGCCT GGTGACAGAA ACCAAGACAA GCGTGTCCAG   4381 GCACATCTAC TTTTTCAGCG CCAGAGGCAG GATCGACCCC CTGGTGTACC TGGACGAGTT   4441 TCTGAGGAAC AGCGAGCCCG TGCTGAAGAG AGTGAACAGG ACCGGCAACA GCAGCAGCAA   4501 CAAGCAGGAG TACCAGCTGC TGAAGGACAA CCTGGTGCGC AGCTACAACA AGGCCCTGAA   4561 GAAGAACGCC CCCTACCCCA TCTTCGCTAT CAAGAACGGC CCTAAGAGCC ACATCGGCAG   4621 GCACCTGATG ACCAGCTTTC TGAGCATGAA GGGCCTGACC GAGCTGACAA ACGTGGTGGG   4681 CAACTGGAGC GACAAGAGGG CCTCCGCCGT GGCCAGGACC ACCTACACCC ACCAGATCAC   4741 CGCCATCCCC GACCACTACT TCGCCCTGGT GTCCAGGTAC TACGCCTACG ACCCCATCAG   4801 CAAGGAGATG ATCGCCCTGA AGGACGAAAC CAACCCCATC GAGGAGTGGC AGCACATCGA   4861 GCAGCTGAAG GGCAGCGCCG AGGGCAGCAT CAGATACCCC GCCTGGAACG GCATCATCAG   4921 CCAGGAGGTG CTGGACTACC TGAGCAGCTA CATCAACAGG CGGATCACCG GTTGCGTACG   4981 CGGATCCTCT GCTGGAGACA TGAGAGCTGC CAACCTTTGG CCAAGCCCGC TCATGATCAA   5041 ACGCTCTAAG AAGAACAGCC TGGCCTTGTC CCTGACGGCC GACCAGATGG TCAGTGCCTT   5101 GTTGGATGCT GAGCCCCCCA TACTCTATTC CGAGTATGAT CCTACCAGAC CCTTCAGTGA   5161 AGCTTCGATG ATGGGCTTAC TGACCAACCT GGCAGACAGG GAGCTGGTTC ACATGATCAA   5221 CTGGGCGAAG AGGGTGCCAG GCTTTGTGGA TTTGACCCTC CATGATCAGG TCCACCTTCT   5281 AGAATGTGCC TGGCTAGAGA TCCTGATGAT TGGTCTCGTC TGGCGCTCCA TGGAGCACCC   5341 AGTGAAGCTA CTGTTTGCTC CTAACTTGCT CTTGGACAGG AACCAGGGAA AATGTGTAGA   5401 GGGCATGGTG GAGATCTTCG ACATGCTGCT GGCTACATCA TCTCGGTTCC GCATGATGAA   5461 TCTGCAGGGA GAGGAGTTTG TGTGCCTCAA ATCTATTATT TTGCTTAATT CTGGAGTGTA   5521 CACATTTCTG TCCAGCACCC TGAAGTCTCT GGAAGAGAAG GACCATATCC ACCGAGTCCT   5581 GGACAAGATC ACAGACACTT TGATCCACCT GATGGCCAAG GCAGGCCTGA CCCTGCAGCA   5641 GCAGCACCAG CGGCTGGCCC AGCTCCTCCT CATCCTCTCC CACATCAGGC ACATGAGTAA   5701 CAAAGGCATG GAGCATCTGT ACAGCATGAA GTGCAAGAAC GTGGTGCCCC TCTATGACCT   5761 GCTGCTGGAG GCGGCGGACG CCCACCGCCT ACATGCGCCC ACTAGCCGTG GAGGGGCATC   5821 CGTGGAGGAG ACGGACCAAA GCCACTTGGC CACTGCGGGC TCTACTTCAT CGCATTCCTT   5881 GCAAAAGTAT TACATCACGG GGGAGGCAGA GGGTTTCCCT GCCACAGCTG GCTCCGGCGA   5941 GGGCAGGGGA AGTCTTCTAA CATGCGGGGA CGTGGAGGAA AATCCCGGCC CAGTGAGCAA   6001 GGGTGAGGAG GATAACATGG CCTCTCTCCC AGCGACACAT GAGTTACACA TCTTTGGCTC   6061 CATCAACGGT GTGGACTTTG ACATGGTGGG TCAGGGCACC GGCAATCCAA ATGATGGTTA   6121 TGAGGAGTTA AACCTGAAGT CCACCAAGGG CGACCTCCAG TTCTCCCCCT GGATTCTGGT   6181 CCCTCATATC GGGTATGGCT TCCATCAGTA CCTGCCCTAC CCTGACGGGA TGTCGCCTTT   6241 CCAGGCCGCC ATGGTAGATG GCTCTGGATA CCAAGTCCAT CGCACAATGC AGTTTGAAGA   6301 TGGTGCCTCC CTTACTGTGA ACTACCGCTA CACCTACGAG GGAAGCCACA TCAAAGGAGA   6361 GGCCCAGGTG AAGGGGACTG GTTTCCCTGC TGACGGTCCT GTGATGACCA ACTCGCTGAC   6421 CGCTGCGGAC TGGTGCAGGT CGAAGAAGAC TTACCCCAAC GACAAAACCA TCATCAGTAC   6481 CTTTAAGTGG AGTTACACCA CTGGAAATGG CAAGCGCTAC CGGAGCACTG CGCGGACCAC   6541 CTACACCTTT GCCAAGCCAA TGGCGGCTAA CTATCTGAAG AACCAGCCGA TGTACGTGTT   6601 CCGTAAGACG GAACTCAAGC ACTCCAAGAC CGAGCTGAAC TTCAAGGAGT GGCAAAAGGC   6661 GTTTACCGAT GTGATGGGCA TGGACGAGCT GTACAAGTGA ATTCGATCAT AATCAGCCAT   6721 ACCACATTTG TAGAGGTTTT ACTTGCTTTA AAAAACCTCC CACACCTCCC CCTGAACCTG   6781 AAACATAAAA TGAATGCAAT TGTTGTTGTT AACTTGTTTA TTGCAGCTTA TAATGGTTAC   6841 AAATAAAGCA ATAGCATCAC AAATTTCACA AATAAAGCAT TTTTTTCACT GCATTCTAGT   6901 TGTGGTTTGT CCAAACTCAT CAATGTATCT TATCATGTCT GGCTCGAGGG AAGTTCCTAT   6961 ACTCTAGAAA GAATAGGAAC TTCAAAGGAA GTGCTTCAGG GTGAAGGAAA ATGATACTAG   7021 ATGGTGACCC AGATATACAG AAAGGAACAA TTAACAACAG AAATGATGCA CATACACATG   7081 TCACATTCAC ACTCATTTTC TTAATTTCCT GAAGACATAT GGCTACTTGT TTAAAACAAA   7141 AAGTATTACA CTGTATCATT GAGCTTATAA TATAGGTTGA TGTAATATAT ACAACAATAA   7201 TAGCACAATG GTAGGTTACA AGAAACTACA CTGTTAGAAG TGTCCTTTAT TTTCTGGATG   7261 CAGOTTAATA TAACCTGAAC TTCACTGTGA AAAGTCAAGG AATCGGGTTT CCATTCTTTG   7321 CTATTGTGTA AAGAAATATA GCCAAAAGCC ACTAGGAGAA TTAAAACCAT AAACTAAAAA   7381 ATGTTTATTT GACACATAAG AAAGTAGTAA AGGAGGAACA GAAACAAAAA GATATGAGAC   7441 AAATTGAAAA CGTATAGCAA AATTGTAGAC CAAAACCCAA CCATTGCAAG TGAAGAAATG   7501 ACATGACCTG AGTCACATTA GCAGGACTGC TGAGCACTGT GGGGAGAACA GATATGGGCA   7561 GGAGGTGAGG GACAGTGTTA GTGCCACAAT TCAGGAGGGA AAGGGTGGCA GGGACTAACG   7621 GGGGTGGTGT GAAGGATGAG AAGGGCAGAC AGAAGGGCTG GAGAGGCAGG AGGAGAGGAA   7681 AAGGAGCAGG AGAAAGAATT CTAAAGCAGT GGAAGAGCCT GGCAGAGGGT TCTTTGCATT   7741 CGGTATTTAA TACATTTTGT TGGACTTCCT AAAAACTAAT TGGCTCCTTA TGATTAAAAA   7801 AAAAAGAGTT ACAAAAATAC CAAGTGTTCA GATAAAATAT GCACACTGCT TGGATGTGCA   7861 GAGTTCAGGA AAACAGGCAG TGCTTGAGCG CTGGTGAAGA GCATTGGGAC TGCATGGAGC   7921 CCTCGCAACT TTGAGGTGAT GACTACAGGT TCCCGGTTGC AATAGACAGT AACAAACCCT   7981 GCTTCTTTAT ATTCAGGAGA TGTTCTGGAC TCACACAGGG AAACTCAGGG TGGGGAATGA   8041 AGATAATTTT AAATGCAACA ACCCAGAGTC ACAGATCCAT AGTCTGGGAA AGTAAAACTT   8101 AGGAGCTTTG AGAGTTTAAT TGTAATGCTG TTTTGACACA GGTCTTTTGC AGATTGGAAT   8161 TCTAATCATT CAGGGATTAC CAATATTGTG CTACCTACTG TATTAATAAA CAAAAAGGAA   8221 ACTGGTCTCT ATGAGAATCT CTGTGTGGTG GCTTCAGACA AAACTTCGCC AGGTTTAGAG   8281 AGAAAACCCC TGTCTCTACA CCTCCATTCC CAGGGCGAGC TCACTCTCTG GCATCAAGTT   8341 CTCCGTGATC AGCTTCCCTA CACAAGANTC CAAGAGGAGA GGTAAGGAGT GAGAGGCAGG   8401 GAGTCCAGTT CAGGGACAGG GATTCCAGGA GGAGAAGTGA AGGGGAAGCG GGTGGGCGCA   8461 GCCTGGGGGT CTCTCCCTGG TTTCCACAGA CAGATCCTTG TGCAGGACTC AGGCAGACAG   8521 TGTGACAAAG AGGCTGGTGT AGGAGAAGAG GGATCAGGAC GAAGTCCCAT GTCCCGGACG   8581 GGGCTCTCAG GGTCTCAGGC TCCGAGGGCC GCGTCTGCAT TGGGGAGGCG CAGCGTTGGG   8641 GATTCCCCAC TCCCACGAGT TTCACTTCTT CTCCCAACCT ATGTCGGGTC CTTCTTCCAG   8701 GATACTCGTG ACGCGTCCCC ATTTCCCACT CCCATTGGGT GTCGGGTGTC TAGAGAAGCC   8761 AATCAGTGTC GCCGGGGTCC CAGTTCTAAA GTCCCCACGC ACCCACCCGG ACTCAGAGTC   8821 TCCTCAGACA CCGAGATGCG GGTCACGGCA CCCCGAACCC TCCTCCTGCT GCTCTGGGGG   8881 GCCCTGGCCC TGACCGAGAC CTGGGCCGGT GAGTGCGGGT CGGGAGGGAA ATGGCCTCTG   8941 TGGGGAGGAG CGAGGGGACC GCAGGCGGGG GCGCAGGACC CGGGGAGCCG CGCCGGGAGG   9001 AGGGTCTGGC GGGTCTCAGC CCCTCCTCGC CCCCAGGCTC CCACTCCATG AGGTATTTCT   9061 ACACCGCCAT GTCCCGGCCC GGCCGCGGGG AGCCCCGCTT CATCGCAGTG GGCTACGTGG   9121 ACGACACGCA GTTCGTGAGG TTCGACAGCG ACGCCGCGAG TCCGAGAGAG GAGCCGCGGG   9181 CGCCGTGGAT AGAGCAGGAG GGGCCGGAGT ATTGGGACCG GAACACACAG ATCTACAAGG   9241 CCCAGGCACA GACTGACCGA GAGAGCCTGC GGAACCTGCG CGGCTACTAC AACCAGAGCG   9301 AGGCCGGTGA GTGACCCCGG CCCGGGGCGC AGGTCACGAC TCCCCATCCC CCACGTACGG   9361 CCCGGGTCGC CCCGAGTCTC CGGGTCCGAG ATCCGCCTCC CTGAGGCCAC GGGACCCGCC   9421 CAGACCCTCG ACCGGCGAGA GCCCCAGGCG CGTTTACCCG GTTTCATTTT CAGTTGAGGC   9481 CAAAATCCCC GCGGGTTGGT CGGGGCGGGG CGGGGCTCGG GGGACGGGGC TGACCGCGGG   9541 GCCGGGGCCA GGGTCTCACA CTTGGCAGAC GATGTATGGC TGCGACCTGG GGCCGGACGG   9601 GCGCCTCCTC CGCGGGCATA ACCAGTTAGC CTACGACGGC AAGGATTACA TCGCCCTGAA   9661 CGAGGACCTG AGCTCCTGGA CCGCGGCGGA CACCGCGGCT CAGATCACCC AGCGCAAGTG   9721 GGAGGCGGCC CGTGAGGCGG AGCAGCTGAG AGCCTACCTG GAGGGCACGT GCGTGGAGTG   9781 GCTCCGCAGA TACCTGGAGA ACGGGAAGGA GACGCTGCAG CGCGCGGGTA CCAGGGGCAG   9841 TGGGGAGCCT TCCCCATCTC CTATAGGTCG CCGGGGATGG CCTCCCACGA GAAGAGGAGG   9901 AAAATGGGAT CAGCGCTAGA ATGTCGCCCT CCCTTGAATG GAGAATGGCA TGAGTTTTCC   9961 TGAGTTTCCT CTGAGGGCCC CCTCTTCTCT CTAGGACAAT TAAGGGATGA CGTCTCTGAG  10021 GAAATGGAGG GGAAGACAGT CCCTAGAATA CTGATCAGGG GTCCTCTTTG ACCCCTGCAG  10081 CAGCCTTGGG AACCGTGACT TTTCCTCTCA GGCCTTGTTC TCTGCCTCAC ACTCAGTGTG  10141 TTTGGGGCTC TGATTCCAGC ACTTCTGAGT CACTTTACCT CCACTCAGCT CAGGAGCAGA  10201 AGTCCCTGTT CCCCGCTCAG AGACTCGAAC TTTCCAATGA ATAGGAGATT ATCCCAGGTG  10261 CCTGCGTCCA GGCTGGTGTC TGGGTTCTGT GCCCCTTCCC CACCCCAGGT GTCCTGTCCA  10321 TTCTCAGGCT GGTCACATGG GTGGTCCTAG GGTGTCCTAT GAGAGATGCA AAGCGCCTGA  10381 ATTTTCTGAC TCTTCCCATC AGACCCCCCA AAGACACACG TGACCCACCA CCCCATCTCT  10441 GACCATGAGG CCACCCTGAG GTGCTGGGCC CTGGGCTTCT ACCCTGCGGA GATCACACTG  10501 ACCTGGCAGC GGGATGGCGA GGACCAAACT CAGGACACTG AGCTTGTGGA GACCAGACCA  10561 GCAGGAGATA GAACCTTCCA GAAGTGGGCA GCTGTGGTGG TGCCTTCTGG AGAAGAGCAG  10621 AGATACACAT GCCATGTACA GCATGAGGGG CTGCCGAAGC CCCTCACCCT GAGATGGGGT  10681 AAGGAGGGGG ATGAGGGGTC ATATCTCTTC TCAGGGAAAG CAGGAGCCCT TCTGGAGCCC  10741 TTCAGCAGGG TCAGGGCCCC TCGTCTTCCC CTCCTTTCCC AGAGCCATCT TCCCAGTCCA  10801 CCATCCCCAT CGTGGGCATT GTTGCTGGCC TGGCTGTCCT AGCAGTTGTG GTCATCGGAG  10861 CTGTGGTCGC TACTGTGATG TGTAGGAGGA AGAGCTCAGG TAGGGAAGGG GTGAGGGGTG  10921 GGGTCTGGGT TTTCTTGTCC CACTGGGGGT TTCAAGCCCC AGGTAGAAGT GTTCCCTGCC  10981 TCATTACTGG GAAGCAGCAT CCACACAGGG GCTAATGCAG CCTGGGACCC TGTGTGCCAG  11041 CACTTACTCT TTTGTGCAGC ACATGTGACA ATGAAGGACG GATGTATCAC CTTGATGGTT  11101 GTGGTGTTGG GGTCCTGATT TCAGCATTCA TGAGTCAGGG GAAGGTCCCT GCTAAGGACA  11161 GACCTTAGGA GGGCAGTTGG TCCAGGACCC ACACTTGCTT TCCTCGTGTT TCCTGATCCT  11221 GCCTTGGGTC TGTAGTCATA CTTCTGGAAA TTCCTTTTGG GTCCAAGACG AGGAGGTTCC  11281 TCTAAGATCT CATGGCCCTG CTTCCTCCCA GTCCCCTCAC AGGACATTTT CTTCCCACAG  11341 GTGGAAAAGG AGGGAGCTAC TCTCAGGCTG CGTGTAAGTG GTGGGGGTGG GAGTGTGGAG  11401 GAGCTCACCC ACCCCATAAT TCCTCCTGTC CCACGTCTCC TGCGGGCTCT GACCAGGTCC  11461 TGTTTTTGTT CTACTCCAGC CAGCGACAGT GCCCAGGGCT CTGATGTGTC TCTCACAGCT  11521 TGAAAAGGTG AGATTCTTGG GGTCTAGAGT GGGCGGGGGG GGGTGGGGTG GGGAGGGGGC  11581 AGAGGGGAAA GGCCTGGGTA ATGGAGATTC TTTGATTGGG ATGTTTCGCG TGTGTGGTGG  11641 GCTGTTTAGA GTGTCATCAC TTACCATGAC TAACCAGAAT TTGTTCATGA CTGTTGTTTT  11701 CTGTAGCCTG AGACAGCTGT CTTGTGAGGG ACTGAGATGC AGGATTTCTT CACTCCTCCC  11761 CTTTGTGACT TCAAGAGCCT CTGGCATCTC TTTCTGCAAA GGCACCTGAA TGTGTCTGCG  11821 TCCCTGTTAG CATAATGTGA GGAGGTGGAG AGACAGCCCA CCCCCGTGTC CACTGTGACC  11881 CCTGTTCCCA TGCTGACCTG TGTTTCCTCC CCAGTCATCT TTCCTGTTCC AGAGGGGTGG  11941 GGCTGGATGT CTCCATCTCT GTCTCAACTT TATGTGCACT GAGCTGCAAC TTCTTACTTC  12001 CCTACTGAAA ATAAGAATCT GAATATAAAT TTGTTTTCTC AAATATTTGC TATGAGAGGT  12061 TGATGGATTA ATTAAATAAG TCAATTCCTG GAATGTGAGA GAGCAAATAA AGACCTGAGA  12121 ACTTTCCAGA ATCTGCATGT TCGCTGTGCT GAGTCTGTTG CAGGTGGGGT GTGGAGAAGG  12181 CTGTGGGGGG CCGAGTGTGG ACAGGGCCTG TGCCCAGTTG TTGTTGAGCC CATCATGGGC  12241 TCTATGTGGT TAGTCCTCAG CTGGGTCACC TTCACTGCCC CATTGTCCTT GTCCCTTCAG  12301 CGGAAACTTG TCCAGTGGGA GCTGTGACCA CAGAGGCTCA CACATCGCCC AGGGTGGCCC  12361 CTGCACACGG GGGTCTCTGT GCATTCTGAG ACAAATTTTC AGAGCCATTC ACCTCCTGCC  12421 CTGCTTCTAG AGCTCCTTTT CTGCTCTGCT CTCCTGCCCT CTCTCCCTGC CCTGGTTCTA  12481 GTGATCTTGG TGCTGAATCC AATCCCAACT CCTGAATCTG TAAAGCAGAG TCTAATTTAG  12541 ACTTACATTT GTCTGTGAAA TTGGACCCAT CATCAAGGAC TGTTCTTTCC TGAAGGGAGA  12601 ACCTGATTGT GTGCTGCAGT GTGCTGGGGC AGGGGGTGCG GGGAGGGGGT TGCTGTAGAA  12661 AGAGGGATGG GGAGGGATGG CCTGAGGCTA TGTTAATAAA GATACTGCCT TCAAAATAGG  12721 GAGGTGCTCT ACAGTGATCA TTCATTCAAC TGACCTTTGT CATTGGCCAG ACATAGGACA  12781 GAATGGTTCT GCATCTGGGG AACACCACTG AAGTAAAATC AGAAAAATCT CTGGCCTTTT  12841 GTAGCATATG TTCCAGTGGG AAGAGGCAGA CGATAGATAC ACTATAACCA GAGTAAGGAA  12901 GGAAAGTGCT AGAAGGTGGT AAGTGCTGTG AGGCAGGTGA TCCAGGATGT GGGCAGTGGG  12961 GACAGGGAAG GTGGCTGTTG TGCTGGGTAG TCAGTGTGTG CCTTGTTGCA AAGGTGACTT  13021 TTGAGGAAAG ATTTGAGAGA CATGAGGATG TCTGGGGAAG TTCTTTCCAG GCAGAGGAAG  13081 CTCCAGTCCA AATGCACTAT GGCAGGAAGG TGTTTGTGTT CCCAGAAGAG CAAGGAGGCC  13141 AGGAGGGCTG GACGGAGAGA AACTGAGGTG AGGTCAGAGG TGCGGCCAGA ACAGGTGGGC  13201 TTGAGGGGAG TGGGGTTGGA TCTGGCCTTT GCTCTGAGTG GGATGGGGAG TTAGAGGACA  13261 GTTTTGAGCA GAAGAGAGCC ATGATATGAC TTCTGTTTTA AAAGGATCTC TCTGACGGCT  13321 GTGCTGAGAA CAGAATTGAG AGGCAAGGGA CGAGGGAGGC AGAAGGGAAA ACAGTAGGAA  13381 TCAAGTGCAG TATTCCAGGC TGGAGATGTC GGTTACCTTG ACTGGGGCGT GAGCAGGGGA  13441 AATAGTGGGA CGTGAGGGGA TTCTGGATGC ATTTGAAGAT GGACTCACAG CATTTGCCAA  13501 TGGATTGTAT CTGTGATGTG AGAAAGACGA ATCAAGGACA CCCATAGTTG TAAAATGAGT  13561 GAGTAGAAGG ATGGAGCTGC TGTCAGTGGA GATGGGGAGA CTCTGGCAGG AGCGTCCTGA  13621 AGAGGGGACA TCACAGGCAC TCAGTGGAGG AGATGTCTAC TAGGAGGGCG GGTGGGGGAG  13681 CTGGGTGGAA TTTGGACAGA CAACTCCAGA GTTTAGGGGA AAGGACTGGG CTGGAGAAAT  13741 AGATTTAGGA GGTCACACCA TATATATGAG ACTTAAAACC TCAAGCATGG ATGAGGCACA  13801 AAGGGAGTGA CTGACTATGG AAAAGAATGA GCACAAGGAC TGAACCCTGG ACCTCCAGTT  13861 CTAAGGGGTG TGATCAGATC ACACCCAGAG CAGACTGCAC AGTTCTGGCC CCATGTCTAG  13921 AGGACACTCA GACAAGGAAA CCCCATGTGC ACCAGGATCA TCTGGATGTG GTGCTGAGAT  13981 CCTGGAAGTC TGGAGTTGAG CAAGAGATTC TGGATTTATG ACAAGGCTGG AGCTCATGTT  14041 GCTGGTCTCC AGATCACACT TGGAGTAGCA AGAACACCAG GATCCCACAC GTCTGAGCAT  14101 CAGCCTCACC TCTAGGGCTT GTCATATAAA TGATTCCTTG GTCTTGTGCA TAATTCTCTG  14161 AGACAAGGGT TCTGGGGAGT GGCCTGTGTA TTTTCTAAGT CCCCACCAGC AATCCTATTG  14221 CTCAGACAGA TTGGGAGCCA CTGAGATCAG TGATCAGAGA GTGCCCAGGG TGGGTGGGTG  14281 GGGTGGGTTT TCAAACCCTG TTGAAAAGAG GATTTTTCTC ACAGAAAGAA AAGGGAGGAT  14341 GTATATCATC AGTTATGAGA GGTGATATTC TCTGTTGTTC TCTCCACCAT GGGGTAGAGG  14401 CCAGGTAGAC AATTCAGGAT GTGGCTCTCG CACAAAGAAC ACCTCTGAAT GCCGCTCTCT  14461 GACACTCGCC CGCAGACTCA TTTCTCACTC ACTTCTTGGA GAAAACTATG GAAACCAAAT  14521 TTCTGTAATG TACACATAAA GTTGTATATT GGTATTGGGG GCTAGTTTTA TTGTGGGGAA  14581 GGCCACAGAA CCAGGCTGGA AACTACACAT CCAAGAACAG AATTCACAGC CCACCCTGGA  14641 TCAGGTCCCT CCTAGGAACA ACTGCCCCTG CTGCTGAGCA CAGACAGCAC TGCTCACACC  14701 TCTGACATCC TGGTGCTGGA CACTGGACCC TGAGGCTAGG ACAGATGTCA CTGCTGCACC  14761 TGGAAATTGG ACATCACTAC TGTCACTCAG CCATCTTTAC TAAAATGCTT TCTGCACAGT  14821 CCTAGCCTCT CTGTCACCTC ATTCTGGCTG AGTCTGGCAG TGATATAGGA GTTAAGAAGA  14881 AATTATTTAG ACAGGTAGTG AGGGTACGCA AGGCTTTTAA TGGAAAGCAG GCTCCAAATT  14941 ATTTTCTTTT CTAACAAGGA GCAGCCTGTA ATATCAAGCT TCAGACATAG ACAAGTAAGC  15001 TGGAAGTTTG CACGGGTGAA TGCCAGCAGC TGTCCAATAG GAATAGGACG CCTGGGACTG  15061 GGCATGTTCA CTATGGCGGC TCCATCTTCC CTTCTCTTTG CCAGGCACGT TTATAGTAAG  15121 GAGCAGACAA CATGTCACCG GCCAAGTGGA AAGCCCATTT GCATAATAGG ATGAGGGTGG  15181 GGTGAACAGC CTTCCACACG CACTATGTAA ATATCACACC TGGTACAACC AACCTGTGGG  15241 CCCTACATAA ATCAGACACC ATCTCCTCAA GCCTGCCTGT AAAATCCGAT GCACTCCATT  15301 CCAGGCTGGA ATTCCCTTTT GGGTGCCCCT CTCTCTCACA AGAAGGAGCT GTTTCCCTTT  15361 GTCTTTCTTT TGCCTATTAA ACCCTTTGAT CCTAACTCAC TCCTCGTGTG TCAGTGTCCT  15421 TAATCTTCTT GGCGTGAGAT GACGAACACT TAGTATTTAC CTGAGACAAT GACACCTCTT  15481 CAGCAGGTGG TCATCAGACT GGTGGAGCTT AAAATTCATG TCCATGATCA ACTGCAGGGG  15541 TGACTGGAGT GTTGTTGTCC TCTTCCAGGG AGGGAGGTGG TGTCTGTCTC CTCTCAACAT  15601 TTTACATGTT GTAAACCAAA AATAAACATC AAAGCCACCC CTTCCCAATC ATTTTAATGG  15661 ACACCCTCAG CCAGGGTGCT CAAAAGTTAA CCTGAAAGAG TGGCTCAGGC CACCATGGGA  15721 AGCAGGTATT GAACATGTCT TATTATGCCC TCTTCCCTCT TGGAATTCAG GAAAAGTTGA  15781 CCAGCATTTA CCATCAACAC AGACCTTCAG TCTGATCAGA AACATTTACA ATCTATTCTC  15841 TTTGAAGCCT GGCACCTGGA GGCGTCATCT GTATGAGAAT TTTGGACTCC ACAACCTTTT  15901 ATCATAACCC AGACATTCCT TTCTATTGAT AATAACAACC AATTGCCAAT CAGAAAAATT  15961 AAAAATCTAC TTATAACCCA GAAGCACTAC CCCGCAACCC TTGCTTGCTT CAAATTGTTC  16021 CAACTTTCTG GACCGAACCA ATGTATAGCT TAAATGTATT TGATTGATGT CTCATATCTT  16081 CCTTAAATGT GTAAAACCAT GTATTTGATT GATGTCTCAT ATCTTCCTTA AATGTGTAAA  16141 ACCAACCTGT GCCTCAACCA CCTTGAGCAC ATGTTCTCGG TCTCCTGAGG GCTGTGTCAT  16201 GGGCTGTGGT CACTCATTTT TGGCTCAGAA TAAATCTCTT TAAATATGTT ACTGCGTTTG  16261 ACTCTTTTCA TTGACAGTGT GGAATTTTGA TGTAGTAAGC GGGTTCAAGT GCTGGAGTGT  16321 GAGGGGTGGG GAAAAGTGAC AAATTTTAAT TCTTGGAGCA GTGATCCAGG ACGAGAACTT  16381 TATCTAGTAC CCAGTAGGCA CGAAGAGTGG CTGAATGAAC CAGTGACTAA TAAATAACAT  16441 ATTTCCACCC ATTCCCTTGA GGATAGGTTT ACATCAAGTT TTTGTCTATC CCAGTTTATA  16501 GTCTAGATTA TTGGAGTGGC ATTCTGTAAT GATGAAATGA TTATTCAAAC CTCTTCCCTC  16561 AGCATGACTC TTACTAGGAT TAAAACTCCC AGGTTTGTAA GATATCAGAG GTTCTGGTTC  16621 CACACGATGT TTTATATTAA TATTTATATT TTCTTGTGTG TGGAAATATT TCTGGGGAGA  16681 GAATCTCTAA CATTTATTAG TTTTTATGTG ACACCCTCAA AGGCCTAAAA AATCCTAACT  16741 TCTAGATTAA AGGTAGGACC ACTCCACGTC TAGACAATGA ACAGCTGGTA GCAACCTGTG  16801 TTTAGGGACA TGAAACAAAT GCTTACATTT GTTTATCTTT TCCTCTGGGA CCAAAGAAGG  16861 TAGAGGTTTA CTTGCTTACT CTTACTATAA GTTTCTCTCT GTGGGATGGT GATGGGGTTT  16921 TCTTCCACCC AAATAACTTT CTGATTCTCC AACAGCAGCT GGGAGTCCCA CAATTTGACT  16981 CAATTCTGAC ACTAACTACC TGGAGTTCGC CTCAGACTCT ACAGGTTTAC CAGCTCAGTC  17041 CTACAAGTCT GTCCTCACTT CAGAAGCAAG TCACAAGTAT CGGGTCCCAG GTTACCTGCA  17101 CTTCTGTCTA ACATGGCTGC AAAGTCAGGG GTTTCTCACC TCCCAAGGAT TGAGAATTCT  17161 TAAACTAACT CAAAGAACTC AGGAAGTTGC TATAGCCGTG TAAACCAAAA AACGTCTGAG  17221 ACAGGTCTCA GTCAGTTTAG AAGTTTATTT TGCCAAGCTG AAGACGCACC TTGGAAACAG  17281 AGACACAAAT CATTGTAGCA TCTGTGGCCC ATGCTCTTTC CTAACAGGCT TTTGAGGACT  17341 TCAATATGTA CAGGGGAAAG AGCAGCCAGG AGAGGAAAAA AATAGTCAAC TATGCATTCA  17401 TCTCATGCTC AGTAAATCTG CATTTTAAAT AAGATAAAGT AAACATTGGG TGGAAAAGTC  17461 AAATATGCGT TTGACTCTGG GTGGGTGGAG GGATGATTTC TAGTCTTGTC TTTGTCCTGT  17521 ACCTGTGAAG ATAAGCTGTT AATTTACATT GTCAGGGGAA AATTCAACAA AACTGTTTTA  17581 GGGTAAACAC GTTGGGGCCC ACAAGGAATT ATCTTGTGAG CAGTTTGTGA GGGAGGCCAC  17641 CTGGGGAGAT ATGTGGTCTT CTATCTTTGC AGTTATTTGT TTAGGAACGA AAGAAAGGCA  17701 GTTTTTCCAT CAGTCTCCAA ACTTAATTTT TCCTTTTGGT ATAGTGAATT TGGAGTCCTG  17761 AAATTTTATT TTCTTTTCAC ACTCAGTATT GCAGTTTTTT ATTGTTATAG CTTAAATCCC  17821 CACCTTTTTG GCACCTGGGA CCGGTTTCAT GGAAGACAGT TTTTCCATGG ACTAGTGGAG  17881 GTGGTGGAGG GCAGAGGGAA ATGGTTTCGG ATGAAACTGT TGTACCTCAG ATGATCAGGC  17941 ATTAGCGCTT CATAAGGAGC ATGCAACCTA GATCTCTCGC ATGCAGAGTT CACAATAGGG  18001 TTCGTGCTTC TATGAGAATC TAATTCCGCC ACTGATCTGA CAGGAGGCGG AACTCTGGTG  18061 TCATGCTCAT GCTCTCTCAC CCACTGATCA CCTCCTGCTG TGCAGTCTGG TTCCTACCAG  18121 GCCAGGAACC TGTACCAGTC CGCAGCCCGG GGGTTAAGGA CCCCTGGTTT AAATTATGCC  18181 ACTAGAGCAG AACTCCTGAG ACTGGATAAC TTATAACAAA CAGAAATTTG TCTCGTTCAT  18241 GGTGTCGAGG ATGAGAATTC CCAGATCAAG GGACTCTATC TGGTAGAAAA CAAAAGGACA  18301 AGAGAGGGTG AGAGGTGGGG GGAAAAGGAA GTCAAACTCA CAGCCTCAGG TCCTTTTATC  18361 ATGAGCOTTA GTCCATGAAT GAAGGCAGAG CTCTGATGGT CCAATCACCT CTCAAAAGTC  18421 CCATTTCTTA AAAATGTTGC ATTTGGGATG AAATATCCAA CAGATGOTTT TTTGGGGAAA  18481 CATTCAAACC ATAGCAGTTA TAAAGGATAC CAAGGAGCAG CCAGATGAAG AGGTGCACAG  18541 GGTGAGGCCT GGAAGGGCTC TGAGCACAGG AGCCTCTGTC CCCATGGAGA TGGGGCTCAC  18601 CATCCTCCCA GCATGTGGAC ACACAGATGT GCTCTCCGAA ACCCAATCTC CAGAGGTTTC  18661 TATGGAAATT TCATTGTGGA GGCAAGACTA ATTAAATCAC TGGTCATTGT GTGACTGAAC  18721 TCAACCTCGA ACCTCTCTTT CCTTCCCAGA CTTTAGGGAT GGGGTTAACA GTTCCAATCC  18781 TCTAATCACA ACTTCGTGTT TCTGGCAACC AGCCCCCATC CTGAAGCTAT CTAGGAGCCC  18841 CTCACCCCAT AGTCATCTCA TTGCCATATT GAACTCATGT TTATCACTGA GGAGATTGCA  18901 AATGTTTTAG AACCTGGTTG TCAGGAAACA GGGAAAAGAC CAAATATTTT TATTGGACCA  18961 CAGATCACAC CCTGGTTTTG ACCACATTAT CTCTTTTTAT AATATTTATT ATTTTATTTT  19021 AGAGATAATC TOTTGCTCTG TTGCCCAGGG TAGAATGCAG TGGCACAATC ATAGCTCACT  19081 CTAACCTCGA ATTCCTGGAC TCAAGTGATC CTTCTGCCTC AGCCTCCTGA GTAGATAGCA  19141 TTACAGGTGC ACACCAACAT GCCCAACTAA TTTTTAAATA TTTTGTAGGA ATGGGTCTCA  19201 CTATTCTGCC CAGTCTGGTC TCAAACTCCT GGACTTAAAC AATGTTCCTA CCATTGCCTC  19261 CCAAACTGAT GGAATTATAA GTGTGAGCCA CTGTGCCTGG CCAATCACAG ATCTCCTACA  19321 CCAGAAGAAT CATAACAGTG AAAAGATCCT GGCACATTAC CAGAATCCTC TTTGGTCATT  19381 AACAATGATC CCAGTGCAAT CCATAAACAG GAATAGTTTC AGCAACATAT GGCTGCACCC  19441 TTTCAGGCGT CTGGTAAAAT TGAGCTAAGA GACAATATCA TCTCTTGCTT ATACCTTTTT  19501 CAAGTAGTTC ATGTAACATT GGATTTTCCT CATTACATAA CCCATTTATT CATTCATTTA  19561 CCCTCAGCTA CTATTTCTCC TTCCCTTCAT TTATACTAAA CATTTATAAT TTTGGAAGGA  19621 ACACTAGCTT CTGCTGCTGT GCTGGCTGAG ACTGCAGGGA CCAATAGAGT TCTAGCAAGT  19681 GTCTCCCGTC ATCCATTCCA GTTCATAGAG GGTAGGGTTA TACAGGTAGA GAACTGGTTG  19741 GCTATCTGAT CCCAGGCAAT ATAGCTGCAT TCAGTGTTAG CCCCAACTTT GCCAGATGCA  19801 GTGAAGGCAC AACCTACTTC TACAGGCCCT TAGGAATTAT TACATAATGG ACATAAAATA  19861 TATTTACAGT TTCTTGCTTA GGAATAATTC CTGTTTCTGA ACTCTATTTG CATCCCTAGT  19921 CCTGGGACCA CTGCATCAGG TATGAGAAAA GCAAGTTGAG GTGAATTACA GTCATCATTC  19981 CAGTGTCCTC CCACCTTGGG GAGGAATATA TGTAGATCAT ACCAGCACCT TCCCCTGATC  20041 CACCAGGAAA AGAGAGGATA CTCTCATGTC AAGTGTGAGC ACACTCATGA AGGTGTATAA  20101 GCCCACCCTT TGTGCTTGTT TCCCCACTCT TTCCTTTACA CACCCAATTG ACTATTTTAA  20161 TTCTCTATGG AACTCTTCCT CTGAGGAGGA TATCTCTCTG TGACCATTGT TGGACATTTT  20221 GAGCAGGTGC ATTTTCTGGT GTAAAGAAAT ATGACTCGGT GGTCCACGTG GTTGCAGTAC  20281 CTCCCATTCA AGTTCTTTTG TAACACTCGA GCATTTGCAT CTGAGATAAA GCAGGGACCT  20341 CTTTTAGAAG CCTGCCGGGG CCTCCCAATC TGGAAATAAA GAAAAACCTT CAGTTCCTTC  20401 AAGAGAAATT CCAGGCACCT AGCCAGCCCT AAAAAGTAAG TCGGTGACCT TATAAGCAAG  20461 AAGGAATGAT AGOTTGAAAC AATAGCCAAG GAAGTTAGAG TCACAAGATG TTTCATTCTC  20521 TATAGAAACT AAAAATAACA TCTTAACATA TGTCCCTGAG TTGTTTTTCA GAAACATGGA  20581 TTCCCTCCTA ATAGATCCAC TGACAGGGAG ACCTTATAAA GGGGAAACTG AGAACTGAAC  20641 TCTGACCGCC GTTCTTTGTT CTAAATTTCT TCCTGAGGGA CCTGGAGAGA GTCAAGCCCA  20701 CAGGCCAGGC CTGAACATTC CTCTCTACTG CCCCCAACTG TGTAAGGAAG CTGTGTAAAG  20761 AAGCTTTGCT TCCTTATCTA TCACAAATCA GAGAATCTTT AAATCTACCT AAGACCTGTA  20821 AGCTCCCTCA TCAGGATATT CTACCTTTTA AGGCCAAAGC AGTGTAACTT GTATGCATTG  20881 ATTTATGATG TTGCCTGTAA CTCTGCTTTC CCGAAATTTG CCCCTGCCTT TAAAAATTCT  20941 TGCTTGTGAG CCATCAAAAA NGTTGGGTCT TAAGCGTGAG CTGCCTGATT CTCCTTGTTT  21001 GGCGCCCTAC ACATAAATGC CCTCCTTTGT CCCACTACAA TCTCAGTGTG GATGTTTGCT  21061 TTTACTGCCC CAGGTGAGTG GACCCCAGTT CAGTTTGGTA ACACACCTAC CACCAGCTGA  21121 ACAAAGCCCA CTCCAGGGTG AGGATCTATT CCTGCCAAGA CCCGTTTGCT GCTTCCTGGG  21181 GCTACTGGTA TCAGTCTAAC TTGCCAGCTA TGTATTTTCA AGGCCCTCCC ATAAAAGAAT  21241 CTGCCACATA GCCATATGCT ATCTCTCTTT TTTTTTGTTA AAGAAAGGAC TTCTTATGTG  21301 TATTTTGTGC CTGTGATGTG TGGAATGCAA GAGGACTATG TCTTGATTCC ACCTATCTCT  21361 GCATTGCTAC AGCCCCAATG TCTACTTATT TCATGGACTC AGGTGATCAC CACAAGCAAA  21421 CCTGGATTTT TTGTTGTTGT TGTTTTTGAG ATGTGGTCTT GATATGTTTC CCTGGCTGGC  21481 CTCAAATGTT GCTCAGGTTA AACTCTAACT CCTGGACTCA AGATATCCTT CTGCCTCAGC  21541 CGCTCTCATA GCTGGAATTA CAAGTGCACC TGGCAAACAC TTGGAGATAA ATTCTTGTTG  21601 ATTTCAATCA CTTTCCAAAC CTGAAAGGGA GTTATTCTGA AGGACACTGA ACAGCACTGA  21661 GGGGACGGTG CTAAACCATT CATGAGAAAC TGACCTCGTG ATCCAACCAC CTCCCTCCCT  21721 CCAGGCCCCA CCTATAATGC TGGGGATCAC ATCTCGACAT GAGATCTGCA CAAGAACAAC  21781 ATCCAATCTA TATCAGGCAT CAACAGATCT TACATTAATG AACCCCTCAA ATTACCATAG  21841 TGATTTCTGT GGGACTTGGC TCATATGGGC ATTCTTTTCA TAGGCAAGTT TTTCATTGCT  21901 TTCCTGATTA ATTATACGGC CAGGCCATTA GTCACTCCCT GTAAGTCAGT AAAAACTAAA  21961 ACGTAGGAGC TTTATCATTG TTCAATTCTT CCACCACTGC TAAGAAAACA CCATGCAATT  22021 AAGTCCACAA CAGCTTTTCT GTTTTTACCT TCTTTGATCA AAGAGGTGGA CTTCCAAACA  22081 GTATGTTGTC CATTCATCTT GCAAATGCTG TACACAAACC AACCAGCTGT TAGTGGGTCA  22141 GTTGACTGAT ACTGCAGTTC AAATCCCAGC GCTGTCTGCT ACAGAGTTCC ATCTTGCTCA  22201 AGAGAGGTCA GTGTTTTGTT TAATTTACAC CTTCAGTGAA TTGAATGAAG CCCACTCACA  22261 TTATAGACAT TAATCTACTT TATTCAAAGT CTGGCTATTT ATGTGTTAAT CTCATCCAAC  22321 AAACATCCTC ACAAATCATC CAGAATAATG CTTGACCACC TCTCCAGGCA CGATGCTTTA  22381 CCCAAGATGA CCAATAAATT TTTTTTTATT ATTATACTTT AAGTTCTAGG GTACATGTGT  22441 ACAACGTGCA GGTTTGTTAC ATATGTATAC ATGTGCCATG TTGGTCTGCT GCACCTGTTA  22501 ACTCATTATT TACATTAGGT ATTTCTCCTA GTACTATCCC TCCCCACTGC CCCCACCCCA  22561 CGACAGGCCC CGGTGTGTGA TGTTCCCCCC TGTGTCCAAG TGTTCTCATT GTTCAATTCC  22621 CACCTATGAG TGAGAACATG CGGTGTTTGG TTTTCTGTCC TTGTGATAGT TTGAACAATG  22681 AGAACACTTG GACACTTGTG ATAGTTTGCT CAGAATGATG GTTTCCAGCT TCATCCACGT  22741 CCCTGCAAAG GACATGAACT CATCCTTTTT ATGGCTGCAT AGTATTCCAT GGTGTATATG  22801 TGACACATTT TCTCCCAGCA CCTGTTGTTT CCTGACTTTT TAATGATCGC CATTCTTACT  22861 GGTGTGAGAT GGGATACCAT TGTGGTTTTG ATTTGCATTT CTCTGATGGC CAGTGATGAT  22921 GAGCATTTTT TCATGTGTCT GTTGGCTGCA TAAATGTCTT CTTTGGAGAA GTGTCTGTTC  22981 ATATCCTTTG CCCACTTTTT GATGGGGTTG TTTGATTTTT TCTTGTAAAT TTGTTTGAGT  23041 TCCTTGTAGA TTCTGGATAT TAGCCCTTTG TTAGATGGGT AGATTGTAAA TATTTTCTCC  23101 CATTTTGTAG GTTGCCTGTT CACTGTGATG GTAGTTTCTT TTGCAGTGCA GAAGCTCTTT  23161 AGTTTAATTA GATCCCATTT GTCAATTTTG GTTTTTGATG CCATTGCTTT TGGTGTTTTA  23221 GTCATGAAGT CCTTGCCCAT GCCTATGGCC TGAAAGGTAT TGCCTAGGTT TTCTTCTAGG  23281 GTTTTTATGG TTTTAGGGAT GATCAGTAAA ATTAATTATG ACATTCTTCA ATATAAGAAT  23341 ACTCTGAGGA AATTAGCCTG TGATCTAATA AAACAAGGAG CAAACAACTG TTTCTAAAAA  23401 TTTATAACAA ATAGTCAAAA AGCCCTCGCT AGAGATTGTT TCTCACATTC ACTCTATAAT  23461 TCTGGGTAAA AAAAAAAGCA CGTATTTGTT GAAAACCACA GAAGAAGAGA AAATTGAAAA  23521 AGCAGAAAGT GAAAAAAATA AGAATAATAA TAAAGATGAC AGCAGTTATT TCATTGGAAA  23581 CAATGCAAAT GAGGAGACAG ATGAGCAACA TCTTTAGAGT CCTAAAAGGA AAATGCTGTG  23641 AAACTAGATT CTATTCCCAG AAAATAATAC CTTTTTCAAA TATATATGTA TAGTTTTAAT  23701 TGACAAAGTA TAATACATTC ATGAGATATT GTTTGATGTA TTGATATATG TGTACCCTAT  23761 GTAATGATTA AATTAAGCTA ACACACCTTG AATATATCTA TCAAAAAATA AAGGGATTTT  23821 AGGCCAGGCA TGGTGGCTCA TGTCTGTCAT CCCAACACTT TGGGAGGCCA AGGTAGGTAG  23881 ATCACGAAGT CAGGAGTCAA AACCAGCCTG ACCAACATGG TGAAACCTCG TCTCTACTAA  23941 AAATACAAAA ATTAGCTAGG CATGGTGGCA TGCTCCTGTA ATTCCCAGCT ACTCAGGAGG  24001 CTGAGGCAGG AGAATCACTT GAACATGGGA GGCGGAGGTT GCAGTAGGCC AATATCACAC  24061 CATTGCACTC CAGCCTGGGC AGTAGAGTGA GACTCTGTCT CAAAAATAAA CAAACAAACA  24121 AACAAACAAA CAAACAAATG GATTTTAGAC ATACAGGGAG TGAAAAAATA ACCAGCAGAC  24181 CTAAACTATA ATAAATGTTT CAGTCCTATA GGCAAAAAGA AAATTAAGGG ACTAGTTGGC  24241 ACAGCATTTA ACGATGAAGA GACAGCTTCA TCGCCCCCTC CCACTGAGAC AGAGAACACA  24301 GCCCCAGGGC CTGGGAATTC CTCAACCCAA TCCACCACCT TGGGCACCTG TGCACTCCTC  24361 CTGGGTACCT GAGGTTGGAT GCAATCACCT TAGCTATCAC CTACCTGCAA ACACCACCTA  24421 TGGGCATCCC ACCCAGCCTA TCGCATCTGC TGCTAACAAT GCACACTGCT TGGGACCCAG  24481 AGAAGCAGCC CACGACTGCC ACTGCCAAGC TGGTTGCCCA GGAGCTGAAG TCCCCAGCAC  24541 CTACCGAGTC AACCACTGCC ACTACTGCCA TCCAAGCAAG CCACCTGGAG GTCCAGGAAT  24601 CAGCCCACCA GTAACCACCA ATACAAATGC CAGTATATAC CACCTTGGGG CACAAAGATA  24661 GGAACACTCA GCACACCACT GCCACCACTG GAGCCTGAAG ACTGTCTCAT GTGGCATCCC  24721 AGTCCCCAGC ACATTTTCAC CACAGCCTCA CTAATAACCA CACCCTAATG CACAGAAGAA  24781 ATCACAGATA CCATTAACAC TGTCTACAGC CAAAGAAATT ATACAGAGAC CATAGTACTC  24841 TACTATGTAC TACACCCAGA ATCAAATCCA AAGTACCCCA GGCAACCAAC ACCATAGACT  24901 CATCTTCAGG AAAATGCTCT CCACTATGAA ACAAAATTCA AAAATAGGAA GAACTGACTG  24961 TTATATCAGA TGCAAAAATA TTAATGTTAG GACACAGAAA CATGAAAAAG CAAAAAAGAA  25021 AAAAAAAGCC GCAAAGGAAG ACAATAGATC TTAATCAAAA AGAAATTTTC AAGATTCTAG  25081 ATAAAGGACT CAAAACATTT ATTTTACAGA AGTTCAGTGA GATACAAAAG AATTCTGAAA  25141 AAAAAAATAC AAAGAAAACA TAAAAATAAT TCAGGATACA AATAAGAAGT TTACAAAAGA  25201 TATAGATTTA AAAAAAAACA ACAGAAATTC TGGAATTAAA GAATACATGA CATGAAATTC  25261 CAAATACATT TGAAAGCTTC AACAATATAC TAGGTCAGGC AGAAGGAAGA ATTCCAAAAC  25321 TTGAAGATAT ACATTGTGAA ATAATTCAAT AAGACAAAAA CACACACAAA AAAAGAATGA  25381 GCAAAGCCTT TGTGACATTT GGTACAATAT AAACAACCAA ATATTCAAAT TATTGGTATC  25441 CTCAAGAGCG AAGAGACAAA GAACAGATTA GAAAACCTAT TTAATGAAAG AATAGATGAA  25501 TAATTCCCAA CTCTAGCAAG TGATTTAGAC ATTCAGATAC AAAATATTCA ACAATTCTGA  25561 GAAAAATACA ATGCAAAAAG TTCCTCTCCA TGGCATATAA TCAGACTTTC TATAGTATAA  25621 GGTAAAATGC AAATCCTAAA AATAGCAAGA GGAAAGTGTT TAGTCACCTA TAAAGGAAAC  25681 CCCATCAGAC TAACAGCAGA TTTCTTTTTC TTTTTTCTTT CTTTTTTTTT TTTTTGAGAC  25741 GGAGTCTCGC TGTGCTGCCA GGCTGGAGTG CAGTGGCGTG ATCTCGGTTC ACTGCAACCT  25801 CTGCCCCCTG GGTTCAGGTG ATTCTCCTCC CTCAGCCTCC CAAGTAGCTG GGATGACAGG  25861 CACATGCCAC CACACACAGC TAATTTTTTT TTTTTTGTAT TTTTAGTAGA GACAGGATTT  25921 CACCAAGTTG GCCAGGATGG TCTCAATCTC TTGACATCAT GATCCGCCCA CCTCAGCCTC  25981 CCAAAGTGCT GGGATTACAG GTGTGAGCCA CTGTGCCCAG CTCTAACAGC AGATTTCTTN  26041 GCAGAAATCT TACAGGCCAG AAGAGAATAG GATAGCATAA TCAAAGTCCT GAAAGAAAAG  26101 AACTGCCAAG CCAAGAGTAA TAAACCAAAC ATAAATTATT CTTCATAATT GAAAAAGAAA  26161 TTATCTTTCC AAGACAAGCA AATGCTGAAA GGCTTCATTA CCACTAGACA GGGCCTACAG  26221 GAAATGCTCA AGAAAGTCCT AAACCTGGAA TTGAAAGGAC AACATTTTCA ACATTTCCAC  26281 ATTATCACCA TGAGAACATA CACAAGTATA AAACTCACTG GTAAAGCAAT CACACAAAAG  26341 AGGAAGAGAA AGTTCTCAGA TGGTCCTACT ACAGAAATCC ACCAAAGCAT AATGACAAGC  26401 AATAAGAGAA AAAGACAATA ACAAAAGACA TATAAAACAA CCAGAGAACA ACAATGTGAA  26461 AGGAACAAAG CTGTTGGGAA CAGGACCCCA AAAATCTGGC CATAAACTGG CCCCAAAACT  26521 GGCCATAAAC AAAATCTCTG CAGCACTGTG ACATGTTAAT GATGGCCATG ACGCCCACAC  26581 TGGAAGGTTG TGGGTTTACC AGAATGAGGG CAAGGAACAC CTGGCCCACT CAGGGCAGAA  26641 AACTGCTTCA AGTTGTTCTT CAACCACCAA CAATAGCATG AGCGATCTGT GCCTTAAAGA  26701 CATGCTCCTG CTGCAGATAA CTAGCCAAAC CTATCCTTTT ATTTTGGCCC ATCCCTTTGT  26761 TTCCCATAAG GAATACTTTT AGTTAATCTA TAATCTATAG AAACAATGCT TATCACTGGC  26821 TTGAGTTAAT AAATACGGGG GTAAATCTCT ATTCGAGGCT GTCAGCTCTG AAGGCTGGGA  26881 GACCCCTGAT TTCCCACTTC ACACCTGTAT ATTTCTGTGT GTGTGTCTTT AATTTCTCTA  26941 GCGCCGCTGG GTTAGGGTCT CCCCAGCTGA GTTGGTCTCA GCACAAAGCC TCACATATTA  27001 ATAAAAATCT GGAATGTAAA CAGATTAAAT TCTCCACTTA TAAGATGTAG AATGGCTGAA  27061 TGGGTAGAAA ACATGATCTA ACTACATTCT GOTTACAAAA AAACTCACTG GTAATACCAC  27121 CTCACCACAA TCATAGAGAC AGAAGGTAAA AGAATGGCAA CAGGTTATCT ATCGAAACCA  27181 AAAGTGAGCA GGAGTAGCTA TACTTATAGC AGATAAAATA AACTGTAAGT CAAGAACAAT  27241 TTTTTTAAAA GATAAGGAAG GCCATCACAT AATCATAAAG AGATCCATCC AAGAAGAGAA  27301 TAGAACAATT CTAAATATAT ATGCACTAAA CATTGGAGCA NCTAGATTCA TAAAACAAAT  27361 ATTACTACAT CTAACAAGAG AGATAGACTC CAATACAATA ATAGTGGGGG ACTTCAACAT  27421 CCCAACCTCA GCATAAGACA GATCACCTAC ACAGAAAATC AAGAAAGAAA CATTGGATTT  27481 AAACTGAATT TTACACCAAA TAAAGCTAAC AGATATTTAC AGAGCATTCT GTCTAACACT  27541 ACAGAATATA CACTCTTTTC ATGAACACAT GGAACATTTT CCAGGAGAGA GCCTATGTTA  27601 AGCCACAAAA CAAGTCTCAA CAAATTTTCA AAAATTGAAA TCATATTAAA TATCTTCTCT  27661 GGCCACAATG GAATAAAACT AGAAATATAC ACCAAGAGAA ATGTTGGCAA CAAGACCAAT  27721 ACATGGAAAT TAAACAACCT GCTCCTGAAT AACCATTGAG TCAACAGAGA AATTAAGATG  27781 TAAATCAAAA AGTTTCTTGA AATAAATGAA AATGGAAACA CAACATACCA AAACCTGTGC  27841 GATACAGCTA AACAGGGCTA AAAGGGAGGT TTATAGCAAT AAATACCCAC CTAAGAAAAG  27901 TAGAAACATT ACAAATTAAC AATATAACAA TGAACCTCAT GGAACCAGAA AAGCAAGAAA  27961 AAAAATATAC AAAATTAGCA GAAAAGAAAT AATAAAGATC ATAGTAGAAA TAAAGACTTT  28021 TAAAAACCAT GTAAATGATC AACAAAGTGA AAAGTTTGTT CTTCAAAAAC ATAAACAAAA  28081 TTGATAAACC ACTAGCTAAA CAAACCCAGA AAAAAAGAGA GAAAATTTAT TAAGAATAAA  28141 AGTTCCTCTT CAAAGTTTTC CTTTTTGGTT TAGAATGATA AGTCTTAAGA AGATAGTTCC  28201 TCTTAAAAGC TTCCTTTAAG TTTCCCTCGC TCTTCATACT AACAAATCTT CTATTTTACT  28261 AATGACTCTT TATTGTGCCC CAAAGGAGTT GTTACATACA GTAAANAAAT AAACACATTC  28321 TATGTTCTTG TACTTGAACC AAGGCCTAAC TCCTTTGTTC CCTAGTCTGC CTGGATCTGC  28381 CTGGACACGC CCAGACATGT CACAGOTTGC AGCCTATGCT CTTTCCTTAT TTGGAAATAT  28441 TATTGTCTTC CTGGTTTCCC ATAAGCGACC CCCTCCTTTC CTTGGTTCCC CATTGCGCCT  28501 TTACCTTATT TGGGAAAGTT TAAGTTTTTA GCCAACTGGG ATCAGTTTAG ATTGTGTGGT  28561 CCAGTTCCAG CCAATGGAGA CAGGACACAA TAGTAGAAAC AAATTGCGTT AGGAATAAAA  28621 ACCCCTGCTT TCCTTTGTTC TGGTTGCTCT CGTGGCAATC AGGCTTACAG GTAGCAGCCT  28681 TCTGCAGAAG TAAAAATTGC CTTGCTGAGA AATCCTTTGA TCAAGTGTTC ATTTCCTTTG  28741 TGACTCCAAG CTTTATTTCT AACTATTTTA TGGGGGCTCT TCCAGGATTC CCATTCTCCT  28801 ATGGGAAGGG GTCTTTGGTC ACCCCATCTA GGGGAGGTGT ACCCCACTGC AGTGGCCCCA  28861 GGGACGGGAG ATTGAGACTA CCCATTGTGA TGAATAAATT CAGGCTCTCA GCAATGTGGA  28921 AGGAGAAGGC CCACAAGTAC CACGATGACC AGCTAACTGT GCAGAGACCA AGGTAAAAAA  28981 AGTCACAAGG GCAACAGTAT TTCCTTGGTG GTCGGGATAT TCTGGAGGTT AAAGGGTGTG  29041 AAAGGTAACA AGCACTACTG CTGTGCAGAG TGAGTGAGTT CAATCTGTGG TTCCGTGGTC  29101 ACCTCATGTG GCTTATGATG GCCCTCTTGT AGGGATCCTG ACATTGGGGT TCATACAGTC  29161 CTGCTGATGC TAAGGGGAGC CTAATTTCCT CTGGGAAAGC AGCCAGAGTG GATGAAGCAA  29221 AAGGAGAAGA TTGCAAGAAA CCTCCAGGGT GGGGGTTAAA CCTCCAGGGA AGGATAGGCA  29281 AGAAATCTCT AGTTCGAGGG ACTGAGCCTA ACCAGTATTC AACATGGGAA ATACCCTGAG  29341 TAAGACAGAA GGTAAAAAGG AAAAGGCAAA CAGTGAAATC ACCTCTGATA GTCCTTTAGG  29401 ACTCATGTTA AAATATTGGA AGGATACAAG AGGACTAAAC ATAAGAAAAA GCAACAGATG  29461 ATAAAGTATT ATTGTTTCAT TTGGACCAAG GAACCTATTC TAAAGCCTTC AGTTTTCTGG  29521 CCAAAATTCG GGTCAAATGA GGCTTGGACT TGCCAACTTT TAATAGAATG TGTAAATGAT  29581 AAGAGTCCTG TTTCCCAGGA GGAAATACAT TATGCTCTGT GTTGGCAGCA AGGGCCCATC  29641 CTCCTTTGTC ATCTAAAAAC CAAAGGAGAC AAGCCAGAAA CTACTTCTCA TGAAATTAAT  29701 ACCCCTTACT CCAAGAACCC CACCAACACG TGGGACGCCT TAGACCATCT TCCCCCAACA  29761 AAACTTCTTC CCCCCACCCA GTAGACCAAC ATCCCCCACC TCCCCCTTCA GTAGAAATAA  29821 CAGTCCCAGA CCTTTCCCCT ACTCAGACAT TTTTTCCCTC CTTTTAACCC TGATTCTTGG  29881 GGTCATCCCC AGCTTGAATG CCCTCCCTCA GGAAGACTTC AACGTGAGTT AGAACAATGT  29941 AAAAATGATA TCCAAAACTT CCCTTTTCCC CCTTCCTCTA GGGGTTTGGC TACAAACCTC  30001 TTCCCACTGA GGGAAGTGCC TCTAGGAGGA GCAGGCATTG GCTTTTTAAA TGCTCCCCTG  30061 ACCAGTTCGG AAGTCCAGAG CTTGAAGAGG GAACTCAAGC CACTCTTAGA TGATCCCTAT  30121 GGAGTGGCAG ATCAAATTGA TCAATTTTTA GCACCCCAGT TGTATACTGT GGCTGAGTTT  30181 ATGTCCATCA TAGGCATCCT TTTTTCAGGG GAAGAAAGGA GCATGATGCA TAGGGCCGCT  30241 ATGACCATTT GGGAGTGTGA GCATCCTCCC GGTCAAAACG TCCCTGCAGC CAAACAGAAA  30301 TTTCCTGCTC AAGATCCCCA GTGGGATAAC AACAACATAG CTCATAGGAG GAATATGAGA  30361 GACCTGCAAG AAATGATAAT AAAAGGAATT AGATAATCAG TACCCTGCAC CCAGAATATG  30421 ACCAAAGCTT TTAATATACA GCAAGGAAAA GAAGAGGGGC CTATGGAATA TTTTAATAGG  30481 CTTAAGGAAC AAATGAGGAA ATATGOTGGT TTAGATGGAG GAGACCCACT TGGACAAGGA  30541 ATGTTAAAAG CTTCACTTTG TCACAAATAG CTGGCCAGAC GTTACCAAGA AATTACAAAA  30601 GATAGAAAAT TGAAAGGACT GTCCCATAAA GGAACTCTTA AGGGAGGCCC AAAAGGTGTA  30661 TGTACGAAGG GATGAAGAAA AGCAAAAGCA CAAGGCAAAG ATTATGCTGT TOTTAAAGCA  30721 GGGAACTCCC CAATAGACAG CTCAAAGAAA TATCGCCGGT AAATCTTTTA GGTACCCGAC  30781 TGCCAGACTC TATAATGGAG GTAAAGGAAT CAAACCAGGG AACAAGGGAA TAAAAAGAGG  30841 AATAGGGCAG AATAAATGCT TCAAATGTGG GAAGGAAGGT CACTTTAAAG AGAATGCCCT  30901 GAATGGAAAA AAGAAAAAGA AATCACCCAC TTATGATCTT TGAGGAGGAA TGGGGGGCCA  30961 GGGGCTCTAC TCTTTTTACC TCGAGTCCCA CCAAGACTCC TTGATAAATT TAGAGGTGGG  31021 ACCCAGACCT TTTTAATTGA CTCAGGAGCT GCTGATTCCT CAGTTTGTTA TCTTCCCCCT  31081 GGTGTAACTT GGTCACAAGA AGAACTTTTT ATTTTGGGAG CAAAAGGGGA GGGGTTTAAA  31141 GCAAAAGTCT TAGAAGAAAC AAAAATTAAA TATCAGAACC ACTCAGTAAA TATTAAACTT  31201 CTGTTAATCC TGGAGGCAGG AACAAACCTA TTAGGAAGAG ATTTAATGCT AAAATTAAAC  31261 CTAGGCCTTT GTGTTAATCA AGGAAATCTC CTCCCCTCCT TAAATTTGCT TGCTACTCTA  31321 AATGAGGGAT ACATCCATCC AGATGTATGG TCAAAGGAAG GAAACTGAGG AAAGTTACAA  31381 ATTTCCCCAA TCCAAGTTAA ATTGAAAAAC CTGGGGCAAG AGGTAAAAAG AAAACAATAT  31441 CCAATTCCCT TAGAAGCTAA GATCAATTTA AAGCCCACAA TAGAAAGCCT TCTCCATGGT  31501 GGACTCATTG AACCCTGTAT GTCTCCTTAT AACACTCCCA TACTGCCTGT GAAAAAGCCA  31561 GAGGGGTCAT ATCGGCTAGT GCAAGATCTT CGATCTATTA ATCAAATAGT TCAAACAACT  31621 CACTCTGTCG ATCCTAATCC TTATGCTATT ATTAGTAAAA TTCCTTACAA CCATGAGTGG  31681 TTCACAGTAA TAGATCTAAA GGATGCCTTC TGGGCTTGCC CACTAGCAAA GATAGACTTT  31741 GAATGGGAGG ACCCTCACTC TGGTTGAAAA TAACAGTATC GATGGACAGT TTTGCCCCAG  31801 GGATTTACAG AATCTCCAAA TTTGTTTGGT CAAATACTAG AACAGATCAT AGAAAAGTTT  31861 TACAAACCAC CATATATATG CCTGCTCCAA TACATGGATA ATATCCTTAT TTCAGGGGAG  31921 GATAGACAAA AAGTAGAAGG ATTTTCAATA GGTTTTTTAA AAATAATTTG CAACTGGAGG  31981 GGTTATGAGT GTCAAAAAAG CAAACTTCGG TTTGTAGAAC CTGAAGTCAA GTATTTAGGG  32041 GACTTAATCA GTAAGGGCAA ATGGAGAATT GGATTTGAAT GGATTGAAGG CATCATATCC  32101 TTCATATGAT ATCCTGAGAC AAAGAAGGAA CTTAGAAAGT TTTTAGGGTT AGTAGGGTAT  32161 TGTTGCTTAT AGAGAGACTC TTATGCTTTA GTAACCAAAC CTCTACATAA AAAAAACTTA  32221 CACAGGATGA ATTGGACCCC CTTATATGGT TTTACAAGAA ATACAGCAGA TAAAAAAATT  32281 AAAAGAGTTA CTAGTGACAG CCCATGTTCT AGCCTTACCC TCTTTAGAAT TGCCCTTTCA  32341 TCTTTTTGTT AATGTAGGTA ATGAAGTAGC CTTAGGGGTA CTTACTCAAA CACACGGAGG  32401 CCATTGGCAA CCCATAGCCT TCTTGTCAAA AATTCTTCAC CCAGTAGCCC ATGGATGGCC  32461 CGAGTGTGTC CCATCAGTGG CAGCAACAGC CTTGCTCATA GAGGAGAGCA GAAAATTAAC  32521 CTTTGGGGAA ATCTTATCAT TAGTACTCCT CAACAAGTGA GAACAATTCT CAATCAGAAG  32581 GCAGGAAGGT GGCTTATTGA TTCAAGAATT TTAAAGTATG AAGCCATCTT GTTAGAAAGA  32641 GATGATCTAA TOTTAACCAC TGATGACTCA ATTAATCCAG CTGCTTTCTT AACAGGAAAC  32701 CCCAACCCAC AGACCCCTGA TCTTTGCCCA GAGCACAGAT GTTTAGATTT AATTAGTTAT  32761 CAAACAGAAG TTAGACCTGA TCTAAATGAA ACACCCTTTC ATACTGGGAA ACACCTGTTT  32821 GTAGATGGTT CCTCCCGAGT AATCAAAGGA AAAAGGCATA ACGAGTATTC AACGATAGAT  32881 GGAGATACCC TCACAGAAAT AGAGTCTGAA AGGTTACCAA ATGACTGGTC TGCACAAACA  32941 TGTGAGTTGT TCACATTAAA TCAGGCCTTA AAATTTCTGC AAATCAAGAA GCAACAATCT  33001 ATACAGACTC CAGGTATGCC TTTGGAGTAG TCCATACTTT TGAAAAAATT TGGACTGAGC  33061 GGGGCCTCAT TAACAGCAAA GGTCAAATTT TAGACCATAG GGACCTAATA ATACAAGTAC  33121 TAGAAAATTT ACAATTGCCA AAAGAAATAG CTGTTGTACA TGTCCCACGA CATCAAAGGA  33181 ATCCTTTATT TGAAGGCCAG GGAAATAATC TCACTGACCA AATAGCCAAG CAAGCTGCCT  33241 CTTCTCCAGC AGAACCCATT TTTCGACTAA CCCCTTGTCT TCCATCTTCA GCTGCACTCC  33301 CTATCTTCTC TCAAGCAGAT CAGGAAAAAC TGAAAAAAAT AGGAGCTGAA GAAAACTCAA  33361 AAGGAAAGTG GGTATTACCA GATGGAAGGG AAATGTTACC CAAACTTTAT GAGGGAAATA  33421 TTGTCACAGC TTCATCAAGG ATGTCACTGG GGTCCTCAAA CCATGTGTGA TGCAGTCCTT  33481 AGGGTTTATG GGTGCATAAG AATATACACC CTCGCCAAGC AAATGGTGGA AAGTTATATA  33541 CTGTGCAGAA AATCTAATAA GCAGACCCTC AAAAGACAAC CTCCCGGAGG GAGAAATCCT  33601 GGGTTAAGGC GATTTCAAAG TGTCCAAGTT GACTCTACTG AAATGCCCCC AGTAGGCCGC  33661 CTTAAGTATT TACCGGTAAT AGTAGATCAT CTTACCCACT GGGTAGAAGC CATCCCCTTT  33721 CCAAGTTCAA CAGCCAGTAA TGTGGTCAAA GCTCTGTTAG AACATATCAT ACCCAGGTTT  33781 GGAATAATAG AGAACATTGA TTCAGATAAT GGGACCCAAT TTACCGTGTA CATTATTAAA  33841 AGACTAATCC AAGTATTAGG GATAAAATGG GAATATCATA CTTCCTGGCC TCCACCTTCA  33901 TCTGGGAGAG TAGAAAGAAT GAATCAAACT TTAAAGAGTC ATCTAACCAA ATTAATTTTA  33961 GAAACTCGCC TACCATGGAC AAAATCTCTT CCCATTGCTT TACTAAGAAT CCAAACTTCT  34021 CCTCGGAGGG ATCTTGGCTT GTCTCCTTAT GAAATGCTTT ATGGGTTACC TTATCTAAAC  34081 ACTACTACTG ACCTTCCTAT GATCGAAACA AAAGATCAGT TCCTTAGAAA TTATGTATTT  34141 GGTCTGTCTT CCACTCTTTC GTCCCTCAGG ACTCAAGGTC TGGTAGCACA GACTCCACCC  34201 CTTGAATTCT GGGCCCACCA ACATCAACCC GGAGATCACA CGTCCTTATC AAAGGCTGAA  34261 AAGAGGGAAA GCTTGAGCCT ACCTGGGAAG GACCCTATCT GGTGCTCACA ACAACTGAAA  34321 CAGTAGTTCG GACCACTGAG AAAGGGTGGA CCCATTATAC TCGAGTCAAG TAGGCGTCAC  34381 CTTCTCCAGA GACATGGACC ATTATTCCGT CAACTCCCAC CAGAGTAACG ATAAAAAGAA  34441 AAACTTAATC TATCTCTTTT TCTTCTTTTC TTTCCCTTAA CTGCCCCCAT CTCATCATTA  34501 ATGTAACTAG ATCAAGTTTG CCCAAAATTA TTACCTTTGA TGCTTCTCTA GTCATGCCTT  34561 GTGGAAATTT ACAGGACCAA AGACAGOTTA CTGCCTCAGA TAAATATCTT TGTCCCTCTT  34621 GAACTTCCTC AGATTGGAAA GATATAACAA ATTCTTGTAA AGATCATGAT AACCCCAAAA  34681 ATAGTAGCTG TATGAACTGG TGGGAATGGG ACTCTTGTCC CCTTAAAACA GAGTCCCTAT  34741 GCTATACTTG GTCTAATGTC CTATGGAACA CCAAAGGTCC AGGCTGGACT GCTCCCACCA  34801 GTCTTTGCCA GTCCTTAAAG CCATATATCC ATTTTACAAA AGGGATTGCC TCTTCTAATT  34861 GTCCATATAA CCAGTGTAAT CCTATTCGGC TTACTATTAC TATTGCAACA TCCCAAAACT  34921 CTTTCCCTTC ATTAAGTCAT ATTTATAGCA TAGGGGCCAA CATCTTGGGA AAGGATCCTA  34981 GGGGAATTTT TGAAATCTGC TTTATTGCCC CTTCCACCTC TCTAACACAT CTTCCTCAAA  35041 CCATCACCCC ACCTATACCC AGTGACAAAA CCAAAGTAGC TATAGTAGAA GTAAAAGACC  35101 TGAGGTAAAC TCTAGCCACT GAAACAGGGT CTCAGGATGC AAATGCCTGG CTGGAATGGA  35161 TTAAATATTC CATCCACACT CAAAATAAGA GCGATTGTTA TGCTTGGGCA CAGGGCAGAC  35221 CAGAGGCCCA AACTGTCCCC TTTCCACTCA GATGGTCTTG TAATAGACCA GATATGGACT  35281 GCATGGTAGC TCTGCTCCAA GACCTCACAG CCTGGGGTAA TAAATCGTGT CAAAGACTTT  35341 CTTTGCTGTT CCCTGAGATC AGCCCCCAAA GGCCATTCAG CCTCCATCTT CTGGGACCAA  35401 ATTTGCTTTG TGTCTCTCAC AACAGGGAGA AAACTTGGCT TTCCTTGGAA ACCTGACAGG  35461 ATGCAGTGAG GTCAAGCACT TCCAAGAGCT AACCCATCAG TCCTCCCTTA TCCATCCCCG  35521 AGCAGATGTA TGGTGGTATT GTGGTGGACC TTTGTGGGAG ACTCTGCCAA ATAACTGGAG  35581 TGGTACTTGC ACTCTAATTC AATTGGCTAT CTCTTTCACC CTGACATTTC ATTCACAAAA  35641 ATATTAACAA CTAGGCATCG TAGTACAAGA ACTGTTCCTG TGAGTCTTTT GATCCCAACG  35701 TTTATATAGA TGCTATTGGA GTACCAGATG AATTTAAAGC TTGAAACCAA ATAGCTGCAG  35761 AATTTAAGTC ATTATTCAGG TGGGTGACTA TCAATAAAAA TATAGATTGG ATAGCCAGGC  35821 GCAGTGGCTC ACGTCTGTAA TCGCAGCACT TTGGGAGGCC AAGGCGGGCA GATCACGAGG  35881 TCAGGAGTTT GAGACCAGCC TGACCAACAT AGTGAAACCC TGTTTCTACT AAAAATACAA  35941 AAATTAGCTG AGTGTGGTGG CACGCACCTG TAATCCCAGC TACTCAGGAG AGTCACTTCA  36001 ACCTGGGAGT TGGAGGTTGC AGTGAGCCGA GATCACACCA CTGCACTCCA GCCTGGGCGA  36061 CAGACTGAGA CTCCATCTCG AAAAAAAAAA TGTAGGTTGG GTAAATTATA TTTACTACAA  36121 TCAGCAATGA TTCATTAATT GCACAAGGGA TGCTATGAGG GAATAGCTGA GCAACTAGGA  36181 CCCACCAGTC AGATGACTTG GGAAAATAGA ACAGCACTAG ACATGATACT AGCAGAAAAA  36241 GGCAAGGTTT GTGTTATGAT TGGAACTCAA TGTTGTACTT TTATCCTTAA TAATACTGCC  36301 CCTGATCGAA CTATAATAAA AGCACTACAA GGTCTTACTG CTTCATCAAA TGAACTAGCT  36361 AAAAACTCTG GAATAAATGA TCCTTTCACT AGCTTAATGG AAAGGTGGTT TGCTAAGTGG  36421 AAAGGACTCA TGTCCTCAAT TCTCACCTCA CTGGCTCTCA TAATCAGTGT ACTTATCCTT  36481 GTAGAATGTT GTATTATATC TTGCATTCAT GGATTAGTGC AAAGGCTTAT AGAAAAGGCT  36541 CTTACCAAAA CCCCTTTCAA TTCTCCTCAC CCTTACTCAG ATAAGTTGTT CTTTCTAACT  36601 GATTAAGAAG AGCAACAAAA TCAAGATATG TTAAGGAGAT TTGAAGAGGA AGAACTGTAA  36661 AATCAAGAGG GGGAAACTGT AAAGAATAAA AGTACCTCTC CAAAGTTTTC CTTTTTGGTT  36721 AAGAATGATA AGTGTTAAGA AGATAGTTCC TCTTAAAATC TTTCTTTAAG TTTCCCTTAC  36781 TCTTCATACT AACAAATCTT CTAATTTACT AATGATTCTT TATTGTGCTC CAAGTAGTTG  36841 TTACATACAG TAAAGAAATA AACACATTCT ATGTTCTTGT ACTTGAACCA AGGCCTAACT  36901 CCTAGTCTGC CTGGATCTGA CCAGACATGC CCAGACATGT CCCAGCTTGC AGCCTATGCT  36961 CTTGCCTTAT TTGGAAATCT TATTGTCTTC CTGGTTTCCC ATAAGTGACC CCCTCCTTTC  37021 CTTTGTTCCC CATTGCACCT TTACCTTATT TAGGAAAGTT AAAGTTTTTA GCCAACCGGG  37081 ATCAGTTTAG ACTGTGCGGT CCAGCTCCAG CCAATGGACA CAGGACACAA TAGTAGAAAC  37141 AACTTGCGTT AGGAATAAAA ACCCCTGCTT TCCCTTGTTC TGGGTGCTCT CGTGGCAATC  37201 AGGCTTACAG GTAGCACCCT TCTGCAGAAG TAAAAATTGC CTTGCTGAGA AATACTTTGT  37261 TCAAGTGCTC ATTTTCTTTG TGACTTCGAG CTTTATTTCT AACAGACTCA AACAAAATCA  37321 GAAAAGAAAA GAGAAACATT ACAACTGATA TTGCAAAAGT ACAAAAGACC ATCAGAGACT  37381 ATTATGAACA ATTGTGTACT GACAAACTGG AAAACCTGGA GGAAATGGAT AAATTCCTGG  37441 AAACAAACAA CCTGCCAAGA TTACATTAGG AAGAATAGAA AACCTGAAGC CCTAACATAC  37501 ATGAACCATT CTCACAGTGG TCCCAGTGGG CCCCTGACCT CTCTGTGATT ATTTCCTCAG  37561 TGCTTGTTTG CATAATTGAA ATAGACCTAC TCAGCAACAG CCAAAATCCA CAGATCAGTT  37621 CCTTTTTTTA ACTTTTATTT TCAGTTCAGG GGTACAAGTG CAGGCTGTTT TACAGGTAAA  37681 CTTGTGTTGT GGGAGTTTGG TACACAGATT ATTTAATCAC CCAGGTTTTA AGCCTATTAC  37741 CCATTAGTTA TTTTCCCTGA TCCTCTTCTT CCTCCCACCC TCCACCTTCT GAAAGGCCCC  37801 AGTGCCCAGT GTGTGCTATT CCCCTCTATG TCTCTATGCA TTCTCATCAT TTAGCTCCCA  37861 CATATAAGTG AGAACATGCA GTATTTGGTT TTCTGTTTCT GCATTAGTTT GCTAAGGATA  37921 ATGGCTTCCA GCTCCACCCA TGTCCCTGCA AAGGACATGA TCACATTCCT TTTTCTGGCT  37981 GCATAGTGTT CCATGGTATA CATGTATCAC GTTTTCTTTA TCCAGTCTAT AATTGGTGGG  38041 CATTTAAGTT GATTCCATGT CTTTGCTATT GTGAATAGTG CTGCAATGAA CATATGTGTG  38101 CCTATGTCTT TATAATAGAA TAATTTATAT TCCTTTGGGT AGAATGGTAT TTCTCTCTTT  38161 AGGTCTTCAA GAAATCACCA CACTGTCTTC CACAATGGCT GACCTAATTT GCACTTCCAC  38221 CAAGAGTATA TAAGTATTCC TTTTTCTCCA CAACTTTGCC AGCATCTGTT ATTTTTTGAC  38281 TTTTTAATAA TAGCCATTCT GACTGGTGTG AAATGGCATC TCACTGTGGT TTAGATTTGC  38341 ATTTCTCTAA TCATCAGTGA TGTTGAGCAT TTTTTCATGT TTGTTGGCTG CATGTATGCC  38401 TTCTTTTGAG AAGTGTCTGT TTATATGCTT TGCCCACTTT TTAATGGGGT TGTTTTGTTT  38461 TTTCTTGTAA ATTTGTTTAA ATTCCTTATA GATATTAGAC TTTTGTCAGA TGCATAGTTT  38521 GCAAAAAATT TTCCCCCATT CTGTAGGTTG TTTACTCTGT CGATAGTTTC TTTTGCTGTG  38581 CAGAGCTCTT TAGTCGAATT AGATCCCATT TGACAATTTT TGCTTGTGTT GCACTTGCTT  38641 TTGGCATCTT TGTCATGAAA TCGTTGCCCA TACCTATGTC CTAAATGGTA TTGCCTAGGT  38701 TCTGTTACGG TTTTTACAGT TTTGGATCTT ACATTTAAGT CTTTAATCCA TTTTGAGGTG  38761 ATTTTGGTAT ATGGTGTAAG AAAGGGGTTC CATTTTAATC TTCTGCATAT GGCTAGCCAG  38821 TTATCCCAGC ACAATTTATG AATAGGGAAT CCTTTCCCCA TTGCTTGTTT TTGTCAGGTT  38881 TGTCAATGAT CATAGTTTGT GTGGTCTTAT TTCTGGGTTC TCTATTCTGT TCCATTGGTC  38941 TATATGTCTA TTTTTGTACC AGTACCATGC TGTTTCGGTT ACTGTAGCCT TGAAGTATAG  39001 TTGAAATCAG GTAGCATACA CTGGACGTGG TGGCTCATGC CTGTAATCCC AGCACTTTGG  39061 GAGGCAGAGG CAGGTGGATC ATGAGGTCAG GAGTTCGAGA CCAGTCTGGT CAACAAGGTG  39121 AAACCTTGTC TCTACTAAAG ATACAAAAAA TTAGCTGAGC GTGGTGGCAT GTGCCTGTAA  39181 TCCCAGCTAC TCAGGAGGCT GAGAAAAGGA GAATCACTTG AACCCAGGAG GCAGAGGTTG  39241 CAGTGAGCCA GGATTACACA ATTGCACCCC AGCCTGGATG ACAGGGTGAG ACTCCATCTC  39301 AAAAAAAAAA AAAAAAAATC AGGTAGTGTA ATGCCTCCAG CTTTGTTCCT TTTGTTTAGG  39361 ATTGCCTTGG CTATTCAGGC TCTTTTTTGG TTCCAGGTGA ATTTTAAAAT AGTTTTTTCT  39421 AGTTCTGTGA AGAATGTCAG TGGTAGTGGC CGGGCACGGT GGCTCACGCC TGTAATCCCA  39481 GCACTTTGGG AGGCTGAGGC AGTGGATCAT GAGGTCAGGA GATGGAGACC ATCCTGGCTA  39541 ACGGGGTGAA ACCCCATCTT TACTAAAAGT ACAAAAACTT AGCCCAGCAT GGTGGCGGGT  39601 ACCTATAGTC CCAGCTACTC GGGAGGCTGA GGTAGGAGAA TAAAAAAAAC CTCCTGAATT  39661 CGTTGATCTT TTGAGTGGTT TTTCATGTCT CTGTCTCCTT CAGGAGACAA TACCTTTGTT  39721 AATTTTTTAT TATTACGTCT TGTCTTCTGC TAGCTTAGGG ATATGTTTGC TCTTTGTTCT  39781 CAAGTTCTTT TGGTTGTGAT TTTAGGTTGT TAACTTGAAA TCTTTCTAAC TTTTTGATGT  39841 GGGCATTTAA TGCTATAAAT TTCTCTCTTA ACACTGCCTT AGCTCTTTCC CAGAGATTCT  39901 GGTACATTGT ATCTTTGTTC TAATTATCTT CAAAGAACTT CTTGATTTGT GCCTTAATTT  39961 CATTATTTAC CCAAAAGTCG TTCAAGAACA GGTTATTCAA TTTCTATGTA ATTGTATGGT  40021 TTGAGTGAAT TTCTTAGTCT TTATTTTGAA TTTGATTGCA CTGTGGTCCA AGTGACTATT  40081 TGTTATGATT TCAGTTCTTT TGCATTTGCT GAGGAGTGTT TTACTTCCAA TTGTGTGATT  40141 GATTTTAGAG TAAGTGCCAT GTGACAATGC AAAAAATGTA TATTCCATTG CTTTGGGGTG  40201 AAGACTTCTG TAGATATTTA TCAGGTCCAT TTGATGCAGG GCTGAGTTCA GGTCCTGAAT  40261 ATCTTCGTTA ATTTTCTGTC TTGATAATCT GTCTAATATT GTCAGTGGAG TATTAAAATC  40321 TCTTACTATT ATTGTGTGAG ATTCTAAGTC TCTTTGAAGG TCTCTAGGAA CCTACTTTAT  40381 GAATGTGGGT GTTCCTGTAT AGGATGCATA TATATTTCAG ATAGTTAGAT CTCCTTGTTG  40441 AATTGAACCC TTTACCATTA TGTAATGCCC TTCTTTGTCT TTTTTTTATC TTTTTTGGTT  40501 TAACACCTGT TTTGTCAGAA ACAAGAGTTG CAACCCTGGC TTTTTTTCTG CTTTCCATTT  40561 GCTTGGTAAA TTTTCTTCCA TCTTTTTGTT TTGAGCCTAT GTGTGTCATT GCATGTGAAA  40621 TGGGTGTATT GAAGACAGCA TACTGATAGG TOTTGGTTCT TTATCCAGCT TGCCACTCTA  40681 TGTCTTTTAA ATGGGGCATT TAGCCCATTT ACATTTAAGG TTAGTATTGA TATGTATGGA  40741 TTTGATCCTA TCATCATGAT GTTAGCTACT TACTTTGCAG ACTTTCTTAT GTGGTTGCTT  40801 TATTGTGTCA CTAGTCTGTG TACTTCATTG TGTTTTTGTA GTGGCTGGTA ACTGTCTTTC  40861 CATGTTTAGT GCTTCCTTCA GGAGTTCTTG TAATGCAGGT CTGGTAGTAA TGAATTCCCT  40921 TGGCATTTGT TTGCCTGAAA AGAATCTGAT TTCTCCTTTG CTTATGAAGC TTAGTTTGTT  40981 TGGATATGAA ATTCTGGGTT GGAAACTCTT TTCTTTGAGA ATGTTGAATA CTGGACCTCA  41041 GTCTCTTCTG GCTTGTAGGA TTTCCACTGA GACATCCACT GTTAGTCTGA TGGGCTTCCC  41101 TTTGTAGGTG ATCTGGCCTT TCTCTCTGGA TACCCTTGAC ATTTTTTCTT TCATTTTAAC  41161 CTTGGAGCAT CTGATGATTA TTTGTCTTGG GGATGATCTT CTCATGGAGC AGCTTACTGG  41221 GGTCCTCTGC ATTTCTGAAT TTGAATGTTG GCCTGTCTAG CTAGGTTGGG GAAGTTCTCA  41281 TGGATCATAT CCTGAAATGT TTTCCAAATT GGTTCCATTC TCCCCATCTC TTTCAGGTAC  41341 ACCAATCATT CATACATTTG TTTCTTTACA TAATCCCATG TTTTTCAGAT GTTTTGTTCA  41401 TTCCTTTTCA TTCTTTTTTC TCTAGTCTTG TCTTCTTGTC TTATTTCAGA AAGCCAGTCT  41461 TCAAGCACTG AGATTCTTTT CTCCACTTGC TCTATTCTGC TATTAATACT TGTGAGTGCA  41521 CCACGAAATT CTTATAAAGT GTTTTTTACC TCTATCAGGT TGGTTATCAG ATTCTTTTGC  41581 TGATTCCTTC TCATCTCTAT GGGCTTATCT ACCCTCAATC TTTGAGGTTG CTGACCTTTG  41641 AGTGGATTTT TTTTCTCTTC TTTTGTTTTC TCTTTTAACA GTCTGGCCAC TTTTCTATAG  41701 GGCTGTACAG TTTGCTAGGG GCCTGCTACA GTCCCTAGTT GCCTCAGATT TTCCAGTACC  41761 TGAAGGTATC ACCAGTGAAG GCTATGTAAC AGCAAAGATG GCAGTCTGCC CCTTCCTCTG  41821 GGAGGTCTGT TCCAGGAAAG TACAGACTTG TTGCCAGCCT GAACACACCT GTAGGAGGTG  41881 CTGGAGACCC TGGTTGGGAG GTCTTGCCCA GTCAGGAGGA ACAGGATCAG GATCTAGAGG  41941 TTTACTAAAG GAGGAATGCT CCCACAGGAG ACACAGAAAT GAACCATTGA GCTGGAAGCT  42001 AAGACAGCTA CCCAGGCCCT TCAGAGCCTC ATGATTCTGA ATCAACAAAG GAAGGAGTTA  42061 CTGCACTGTC TGGGGTGATT GGTCCTGGCC ATCAGGGGGA ATTGGTCTAC TACTACACAA  42121 TGGCAGTAAA TAGGACTGTG TCTGGAACAC AGGAGATCTT TTAGAGCATC TOTTAGTAAT  42181 ACTCTGCCGT ATAATTAAAG TCAATAAAAA CGGCAACAAC CCAAGTCAGG TAGGACTAGT  42241 AATGACACAT ACCCTTCAGG AATGAAGGTT TGAGTCACCC AAGCAGGAAA AGAAACCTGA  42301 TCAGCTGACG GACTTGCTGA AAGAAATGGG AATATGGGAT GGTTAGTGAA AAACAACAAA  42361 AAAAGTATTT ATAAATACTA GTTGTGGCCG GCACAGTGGC TTGTGCCTGT AATCCCAGCA  42421 CTTTGGGAGG CGGAGGCAGG TGGATTGCTT AAGTCTAGGA ATGTGAGACC AACCTGAGCA  42481 AAATGCTGAA ACTCCATCTC TACTGAAAAT AAATACAAAA AATTAGTCAG ACTTGGTGGT  42541 GTGCTTGTAG TCCCAGCTAC TTAGGAGGTT GAGGTAGGAG GATCACTTGT GCCCAGGAGG  42601 TGGAGGTTGT AGTGAGCCAA GGTAATGCCA CTGCACTCCA GCCTGGGCAA CAGAACAAGA  42661 CCCTGTCTCA AATAAATAAG TAANTAANTA AGTAAATAAA TAAATAAATA ACCAGCTGTA  42721 ACCATGTGAG CACTTACAGA AATAAAGACA GTAAATGTTA TCAGCATTAC TTCTTTATGT  42781 TTTTATAATG ATATTTATGT CTGTGTGTAT GTATCCTTAC ATGTATTGAG CAAATACCTT  42841 TCTTTTCATC TTTTCCTGAT GATCTGTAAT AAAACATAAG ATGTGCTAAC AATAATTCCC  42901 TTTTATTAAT AAAAGTTAAC TTTTATTACG CATGGTATTT AGGTTACAGT ATATCAAAGA  42961 GAAGAGTGCA TATCATGCAT CTTTTTCTGT GGAAAGGGTT AGTGTGTTTC TAGTTGGATG  43021 CAAGTTAATT GTATCATCTT TGGCAAAAGT AAGACTTTAT AATTGTTTTT ATTTGGAGAC  43081 GAAGTAAGGT TTAAGGAAAA TGTTAATGGG TGCCAAGTTC ACAAGCATGG ACTGGGATGG  43141 TGGGTCTTAT GTGTCAATTT TACTAAACCA TAGCACCTAG TTATTTAATC AAACACTAAA  43201 TTTATATGTT GATATGATGG TGTTTTGCAG TTGTGATTAA AATCTGATAT CAGTTGATTT  43261 CATGAAAAGG AAATTACCCT AAAACATGTG GGTGGGACTT TTTGAATCAC TTGAAGGCCT  43321 TTGGGCGAAA TGTGAGTCTT CCCAGAGAAG AAAAAATTCT GCCTCAAGAT GACAGTAGCA  43381 ACTACACTTT AGGTTTCCAA TCTGCCAGCC TGGTCTACAA ATTTTAGATT GAAGGCTGCA  43441 ACATTATGAC TTTCCAGCCT TCCAGCCTGC CGAGGTGTAA CTTGTGACAT CAATAACGTA  43501 AAATGAGGGG TGGGAAAAGA TGTAAAGAAG CAGAGTTTCA TATTGATTTC AGTTCAAGAT  43561 TGTTATAACT GTATTGTTAT ATATAATACC ACAGTAATCA CAAAGAAATA TACATAAAAT  43621 ATACACAAAA GAAAATGAGA AGGCAGTTAA AACATATCAC TAGAAAAAAA TCGACTAAAT  43681 GAAAAATGAC TAAAAACAAA AGAAGGTTGG AATGAAGGAG ATGAAGGACA AAACAGCTAT  43741 AAGACATGCA TAAAACCAAC ATCACAATTA CAGAAGTAAA TCCTTCCTTA TCAGTAATTA  43801 CTTTAAATGT AAATGTAAAT GGATTAAACT TCCCAATCAG AATTCAGAGA TTATCACAAT  43861 GGACAGAATA AAAAGGATCT GGCTGGGCAC GGTGGCTCAC ACTTTTAATC TCAGCACTTT  43921 GGGAGACGGT GGCTGGCAGA TCACAAGGTC AGGAGTTCGA GACCAGCCTG GCCAACATGA  43981 TGAAACCCCG TCTCTACTAA AAATAGAAAA AAATTAGCCG GGTGTAGTGG CAGGTGCCTG  44041 TAATCTCAGT TACAAGGGAG GCTAAGGCAG GAGAATTGCT GGAACCGGGG AGGCAGAGGT  44101 TTCAGTGAGC TAAGATCGTA CCACTGCACT CCAGCCTGGG CAACAGAGTG AGACTCCGTC  44161 TCAAAAAAAA AAAAAAAAGA TTCTCACTTT GGATCTAACG ACACACAGAA GTTGAAATTG  44221 GAAAGACAGA GAAGGATATT CACAAAAATA GTAACTAAGA ATTTTTAATG ATCTCTTATA  44281 GGGTTCTATG TGTTGGCTGG GCTCAGATGA TGGCCTGGGA GTGTTACATG GTCCAGGGAT  44341 TGAAGTGGAA GGAACCAGAC GCAGGCAGGA TGGTTAACAG CAGTGCCCAG ACTGACACAG  44401 CCACACTTCT GCCATATTTT ATTGGGTAAC GCAGATATCA GATCTGCTTA TGTTTAAGGA  44461 GTGGAGAGAA CTTACCTCTT GATGAGGGAG TGGTGGGTCA AACTAAAGAA AAGCAAGTGC  44521 GATGGAAGAT ATTTAGATAT TTTTGCAGCC CTCTTTGGAA AATACATGCA ATTCAAAACA  44581 TCCTATCTGC CAGAAAGGAA GAACACCATT ACGCCTTACC CCTCCAGTTT AAGCCCTGTG  44641 ATTCTATAGT ATCCTGGGGA AGGATCATGT CTTAGGAAGC AGGTGGGGAG TCGAAGCTCT  44701 AAATAAAGCC CCATCTACAC CCACAATTTC ACTTTATTTT GATGAAATTT TGTGTCATTT  44761 TTGATGAAAT GGGGGCTCAC AAATCTCTCT TCAGGGATCT CTCCAGTGGC GGGGACGATA  44821 TGCTCCCTTC TCCACAGTTC TACTTTATAG ATAAGTGGAA CTAGATCTCA GTTTCAGTTA  44881 TTTAAAACAC CAGAGACTTG GATGCATGCA TGTCACAAAA AGGTGAAAGA ATGCTCTCTG  44941 TCACTTTCCC TTCTCTCACT CACTGCGCCC TGAACAAGAA CCTGCTCTAC CCTGACCTTT  45001 TGAATGAGGA GGAGGGTCGC ACTCCTGCCT AACCTTCAAC TTTCCAGAGA TAAACCTCCT  45061 GCCCAAACAG CATGGTTCAT TATAAAGACC AAACCCTACA CCAAGAGCTC TCCCCTTATC  45121 CACCATGGCA GAAACTGAAT CCTATGGAAA GGCCCAGAAA ATTCTGGCTC GAAATGACCA  45181 GCGTCATGTC CCTTCCACCA AAATAAAGCC AACATATTCA TCACAACATG GGGTATTGAT  45241 AAGGATATCA AAATGATTAC CAAAAAAATT TGACAAATAT GTTCTTTTTA TTACATCAAC  45301 TTTTGTTTCC CTCCAAATAT AAAGAAAATA AGCCTGCACA GCAGGAGAAG TTGTTCCCCT  45361 GGGAGAGCAT CCTCTTTCCA GCTGAAAATC TGGTACTGGA ATCACTAGAA TGGAACAAGG  45421 GTTTCTGGTA TGACACAGCA CCAGGTCTTG GGGCAGCCAG AGTTAGGGAG GGCTCACCCT  45481 CTGGGTGACA CCAACCTTTG GTTCTCCATT TTTTTGTTCT CATTGCAAGA ACAAAATTTC  45541 AGAGTATCAG AGCCAAAGAA ATTTACTCTA TTTTATTCTT TAGAAAATGC AATCTCAAGG  45601 ATAATCAGAC TGTTATGGGC TAAATTGTAT CCCCCCAAAA TTGGCATGTT GATGTCCTAA  45661 CCCCCAGTAC CTGAGAGAGT GACTGCATTT GGAGAGGTTT TAAGGAGGTC ATTAAGGTAA  45721 AATGAGGTCA TGTGAGTGTG CCCTAATTCA ATGTGACTAG TGTCTTCATA AAAAGAGAAG  45781 ATTAGACACA GACAGATACG GAGGAATGAC CATGTGAAGA CAGAGAGAGA ACACATCTAC  45841 AAGCCAAGGA AAGAACCTTA GAAGAAATCA GCACTGCCAA CACCATGATC TTGAACTTCC  45901 AGCCTCCAGA ACTGTGAGAC AATGAATTTC TGTTGTTTAA GTCACCCAGT GTGTGGTACT  45961 TTGTTATGGC AGCTCTAGCA AATTAAAACA AACATATTAT ATTGCCCAAT GGAGAGTTTT  46021 ACCTGACTCC ACTCTGGCTC CAATTTGATT AAGGTCTATA TGCTCTGGGA CCTCTCCAGC  46081 TCCTCATGAG AAATGACAAA GAATGCCATG TCCAGCTCCT GGGGTCCCTG ATGGCAGTGA  46141 GAGGCAGCTC CTAATCGAGG GAGCTTTGGG GTGACGAAGG CCTCATAGAC TTCATCACTG  46201 TTGGGCCACT TGGCTTCAGT CCCCTGACCA CAATGGATCC ATGGGCCTGG ATTCACCTCT  46261 GACATTCGTG TCTTTTTTTT CCACAAGTGG TCTCTGGTAG AGATGGAGGG AAAGGACACA  46321 GGGATTCAAA ATCCTGACTA TCCTAGTGTC CTCCCCTCAC TTCCACTCAG AGACAACACG  46381 GCCATTTCTC TAAACTCCTG AGGACGTGGC CAACATAAGT AATGGAGCAC GGGGAGGTGC  46441 CTTGAACAGA GCTGCATGGA AGGGTGGCTG GTGGCCTCTA GACCCTTTGT CTATACGTGC  46501 TGGGCTTCTT TAGTATGAAA TGTCCCAGAG ACAGCCACAT TCTATGCTTG GATCCTCAAA  46561 CCAAAATGTG TGAGGGTCTT AGCCCTGGCC AACTGAGCAC TGAATTCAAG AGAGACCAGG  46621 AAACCTTCTG AATATTGGGA CACTTTATTC CTGAATCCTG AATCCTGGAA GTTGGCTTCT  46681 GGCCAGGGAG GCAGGTGTCA TTATATCTGG GCTGCCTCTG TGAGGCCTCT TTTCCCTCTG  46741 CCTTTCACAT CTTTCTACCC CTGTTAAAAT CCCAGAACAG ATAGAAACAT TCTGCCTTCT  46801 TAGATGCCTC TTGCTACAAA TTTCAATGCC ATTTGATTGA ATTAATAAAT GAAAGCAACT  46861 TTAATACAAG ATGAGGTTTA AAGAATGGTA TTTGACATGG GTTTAGAATG AATAAATGGA  46921 TCAAGTAATG AATTTTGAGA AAATTCATGT AAAATTTATT TTTAACCATT TTATTAACTT  46981 GACTGTGGAA TTAATAAATG ATTCCAAATT AATACAAAAA AGTGCAATCA CAAATGTATG  47041 AATGCCCAGA AGTGTGAATG AGGGGCAATG CACACAAGAA AAAAGGTGTG CACAGGAAGA  47101 AATTCTTCAT TCCACGTTTT TACTGATCCC TCTGGTCAAG ATGGGCTAAA AGTCCAAAAA  47161 TCTGCTTTCC TCACATGGTC AAATGATTCA GCATAAAATA CAACTGACTG AACACAATTA  47221 TCAATGCTTT AAATATATTA GAAAAAATCA ATAAGGAAAA ATAATCCTAC CATCACTAAG  47281 ATTTTAAGTT ATAATAAAAT AAAGCCTAGA AACGTATCGT TTGTTCCCAA TTCCAATGAT  47341 TATAGGATTG CAGTGTTTGG CTTTCAAAAG ACCATTTAAA ACAACTCAGG GAAGTTTTCT  47401 TAACAAACTC TATAGCAGGA CCACAGCTAA ACCTATGAGT AGTAGTAGAA GTAAACAATG  47461 ACACTGTCTT TAAAATTTCA TTTTGAAAAA CATGTTTGAA AGTGGCTGAC TGGCTCCTAA  47521 TTTAACCACT ACCATTTGAA GTCATATGTT AGATTGGCAA AGTCGTCGTA ATTTTTATGT  47581 ATTTTATTTT TGTAATGCAA GTGCTTCACT CTGCTATCTG ATAAAAGAAA ATACCAAGCC  47641 AGGCATGGTG ATGCATGCCT TGTAGTCCCA GCTACTCAAG AGCCTGAGGC AGGAGGTTCC  47701 TTCAGCCCAG GAGTTCAAGG CTGCAGCAAG CTATGATGGT GCCACTGCAC TCCAGCCTGG  47761 GCAACAGATA ATGCAATTTT AATGTAAAAT TTTAGTGTTA GGAGTTCAAC CTTGAACTGA  47821 TTCTGTGAGA TCCTATTTGA GAGAAGCTGT TGTGTACAAT GAAGTTTGGG GAATATCAAC  47881 AAGAAGTAAA TGCCTACCTT GTTTCTAATT TACAAACTAA AAGGAAATTC CATAAACTTT  47941 TAATGCTAAG CTAAATCATT GTAGAATGAA TGACAAAAAA ATTATCCTAC AAAACATAAC  48001 TAGTTGCTAG ATATATTTGA ACATTAATTA GAAAAAAGAT GAATGAAAGC CATGTTTTAG  48061 GAATAAAAAC TACAAAAGAA CTGTAAAAGC TTATCATGCC CTTGGCTGGA GTTACGCAAA  48121 GTTACTACTC ACCCGTAAAT TGGGATTAGC ATGGTGGCTA CTTCTTAAAG TTGATACAAG  48181 GATTAAATGT GTTTTAATGC ATCAAAAGCA TCTAGAAAAG TGCCTGAGAC ATAGTAAGTG  48241 CTAAAGTCTC TCTAAGTAAA TAAAAAATAT ATAAAAGTGA TGCTAAATTC ACGATTCTGA  48301 TCCTCTGTGC ACACCCAATG TGTTTAAAAT TCTGTTCATC TTCCCTTCCA CATTCACAGT  48361 GAAATGTTTC TGATTAATTT AATGGGCTGT GTGAGGTGTT CATTATCTTT TACATTAAAC  48421 TTGGTACATT GTACAACACT CTTATATTGT GATAATTTAC CAAGCTAACA CAGGCTTACC  48481 TTGTTTTTAA TCCTTTTCAC ACACAGCATA GAATTATATT GCTATATTTT TAAATTTCAG  48541 ATGATTTGAA AAATATTTAC ACTATAGTAG CCAAACAGTA ATAATTATAA GCAACTTGGA  48601 TAAAACATTT GAAATTAGAG AACTATATTT AGAATAAATT TCTCACCTTA CAGAAAAATT  48661 TCCCATTGAA AACCCCTTTA TTTCGCATAC AAATAAGAAT TCAGCATGTT TTTCTATACC  48721 CAGAGAGAAC AGAGATAAAC AGGGTCCTTT CGTGTGGTTT GGGTATTTTA TTAGATGCTG  48781 AGTTCAAGAA AGTCTCACCC CTGAAGAAGC TGAAATTCCA TTTTTCGAAG CTTGCTCCTC  48841 AATTCCACAT GCTTATCATA GATATCAAGC AGTGCCCTTG CTGTCTGCCC ATCTTTTCTG  48901 ACCCTGGGAC ACCACCCTTT ATTTACTTTC CCCACAACTC CTTGAAGGTC AAGCCCCCTT  48961 GGCTGATACT CTGGGTTATC ACAGTAAATG TGCCCTCTAT CTTTTGCAGG TCACTGGAAA  49021 GGAGGGTTCC TAAAGCATTC ACTCCTGACC CTGAGGGAGG TGGGTGCACT CACTCCAGGA  49081 CTCAGGTTCA CCACAGATAA GCAAAAAAGT CCTCACATTC AAAATTGTCC TGGGCCACAT  49141 GCAGCCCACG AGCCGCGGGT TGGACAAGCC TGCATCTAGA ACGTATGCAC CATAACCCCA  49201 GACATTTTTC TGTTTTTACT TTAAGGATGC TTTCTAAATG CAAAAGCAGT CATATCCCTA  49261 GCAGACAACA AATGTCAGTT GAATGAATGA TCACTGTAGA GCACCTCCCT ATTCTAAAGC  49321 CCATATCTTT ATTAATGTAG CCACAGGGCA AATGCTGTTT TGTGGCAGCT AAAGAACATA  49381 AGTTCACGTG GACATCCATG CCGCCAGTGC TTTTCTCACC AGGGCTGCTT GTGTGTCCTC  49441 CCTCCTCCCA CACCAACCCT CCTGCACACT TCAGCACAAA ACTATATATT TCTCTTCAGG  49501 AACAATAACC CTAGCCTTAT GGGTACAATT TTCCAACCAC ATATGAATCT AAATTAGACT  49561 CTGCTTTATA AATCTATGAG TTTGGATTGG AGCCAGCACT AGGATTACTA CAACTCAGAG  49621 CAGGAAGAAG AGTAGGAGGG CAGAAGAGGA GTTCCAACAG AAAGTTAACC ATGATGAGAA  49681 ACTATGGGAC CCCTCCTCTC TGCAAATGTC ACAATCTGGT TCCTTTAAAA AGATTGGAGA  49741 AAAATCGAAA ATACCATTAA GGAAAAAGCC CTGGGAGGAA GGCAAGACCT GGACAGGTCT  49801 GAAAATTTGT CTCTTGATAC CACAAGGAGA TTTGTATGCA GGGACCACCC TAGGTGACAT  49861 CCAACTCCCT GTGATCACAG GTCTTGGTGG GACAAGGTTC TACTGAAGGG CCAAGGACAA  49921 TGGAGCAGCA AAGATGACCC AGGTGAGCTG TGACCACATA AAGCCCATGG TGGCCAGAAC  49981 AGAAACTGGG CACAGCCCCA TCTACTCTCC TCCCCTGCAA CAAATCAGCA CAAGAAACAC  50041 GTGGACTCTG GAAGGTTCTC ATGTCTTCCA TTTATTTTGT CTCTCAAATT TTAGGAATCT  50101 TCTCCTTTAA TTAACTCATC AACCTCTCAT GGCAAGAATT TGAGAAAGTA AATTTATACT  50161 CAGGTTCTAA TTTTAATAGG GAAGGAAGAA GTTACAGCTC AGTGCACCAT GAAGTTGAGA  50221 CAGAGATGGA GACACCTCAG CCCCACCTCT CTGGAACAGG AAAGATGATT GGGGAGGGAG  50281 CACAGGTCAG CGTGGGAAGA GGGTCATGGT GGACATGGGG GTGGGGTGGT CTCCCCACCT  50341 CCTCACATTA TGCCTACACG AACACAGACA CATGCAGGTG CCTTTGCAGA AACAAAGTCA  50401 GGGTTCTTCA AGTCACAAAG GGAAGGGCAG GAACAACTCT TGCCTCTCAG TCCCACACAA  50461 GGCAGCTGTC TCACACTATA GAAAAAAATA TTCATGAACA AATTCATATC CATCACAGTG  50521 AGGGGTCACA CCTTAAACAG CCCATCGCAT GCTCAATACA TCCAATGCAA AGAAACCCCA  50581 TAGCACAGCT GTGTCCACTG TTCCGCCCAA CACCCAACAC ACATTAGGTC CTCCAAGCTC  50641 TCACCTTTAC AAGCTGTGAG AGACACATCA GAGCCCTGGG CACTGTCACT GCCTGGGGTA  50701 GAACAAAAAC AGAACCTGGT CAGATCCCAC AGAAGATGTG GCTAGAGGAG GAATTGTGGG  50761 GTGGGTGAGC TCCCCCATGG GCTCCCAAAC ACAATATCCC AAGGACCTCA GGCATCAGCC  50821 TCCTTCATAC TTACTTGCAG CCTGAGTGTA ACTCCCTCCT TTTCTATCTG TGAGAAGAAA  50881 ATGTCCTGTG AGATACCAGA AAGGAGCCAG GGCCTTAAGG TCCTAGAGGA ACCTCCTAGT  50941 CTTGGACCCC AGAGAAGTTT CCAGAAATGT GTGACTGCAG ACCCAGGGCG GGATCAGGAA  51001 ACATGAAGAA AGCAGGTGTG GGTCCTGGAC CAATAGCCCT CCTGAGGTCT GTCCTCAGGG  51061 ACCTTCCCCT GTGACTTGTG ACTGCTGGGA TCAGGTCCCA TCACCGCCGT AATCAAGGTG  51121 ATAAATCTGT CCTTCATTTT AACAGGTGCT TTACAAAAGA GTAAGTGCTG GCACACAGGG  51181 CCCAGGCTGG GTAGGCCCAT GATTGTGGAT GGTGCTTCCC AGTAATGAGA CAGGGCACAT  51241 TTCTAGCTGG GGCTTGGAAC CCTCAGTGAG ACAAGAAATC TCAGACCCCA CCCTTCACCC  51301 CTTCTCCACC TGAGCTCTTC CTCCTCCACA TCACGGCAGC GACCACAGCT CCAGTGATCA  51361 CAGCTCCAAG GAGAACCAGG CCAGCAATGA TGCCCACGAT GGGGATGGTG GGCTGGGAAG  51421 ACAGCTCTGG GAAAAGAGGG GAAGGTGAGG GGCCCTGACC CTGCTAAAGG TCTCCAGAGA  51481 GGCTCCTGCT TTCCCTAAGA GACATGACAC CCCCATCTCC CTCCTTACCC CATCTCAGGG  51541 TGAGGGGCTT GGGCAGACCC TCATGCTGCA CATGGCAGGT GTATCTCTGC TCCTCTCCAG  51601 AAGGCACCAC CACAGCCGCC CACTTCTGGA AGGTTCCATC CCCTGCAGGC CTGGTCTCCA  51661 CGAGCTCCGT GTCCTGGGTC TGGTCCTCCC CATCCCGCTG CCAGGTCAGT GTGATCTCCG  51721 CAGGGTAGAA GCCCAGGGCC CAGCACCTCA GGGTGGCCTC ATGGTCAGAG ATGGGGTGGT  51781 GGGTCATATG TGTCTTGGGG GGGTCTGACG GGAAGAGTCA GAAAATTCAG GCATTTTGCA  51841 TCTGTCATGG GACACTCCAC CAGCACGCAT GTGGCCATCT TGAGAATGGA CAGGACACCC  51901 GGGATGGGGA AGAGAGCACA GAACCCAGAC ACCAGCCTGG ACACAGGCAC CTGGGATAAT  51961 CTTCTATTCC CTGAGAAGGG AACAGCGACT TCTGGTCCTG ACCTGAGTGG AGGCTGAGGG  52021 ACTCAGAAGT GCTGGACTCA GACCCCCACA CACATTGAGT GTGAAGCAGA GAACAAGGCC  52081 TGAGAGGAAA AGTCACGGGC CCAAGGCTGC TGCCGGTGTC AAAGGGAACC ACTCATCAGT  52141 ATTCGAGGGA TCGTCTTCCC GTCACTCCTT CAGAGATTTT ATCCCTTAAT TGTGTCAGAG  52201 AGCAGGGCGG AACCTCAGAG TCACTCTCTG GTACAGGATC TGGAAACCCA GGAGGATTCC  52261 TCTCCCTCAG GACCAGAGGG AGGGTGATAT TCTAGTGTTG GTCCCAATTG TCTCCCCTCC  52321 TTGTGGGAGG CCAGCCCGGG AGATCTACAG GCGATCAGGA AGGCGCCCCG TGGCCCCTGG  52381 TACCCGTGCG CTGCAGCGTC TCCTTCCCGT TCTCCAGGTA TCTGCGGAGC CACTCCACGC  52441 ACGTGCCCTC CAGGTAGGCT CTCAACTGCT CCGCCCAACG GGCCGCCTCC CACTTGCGCT  52501 GGGTGATCTG AGCCGCCATG TCCGCCGCGG TCCAAGAGCG CAGGTCCTCG TTCAGGGCGA  52561 TGTAATCCTT GCCGTCGTAG GCGTGCTGTT CATACCCGCG GAGGAAGCGC CCGTCCGACC  52621 CCACGTCGCA GCCATACATT ATCTGGATGG TGTGAGAACC TGGCCCCGAC CCCGCGGTCA  52681 GCCCAGTCCC CCGAGCCCCG CCCAGCCCCG ACCAACCCGG GGGAATTTTT GGCCTAAACT  52741 GAAAATGAAA CCGGGTAAAG GCGCCTGGGC CTCTCCCGGG TCAAGGGTCT CGGGGTCCCG  52801 CGGCTTCGGG GTGGATCTCG GACCCGGAGA CTGTGGGCGA CCTGGCCCGT CCGTGGGGGA  52861 TGAGGGGTCG TGACCTGCGC CCCCGGCCGG GGTCACTCAC CGGCCTCGCT CTGGTTGTAG  52921 TAGCCGCGCA GGGTCCCCAG GTCCACTCGG TCAGTCTGTG ACTGGGCCTT CACATTCCGT  52981 GTCTCCTGGT CCCAATACTC AGGCCTCTCC TGCTCTATCC ACGGCGCCCG CGGCTCCATC  53041 CTCTGGCTCG CGGCGTCGCT GTCGAACCGC ACGAACTGCG TGTCGTCCAC GTAGCCCACT  53101 GCGATGAAGC GGGGCTCTCC ACTGCCGGGC CGGGACACGG ATGTGGAGAA ATACCTCATG  53161 GAGTGGGAGC CTGGGGGCGA GCAGTGGCTG AGACCTGACC GACCCTCCTC CCGGCGCGGC  53221 TCCCCCGGTC CTGCGCCCCC GCCAGGAGGG CCCCTTGCTT CTCCCCGCAG AGGCGGTTTC  53281 CCTCCCGACC CCGCACTCAC CCGCCCAGGT CTGGGTCAGG GCCAGGGCCC CCGAGAGTAG  53341 CAGGAGGAGG GTTCGGGGCG CCATGACGGC CATCCTCGGC GTCTGGGGAG AATCTGAGTC  53401 CCGGTGGGTG CGTGCGGGCT TTAGAACAGC GACCGCGACG ACACTGATTG GCTTCTCTGG  53461 AAACCCGACA CCCAATGGGA GTGAGAACTG GGTCCGCGTC GTGAGTATCC AGGATGAAGG  53521 ACCCTACGTA GGTTGGGAGA GGGAGAAAAG AAACTGCGGA GTTGGGGAAT CCCCAAGGCT  53581 GTGACTCCCC AATCCATACA CCGCCTTCGG GGCCTGAGAC CCTGAGAGCC ACGCCTGGGG  53641 CCCTGGGACT TCGCCCTGAC CCCTCTGCTC CTGTGCGAAG CGCTCTGTCT CAATGTCTCC  53701 CTGAGTCTTG GCCCAAGAGC TGTCTGAGAA ACAAGGGAGA AACCCTCGGT TCACTTTTCA  53761 TCCCATTATC TCTGTCCCTG AACTGGACTC CCTGACTCCC ACTCCTTACC TGTCCACCTG  53821 GACTCTTCTA GAAGAAAAAT CACCCCATGG AGTTTGGTGC CAGAGAGTAA GCTTGCTCTG  53881 GGAATGGAGG TGTAGATTTT TGTTGTTGTT GTTTTTGTTT TTAATCCGGA AAAGTTGTGC  53941 CTGAGTGCAT GAGACAGAAT AGAGACCAAT TTGCTCTTTG TTTATTAACT ACAGTGGGTA  54001 GCAGAATCTT GGTAACCCCT GAATGATCAG GAATCTAATA GGTAAAAAAA TGTGACTTTG  54061 GCCCCTTAAT GTATAAATGT GTCCAAAAGC ATTACAACAG GACTCACAAA GCTACTAAGT  54121 TGCACTTTCC CAGACAATGT ATCTGTGACT CCTGCTTGTC TTACTTTAAA TTTGCCATCA  54181 TTCCTTAGCT CTGAGTTTCT GTGTGAGTCC ACGACATCTC CTCAATACAA AGTAGCCACT  54241 GTGTTCCTAT ATGTTGCAAC CAGAAGCCAT TACAGGCTTT ATTCACCTCA AAGTTGCAAC  54301 TGTTCAAGGC AGTCACAATG CCCCTCACTA GTGCTCATGC ACTGCCTGTT TTTAGGAAGT  54361 ATCCACTTCT AAGTGTTGTG TATATTTTAT AGGAACACTT AGTAATTTTT AAACCTGATT  54421 AACATAAAAA ATAGTTTTTA GGCAGACCCA CATGAGGTAT TAAAAGACAA CTGCCAAGGA  54481 CACCCTGCTA GGCTCTGTAG ATTGATGTAT TAAAATCCAT AAAACAATGT CTTTAAACCT  54541 AAGAATTCTG CTGCTTTCAA ATTCTTTCCT CTGCTCCTTT TCCTCACCTC CTGCTTCTCC  54601 AGCCCTTCCC TCCATCCTTC TCATCCTTCA GGCCCTCCTC TCCCCTTAGT CCCCACCACA  54661 CTGTCACTCA TGAATTGTGA CACTAGCACT GTCCCATGAC CTGCTACGTA ACTGTTCTTT  54721 TCACAGTGGC CCTGCTCCTG TGAGTCGGAG TGTGTCATTT CTCCACTTAA AACACTCCAG  54781 TGTCTCCACC TCGGTCTTGT GAAGCTTCTG GAGTGTCAGG CACTTGAGCA TATGAGGGGA  54841 TACCTCGTTC ATTGTAGGGA CTAAGTTAAT TTTTGTTGAC TTAATGAATG AAATATGAGT  54901 GTATTAAATT GCATCACAGA TAATTATAAA CTGTAAAACA CTGAAAAAGT TCAGAAAGAT  54961 TTTATTTTAT GCAACTAGTG TGTATATCAA TTCATCAATT CATTCGCACA CTACCATGCC  55021 TGGCAAAACA ACACACATTT ATCTGCTTAT AGTTCCTTGG TCAGAAATCT GGGCAAGATG  55081 TGGATAGAAT CTCCATTCTG GGCTTCCAAA AGCTGTGTTT TCATTTTGAA TCCTCCTTCG  55141 GGTTTATACA GAGGTGGCAG AATGCAGTTT CTTGCAGTTG TAAGACTGAG GTCCCTGTTC  55201 CTGGCTAGCT GTCAATGTAG AGAACTGGGA GGGGCTCAAT TCCCGGTGCT CACCAGCGTT  55261 CTTTCCTACA CAGCCCCTTA ATTTTTCTTT TTTTTTTTTT TTTTGAGACG GAGTCTGGCT  55321 CTGTAGCCCA GGCTGGGGTA CAGTGGCCCA ATGATCTCTG CTCACTACAA GTTCTGCCTC  55381 CTGGGTTCAC ACCATTCTCC TGTCTCAGTC CCAAGTAGCT GGGACTACAG GCGCCCACCA  55441 CTATGCTCTA ATTTTTTTTT TCTTAGTAGA GACAGGGTTT CACCTTGTTA GCCAGGATTG  55501 TCTCGACCTC CTGACCTCAT GATCCGCCCG CCTCGGCCTC CCAAAGTGTC GGGATTACAG  55561 GCGTGAGCCA CCGCGCCCGG CCCATAGCCC CTTCCTTTTC AAAGCCCATG GTGGAGGAAA  55621 CCCCTCATGC TGAGTCCCTT TCACACTGTA AGTCTCTATG CTCATGAAGA ACCCAGTCCT  55681 TTCAAGGGCT CACCTGATTA GGACAGTCCA AGCAGGATAA ACCCAGCATA AAGTCAACTA  55741 ATTGAGACCC TTAATTATAT CTGCTAAATC CCTTCACAGC AGCACCTACA TTAGAGTTGG  55801 TTGAATAACT GGAGGAAGGT GAATGACCAG GAGCTGCTTG TTGAGGCCAT CATAGAATCA  55861 GCCTAGCAAG GGTTGGATCT TCCTTTTGTG TTTAATTGGG ACACAGTTGG AAAGTGAAGT  55921 TCAAGTAACG TGATCATTGT GAATGGTCAT AAAATACATC CTCTTCAGCC ATGGAAATTG  55981 TCCTTACTTT TTAAAACTAA GTTACATGTT TAATATCTTA TAATTAATTT AGGCCAGGTG  56041 TGGTGGCTCA CATCTGTCAT CCTAGCACTG TGGAAGGCAG AGGAATGGAG ATTTGTTGAC  56101 TCCAGAAGTT CAAGATCAGC CTGGGCAAAA CCTCCATCTA TACAAAAAAT TAGAAAATTA  56161 GCCAGGCATG GTAGTTCATG ATGGTAGTCG CAGCTACTCA GGAGGCTGAG GTCAGAGAGT  56221 CCCTTGACCC CAGGAGTTCG ACACTGCAGT GCATGGTGAT CATGCCACTG CATTCCAGCC  56281 TGGGTGACAG AGCAAGACCC TGTCTCAAAA ATAATAATGA TGATGATGAC ACATTTAGAG  56341 CAAATGCAAT TTGATGTGTA ATAATACATC CTCTCTTGTG AAAATATATT ATTTACTGTT  56401 GCATAACAAA TTACGTAAAA CTTAGCTCGA AACAACAAAT GTTTCTCATC TCCCACAGTT  56461 TCCAATCGTC AGGAATCCAG GAGAGGTTTC CCTGAGTGCT TCCTGCTCAG GGCCTCTCAC  56521 AAGGTTGCAC TCCAGTTGTC AGCCAGGGGC CGCAGCATCT GAGGGCTTCG CTGGGGCTGG  56581 GAATTCACAA GAAACATGGA TCAGTCACAT GGCTGTTGGA AAAGGCCTGG TTCCTTGTTG  56641 TCTGTTCCCA GAAGGCCTCA GTTCTCAGTC ATGTGGACCT TCCTGCAGGG CTGCTTATGG  56701 CACAGCGGCT GGCTTCCCCA AGAGCTCATG ATCCCAGATT CAGAGAGAGA GAAGGTGGAA  56761 GCCGCAGTTA GTTTTATGTT CTACACCCAG AGTCACAAAC TGTTATGTTG GCACTATTCT  56821 ATAAGTTAGA AGTTGTATTA GTCCATTCTC ACACTGCTAT AAAGAAATAC CTGAGACTGG  56881 GTAATTTATA AAGGAAAGAG GTTTAATTGA CCCACAGTTC TGCATGACTG AGGAGGCTGC  56941 CCCAGGAAAC TTACAGTCAT GGCAGAAGTG GAAGCAAACC CGTCCTTCTT CATGTGGTGA  57001 CAGGAGAGAG AAATGCACAA TGAAGCAGGG AAAAGCCCCT TATAAAACCA TCAGATCTCA  57061 TGAGTATTCC CTCAGCATCA GGAGAACAGC ATGGGGGCAC CGTCCCCATG ATCCAATCAA  57121 CTCCCATGAG GTCCCTCCCC CAATAGGTAG GGATTACAAT TTGCATAACA ACTCAAGATG  57181 ACATTTGGGT GGGAACACAG AACCAGGCCA TTTCAGAAGT GCCTCATTAA GTCCAAGCCA  57241 CACTCAAGAG AGGGAATTAA GCTGCACCTC CAGAAAGGAA CAGTATCAAA GGATTTGAAT  57301 ATATGTTAAA AGCAAAATTA TAACTATTGT TTCAGGTTTC TGAAAATCAA AGTCTTCTTG  57361 TATCTAATTA TTTTTCATTA ACTCTTTAAG CTTGTCTTTT AATTTAATTT TTTTTTTAAG  57421 TTCCAGGGTA CATGTGTAGG ATGTGCAGGT TTGTTACATA GGTAAATGTG TGCCATGTTG  57481 GTTTGCTGCA CCTGTCAACT CATCACCTAG GTATTAACCC TGGCATGCAT TAGCTATTTT  57541 TGCTAATGAT CCTCTCATCA CCACCCTCCC CCAACAGGCC CCAGTATGTG TTGTTCCTCT  57601 CCCTGTGTCC ATCTGTTCTC ATTGCTCAGT TCCCAGTTAT ATATGAGAAC ATGTGGTGTT  57661 TGGTTTTCTG TTCCTGTGTG AGTTTGCTGA GGATAATGGC TTCCACCTTC ATCCATATCC  57721 CTGCAAAGGA CTTGATCTCC TTCCTTTTTA TGGCTGCATA ATATTCCATG GTGTATATGT  57781 ACCATATTTT CTTTATCCAG ACCATCATTG ATGGGCATTT GGGTTGATTC CATGTCTTTG  57841 CTATTGTGAA TAGTGCTGCC ATGAATGTAA ACATGCATAT GTCTTTATAA TAGAATGATT  57901 TATATTCCTT TGGGTATATA CCCTGCAATG GGATTGCTGG GTCAAATGGT ATTTCTGGTT  57961 CTAAATCTTT GAGGAATCGC CACACTGTCA CTGTCTTCCA CAATGGATTA ACCATTTACT  58021 TTTCCACCAA CAGTGTAAAA GCATTCCTAT TTCTCCGCAA CCTTGCCAGC ATCTGTTGTT  58081 TCTTGACTAT TTAATAATTG CCATTCTGAC TGGCATAAAA TGGTATCTCA TTTGTCGTTT  58141 TGATTTGCAT TTCTCTAATG ATCAGTGATG GGAGCTTTCT TTTTCATATT TTTGTTGGCC  58201 ACATGTATGT CTTCTTTAGA AGTGTCTGTT CATGTTCTTT GTCCACTTTT TAATGAAGTT  58261 TTTTTTCATG TAAATTTGCT TAAGTTCTTT GTGGATTCTG AATACTAGAC TTTTGTCAGA  58321 TGAACAGATG GCAAAATTTT TCTCCCATTC TGTAGCATGT CTGTTCACTC TGATTGATGA  58381 TAGTTTCTTT TGCTGTGCAG AAAAAAATTG CCTAATCTGA TTGCTTTTCA TTTACAAAAA  58441 TGAGAATCTC ATACTTCAGT TAACACATCT AGCTTAGCAT GATGCCAATA ATTTTGGCTT  58501 GATGCTGTAG CCCGAAATGG TTAGCTCGAA TTGAGAGACA AGTTATTTTC AAAAACTGGC  58561 TATCCGATGG GCATTCTATA ACACACTTAA CATCTTTTGT TGTGGTATTG AATGAGATGT  58621 GATAGAAGTG ATTTGGACAC CACTATGATT CTAAATAGCA CTGCTATTAT GTGCTTCTGA  58681 ATTTTTTTTC TTTTTAGCAG TCCTATTCTG TTTCCATTCA TATTTGCTAT TCCATCACTG  58741 GGTATTCCTT CCTACTCTTT TCATGTTTCA TTTATTTTGA TCAGTGATGT GCATTTCCAA  58801 TTCTGTAAAA GTTTAATTCA GTTGTATGTG TGGTAAAATG TAACATAGAA TCTTTGCAAG  58861 ATGAAATTAC CTTGCACAGC ATATTGAACA TTGTATTATT GAAAATCTAG AGAGATGCCA  58921 GTGAGCCAAG GATCGAATGA CCTATATGTA GCCAAGGCCG TTTTCATGGC ATCCTGGTCC  58981 TCTCTGTCAC ATAGCTCCTT ACAATTCTCT GTGGTTTTCT TCCAATGTAA GTAGTTCTTG  59041 TTAAGAATCT TTGCAATGAA CTTTGAAATT CTTTTCTTTT TCATTGCTAT AAAAAACAGG  59101 TATATTTTAA TTTGGAAAAC TCTGTTTAAG GAATTATAAT CAAGTAACTA CCAGGGGGCC  59161 CAGCACTGGT GTAAAACACA AAACTGTAAA ACTACCCTGG GCTGCTACCC TTCGAAATGG  59221 GGTCTTTTCA AAGTTAGTAA CAATGAAGCT GTCATTCACA CGATGCATGG CTGAACAAAA  59281 AGACAGAGAC AGCGGGTGCT GCATTTTATT TTTGTAATGT TGCCTTGTCC ACAAGACACT  59341 ATTTACACTT AAATCAATTA AAATTATATT AATTTTAAAA GTCAGTTTTC CCAGTTTCTC  59401 ATTTGTACTA GCCACATTTC AAATACTCAG AATTCATGGG TGGCCGGTGA CTGACGTAAT  59461 GAACAGCACA GATATAGGCA TTCCATCACT ACAGAAGGGA GCTGGACAGC AGTGTGCCAA  59521 TGTTTTAAGG ACAGAATCCT GAGTAGAATT ATAGGATGAT GACAATTCCG AGTTCCCATT  59581 CCAATTCATG GTCTCTTCTC TGATGAGTGG TGTAGGGGGA AATCCATCTC TTTTGTGAGT  59641 AAAGGTTAAT TTTTCCAACT ACAGATAAAT AATTAACATT ACTTTTTTTA AAACCAGTTT  59701 TACACTGTTA AGTTACAACC AAAAGTGAAG GGCTTGAATT ACATTTACAT TTTAACACAT  59761 GGTTTTAAAG GGAAGATCCG TGTGAAAAAG AAACAAAACT CAGAAAAAAA ACCCAGAAGT  59821 TTTCATACCA ATTCCCATAG CAATAACAAT CCCTTTTCTG TCGTTAGAGT TCACCCTCAT  59881 TCTGATTTCA TAGTAATCCT GTTCATGTCT TTCTTTAAAG CTTTACCCCA TGCATATATT  59941 TCTAAAACAA CACAGGTTAT CTCAAACTTT ATATAAATTT TGAATTTTTC ATACAAATGG  60001 AATCATGOTG TGTATATTCT TACAAGACCT CATTTTAGAT CAAATGTATG TTTGCTAAGT  60061 TTTTATAGGT GTCTGTATTC ATGTTTATTA TTTGTAACAT TTCATTGAAT AAATACATCA  60121 TATATTAAAT TAACCCTTCT CTCGTTTATG GTCATTTCAT TTGTTGTCAG ATTTTTTAAA  60181 ATTACAAGCA ATGCTGTTAC AAGTCTTCTA GCACTAGTCT GTTGGCACAA TGGGCACATA  60241 TCTGTCAAAA TTATACACCT AGGAGTGGAG TTACTGGTAT ATGTGTATGA TATCCCACTC  60301 AAAGAGATGA TGCCACACTG CTAGATAAAG TGGCTGTGGC AAGCAATGTG TGGTAGATCT  60361 TGATGGTCTG TATTCTCATC AGTGTTTGGA AAACTCAATA ATTTTAATAT AGAAATTCTA  60421 GTGCATTTTT CAAAATATCT CATTATGTTT TCCTCATTAA ACTTTATTGA GATATAAATC  60481 ACATACTACT CACCCATCTA AAGTATGCAA TTCAATGGTT TTTCACATAT TCAGAGTTTT  60541 AAATCTGCAT ATTTAATTTT AGAACATTTT CATCATCCCA AGATAATCAA CGGCTTTATA  60601 ATATGTCTCT CTATACAATG AAGTAAATCC ATAAATTTTG AGTTTTCACT TCAGGAGTGT  60661 TTTTTCTATC ATTGGCAACT TTCCTAGCTT GACAGGCACC TTTCCAAGTA CCTTTAACAA  60721 TTTTATTTTT AATAGAGATT TCATTCAGTA ATCAGATTTG GAGAGCACTG ACAAATTTTG  60781 CCACATTGAG ACTTATAATT CATGAACATG TAATGTTTAC TTATTAAATA CTCTTAAATA  60841 AAGTATTGCT GGTTTTACTT GTGCATCTTT TAGTAGATTT ATTCCAAAGA TCTTGAAATA  60901 TGGTGCTAGT GTTCACAGTA TCTCTTTCTT TGTTGAATTT CAGTGTTGGT TGTGGTATGT  60961 ATAAATATAA ATAATTTTAT ATAGTTTTAA TTCAATGACT TTGCTTAAAG CTTTTATTAA  61021 TTCATGTAGT TGATATATTC TGTTGCCTGA TTGCACTAGC TAGGAAATCC AGTGTGATTT  61081 TGAGTGCAAT GGAGAGGGCA GGTCTGCTGG TATCTTCTCT GTGCACTCCT GATCCACACT  61141 CCATGTACTC TCCCTGCTCC GTGTCCTGGA CACTGTGCTG CATGGCCTGC TGGACCACAA  61201 AAGGCAGCCT TGCTTTCTGG CTTTTATTTG GGATCGGCTA AATGGGAGCA TCATCACGGA  61261 GAGAGTGATG AGGAGCACTG GTTGGAGGGA TTTCTCCCCA TAGCTTTCAG TATTGACATA  61321 GGGAGAAATG AGATGTGATT GGCCTGGATT CATCAATATG GGATCTTCAC CCAGTATCTT  61381 AGATTAAATG TGTTATTTTG AACACCTAAG AGTGATGTTA ATAGTCAGCC AGGTTAGCTA  61441 ATTAAAACCC GAATTCAACT GTGGCCTAGC ACAGTGTTTC TCAAATTTGA CTGAGCTTTC  61501 CATCACGTGG GAGATTTTAA ATAGCCCCAG GTCTAGATCA ACATGTAAAA CCAATGAAAT  61561 CTAATTCATC AAAAGTAGGA TCCTGGAAAC AGTATTGTTC CTAAAACTCT CCAGGTTTGA  61621 CTCCAATCAA CAGCCAAGTT AAAAACTAGT AGCTCAAAGC AGTGGTTCTC AATATTTGGT  61681 ATGTATCAAA ATCATCTGGG AATTGTAGCA AAACTACACA GGCCCAGATA TTATTCTAAT  61741 TTAACAGGCT AGAGCCTTGA GTTTATTAAA ACAAATCATC TCTCCAGATT TTGCTATATG  61801 CAACAGTTTG TGAAAACCAC TAGCCTATAT CAACAGAATC CCTATCACAG GCATACTGCA  61861 GAGGAAAGTG TCTGAACACA GCTCAGAGAG ACGGAAAAGT GGGAATGTAT CCATTATGTG  61921 CAACCTACTT AACATCTCCT AACCACATCT CCCGGGAGGG CTGAGAGGAT GCCCCCCTTA  61981 CCAAGGCATT AAGGTGCCAC ATGACACATA CAGGTATAAA AACTGCTAGG TCTGCTGAGC  62041 AGTCACCAAT CTTGAGTCCT GGATATTCAG AAATTCTTAT CCAGTAGCTA CACCAAAGCC  62101 AGCTGATATG TCAGAGCCCC TCAAATAAGC AGAAGGCTGG TGCCCTTGAG AAAGGACCCT  62161 ATAATTCACT CTGAGATAAA TTCTTTTTAC AGGACTTTCC CAGAGGAACA TTTAGTCATT  62221 TATCGCTGTC CACTGGGGAA TGGAAAACCC CAAATAATCT GGGAGCTCAA CTTTAATGTC  62281 TTTAATCCTG TCAAAGATTA CCCTGGGGTT AATACTTTGT TGTAACCTGC ATAAAAATCT  62341 TTCCCTACAC TAAAGTAATG AAGATATTCT ACTATATTAC TGTAAAGAGA TGAGTACAAT  62401 CACATTTTTT TACAAGAGAT GAGTACAATT GCATTTTTCC AGATAGATAA CCAATTGTTG  62461 TTAAATTATT TTCTAAATCG TTTTCCTTTA CCCACTGATC TGTAATGTTG CCTCTGCTCT  62521 ACATACGTTC AGGGCTTTCT ATTCTGTTCC CAAGTTCTAG TTTACTACCC TGTCTCAACA  62581 TCTCGACTCT CTTAATTAAA ATAACTCTAA CATAAGTCTT AATATCTGCT AAGGAAATTC  62641 TCTCTGCTTA TTATTCTTAT TTAGAGTGTC ATAGCTACTT TTTCTCTTTC ATATTTCAAT  62701 ATAAGGCTTA AAATTGGCTT ACTATGTGTT GCAAAAATGC TTGATAAACA TTTGATTGAG  62761 ATGTGTTTGA GTTCTTAGAG TACTGTAGGA AATTAATGTC ATTATTATAT TGAACCATCC  62821 AAGCCAGGAT CCTGGTAAAT TGATTCAGTT AATTCACTGT CTTCTTTAAT TACTGTCTTC  62881 TATTATTACT CAGTAGGGTT TTTTAAATAT CCCAATTGAT ATCTTGTACA GAATTTGTTA  62941 GGTTTAGTTT TAGAAGTTTA TATGTACGCA CTTTTGCTGA ATCAATTTTT TAAAATTTTC  63001 ATTTTATATC TGTGCAAAAC AGCTCTATAA TTTCTTCTAC CTACCAAGCA AAAATATCTT  63061 ATTAACTTCC GGATCACGAG GTCAGGAGAT CAAGACCATC CTGGCTAACA TGGTGAAACC  63121 CCATCTCTAC TAAAAATACA AAAAATTAGC CGGGCATGGT GGCGGGCGCC TGTAATCCCA  63181 GCTACTCGGG AGGCTGAGGC AGGAGAATGG CCTAAGTAAA TCTGGGAGGC GGAGCTTGCA  63241 GTGAGCCGAG ATCTCGCCAC TGCACTCCAG CCTGGGCGAC AGAGCGAGAC TCCNTCTCAA  63301 AAAAAAAAAA AAAAAAAAAA AATATATATA TATATATATA TAAATATATT TATATATATA  63361 TGTATCTTAT TAACTTCAAG AGTGTTCTAA TCATTTGTAT TTTCTGCATT CAGCATATTA  63421 CCATTTGCAA ATTATAAGAG TTTTGTGCCT TCTTTTCAAA CCTTTTTAAG TATATTTCTT  63481 TTCTTCTTTA TGACACTGGG AAGATCCTCA ATTACAATTT TTAATAAGAG CAGTGAAAAC  63541 TGCTGGACCA CTCAAACAAA AATTGAGCTG CCACTCCTGA GAACTGACTG TGTTGCTCTT  63601 ATGGATCAGC CCTTTGGGAC CCATCCTAAT CCCAGGGATT TACAGTGCCA CATATGCACC  63661 CGCAGCCTTT AGATGTAGAC TTTATCCACC TAGCCCTCAA AGGTCTCAGA CACTGCCCAG  63721 AGCAGCCAAC ATCACCCAGG ACAAAAGCAA CCCTGCAGCT CAACTTGCTC TTCTAGATTT  63781 CTGCCTTCTC CTGGTTCCTG GCCTGGCAAA TCTTTACTGC TTGGTTAGCC CCTTCATACT  63841 TTCCATCAGA TTTTTCAAAT ATGTACCCTT TTCCCACTTG TCCAGTAGTA CTCAATGGGA  63901 GGGATGATCC AAATTACATA ATTAATAATT GOTGAAAACT AAAGTACAAT GTACAATTTT  63961 TATGTCAATG TCACATGCCA AGGGAGAAAA TGCATAGGTA TCAGTAGTGA CTACTTAAGC  64021 ATGTGTAACT TAGAGGTAAT AAAAACAAAA ATGTTAGGTA ATATCTATCT ATTCCAGATT  64081 AAAATCTACA TCAATAAATT CAAACTTCTA GGAAAAATAT CTGCATATGT AATATATGAC  64141 TGTGACTCCG ATAGACGAAC GTGGGAATAT AGTATGAAGA TACTTCTCAT CGTCTTCACT  64201 CTGTGAGGCA GTCAGTGTGA AATGAGAACC AGGGATTCAA AATGTGTTGC AAGACTATGA  64261 AAAGCACTAG AGTAAGTTCT ACACAAATAA AGCAATCTCC TCATAAATTA CACTGGGCTT  64321 ATCTGTGAGA TGCATGTCCT TATCAAAATG GAGTTAATTC TAGGTAGGTG ATCTTGTTTA  64381 AATAAAATGG ACTCTGACTC ACTAGCTACT GGTCCACCAT CGGTTTTTCC CTTTACTAAA  64441 AGGGAGGCCC CACACTGAGC CAGCATTTCC CAAGAGGAGG TGTCTTGCTG ACATCAACTT  64501 CCAACAGGGT AAATTTTCAT GGGAACCCAA AGAGAAGAGG AAGACCTCAA GAAAAAGGGC  64561 CTAAAGAAAT GACAAGAATG ATAACATTTT ACACTTTTAT TGTGCTATGT GTCAAATAGT  64621 GGTCTTCGCA CTTTAAAAAT GCCAATTCAT TTTATTCTGA CTACACATCC ATGGCTTGTG  64681 CCTGTTATTT TTCCCTTTCA TAGTTAATGC CATAGGAATG AAGATCACAC AAAAGTAGGG  64741 ATGGAGCCGG GTTTGCACCC AGACAATTCT GCCCCAGGGC CATGCTCACA CCACTGCACT  64801 TTTCCAGAAT GTGAGGGTGG GCGGAGAGTC CAGCTCAGGG AGAGAGATTG GAGTGAGAGA  64861 AGAAGGAGAG GGGGCCGACT GGATCACTGT GATGGTCTGG ACCCACGATT CCAGGAGAGA  64921 AAGACAAGGA TTATGTCACT CAGGGAAAAT ATCCAAAGTC TCTGGTTTAA ACTTAAGCAT  64981 CTCCAGCTCC AGGACAGGTG GCTGGTGGGA AGACAAACTA AGCCAAAGCC ACAGCTCTGA  65041 AGATTTCCCT CTCCTGAGAA TTCTGCAGGG GTTTCCCTGA CCTCATGGCC ACCTCTCACC  65101 CTTGGCTCTT GTTTTTCCCC CAGGACTGAT AAGGGCGTCC AGATGGGACG CCTTTATCAG  65161 TTGGTCTCGG GTTCTAGAGA AGCCATCAGA GTCAGTGGAG GATGAGCTTC ATAAAGTGGG  65221 AGATCTCCAG GATCCTTCCT GGACTCCAAG ATACCCAGAG AAGCCGGATC CTGTGTCCCG  65281 GAACCCCCTT CCTGTTCCTT TGTGGGCCCT GACCTTAGGG AGAACTGGGC TGGTGAGAAG  65341 ATCAGGATGA ACTGGGCTGG GGAGGCAAGA GGGAAAGGGC GGCTTGGAGG GCTTAGTAGC  65401 TCCTCTCGCG GCGCCTCCGT CCCGGGCTGG GATCTGCAGA CTCCTCAGGT CACTTCTCCC  65461 AGAGCCGCCG CCCCAAGCCA CCCTCCCCTG GTTCCCGTCC CTCTGTCCCC TCCCCAGCTC  65521 CCCCCACACA GTAAGAAGCT CCCAAGTGAG CGGCTCCGGT GCCGGGCGGG ACGTGGGAGG  65581 GAGGCTGTGT CCCCGCGGGG AGGCAGGGCG ACGGCGTCCA GGAGAGAGGG GAGCGGGGCG  65641 GTGTCCCAGG CACCCTGCGC CTCTCCCGCC CGCAATGTGC GGGTTCCCGG AGCCCAGGCC  65701 CGCACCCCGG GTACTTGAAG GCCGCCGGGC TCCGCCTTCA CCACGTGGGC CCTGAGTTCC  65761 TCCGCGGCGC CTTCGTGGGC GACACGCGAT TCCTGAGCTT CCACAGCCGC GGCGAGAATC  65821 AGAGCGTGAA GCGCGGGTGG AGAAGATGGC ACAGGGCTGT GGGCGCCCTG AGGAAAGTTC  65881 TCGAAGACCG CAGGGAATGT GTTACTGAGG GGCCTGAGGT TCCTGGGCCC GCACCACCAC  65941 CAGGGTCAGC CGGTGAGTGA CCTCAGACTC CGGGCACAGG TGTGCCCCGC CCCGACCCCA  66001 GAGTGACCAG CCCGGTTCTC CCAGGGATGG GGGGGCGGGG CCTCAGCTGA TCCCTCTCAG  66061 GTGGGGAAGC GCTGGGGCCA TTTTGCTCCA GGTTTCTCCT TCAATCTGGA TCATGACTGA  66121 CTTGTTCTGT GACCAATGAC AGAGGGAGGA AGGAGCTGGG GTGGGCGGGG CGACCTCCCT  66181 CCCCTCCCTG GCCCCGCCTC CGGCTCACCC TGGGGCAGGT CCAGGGCACC GCACCTGCAG  66241 ATGCTGCTGT CTGGCTGGGT GGTGGCTCCG GACAGGAGCT TCCTCGAAGG ACACTTTAAG  66301 TCCGCCTACG ACAAGGAGAT TTCATGTCCC TGAACGAGGA CCTGCAGACC TGGACAGCGG  66361 CTCAAAGAGC GGCTTGGAGG ATCCATCACA CCTGGGAGAG GTTCTGGACC GCGGAGGCCA  66421 CAAGGGAAGC CCCGATGGGT CACTGCACTA GGTGGCTGCT CAGACACCTG GAGGATGGCA  66481 AGGAGATGAT GCTGCCGGCA GGTACTGGGG TCCTCCAGGC CCCACGTCAG GACCTCTTGG  66541 AGCTGGAATT ATGTTCCTTG GAGGCATCCA TATTTGAGGA AAGAGGAGAC CGAACAGTCT  66601 CCGTCTCCTC CTCCTCCTCC TTCTCCTCCT CCGTCGCCGC CTCCTCCTCC TCCTCCCTAC  66661 TGCGGGGTTG GGGATTCTGG CCCAGGCTCC TGAGGCTCTC CCATGGGTGG GTGGGGAGGG  66721 AGGACAGAGA AGAAGGAGTG CAGGGAGGTA AATAGGAAAG GACAGTAGTT ACCCTTGTCA  66781 ACAGTGATGT ACTTGGGTCT AGCTTCACCG GGAATCTTTT TCTTTCCTGG CCCTCTGTGC  66841 CCAACAATTA CATATAATCT TTAACCCAAC CAGAAGATAA AACACCAGGA AACGGAATCG  66901 GCAGAGACAC AGTAGATGAA AGTACCACGA AGGACTGCTA GGTTCTAATA GAAAGTAGCA  66961 GATGTGAGTA TCAAAAGTTA TAAACCTTTT TGCAAATCAG AAAAGAAACA GACTTTTTTT  67021 TTTTTTTTTT TTTTTTTTTT TTTTTTTTGA GACGGAGTCT CTCTCTGTCA CCCAGGCTGG  67081 AGTGCAGTGG CGCGATCTCA GCTCACTGCA AGCTCCGCCT CCCAGGTTCA CGCCATTCTC  67141 CTGCCTCAGC CTCCCGAGTA GCTGGGACTA CAGGCGCCCG CCACTAAGCC CGGCTAATTT  67201 TTTGTATTTT TAGTAGAGAC GGGGTTTCAC TGTGTTAGCC AGGATGGTCT CGATCTCCTG  67261 ACCTCATGAT CCGCCCGCCT CGGCCTCCCA GAGTGCTGGG ATTACAGGCG TGAGCCACCG  67321 CGCCTGGCCG AAAAAGACAT TTAAAGACTG AAAAGTGGTA TCACCAATGT TAGAACCAAA  67381 AAACTGGACC TGAGGGTGCA TCACCCGAGG GGGTTAAGTT AAACTCTGTC CCTGTTCCTT  67441 CTAGAGCCCC GTGGAGATTC CTGCTGTGCA GCAAAGCCTG GGAGGGGCCC CTGGCTGTGG  67501 AAGGCAGGCT GAGACGTCAT AGGTGAGATA GGAGGAAGGG GACCTGCTGG ACTCCCGGGG  67561 ACCTGCTGGA CTCCCGGAGG CCTGGTACCC AGGGAAGGCC AGTTCCTAGG GCTGCCTCTG  67621 GACTTCAGAA CCTTGATGTT AAGTCATATT TTCCCGCTCC TCCATGAGCT TCCAGGAGCA  67681 GGGCCACATG GGGCTCAGAA AGTCCCACAG TGCCTAGGAA GTGGGTCTGT CTCTTGTGGG  67741 ACAAAAATTC TCAGGTCTTT CTCTTTCAGA TTCTTAAATT TCTTAAAAGA GATTGAACTG  67801 GAATTACCCA GGCCCCAAAC TGAATCAAGG AATTGGGACT GTGTAATGTG CGTGTGTCTG  67861 TCTGTGCACA TGTGGATGTA TAAACAGGTA TGGGCATCTA TGTGTATGTG CGTGTTTATA  67921 AGTGCGTATA TGTATGTATC TGTACATATT TATGTATATA AGCAGGTATG GGTATGTATG  67981 TGTGTATGTG TGTGTGTTAC TCTGTGACTT CCTCATACTT GGCACCACCC TGGCCTTTTC  68041 CTGGTTGCCC CCCACACCAT AGGTTGTAAG GGACAGAACA GCGCTCCACC TGCAGACATA  68101 GAACGGGGGT CAGGATAAGT GTTGGGGAGA GCTGGTTTCA TCACACCTGG AATAAGGAAA  68161 CAGGACCTAA ATGGATGGGT CCCACTCTTT TACAGAATTG TACCTTAAAA AAAGTGTCAG  68221 TCACGTTCCT AAGGGATTTA CATGAATTAA ATCATTTAAA CCTCACAAGA GCCCTATGAC  68281 CTAGAGACAG CTATCAGCCC CATTTTACAG ACAAGGAAAC TGAGGTCACT AGGAAGTTTA  68341 GTAACTGTCA GTGGGCTGAC TCATGACTCT AAGGAGACAG TCTGACTGCT GAGCCCAAGT  68401 AACTGCTCTG TCATACTCAC CCTCACACCC ACCTACTACT GGCTCCCTGT GGGTCACCTC  68461 CTCCTGTGGG CTCTGACCAG CTTCCCTTTC TTCTCCAGGC ACAGAGACTG GACTGAAGTC  68521 TATTGCATTT GCCACAGTCC CGACTGGGGA GTCATGGGGT TGAAGTGACC CATAGGCTGA  68581 TGGAGTGTGC TTGCTGGATG CGGGGGAAAG GGAGATTTAT ATCTGCCCTG GAGGGAGTCA  68641 ATGGTGTTTG CATCATGGCA TATGAGGTGC ACTATCTAGA ATGCTGAAGG GTAAAGACCA  68701 GCAGGGGCCA TGCAGAGTCT ATTCATCACG GTTTTATTTC ACAGCCTGCA TGGGCCTGAG  68761 AGTGGTGGGG TGTTCACTCA TCTCCATCCA ATCCCTACTG GTTCCTGACC TCTCTTCTTC  68821 CAACTGGTAA TACCTGCACT CAAGGTTGAA CCATGAGGAG GAGTCTACCC ACACCCCACA  68881 CTTCCTCCTC TCTGCCTGCC ACTCCCTAGT GGGGCCTCCT GGATGGTGTG AGAGGAGAGT  68941 GACGGAGATA GTAAGAGAAC TTGACATTCA CACTGGTAAA GAGAAAGTGG GATGTCAACC  69001 TATGAGAAAG ATAAGGGCTG CCACAGGGAA GGGGATGAGA TAAGTTCTAA CTGGCCCCAA  69061 GGGTCGCTTA ACTCAGTGAA AGCTGTGGGA GGTGTTTTCA GCTATCCATT GCTATGTAAG  69121 AAATTGCCAC AAACTTAGCA GOTTACAACA ACACACATGT ATTATCCCAC ATTTCTATGG  69181 GTCAGGAATC CAGACACAGC TATGCAGCTT TCTCACATGA TTTTCATCAG AGTGCCATGG  69241 CTGGGTCTTA TCTGGAGGCT GAACTGGGGA AGGATCCACT TCCAAGCTCA AGCAATTGTT  69301 GGCAGGATTC ATTCCTCCAT GCCTGTTAGA CTGACAGCCT CAGTTCCTTA CTGGCTGGTG  69361 GCCAGAGGCT GACTTCAGTT CCTTGCCACA TGGGCCTTTC TGCTTCATCA AAACTTGCAA  69421 ACAAAGAAGG TAGAAGACAG AGTCATCTAG TAATACAGAA GTGCGGCTGT AATATGACCT  69481 CATTACGGAA GTGACATCAT TTTTGTCACT TTCTATTGGT TAGAAGCAAG TTTAGGCCCC  69541 ATCGGTTCTC AGCTGGATGA GATGCCAAGA GACAGGATCA CCGGGCATCA TCTTAGGGTC  69601 TCTATACACA GGCTGGACCA TGACTGAACA AGATCATTAC AAACCCGGGT CCTGGACTGG  69661 GCCAGATGAT CTGCAGAGCT GAGCTGTGTT TATGAAATCG AATCCCTGGA AACAAAAATC  69721 AAGAGACGCC CACTGGAAAG GCTGGTCTTG CATTCTGTGT GAAAGCTAAG ATGGCGTTCT  69781 CTCCAAATGT TTTTCTCTAT TACTTTTCAA ACCTCCTGCA TCTGTAAAGA AGCAACACCA  69841 CTAAGCCTAT CTGGTTTTTT TTTCATTCGA GTGTCATACT GTTAGGCAAA TCTTCTGCTT  69901 TCACTATTTC TTCAAGCTTG TTTTCATGCA GAATCCCACG AACTTCTGGT AATTACACTT  69961 TATTGATTTC TTTTCCTTCA CTCAGTTTAT TTTTTAGTGA TTTTATTTCT CTTGTATGGA  70021 TAAATTAGTC CATTTAATTA GGGAATTTGT GTCTTCTAAA GAAATATTTC TACTATTTTT  70081 TGGACCATAT GGGCTAAGAT CCTCTTGCCA AGCCTCAGCT CACTTCCCAC ATGGACACGA  70141 CAAAATTACT GGGGGTCCTG GAAAGTCGGG GATTGGCATA GTTCTTAAGC AGGATCAGAC  70201 ATGTAAGTCA CAAAGATATG AGGCAGATAC CTTTGATTTC CTTATGACCC TGATGACAGC  70261 ATACCTGGCA CTCAATACCT GTCTGTAGAG GTGAACTCAA CTAAACTCCC TGATCACTCA  70321 ATACCATGTG AGCCCAAGGA CCTCTTATGT CATGGGCCAA ATTCCCTTGT TTTATGCCAT  70381 TTTTCCAGAT GGGGTGCTGT TCACATGGGG ACGTTTCTCC TTTTCCACCT CATTTTCCAT  70441 GTGTGAAACA CTGGGTCTTG ATTACTCAGA TCTCTCAGGG TCCTTTCTAC CTTTTCCTCC  70501 ATCCTAACAT TCTCCCTACA GTTCCCGCCA GGGTTTCCCC GAACCTCTTC TTCTCCATGT  70561 ATTCAGTCTA GCATCTCTCA GTTCATTCTT CACACTTCAC CAAAGTGATA TTCTGGAATG  70621 CAGATCTGAT CAAGGTTCTT CCTGACTTCA GTGCTGCCAG TGCTGCACAT TGTCCTCGGA  70681 TAAAAGCCAA AGGTTCTCCC CAACCCCACA AGCCTTAGTC ATTGAATCTG CTCACTGCTC  70741 CAAGCTTGCT TTTTGCCCCT GTGCTCCTCT TTTTCTAATC TCTACCCTGA ACTGCTGACA  70801 GTTCCCCTAG ACTCCCTGTG TGTTCTTTCT TCTGAGCCTT TGTTTGTGAT ACTGATTCCC  70861 TAAAAGATTT CTCCTGCCAT TCACCTGGAT TAACTGTGTT CCTCATCCAG TTCTCTGTTT  70921 AGACATTGCA TCCTCTTGGA AGCAGTTTTC CCGCACTAAT TATAGTAGCC TGCATTTAGC  70981 TGTTTTTTTA GTCCCCTTGT GGAATCTTTG ATGTTTCACT CATTGAGGGC TAGGAGACCC  71041 TGACACATAG TAACTGCCTA ATAAATGTTT GCTAAATAAA TGTGGGGTTC ACCATGAGAT  71101 ACCACGTTAT ACATGCAAGA ATGGCATTAA TTTGGCTGGG CGCGGTGGCT CAAGTCTGTA  71161 ATCCCAGCAC TTTGGGAGGC CAAAGCAGGC AGATCACGAG ATCAGGAGAT CGAAACCATC  71221 CTGGCTAACA CGGTGAAACC CTGTCTCTAC CAGAAATACA AAAAATTATC TGGGCGTGGT  71281 GGCATGCACC TGTAATCCCA GCTACTCGGG ACGCTGAGGC AGGAGAATTG CTGGAACCTG  71341 GGAGGTGGAG GTTGCAGTGA ACCAAGATCA TACCACTGCA CTCCAGCCTG GGAGACAGAG  71401 TGAGATTCTG TCTCAAAAAA AAAAATGGCA TTAATTAAAA AGTCAAAAAA CAATAGATGT  71461 TGGCATGGAT GGATTACACT GCTGGTTGTG AGAATGTAAA TTAGTACAAC TACTATGGAA  71521 AACAGTATGG AGATTCCTTA AAGAACTAAA ACTAGATCTA TCATTTGATC CAGCAATCCC  71581 ACTACTGGGT ATCTACCCAA AGGAAAATAA GTCATTATAT GAAAAAGACA CATGCACACG  71641 CATGTTTATA GCAACACAAT TCATAATTGC AGGGATGTGG AACCAGCCTA AGTGCTCATT  71701 GACCAACCAG TGGCTAAAGA AAGTGTGGTG TATGTACACC ATGGATTACT ACTCAGCCAT  71761 AAAAAGGAAT GAAATAATGC CTTATGTAGC AACTTAGATG GAGCTGGAGG CCATTATCCT  71821 AAGTGGAGTA ACTCAGGAAT GGAAAAACCA AATACTGAAT GTTCTCACTT ATAAATGAGA  71881 GCTAAGCTAT GAGGACACAA AAACATGCAA AATGACATAA TGGACTCTAG GGGCTTCTTG  71941 GTGGAGGTTG GGAATAGGGT GAGGGATAAA AGTCAACACT GGGTAGAGTA CACTGCTCGG  72001 GTGATGGTGC ACCAAAATCT CAGAATTCAC TACTAAAGAA CTCACACACA TAACCAAAAA  72061 CTACCTGTCC CCCAAAAACT ATTGAAATAA AAAAATTTTT TTAAATAAAT GTGGGGTTGA  72121 TTTGTAATTT AAAATTTATT TTGAATAGCT AATACAAGAA CAATATTTAA AAGATTATAA  72181 TAATAAAAAT GTGTATAGTG TGCAACGCAA ATTTCCTTCT CCACCCCATC CACAATTCTT  72241 CCAAATTCCT TGCCTGGATG CAACCACTGT TACCAGTTTC AGCAAGAAAT TAAGACAGAA  72301 ATTAAAGTTC TGCTCCTCAT AATAATCACG ATCAATTATC CCTGCTTATA CAGTAACCCC  72361 TCCTTTTCCC AACAGCCTCC TAGCATGAGG AACCCAAATT GAACAGGTAA CAAACATACC  72421 CCTAAACGTA ATGTAACTTG TACTCTGTTC CATGGTAGGA ACTTCCTTCT CTGGGATCCC  72481 AAACTCCTAG ACCAGCTGAG TACGTTGAGG GGATGGGAAG CACCAACACC CCACGCAGGT  72541 TACCGGAAGT GCTGGTGAGT ATAGTCATTC CTTCTTCCAG CACTGGTGGT TAGAGACTTA  72601 CTCTACCTGT TGGAGACTTG GCACCATATA ACAGCTGCTG GCGTAACCTT AGTGTATGCT  72661 TCATCCTGAA GGACATTACC CATCCTGATA GGATGTGATC TTCAAGATAA AACCCAGCTG  72721 CACCCTCAAG AGACCATTCC ACTGCTCTAT CAGCTCGCAG AGTGTGTGAT GCAGTATGGG  72781 GTAGAACCAG GAGATCTCAT GGTCATGTGC CCACTACCAG ACATCCTTCG CTATAAAGTA  72841 GGTCCCTTAG TCTGGGGCAA TGATATGTGG GTCCCCTATT AGAAGATCAT ACATATGTGA  72901 GCCCTTAGAT AATGTTTCTG AGTGTGGCAC TGTGGGAAGA AAGAACAAAC TCATACCGCT  72961 AATACAAGGC AACCTAAATC TGACAGAACC CCTGCCTTTT TCATTGTGAA AAAGTAAGAA  73021 TAGAATCAAT TTGCCATCAA ATTGCTCATT GGCTTCCATA AGCGAAGGTA ATCTGTTGGA  73081 GTTTATTTAT CGCTGGAAAG TAGATTGTGA CAATAACCAC GTCAGCCATG CTGAAGGCAG  73141 CCCAAGCCTT GGGACCCACC CACAGTGCAT CTCTTCCACC ATAGATAACT GCTTTCAAGA  73201 GCCTGTTTCA TGAGCACTGG GATGGTTAAG GACAGAGGCT GGCTGATGTG TACCGAATGA  73261 TTCATCCTGG ACACCTGGTT GTTTAGACTA CTTGTATAGA GGGTAATTTT TGCTGAGTAG  73321 TAACATCTGA TACAAAAGAT CCAAGCACTT TGTGTCTACT GTATGCCTCT TTCCAGATAT  73381 TCCTGTTCCT GATCTTCCAA TCTTGCTCCT TCCAGGCCCC TGACCTGCTA TTTAAGCCAC  73441 TTGCTGTTGC CTATAAGTCT GTGCATATTC TCACCTCAGG CCACTTCTGT CTACACAAAG  73501 TGGGTGAATC AGAGCCCCAC CTGCCTATTG GCAGGACCCT CTTCAATGCT GTCTCTACTC  73561 ATTCCTGAGT TGCCCACACT GCAGACACAC TCTACTGCTG CCTCACACCA ACACACTAAG  73621 CTGGCATGTT TATGAAGAAG CTCAGAATTT TCCTCTTAAG TCAGCTGGTC ATAGAAACTA  73681 CCCATAAGGT CATTGGTGAG AGTCGAGGTC AAGGCAAAGG TCCAGCAGTG CGAGGTGACA  73741 TGGGGTCTGA GCAAGGTCTT TACGTAATTA ACACCAGTAC TCAGAACATA CGTACTTTAA  73801 CCCAGGGGTC AGCCAATGGT TTCAATAAAG GCCCAGATGG TTTCCCTTTG CTGTGTGTGT  73861 GTTCATTCCC CTCTCCGAAG CTATGTGTAA CCCCATAGAG ATCACAGGGG TTCCCATCAA  73921 CCACAGCCAG TTACATCCAC AAAAACCTTG ATCCTTGTTA GCAGATGGGA GAGGGTGGCT  73981 TGGAGGATTG AAATCCCTAC TTCATGGGAC TCTGGATACT TACACAGTTG CTTCCTTCTG  74041 TGTGTCTACA TGAATCTCAG CACTGTGTTT GGGACACCAT CTACACTCTT ATTCTTCATG  74101 CAATTCTGTT TGCTCCTCAG ATGGCCGCTT TTCCTTTGAA GCTCAACAGT AGCCATCACG  74161 TACTTGGGCT GAGGGTTACT GATTAACTCT GTGGGATTCT GGGATCAGTT CCTTCCCTTT  74221 CTTAGCCATC CCTGTGCTTT ACAAAACTTA GCTTCACAAT TATACTCATC TCTCCCTGTG  74281 TGCACCTCTA AGAAATTACT GATAAAACAC GAGTTTTTTT GAAATTACAA AAATATATGC  74341 AAGAAAATGT TTATGGGGCC AATTGATCAG CACGGAAAAG CATAAACTTT CCTGTTTTCT  74401 GCCTCTCATT AGAATTTAAT CCCCCAAAAT TGAACTCATT CCAAACTTCT GGCTTAACTA  74461 GGAGTTGCTG TAGCCAGCCT ATTCTAGACA GCATCCTGTA AGCCCCTGGG ATTGGCAGAC  74521 ACAAGACACT TTTTCCATTC ATATATGTGG TTCTGTTCTG GCCAGATCAG TGGACTTCCA  74581 GTGCCCTTCT TGAGTCATAC TGAGGTAAAT TACTCAGACC ACGAACTCAC ATTTTTAAAT  74641 AAATAAAATA GCAGCATAGT TAAGAATTTA TTTATCCCAT TACTGGGTAT ATATGCAAAG  74701 GATTATAAAT CATTCTACTA TAAAGACACA TGCACACATA TGTTCACTGC AGCACTATTT  74761 ACAATAGCAA AGACTTGGAA CCAATCCAAA TGCCCATCAA TGATAGACTG GACAAAGAAA  74821 ATGTGGCACA TACACACCAT GGAATGTTAT GCAGCCATAA AAAAGAATGA GTTAATGTCC  74881 TTTGCAGAGA CATGGATGAA GCTGGAAACA ATCGTTCTCA GCAAACTAAC ACAGAAACAG  74941 AAAACCAAAC ACCGCATGTT CTCACTTATA AGCAGGAGTT GAACAATGAG AACATGTGGA  75001 CACAGGGAGG GAAACATCAC ATACCGGGGT CTGTCAGGGG ATGGGGGCAA GGGGTGGGAT  75061 AGCATTAGGA GAAATACCCA ATGCATGCGG GGCTTAAAAC CTAGATGACG GGTTGATGGA  75121 TGCAGCAAAC CACCATGGCA CATGTGTACC TATGTAATGA ACCTGTACAT TCTGCACATA  75181 TATCCCAGAA CTTAAAAGTA TAATTTAAAA AAAAGAATTT ATTTCATTTG TATANNNNAT  75241 GAAATTTTTT GGACATTTTT TAAACCTGCA CTTTTCATAG TTTTTGATAC ATCCTTGCTC  75301 CAATAAATAA TTTGCTAAAA TTACTAAATC TCATAGATAT ACCAATGGTT TGCATCAGCT  75361 AATGGCATAT TTGCTTGTCA AACTGAGGTC AGCCAGTCCC CCTTCATTCA CTGTTAGTAA  75421 CTCATGTGTT GCATTGTTAA AAACCCAGTA TCACCTCATC TCCCCTCTAG CATCTTCTCT  75481 GCAGAGGAGA AGCCAGGCAC TATATCTCCC AGGATCCCCT TCCCTGGATA GTTCCAGTTT  75541 ACATTTTCCA GTGAGAGAGA CTTGCATAAG AAATGGGGCC CTGGAGAGAT GGCGGGACAG  75601 ACCTGTACCC ATCAGTGGTG GCTGCAGGTG GAGGAGCAGG CAGATGTCAG GTTCTCAGTG  75661 GCTTCCCTGC TAGGCTAGAG ACCCACCTGC TTTGCTTGTG CGGACTAAGA TGAGTGATAA  75721 GAGCTTCCTC ATAGGTTCTG GAGAATATAG CAATCTCGCA GCAGGATTCT GAGAACCTCC  75781 CATCCATGCT TCAAGCTGAA GTCTTCAGTA TATGOTTCCC TGACCTCCCT ACTGCAGCTT  75841 CCAGGAGCTC CAATGGTGAC TGGTATTATT ATAGTATCCC ACTGCTGCTA TAACAAACTA  75901 CCACAACTAT GTGGCTTAAA ACAACACCAA TGTATTCTCT TATAGTTCTG GAGGTAAGAA  75961 GTCAAAAATG GGTCACTATG GGCTAAAATT AACATGTCGT CAGAGCTGCA TTTCTTCTGA  76021 GGCTCTAAAG GAAAATCTGT TTCCTCGCCC TTTCTAGCTT CTTGGGGCTG CCCGCATTCT  76081 TTGGCTTGTG GTCTCTTCTT CCATCTTCCA AGTCAGCAGT CACATCACTT TGACCTCTGA  76141 TTCTGTTATC ACAGCTCTAA CTCTGATGCT GCTTTCTACT CCTTTCACTT ATAAGGACTA  76201 TTGTGATTAC ATCGAACCTG CCCAGATAAT CCAGGATAAT CTTCCCATCT CAAGAGCCTC  76261 AGCTTAATCA CATCTGAAAA TTTCCTTTTG CCCTATTAGG AGACATTTTT ATAAGTTCCA  76321 GGGATTAGGA CACAGACATA TTTAGGAGAC CGTTATTCTG CCTGTCACAT GACTTCACCA  76381 ATATTTGCTA CCCGTGGTTT CCAAACATTA GTGTATGCTC TTATTTCTAT TTATTCCTGA  76441 AATACCAGAG TGAGTCTGTT TTTCTGAAAA CAGCTCACTA ATGCCCAGAG GAGCTCAAAA  76501 ATTTTCTGTC TGTTGTCTCA AAGTCTCCAA ATTGTACTGA TTCTTCAATG TGCATGGCTG  76561 TAAATTAGGC AATAATCTTG CTGGGGTGTT GGAAGGAGAA GAAAGGGAAT GATTAGACAG  76621 CCCTTCTGAT TCGGGACAGA ATCTGATTCG GGACACTGTC CCTGATGGCT GGCCATCTTG  76681 GGCTGTAATC CAGTTTCCCT CCCACGTAGA CCCGGTCATT TCTGACTCCC CAAGAGGTTT  76741 TCACAGTATT CATGTCCACT TCCTTCATCA GTCATCTTCT TGTCTTATAT CTCCATGTTT  76801 ACATTTTTCT TCTCTTCTAC CACTGCAGTT CTGCCTTGAT TCTTCAGCCA TTGCCTTCCT  76861 TTTGCATGCA TGTGCTTCAG CCAGTTCTCT AGGAAGACAT TCCAGACAGC TCATTATCAC  76921 TTGTTACTAT GTTTATTTGA CTGCAGAGCT TTCAAGATTT GTAACTTTCT ATTTTTTAAA  76981 TTTTAGTGTA AAAATAATTC TTGCTCACAG TAGGAAATGA AACAATCAAA ATATGCATAA  77041 ATATACTTTT AAATCTCTCC TTTCACTAAA TCCAAACCCA CTTAACTAAG GTGATTACTA  77101 TTGTATCAGC CTACTCTCTG CATGTCTACT TTCTTCACTT GCACGCAAAC CATAGTGAGT  77161 GTTTTTATCT GGTAGCTTTT GTTGAGCTGT AATGACTATA AGTTTTATAT GTAATTTAAT  77221 CATTTTCAGG GCAACTTGAG ATATAATTTA AATAGTATAA AATCCGCACA TTCAAAATAT  77281 ACAATTCAGT GGCTTTTAGA ATATTCACAG TTGTGCCTCC ATTACCACAA TCAATTACAG  77341 ATCCTTTTAT CTCCTCCCAG CCCTGCAGAA AAATCCATAT CCAAACCCCA GCCCTAAGAA  77401 ACTACCAACC TATGTTTTAA CTCTACAGAT TTACCTATTC TGAACATTTT ATGTAATGAA  77461 ATTATACAAC ATGTGGCTTT TTGTGTCTGT CTTCTTTTAC TTACCAGAAC ATTTTCAAAG  77521 TTTGTGTGGG TCGTAGCTTG TATCAGTACT TCACATCTTT TTCATCGCTG AATTACATTC  77581 CATTGTATGG ATATATCACA ATTTATTTAT TAGTTGGTGA CATTTTGGTC CTTCTCATTT  77641 GGATTGTGAT TAATAATGCT GCTATAAACA TGGCATATAG GTTTTTATGT GAACTCATGT  77701 TTTCATTTCT CTTGGGTATA CTGTATCATA GGAGGGGATT GCTGGGTCAT GTAATAACTT  77761 AATGTTCACA AATTTGAGCT ACTGCTAGCC TGCTTTCTAA AGGGGCTATG TCTCTTAAAT  77821 CCCCACCAGC AAAGTGTGAG TATTCTAGTA TCTCCACATT CTCATCAACA CTAATTATTA  77881 TCTTTTTAAT TATAGCCATT CTAGTGGGTG GGAAATAGTA TCTCATTTTT GGGTTGATGT  77941 GCATTTCCCT GATGGTTAAT GATGTTGAAC ATGTTTCTAT GTGCTTATGG GCCTTTTGTA  78001 TATTATTTGT CTTATTATTA TTATTATTAT TATTATTATT ATTTATTGTT TATTATTATC  78061 TTATTATTAA TATTATTATA TTGAGTTACA ACCATTOTTT ATATATTCTA GATACAAGTC  78121 CTTTCCTTGC CAGATATAAG ATTTGCAAAA CTTTTCTCCC ATTCAATGAG TTTCTTTTCA  78181 CTTTCTTGAT GGTTTCCTTA GACTCACACA TTTTTAATTT TGATGATGTT CAATTTATCT  78241 TTTATTTCCT CTTTTTGCTT GTGCCTTTGG TATCATTTAA GATCAGGTAT TTTTACCTAA  78301 TCCAAAGTCA TGAAGATTTA TGCTTATGTT TTCTTCTAAG AGTTCTCTAA TATTAAGTCT  78361 CACATTTAGG TCTTTGATAC ACTGAGGTAA TTTTTATATG TGGTGTGAAG TAGGGATCCA  78421 GCTTTATTCT TTTGCATAGG GATAGACTGT TGTTTCTGCA CTGTTTGATG AAAAGATAAT  78481 TTCTTCCCCT CACTGAATTA TATTAGCACT GTTTTATAAA ACCAATTAAC CATATAAGTG  78541 AAGAGTATTG CTGGGCCCTC AATTTTCTTC TGACTTCATT CTTTTTAATG CTGTTGTAAG  78601 TTGGATTTTT AAATAACATT TGTATTAATG CATTGATACT CTATAGAAGC ACACTCAATT  78661 TTTGTATTTT GATCTTGTAG CCTACCAATG TGCTAAACTA ATTTAGTATT AGTGGTTTAG  78721 TAGTTGCTAA GCTTGTTTTT AGTGAATTCT TTCGTATTTC TATATAAGAT TTTATCATCT  78781 GCAATTGAGA TAGTTTTACC TCTTGCTTTT TAATCTAGAT GACTTTTATT TCATCTTATT  78841 GCTCATTGTA GCTTTTGAAA AATTACATTG TATTCACAGT GCCCTACCAT TTGATATTTT  78901 TATTTCTATT ATATCATGAA CATCCTTTGA ATTTCACAGA AAAAATGGTT TAACTCATCA  78961 TTTTAATGCT GTTCCATAGT ATGTTATATG CACCTACTCC CCTGGGGTAA ATATTTAGGT  79021 GGTTTCATTT ATTTGTCACC CACTCTACAG ATGTCTATAT GCACATATTC TCCCAGCCAT  79081 CCCAGAGTTT TCTGATTTCC CATAACGTCA GTGATTAAAC TCCTGATCTG TCTGACTAGC  79141 TAGACATGCT GACTGACTGA CAGTTCCATT GCTACTTTGC ATAATTTAAG ATCAACAGCT  79201 ACATTTGGAT CTCAGATCAT CTAGGCCCAG CTGCAGTTAG TCTTTCCTAG TCTCAGAGAT  79261 TCCCTCTCTG CCTGTTAATT TCTCTATCCC TGAAACTGCC CTTGTACTCC AGCCCAAGCA  79321 GCTTCCTAGC CCAGTAGTCC TGGATCTGCC ACTTGCTAAC TAGAAGGTGT CATCTGCAGA  79381 AGGTAAGTAA GGCATTTATC TCCATTCACT TTATATTTAG TTATCAAATC TCCATGTAGC  79441 TCAGGTAGAT CGAGCTGAAA ACATTCTTGT GTTTAGTAAT ATAGCCATTG AGCACACCAT  79501 CATTGCTCTT TTCATACCTT AGTCCTACTC AAAGATTAAA GTGACAGCTT CCCAGTTATG  79561 ATAAAAAAGT ATAAAACATT CTGAGGGACC TGTAAACTAT AAAGCTAAAA TATCAGCTTC  79621 TGCATGCAAC ATATATGTCA AATTCTATGT CCAATACTCT TCTCATTTTT AGAATTAATT  79681 CTGCAAACTT GAAGATTGAG CTTTTTATGA ACTGATTGGC ATCTGCTATG CTCACCAGAT  79741 TATTCCCACT TGACTGAGAG GATGGTGGTA GCAAGAGCTC CTTCCTTTCA GAGGCTTTTA  79801 AAAATACTTA TTGGGAAGAA TGTACCACAT AAGGCATTTA ACTAATGAAA CCACAGATAT  79861 AACCACTGGC AAAAAAATCA AACAAACATT TCTTTAACTG CCCTGTACTT GGTACATTCT  79921 CTTCCTCCTG CTAGGGAAGT ATCTCCTCTC CCTTCACTTC ACAGACTGGA ATTTTCCAAA  79981 TTCCTAGTCT CAACAAGACA AACTGTATTT TGAAATCACT GTTTTCCCAG AATACCCGGA  80041 GTGTTACCAT GACTCCAGAA GATGCCTTCA ACCAAGACTC ATAATCTGAC TGTAAGAAAC  80101 CTTCAGATAA GGTATTGGGA ACTTCTGTAA AATTGTAGCT GGGCTGTGAT TAGAGAATTT  80161 TCACAATATC AACGAATCTT ACAAAAGAGC TGCTGATCCA ACAGGTCCTC AGAGATCCTG  80221 TGTGGGAACC AGAAGGTATT CTGTGAAAAA CGACAATAAG AATAACCATA ATAACAATAA  80281 TGGCTGCATT TAAAAGGCTC TTGCTATATT TCAGGCACTG GTTTTTGTAC CTACATGGAT  80341 TATTTTGTTC AATATTTATC ACAACCATAT GAGAAGGATG TTATTATCCA CAATAAATAA  80401 ATGAAATCTG TAAACTGTAA CTTGTTCAAG AAAATTAGGT ACAGAGATGT TAAGTTACTT  80461 GCCCAAAGTT CCATAATTTT GAAGATATGA GGCTAGAATT CAGTTCCAGG CCATTTTACA  80521 CTAGATCTAC TAATTTAGCC ACTGTATGAT TGTACCAAGA CTGACCTAAA GCTACCTCCC  80581 CTTCCCCAAC AGGTTCTTTT ATGACAGTGA GTATAAAATA CAGGGCTAAT GACGTATTGG  80641 GTGCAGAGAG GGGTTGGAAA GAATGTGGTA TTTCAGACTA TGCTTACTAT GCTTAAAAAT  80701 CACAATTCCG TGGTGACTAG AGTTTATCTT AAACTTTCCT CCCTGGCATT CCATTGCATC  80761 CAGTTGAGAG AGCACTCTAG CTCCCTACAT CCCAGAACAT GTAGATCTGT CCGTGGTTCT  80821 GAAAGACACA CTGGCAGGTC CCGCCAACTA CATGAATGGC ATTCATATTG TGGAAAACTG  80881 CCCACTAGTA AAAATGTACA GTTGAATTTG TACATTCGTT ACTTACAAGG TTGGAGAACG  80941 TGAAGTACTG GACAATCCAA CAATAGCTTG GAAAGATACC ATAAAAAGAC CCGCAGAATA  81001 TTCTTTTATA TGCATTATTC TGAAATGTAC AAAACAAAAC CAGAATGGGA CACATTATGA  81061 GTGAGAAGTT TATCTTGAAA TTTTAATCAG AATATGAAGA AAAGAAATCC AACATTAGAC  81121 CTGGAAAAAG ATAAAATAAT TTGTATTTCA TTTAACAATA TTTATAGATT CTCAATATAT  81181 ACACTATCCT TTTAAACCTC AATTTATATT TAACCATCCA TTTACCTTTA TTTTTTGTTT  81241 GTTTTTTTCT TTCACCTCAT ACTTTCTACC TGGGATATCT TTTTGTGACT AAAGTACATT  81301 CTTTAGAACT TOTTGTACTT TACTAGGTGT GTTTGTGTTA AATTGTTTGT CTTCAAAATT  81361 CATTGAGATT TAAATTTTAT TATTATATTT TCATGCTTAA GTGTTATGTG TTTGTCTCTT  81421 CAAATTTTTC TGAAGATTAT TTATAGTTTT ATAGTCACTA AATGTATTTA ACAATCTGTT  81481 CTTTAATCAT AGCCCATTTA GCAATTTTAT ATCCTATACA ATTATTCTGA TTTCTCAGTT  81541 ATATGATTGT ATGATTCTGC TGTCTGTTGT ATTTTCTTGT TCTTTCACGG TGCTTTGTCT  81601 CTTATGAACA TTGTTCTCTG TTGTTGTTCT TAACTGTTAA GTGCTCCTTT TGCTGGTGTA  81661 ATGATTTTTT GGAATTTTCA GAGTGCCAAT GACAGTAGAA ATTTTCCAGA GAAGTTTTGC  81721 TTGATTTTCC AAGGTTCCTT GGAGTCTGCA CTACTTTAAA ATAAATTCAT GGCTTGATGA  81781 TTTTCAGACC ACCCAGGGAG TGTGAACTCG GGCTGCAAAT CCACTTCTCT TTAATCTCAG  81841 CAGAAGGTTT TGCCCCTCTC CACTCAGCAC CAAGGTGACT TTCTAGGGAG ACCTTCAAGC  81901 AAGGATGTTT TCCTTATACT GAGGAGCTGG CTTTGGGATC CTGGTGAAAT GAGGAGAACA  81961 CTCTATTAAA TTTCTCACTC TGAGTGCTAC CTGAACTCTG TCTTCTATTC CAAATGCCTT  82021 AGGAGGCCAT GAAAACTAAA CCTTAATTAT CCTACATTAA GTAAATAAGC TCAGCAAAAA  82081 AAGTAAATGC ACAATTCCGT GATTTAGGAT TTGACAATTT TTATTAAAGT TTAAGCCTCT  82141 CAATGCTTCT ACATTGTGTT TTATTTTTTC ACCATCCATT TTTGTTAGCA TGAGGGTAGG  82201 TATGTTTACC TAAATGTGCC ATGTGAGTGG TTCAAATCTC CTCCCCAACG CTCCTTATCA  82261 CAAACCTTAC CATCTTATTC CTTTAAAGTC ACTGACTATC TAAGCAAACT ACTAGCTACT  82321 GCTGTGCATT GATTAGGACC CAACAGTAAG ACGTTTCTCC TTTTGGTAAA CTGCACTTCC  82381 AGATGGTCTA ATTGAACATC TTCTCACTGG AAGTATTTTT ATTTCCATTA CTCTTAATGA  82441 TGATTCCTGA AAGAGACTCT AATGCCCTGA CAGTTAACTC TGGGGTATCC AAGCATACTC  82501 AAATTTTTTT CCTTCTACAG TCAATTGTCC TTAGGGAACT CCTCAAGACC TCAATAATGA  82561 GACAAGGGAG AGTGGACTCT CCAGTGGTAA TAAGAACATT AGGAGTATAG TACAAATTAT  82621 TAGGCAACTT ACCTGGCCTT ATGGAACCTG CTAAAGTCTG ATGCTGTGTA TACCATTTCC  82681 CCTTGCAGAC TGAGGGCTGG TGAGCATGAG TGACCTGATA AAACTCAGGT CATAATGGGC  82741 ATCTCAAGTC ACTTGGTCAT TTTCTGTATC ATGATCATAG AATTCAGAAT CTACCAGGGC  82801 CCAGTAGTAA GCCAGAAGCT ATTACTCAAA TTCAGAAAAA GAATGGAACT TTTTCCCCAA  82861 ACCCTGAAAC TTGGGCAATG AGTCCTATGA CTGCCACACA CAAACACACA CACACACACA  82921 CACACACACA CACACACACA CACATACACT CAACAATATC CAAATAAGCA TTTAGGGCCA  82981 AATGGCAGAT ATGCTTGACT TTTGCCTGGA TCAAAATGAC ATTTCCATTT ATTATGGAAT  83041 GTTTCTGTAC TTGTACTAGC TCATAGGATT TTGGATTAGA GAAATACCCT TGCAGGATAT  83101 GAAGTCATAC TTTTTCATTG GTGAAATCAT CTGTTCTCAT TAGAGTTTAA TAATATCATG  83161 CAGTTATTTC TCAAAGAGCT TGTACTCCTT AGATTTGCTG GAATTCCTCA AGTTAAAAAG  83221 ACCAGGGCCT CAATAATGGG AGGTCTCATT GCCAATAGCT ACAACTGGCT GTAGAATTTA  83281 TTAAAAACAT GTGAGTGCAT TGTTTGGGGA AAGAATCAAG AACAAAAGCA GTGCTTGTTT  83341 TGTACTTCAC TGAACTACTT CCATGGCCTC CATTCAACTT TAGCTGCAGT TTTGGTGACT  83401 TGATTCACAG ACTGTCGGAA AGTTATGAGC TATGGAATGT GCTCTCTCCA ATACTAAAGA  83461 GGCCAGTCAT ATATATGTAG GGTGTCCTTC TTTATCATTG TAGGTTGTAT GAAGTCAGTG  83521 ATTCCCATAG AACCTTGGGG TCACAGATGC CAGGCCTAAT CTTCTTTTAT TATTCATTCA  83581 ATCTTTATTT TTTCAAACAA TGGTCTCACT CTCTTGCCCA GGCTGGAGTC CAATGGTGCG  83641 AACACAACTC ACTGCAGCCT CGACCGCCCC AGGCTTAGGT GATCCTCCCA CCTCAGCCTT  83701 CCAAGTAGCC GGGACTACAG CTGTGTGCCA CCGCACCTGG CTAATTTTTG TGTTTTTTGT  83761 AGAGATGGGT TTTTGTCATG TTACCCAGGC TTGTCTTGAA CTCCTGGGCT CAAGCAATCC  83821 ACCCACCTTG GCCTCCCAAA GTTGTGGGAT TACAGACATG AGCCACTGCA CCCAGCTCTA  83881 ATCTTATTTT AATTTTAGAA ATCTAACTTG ACAGTTTCTG GTGCCTGGAT CCATATTTGT  83941 CTCAGAAGAT TGAATTGTGG ACTGTGACCT TCTCTCCCAA AAGTCTCTTT CAGGGTAGAA  84001 CTTCTGGTTA TGGCAACATG AAGAGATAGA CCAGCAAGTT TTCCTCCAAC AGCAACATGA  84061 AAACTGTACT AAATACTAAA AACAAACATT TGAAGTCACT GGAAAATTAA CAAAGGCAAG  84121 CAATATGTGA TAAGAGCTTT CTTGTTTAAG ACTCCTTCTG TCTTAGGTAA GGACTGCAAG  84181 TTGGTGGCCT TTCCTTCTTA CCTATGAGTG CTCTTCAGCC TCCCAGCAGA TAACTGCAGC  84241 CCTAGTGGCT CAATATGGGC AGTTTATAGA GTTCAGAGCC CAAATCAGCT AGAAATGTAA  84301 ATGAGAATGT TGAAAGAGAG CTGCAGAAGA GTTGAGATCA ACAATGTGAA TGCAAATTAT  84361 GCTCATCCCT AGTTGAACAC TAAACTCTGC ATGGGTGTGG GCCACTTGGG AATCTGGTGA  84421 AAAACCAGAA AGAAACTAGA GGGAGGTCTA CCCTCCAAAG AGATAAATGA TCCTGGTGAG  84481 GTCTGCAAGT CTTCAGTAAC ATGGACTGAG TGCATTTGCC AACCTGCACA GAGCTCAGTA  84541 GAAGAAAGCA AAAATCTTAC TGGCTTGAGA GGTGAAAAGG CAGGATTTGA GGCTAACAAA  84601 ACAATTGGAA ATTCAAAGAG AATTCCAGAA ACAAAGCAAC CACAATGAAG TTGAATCACA  84661 AAATCTGAGT ATAAATGACC CAAATACTTG GTCAACCTCT AAATTACACA GATGCAGGAC  84721 ACACACCCAG AAACCCCTGC TGAAACCACG TAAGATACTA AGTGGAAATT CTCAAACAGA  84781 AAAAAAAGAA AATGAAAGTA TTCTGGAAGA GGTCCACAGA AGTTTTGAGA TGGCAGAATA  84841 AAGAACAAGC CTGTGCCTTT GAATATAAAT CTCCAGAATG TGCTCAATTC TAAAATCCAA  84901 AACACAGATT GAAATAAGAT TAAAGAAAAA AATGAAGAGA ACGTCATGAA CCCATCAGAG  84961 AATATAAAGC AGGTGACCAG ATATGCAAGT GGATCCTCGA AAGAAGACAC AGGATCAGAA  85021 AAAAATATTT GAGAAAATAA TAGTTGAAAG TTTCCCACAT TTGGTGGGGG ATTTTAGCTC  85081 ATATCTAAGG TGTTCAATAA ATGAAAGCAA AATAACTGCA GAGAAAATTA CAAATAGGGT  85141 GACCAAGGCC TTGGCCTGGC CTGAGGCAAC TTAGCTAGCC CCAGGGATGT GTGTTCTGGT  85201 GTGGAGTAAG ATCAGGGAGC TACCAGTGCA ATCTCTGCCT CTACATCAGC GGGACTGATC  85261 ATTTTAATTT TGATTGCAGT TACTGCTGGT ATCTGAATCA AAGTGGTGAT GCTTCCTGAG  85321 GAAATTTCTG AAGCCATTAG TCAATTAGAA CATTATAAGC CATGCCTCCC GTGAAGAGGA  85381 GCATCTAATC CCAGCATTTG CACCAGGGAA CTCTGCCTGA AGGGATTACC AGTGACTTGA  85441 AAGTGTAACC AACAACAATC TTGTCACTAT TACGCACCAG CTAAGCAATC TGAACATACA  85501 TGCTGAAGAC ATATTTGGTG AGCTATTTAA GGAGGCTAAC TACTTCCACA TTAGATCAAA  85561 TTCTCTTAGA ATTTGTTGCC TCATGGTCAA AGTCACTCAG CTGGATTCAG CAGTGGAAGA  85621 GGTGTCACCA CAGGACATCA ACATGGAAAA AGCCCTCAAA AGTTCCCCAG CCCAAGACCA  85681 GCAAGCAGTT TCAAAGAGCA GCATTCCTAC TCCTGCTGCT GACATTTACA ATCAGAGTGA  85741 TTGACCACCT CCCCTGAATA GCATGAGAGC ACATGGAGAT GATAAAGACA GGCTGAAGTT  85801 CTATACTGAT CCTTCCCATT TATTTGACCT CTGGAAAGAA GAAGTGCTGC AGGACACAGA  85861 AGACAAAAGG AAAGACAGAA GGCATCAAAA GTAGCAAAAC CACATAGATG GCACCACTTA  85921 TGATGTGAAA AGGATTACAA AAGCCAGAAA CAAGCACCAT GAGTGGAATA TGATGGCATA  85981 TGACAAAGAG CTTAGACCCA GCAACAGGTT GTCTCAGTGT GTACCATGGA GCATCCTGCA  86041 AGAACCCCTG TCCCTAGACA GCAGGTCCCA TACAATGGAT GTTAGGGATG CTCTTATCGA  86101 GCTACTCCAA ACCATTCTCA CGACCCTTCC TAGGCAGCTG AAGATGCATG TCCACATGGG  86161 CCCACAAACC AGGCCCCTGA GCTTGAGTGC CACCCCTCCT CTGCCTCAGT GAGGCACATG  86221 GCCCTAAATG GACCTCAAGA GCGGCCCCCA CTTCCCTGCC TTACCCCAGC TGTGTTCCAA  86281 TCCTGTGCAC TTATGGCTCC AGGAGACTAC AGGATGCTCC CAGCACAGGT GCTTGCATAT  86341 TACAACCCGT CAAGACCTCC TTCTCTTCCC CCTTTTACAG TACAAACTGC CTTTGTTGCC  86401 TTCTGCAAAT CCTCCTGCCG CCTCCTTCCT CATATCAGCT GGCTCCACAC ACCCTCCTCC  86461 TCACCCTCCC TCCACTGGCC CCTGGGTCCA GCATTCCCTC CTCCAGCCAC ACACTTTCCC  86521 CACCAGGCCT CTTGGCTCAG TTCTTCTTTT TTGTCTTCCC CATGCATTCG CCCCCACACT  86581 GCCACCAGTA GCTGAGGCAA AGTGTCAAGA ACCTGCACAG CCACCAAAAA GTGATACGAG  86641 AAGTGATCTC CTTGCTGCTA CTGGAATGGG GATTTGACTG GAAAAGGTGC AGGATCTGTG  86701 TGAGCAAGAG GCCAAGAGTG AGCCCCTTGG GAAGGACAAG GTCACAACCC TGTCAATACA  86761 TTGCAGTGGA GAAGTACAGG GATTCTGAGG GAGACTTAGA GTTTGACAAA AACAACTGGC  86821 CCAACCAAGG CAGTGCTGGG GCTAGCTCTA TGCAACAGGT GGGTAGCTGG TACCAGGCTG  86881 GGTGACAGCC AGGAGACCAT ATGCTAAGAA TGTACTTAAG ATTTCAAGTG GTCTCAGCAC  86941 TCAATGGTAT TATAATCCCG CAGCTGAGCA CCTTTTGTAT TAATGATGTG ATATTGCTTC  87001 TGCACATCCA AAAATTCTGG GCTTTCTCAG TATTTACTGT GTAACATTTA AATGCCATTA  87061 AGCATAGAAT ATCATGCTGC ACATGAAGAA ATAGGATGTA ACTATTACAT CGTCCTGAAA  87121 AGAGCGTTTT TTTTTTTCCT GTAGGCCATG AAAGTATTTA GTGTATTTTG GGTTTACTCT  87181 TATTGATCAT TACAATTCTG CAGATGTGCT GTGTGAAGCT GCCTGGTGCT AGGCCTTTGA  87241 AGATTAATAA CTGGGTTTCA GGTGGATATC TTCAGATGAG TAATTGATAT TGTTTTACTG  87301 TTTTGGGGTG TTTTATGAGT TTGAAAAGCT GTTGGTTCTA GAGGGAAAGG TTTAACAAAT  87361 AAGGAGAATC CAATATTTCT GCTTTCATTT TCTTGGCGTG GTATCCTCTG TGTGAATTTG  87421 AATGCTCAGT TGAATAGTTT TATTGCCTTA GTACACACTT GTCAAATGTA AAGTTGGAAG  87481 GACCCTTTTC AGGAAGGGTT TCCTGTGAAC ATTCACTTAG TAAATGCTTG TGGATGATTC  87541 TTGTAAGAGG TCTCAGTGCT TAGAAGTAAT GAAAATGAAG AACAAGATCC TTTCACCTTC  87601 AGGGGACTTT GGGACCAATA CTCAAAATAT TTGCCAGCCC TTACAGCTTG GGCACCAGCC  87661 AGCAGGAGCA GAGGTGAGTG GTCCAGGAGC TGGGCAGCTC TGGGCAGAGC AGCTGCATGT  87721 GGGCCCTGGG TGCTAAAGCA GGCCTGCTCA TTGTGTGTCC TGGAAGAGCT GTGTTCTAAA  87781 GGAGGCCACA GGAGTTCTTA GCTCCTTAGT GTGTGACAGA CAGTGCTTCA GAGGGCACTG  87841 TGCTCCACTT GGTCTTAATT TTGAAAGTTT ACATTGAGGT GAAAGTAGAT ATTGACAGCT  87901 GTTCACTCTT CATGTGCTGT GTTCAGATTA CGGATGAATC CATGAGCAGG GCCTTTGCCT  87961 TATCCTAGAA ACACGTGGTT ATCTTCCCTC ATGTTGTTGC TGGCACATCA CATGTTGATA  88021 AGTACCTCTC AAGATTACCT TGATAGACCC GTAGCTGTAG AAGAGCACTT AGTTCTCACC  88081 TCTGCCCTTC CCCTTATTCT TGCACCGTGG TCATGCTAGA GACCCATGGG GTTTATTTTC  88141 CTGGCTAAGG CAAACTGTTG GGAAATGCAA GAATGAGAGC TTCTATTGTG TAATTCTGGA  88201 TGAAGAATAA CTGCTTGTTT AGAACAAATA AATGTCCCAG GCTTTGATTA TAGTTATGAC  88261 TTCAAAAATA TGCTAAGACC ATTTACTTAC TGAGGAAATC TTACCTACTT ATAGTATTTC  88321 AAATTGATTG CAGTCATTAG TGACTTTCAG TTACGATGAA GGGAAGAATC TTGAGCTAAA  88381 CGCAGGGTTG TCTGAGGTGA TGATAGGAGT GGAAACAGGA TGGTAACTAA TGGATTTAGG  88441 TTAATGAGTT CTGAGAAAAT CAACCAGCCC CTGCAAGTCA CAGCTCTGTG TCTCTAAGTG  88501 GACACCTGTC TGTCTTGAGG CAGTCATCAT ATAATACGCA TCACATAGAT TTTAGTCATA  88561 TGGATTTTGA AACTCTGGAA ACCATATGTC TGCAGCTCCC TTTCATGACC ATGCTTGTGC  88621 TGGTTTATCT GATCTCCTCA GCTGTACCAG CTGCTGTGGC ATGAGCTTCT TGAGCTTCTC  88681 TTTTTAGAGC TGATCATTAT CTGGCGGCTG TCGCTATAAT TTTCTTGAAT ACAAGTAAAC  88741 ATTATTTATA AACTTTTAAA TTTCTCTGTT TAATTTTTCT CTCTCTTTTT TTTTTAATGT  88801 AGAGGCCTAC TTTGCTGGCA TCTTTGGGTC CTACTCAGTC ATAAACCACC CTCCCCACCC  88861 TAGAGTAGCC ACTCTTGATT TCTAATACAG ATGAGTTCTG CCAGGTCTAG TTGAATGGCA  88921 TTATACAGTC ACCATCATGA CCCTGGGTCT CATCATCTCG CTGTGTGTGG TCGTAGCCTG  88981 TTCACTCCCA TAGCTGTCCA ATGTTCCACT TTATAAATAA CTCACATTTC TTGTCCTTTC  89041 ACTGTTGATA GACAATTTTG TTGTATACAG ATTTTACAAA TCGTGCTGCT ATGAATAATA  89101 TTTTCATATA GTTTGGCACA CACATACATG CATTTCTATT GGTTTAGAAC TAAGAGTGCT  89161 ATTGCTGGAT CATAGGTGAG TAGATGATTG GCTTAGTCTC TCAAAAACCA AGTTTCTAGT  89221 AGTAAACAAA CAGTAGAGGA GGGTGAATCT CTTACTTAGA AATTATTCAG ATAATAAATG  89281 AAGAAGGAAT GAGAGACTGA GACTATAATA ACTCTTTTGC AACCCATCAT GAATTAACAG  89341 ATTTAGCCAT TGAATAGCAA TGGCAATTAA CAACACAATA AAAGAAAAAA CTAATGTGAG  89401 GTTCTTCCTC TTGATGGAAG AACACAATAC AGCACCATCA AACAAGTCCA AGTGAAAAAG  89461 AAACCAAGCC TGAATAGAAG CTGATCTCCA TAGCCAATTA CCAATTTAGA GGCAATACAG  89521 ATAATAGAAA TACATATTAA ACTATGCOTT GGGGAGCAAT CAGCAAAATG CACACTATGG  89581 GAAGCTCTAC CACACAATAT AAATTTCAAG GAAGAATCTA TAGAATAAAG ACAACAAAAG  89641 CATATTTCTA AAGGTAAAAC TAAATCATAA TATTGGATGA TAAAAATAAA AATAAAACAA  89701 AGAAGTGATG ATCGTAAAAG TCAGGTTGTG TTTTTATTTG AGGGAAGAAA GAGTTTATTG  89761 CTGGGCTGGA GCAAATGATG GGGCTTCTGG TTTGCCCCAC AAACATCTAT CCCTGGTGAT  89821 TAATGGGTGT TTACTTTGTA TTAAAGGACA CAAATTTTAG ACATTTTTTT CTTTTGGAGT  89881 CCTATATTTT ATTTTATGAC ACAAAGGCTA ATGAAAAAAT AATTTATAGA GTATGGTTAC  89941 TGTTTTGCAC AAAGCCTCCT CCCCATCTTC TTTTCTGGAC ACTGAGCACC CAGAACAACC  90001 AGCAGCCCCA GGACCCCCAG CAGGGGTGAC CTCACTTCTA GGTGTGCATG CAGCTTACAT  90061 CACCAGAGGT AACATGCAGG TCTACTCCTT GACTCCTGGA AGAACCTGAT AGGACACAGC  90121 TGAAGGGAAG CCTTCTCCGC CATCTGTAGG CTCTTGGCCA TCAGTGTAGA GGGAGCGGGT  90181 CCTCACTTCT CCACAGGCGT CTTCATGGCC ATAGCCTCCT CTCTGCATGG GGAGTAAGGC  90241 CTGGCCCTTC GCCTGAACAC GGTGACAGGG ATCTCGCCAA AGGTGGAGAT CACACCATTC  90301 CTCCTTTAGC AACCTCACGC TTCTTTTGCT TTACAGGAAA GTTGACTCAG GCTGGTGTCC  90361 AGTAAAGAAA TCCCAAGGAG AGGCCGGGTG CGGTGGCTCA CGCCTGTAAT CCCAGGACTT  90421 TGGGAGGTCG AGGCGGGCGG ATCACGAGGT CAGGAGATTG AGACCATCCT GGCTAACACG  90481 GTGAAACCCC GTCTCTACTA AAAAATACAA AACATTAGCA GGGCGTGGTG GCGGGCACCT  90541 GTAGTCCCAG CTACTCGGAA GGCTGAGCCA GAATGGCGTG AACCCGGGAG GCGGAGCTTG  90601 CAGTGCTCCT GCTCCCAGGA GGCGGATGCC CAGGATGAAC TTTAAGGTGG AGAGAGGAAT  90661 GTCATTGCTC ATCCTCCAGG TTCCAAGTAA GAACCTTCCT GCCCAGCCCA TCTCGATCTC  90721 CCTGAATCCT CAACGCTAAT AAGGACTGTC TCCTTCTCAC CTCCCTAGAC TGGGCTTTTT  90781 AACACTGGAG AGTGGATGTG ATTTCTAGTT TCAGCATGTC CTGGTTTATT GTGCTGCCAG  90841 TAAAATAAAA TCAAAATACA CATTGAATAA ATAATAAATA ACCCATAGTG AGCAAAGGCT  90901 TACAATGTAT TTTTTTGAGT CAAGACCTCA CTCTGGCCTG GGCTGGAGCC CAGTGGTGGG  90961 ATCGTAGCTC AATGCAGCCT TGTATTTATG AGCTCAAGGG ATCTTCCCAC CTCAGCCTCC  91021 ACAATACCTG GAAATACAAG CGCCCACCAC CAGGCCCAGC TGTTTACTTA TTTTTATTTT  91081 TTTAGAGACG AGGGTCTCAC TATGTTGTCC AAGCTGGTCT CTAATTCCTG ATCTCAAGCA  91141 ATCCTCTTGC CTTAGCATCC TGAATTGCTG GGATTACAGG CATGAGCTGT CATGCCCAGC  91201 TTGTAATGTA CTGACACTAT CAAGGTTTCT TTCTCCAAGT GTGGACACAG CAGCAGACAC  91261 CCCTTGTCTC TTGGGTCAGG ACACTGGGTA GAGTGGAAGA GCAGGGCAAC AAAGTCACTG  91321 CAGAAAGCAC CCACGTGGAA GAGGTCCAGC AGGGAGAGCC ACCTGTTCCA GGGACACCAT  91381 ATTTAGGGAT AACTCCTCTT TCTGGGCAGG ACTGTTCTTT GATTACTTTT GTATTCACAA  91441 TAGTTCTGAA ATCGTAGGAT GATGAGACTC AAGACTGGCT AGGGTTTTAT TTTGGTTTAG  91501 TTTTTATTTT GTTTTGTTTT GTTTTTTTCA AAAAACCATC ATGAGATTTG TTAATCTTTT  91561 GAATGGTTTT TGTGTCTCAA TTTCCTTCAG AACTTAACTC TTCTTAACAT TTCACAGTCC  91621 ACTTTCAGTT AAAAATGTAC TAGTACCCAT AAATAGAGAA ATCTTGCAAC CATTTATCCT  91681 CTATAAAATG TCCATCTTTA TGGTACAGAT ATTATATGTA ATATATCTAT ATAGGTTATA  91741 AGTCCCACAA GAAAAAAACT TCTTCTTATC TTTAAACAGT TCTATGTATA TAAATTAGAG  91801 TAAATGAGGG GAACAAGATA GCCTTTTGCA CTTAGCTCAG TATTTACCAT TTTTGATCAT  91861 CTTCATCTTT TCTGATAACC TCATTTCCCA CCTGGTATCA TTTGCCTTTA GCCTGAAGAA  91921 TTTTCTTTAC CAATTGTTAT TGTGCAGATC TGCTGGTGAC AAATTCTCTT AATTTTCTTT  91981 TACCTGAAAC ATCTCCTTAT TTTGCCTGTC CTTGAAGGAC ATCTGTGCTG GATATAGAAT  92041 TCTTAGTTGT CCTTTTTTTC TTCCAGCACT TTAAAGGTGT TATTCTACTT TCTTTTGTTT  92101 CTATGGTTTC TAATAAGAAG TCATTGGTCA GGACAAGAGG AACAGAGAAA CCAAAACTGA  92161 GGAAATAACA TGGTAGACCT AAAACTTATC AATAATGAAA AAAAAACCTA TATGAATCAA  92221 CACTCCAATG AAGGGCAGAG ATTGTGTGAA TTGGTTAAAA AAAAAAACAA AACACAGAAC  92281 CCAACCATAT GCTCTTTCCA GATATGCAGT TTCTTTGTTT CTTTTTTTTT TAATTTAACT  92341 TTTATTTTTA GTTAAGGAGT ACATGTACAG GTTTGTTATA TAGGTAAACT TGTGTCATGC  92401 GGTTTTATTG TACAGATTAT TTCTGTACCC ATTAGTACCC ACCCAAGTAT TAAGCCTTAG  92461 TACCCATTAG CTATTTTTCC TGATCCTCTC CCTCCTCCTC TACCCTCAAG TGGACCCCAG  92521 TGTGTGTTGT TCCCTTCTGC GTGTCCATGT GTTCTCATCA TATAACTCCT ACTTATAAGT  92581 GAGAACATGT GGTAATTGGT TTTCTGTTCC TGCCTCAGTT TGCTAAGGAT AATGGCCTCC  92641 AACTCCATCC ATGTTCCTGC AAAGGACATG ATCTCATTCT TTTTTATGGC TGCATGGTAT  92701 TCTGTGGTGT ATATGTGCCA CATTTTCTTT TTCTTTTTTT TTTAATGGAA AATAACTTTT  92761 ATTGAGATCC CACCAGTTGC AATATCTGTT CCCAGCATTA AGCTCCTTCT TCCTTTGCAA  92821 TTCGGTCTTT CTTGAGTGGT CCCATGAATG CTTTCTTCTC CTCCGTGGTC TGGAAGCGGC  92881 CATGGCCAAA CTTGGAGGGG GTGTCAATGA ACTTAAGGTC AATCTTCTCC AGAGCCCGCT  92941 GCTTTGTCTG CACCAGCAAG GACTTGTGGA GGGTGAGCAC CCACTTCTTG GTTCCCACCA  93001 CACAGCCTTT CAGCATGACA AAGTCATTGG TCACTTCACC ATAGTGGACG AAGCCACCCA  93061 AAGGGTTGAT GCTCTTGTCA GACAGGTCAT AGTCAGTGGA GGCATTGTTC TTGATCAGCT  93121 TGCCATCCTT GATAAGGTAG CCCTAGCCAA TCCTATAGAT CTTGTTGATC TCAGTGCGGT  93181 GATGGTAGCC TTTCTGCCCA CCACGTACCA CAGAGAAGCC CACACGAGCA GGATGCCATG  93241 CCCCAATACA GGCCACCTTG CACAGGCCTT GGTGGGTCTT GCGGGGCAGC TTCTTGGTGT  93301 GCCAACGACT GGTGACCCTT TTGTAGCCTT TGCCCTTGGT CACCCTGATG ACGTCGATCA  93361 TCTCATCCTG CCCAAACACT TGGTTCACAG GTACCTGGTG CTTGAGCCTC TCGCCAGCCC  93421 AGTCCAGCTT CTCAGCCACA GTGCCTCCAT TCACCTGGAT CTCCATCAGG TGGGCCTTCT  93481 TCTGGCACAG AGGAAGCAGG TGCATCTGGG TGTGGGCAAT GACGCAGATG ACTTGGCAGT  93541 ACTTCTTCAT GCTGCTGAAG TCCTTCTCCA GCTGCTTCTT GCCATCCTCA TCCTGCCATT  93601 TCTTGCAGTA CTTGGTAAAG GCCTTCTTCT TAGATTTATG CCAGTTCTTA TAGAAACGCC  93661 TCTTGCATTC ATCACTGATG TGCTCAGCGA AGACAGTCTT GCAAGTCCGG AAGCCTTGAG  93721 GGGTTTCCAC GCAGCCCACA ATGCCCACTG GTGGCCTCTC CACAATGGTC ACAGCCTCCA  93781 CCACCTCCTT CTTGTTCACC TTGGATCCTG GCCTGTCGAC TTCCCGCACG ATGTGGGTCA  93841 TGCCAGCCTT GTATCCCAGG AAGGCTGTGA GGTGGACCGG CTTGGATGGG TCATCCTTAG  93901 GGAAGCTCTT CACCTTCCCA CGATGCCTGC TGCTGCGCTT CCAAGGCAGG AAGCCGAGGG  93961 ACCCATGTCT GGGAGTGGAG AACTTTCTGT GAGACATCAC GCCATCAAAT CCTGCCGGTA  94021 GAGCATATTT GCCACATTTT CTTTATCCAG TCTACCACTG ATGGACATTT AGGTTGATTC  94081 CATGTCTTTG CTATTGTGAA TAGTGCTGCA ATGAACATAT GCATACGTGT AAGACATGGG  94141 CTTTCTTTTT TTAATTTGCT TTGTTTTATT TTACTTTAGG TTCCAGGATA CATGTGCAGA  94201 ACCTGCAGGT TTGTTACATA CGTATAGTCT GCCATGGTGG TTTGCTGCAC CTATTGACCC  94261 ATCCTCTAAG TTCCCGTCCC TTGCCCCCCA CACTCCCCAA AAGGCCCTGA TATGTGTTGT  94321 TCCCCTCCCT GTGTCCATGT GTTGTCATTG TTCAACTCTC ACTTAGGAAT GAGAACATGA  94381 GGTGCTTTGT TTTCTGTTCC CGTGTTAGTT TGCTGAGGAT GATGACTTCC AGCTTCATCC  94441 ATGTCCCTGC AAAGGACATG AACTCATTCC TTTTTCTGGC TGTGTACTAT TCCATGGTGG  94501 TATGCACCAC ATTTTCTTTA TCCATCTATC ACTGATGGAC ATTTGGGTTG GTTCCAAGTC  94561 TTTGCTATTG TAAATAGTGC TGCAGTAAAC ATACGTGTGC ATGTGTCTTT ATAGTAGAAT  94621 GATTTATATT CCTTTGGGTA GATACCCAAA GCGTCAAATA GTATTTCTGG TTCTCGATCT  94681 CTGAGGAATG GCCACACTGT CTTCCACAAT GGTTGAACTA GTTTACATTC CCAACAACAG  94741 TGTAAAAGTG TTCCTATTTC TCCACAGCCT CACCAGCATC TATTGTTTCT TGACTTTTTA  94801 ATAATTACCA TTCTGACTGG CGGGAGATGG TATCTCATTG TGGCTTTGAT TTACATTTCT  94861 CTAATGAGCA GTGATATTGA GCTTTTTTAA TTTTTCTCAT TAAGATTTTA ATGTCTCATT  94921 TTAAAAAATT AAAGGAAGTT TCCATTTATT TTTTAAGATA AAGATTTAGC GCACCCAAAT  94981 GCCCCCAAAG CCAACAGAAA AATAGCTTTG CCCTGTCATT TCCCTAAGAA AGCACTGCAG  95041 TTACTCAAAA TATGCTCAAA GAAAAAAATG CAATCCTCTG AGTTCTAAGT TTCACGAAAG  95101 GACCACATGT TAAACTATGT ATATCGATTT GATGTGTAAG TATGCAATAA ATATGTACAC  95161 ATACATTCCT ATCTGCTTCA CATCATTCTA GAGTATTCAT AGTATATGAA GATGGGATTT  95221 AGAAATGTGA AAAGGCTGTA ACAGTGAAAA GGAAAAAAAG GGTACAATGG TTTTTAGACC  95281 AGTAGAATAA TAATGCTTAG CTAGTTAATT ATTTTAACTT TGGAGCAGAC TAAAAAAGTT  95341 GTTTTGAAAT AAATGGTACC TGTAAGTGAT GOTTACTGCA ATACTTGTTA AGTGTTATTT  95401 GTCACCACTG ACAGGAATTA TATAGTGCTA GTAACACAGC TCCCACTGTC CTAGAATTCC  95461 TCTAAATGGC CAGCTATTGC TACCATTATC TTGATAAGCA TTTCAAGAAT TGTGTTGCTG  95521 AGCCTTTTAA AAGATAACTA GTTTATAACC TATGTCTCCT TATGTGCCTA CATCAGTTAC  95581 TCATGGTCCC AAAGAAGTAT AAAAGAGGAT ATAAGCTGCT GAAGATTTCA CAGAAGAAAC  95641 AGAGATATCA GAAACTTCAT GATCATCAAA CTTAAACCAC CGCTGTTTTG CTGCATTTTT  95701 ACAGTAGGCT GTGTAATGGC CTCCATCCAG CCCACCGCAG TGATCTGAAA CAGAAAACAA  95761 ATTATATTTC TTCAAATTGT TCTTTGGACC AATAACATAC TGTGACAAGG CAAGATTTTC  95821 TAACAGGAAG TCCACAGATG TCTGTAATTT TTGTTTCCAC CTGCCATTGT AGGAAAAATG  95881 TTTCAGATGC ACTAAAAGCA CAGGTGGTAA CTTCCAGATT TCTTTTTTAA GAATCCCGTC  95941 GAGCTCTGCA AAGATTGCAG TAAAATCTGT TATTATCTAT GAGTTTTTCT TCTTTAGAAA  96001 ATAATCTAAG GCAATCCTAT AATGTACATT TACTTGTGGA TGCTATCAGT AGAGACAAAT  96061 ACATGAAGGC CTCAAGTGTC CTAGACTTTT TGTGACGGGT GAGGCACTGT ACTGTAGATT  96121 TGAATTGACC CTGAAAAAGT GCAACAATAA TAGACTCATA GAGCCGCTTG TGTTTCTGCC  96181 AGGCATGTTC TGCAGCTTTA AAGTCATTGA GATGATCATT ATTTTCTTCT TTATATGTCT  96241 TCCGATTATC AGTTTTATTT AGATCTTCAT GGAGACCATC CATTAGGAAC AGAAGAAATT  96301 CTTGTGAATC TTGACTGTAT CCTGCAAACT GGTAATTGAT CTTCCCAATG GTGACTTTAA  96361 GGTCTTTTGG ACTGATATAT CTATACTGTC CTGTCCACGG GGCTTTCATG ATTATACCAA  96421 ATTCTTCTGC CACTTCACCT TTATGCCCCT AACAAATTTG ACTTGTTAAT ATCATCCTGA  96481 TAACAGTTTC GGTTGAAATA ATCAGCCAAA TGTGGAGCAT TACATAGGCA CTGCAATATT  96541 GAGTTCATAT AACAAGTATT TCCTAAGTTA CGAAGTCCAG TAAGAGCTGG TCCAGAACCT  96601 CCAAAAACAG GATTGAGTTT CCAAATCTGA GAAGCAGAAA GCCTTGAGAT CTCAGCTTTA  96661 GGGTAGCATG TTGGCTTGTC TTCCTGATTA ACTGTTGGAG TTACTGCTGG CTTCCTCTTG  96721 AATAGCCTGG GTTATATCTG GGGAGGAGTA AGAGCATTTC AGTTTGGAAG GTTCCCTATC  96781 CTGCTTAGCA GGAATCTGTG GCTTGCCTTT ATGAGTTGGA GGGGTGGAAG GAGGTGCAGA  96841 TGAAGGAGCC ATTTCCAGTG GGTACATATG AACAGTGTTA GTGGTGAATG ATAATAATGA  96901 AACGTTCCAG TGATTGGATC AAGAAACTTG GCCCAGCCTG AAGGCAGTCC TGGTACCATC  96961 CTCCCCATTT CTTCACTTCG TGCTATTATC GAAGGTTCTC GTTGAGTTTT ATTTCTTTCA  97021 GTATCATCTG TATCCTCTCT AAAAGTTTCT GTCCTTAGAA TTCCAGTTTC TGGTTGTCCT  97081 TTAATCTTAA AAGGCTTGCC TGAACCTGAA TCCCCTGTCG CAGATGTATG GGACACATCT  97141 CTTGTTGACT TTTTCTGTAC TTCTGGGGTT GAACATCTTC TCCCCCTGTC CTCTACAGAC  97201 TTCTCGGCAC CAGAGGTTTC ATGATCACTT TTACTTTGTC TTTTTACTCT TGTTATTTCT  97261 TTGCCCTTCT TTGCTGAGAT TTCTTTATCC TCTTTCTTGG CCTGTTCACG TTCTTTCTTC  97321 TCCATTTCTT CTTTTGCTTT TTGTTGCTTC TGTGTAATTT CATTTTCTTC AGCTTCTTGT  97381 TTCTTTTTGG CTTTTTGCTC GTGTTCTTCC CTCCTCAGTT TCTTTCTGTT TCCCTTGCTG  97441 TCTTTCCTGA AGTTCTTTTT CTTGTTTGTT TTTCTCCATT AGAAGAGCAG TTTCTGCATG  97501 AATATGAGCC TTTTCTTCAT CTGTTAACAT GAGAGTTGGA GAGGAAACTA CTGGCTTGGC  97561 GGAACAATCA GGAATAACTT TTTCATTCTG AGGAGACTGT TGCTCATGAT TTGTACTTTC  97621 AGATTTGATT ATATGCTCTT CAGGCAATTT GACTGCCAGT TTTTTAGTAT GATCAATCTG  97681 TGGAACATTC TTTATGCTAG GCACTGGCTG AATGATGGGT GAAACATCAG ATTTAGAAGC  97741 AGCAACTGAT TCAACTGGAA TTGATATATT CAGTGGTCCT GTCCTCTCAT TTTGATCATT  97801 ATCACTTATT TGATCACTTA TCAATTCTAT GTCTTCATCC ACTTCTATAG GTGGAGGTGG  97861 CATCTCGGCA GCAGGTTTAG AAGGAATTGA TTCTTCCAAT GAGGGATAAG TAAAATCCAA  97921 TGAGATAGAC AACTCTTCAT TCTGGTGTTG TGGGGGTGGA GTGACCTTAG CATTTGTTGT  97981 ATACTGGGAA TAGCAAAGGA ACCAGTTTTT ATAGCCTCCC TCTAAAACCA AAGGCCCAAG  98041 GCCCATTGCA CAGGACAGTT TTACTTTCCC ACTTGAAAAG TGCATCTTTC AGATGCCAGA  98101 GTGTTGTTCC AATCTGTAAA TCTTTTGCAG AACTAAACCA GTCAAGAAGT ACCATATACT  98161 CCACATTCCC CCTCTTCTTC CATGTATCTA TAGAATCATC TGGGAGGTGT GCTTCAATCC  98221 AGCTAGCAGT GACTCCTGGA CTGATGGCTT TTCCAGGAAC ACTGAGAGAA TGTAAAATAC  98281 AGGAATCCTG ATAATCCTGC ATTCTTTGAG CATCCATTAT AATCAAGCTG ATGTTTTTAT  98341 CCATCATCAT TGTGTATAGT TCCTTTGCTG TGATTGCTCC TTTCTCTTTG GTCTCACATT  98401 TTTCATTCTT TTCACCATTG CTCTTTTGGG TTTTGTCTTT GGAATCCAAT ACAATCTCCA  98461 AAGAATCTTT AGCCAACGTG CTGCCATCCT CTCTTCCTGT TTCCTGCCTT TTTTGTTGTA  98521 GCCACTGTGC TTCCCCCTGC CTGTCCTTTT CCTCAAGTTT TTTCCAGATT TCAACTTCTT  98581 CATATCTTAG TTTAAGGCTT TCAGAGAGTC GTTCAGTTTC TCCAGTGGCT TTTTTGATGT  98641 TTGCAGGTCC AAGTATTGAA TGGAAGTAAT ACTGCTGTTG CTTGAAATCA GTTCTTTTTT  98701 GGATAGGATT ATAAACAGTC ATGTTTCATA TACATGTGTG AGCTTTTTTT CATATGTTTC  98761 TTGGCCACGT AAATGTCTTC CTCTGAGAAG TGTCTGTTTA TATCCTTTGC CCACTTTTTG  98821 ATGGGGATGG GTTTTTTTCT TGTAAATTTG TTTAAGTTCC TTGTAAACAA ACATGTGAGC  98881 TCTCATCATT CTTGTTTAAA CACCTAACAG TCATCCTAAC CAGTGCAACA AGGACCAGGC  98941 ATGGTGGCTC ATGCCTGTAA TCCCTGCATT TTGGGAGGCT GAGGTGGGAG GATCACTTGA  99001 GATCAGGAGT TTGAGACCAG CCTGATAAGT GAGACCTCAT CTCTACCAAA TAAAAATAAT  99061 TTTAAAAGAA AATAGATCAA TGGATAAGAA AGGAAGAAAT GAAAGTCTTT CTTTGTCACC  99121 AGCTTCATTG TATATGTAGA AAACACTAGG GAATTCTGAA AAAGTCTCTG GAATTAATCA  99181 TTGAATTTGC AAAATAGTTC ATAAAATATA TGTAATAAGT CGCTTAGATG AACATGAAAA  99241 GATAGCAAAC AATACTAGTC ATCAAAGAAG TGCAAGTTAA AACCACAATG AGAAACCATC  99301 ACACATCACC TAGAGCAGGT AAAGTTAAAA AGACATATGA TAAGTCTTAA CACTGGCAAG  99361 AATATGGAAA AAATAGGAAT GTCTGATATT GCTGGTAGGA ATGCAAAAAA TGTGGCAGCC  99421 AATTTGTAAA GTGGTATGGC AGTTTCTTAT ACAGTTACCC ATCTATTACC ACATGGCCCA  99481 GCAATTCCAC AAATACGTAT TTATCCAAAA GAAATAAAAA TGTAAGTCCA CACTTGTAAG  99541 CAGTTATTTA TAGTGGCTTC ATTAATAACA AGCCCTAACT GGAGGAATCC ACATGTCTAT  99601 CAACTGGAGA CACAGAAACC AATGAATAAA CTGGGATTCC AGCAATACTC GGCAGCTGCT  99661 CAGCAACAAA AATGAATGAA TGGCATCATC TCAAACATCG TTATGCTAAG GGAGAGACCA  99721 AACAAAAGAC TACATAACAT ATGATTGCAT GTCCATGAAA TTCTAGAAAT GTCACTATTG  99781 CAGTGACAGA AAGCACAGCA GTGGTTGAAT GAAGGGAAGG GGGTGAGGGT GGGAGGCAAG  99841 GATTAAATAG AAAGGGGCAT AAAGAAAGTT TTTAGGGAAA AGAAACTGTC CTCTACAGCG  99901 CCACAACTCA GGAGTGACTG GGAGGGGGAA GTAAGGGGAG AAGAAGGTCT GAGGGATAAG  99961 GGGCAGAGAG AAGGGCTGGG GAAGCAGGAG GAGAGGACGA GGAGCAGGGG AAAGGACTCT 100021 AAAGCAGTGG AGGGGCCTAG TAGGAGGATC TTTGCATTTG GTGTTTCTCT ACTGGGCAGT 100081 GTGGTAGTTA CACTATAAAT AATTACCAAT ATCCACCAAA AAGTGCAGCT AAAACTGGTG 100141 AATTTTTTTA CACGTAAACG CCCTGATAAG CAAAAAAAAA AAAAAAAAAA AAAAAAAAAA 100201 AAAAAAAAAA GGGGGGGGGG GAGGAAAGAA GGCAAAAATA AAGACATTGT TAGATCATCA 100261 AACCCATAAA ATTCATTTCC TAGGGGTCCT GTACTACATG TAATTTTAAA GGACGTTCTA 100321 CAGGCTGAAG GGAAATGATA CTAGATGGTG ACCCAGATAC ACAGAAAGGA ACAATTAACA 100381 ACAGAAATGA TGCACATACA CATATCACAT ACACACCCAT TTTCTTAATT TCCTGAAGAT 100441 ACGTGACTGC TTGTCTAAAA CAAAAAGTAT TACACTGTAT TGTTGAGTTT ATAACGTATA 100501 TTGATGTAAC ATATACAATA ATAATAGCAT AATGATAGTT TAAATGAAAC TACACCATTT 100561 GAAGTGTCCT TTATTTTGCT GGATGCAGCT TAATATTACC TGAATTTCAC TGTGAAAAGT 100621 CAAGGAATTG GGTTTCAATT CTTACAACAA TAAAAAATTA ATGTAAAGAA ATATAGCTAA 100681 AAGCCACTAG GAGAATTAAA ACCATAAGCT AAAAAATGTT TACTTGAAAC ATAAGAAAGT 100741 AGCAAAGGAG GAACAGAAAC AAAAAGATAT GAGACAAATT GAAAACGTAT AGCAAAATGG 100801 TAGACCAAAA TCCAACCATT ATAAGTGAAG AAATGACACG ACCTGAGTCA CATTAGCAGG 100861 ACTGCTGAGC ACTATGGGGA GAACAGACAT GGGCAGGAAG TGAGGGACAG TGTTAGTGCC 100921 ACAATTCAGG AGTGACAGGG TGGCGGGGAC TAAAGGGGAA AGAGGGTGTG AGGGATGAGA 100981 GGGGCAGACA GAAGGGCTGG AGAGGCAGGA GGTGAGGAAA AGGAGCAGAG GAAAGAATTC 101041 TAAAGCAGTA GAAGAGCCTG GCAGGGGGTT CTTTGCATTC GGTATTTAAT ACATTTTGTG 101101 TGACTGCCTT AAAACTAATG GGCTCCTTAT GATTTTTTTT TAAAAAGGGG TTACAAAAAT 101161 ATCAAGTGTC CAAATAAAAT ATGCACACTG CTTAGATGTG CATAGTTCCG GAAAACGGGC 101221 AGTGCTGGAG CGCTGGTGAA GAGCATTGGG ACTGCATGGA GCCCTCACAA CTTTGAGGTG 101281 ATGACTACAG GCTCCCGGTT GCAATAGACA GTAACAAACC CTGCTTCTTT GTATTCAGGA 101341 GATGTTCTGG ACTCACACAG GGAAACTCTG GCTAGAGAAT GAGGATAACT TTAAATGCAA 101401 CAACCCAGAG TCACAGATCC ATAGTCTGCG AAAGTAAAAC AGGAGCTTTG AGAATTTAAT 101461 TGTAATGCAG TTTTGACACA GGTCTTTCAC AGATTGGAAT TCTAATCATT CAGGGATTAC 101521 CAATATTGTG CTACCTACTG TATCAATAAA CAAAAAGGAA ACTGGTCTCT ATGAGAATCT 101581 CTACCTGGTG CTTTCAGACA AAACTTCACC AGGTTTAAAG AGAAAACTCC TGACTCTACA 101641 CGTCCATTCA CAGGGCGAGC TCACTGTCTG GCATCAAGTT CCCCATGGTG AGTTTCCCTG 101701 TACAAGAGTC CAAGGGGAGA GGTAAGTGTC CTTTATTTTG CTGGATGTAG TTTAATATTA 101761 CCTGAGGTAA GGTAAGGCAA AGAGTGGGAG GCAGGGAGTC CAGTTCAGGG ACGGGGATTC 101821 CAGGAGAAGT GAAGGGGAAG GGGCTGGGCG CAGCCTGGGG GTCTCTCCCT GGTTTCCACA 101881 GACAGATCCT TGGCCAGGAC TCAGGCACAC AGTGTGACAA AGATGOTTGG TGTAGGAGAA 101941 GAGGAATCAG GACGAAGTCC CAGGTCCCGG GCGGGGCTCT CAGGGTCTCA GGCTCCAAGG 102001 GCCGTGTCTG CAATGGGGAG GCGCCGCGTT GAGGATTCTC CACTCCCCTG AGTTTCACTT 102061 CTTCTCTCCC AACCTGCGTC GGGTCCTTCT TCCTGAATAC TCATGACGCG TCCCCAATTC 102121 CCACTCCCAT TGGGTGTCGG ATTCTAGAGA AGCCAATCAG CGTCTCCGCA GTCCCGGTTC 102181 TGAAGTCCCC AGTCACCCAC CCGGACTCAG ATTCTCCCCA GACGCCGAGA TGCGGGTCAT 102241 GGCGCCCCGA ACCCTCATCC TGCTGCTCTC GGGAGCCCTG GCCCTGACCG AGACCTGGGC 102301 CGGTGAGTGC GGGGTTGGGA GGGAATCGGC CTCTGCGGAG AGGAGCGAGG GGCCCGCCCG 102361 GCGAGGGCGC AGGACCCGGG GAGCAGCGCA GGGAGGAGGG TCGGGCGGGT CTCAGCCCCT 102421 CCTCGCCCCC AGGCTCCCAC TCCATGAGGT ATTTCTACAC CGCTGTGTCC CGGCCCGGCC 102481 GCGGGGAGCC CCACTTCATC GCAGTGGGCT ACGTGGACGA CACGCAGTTC GTGCGGTTCG 102541 ACAGCGACGC CGCGAGTCCG AGAGGGGAGC CGCGGGCGCC GTGGGTGGAG CAGGAGGGGC 102601 CGGAGTATTG GGACCGGGAG ACACAGAAGT ACAAGCGCCA GGCACAGACT GACCGAGTGA 102661 GCCTGCGGAA CCTGCGCGGC TACTACAACC AGAGCGAGGC CAGTGAGTGA CCCCGGCCCG 102721 GGGCGCAGGT CACGACCCCT CCTCATCCCC CACGGACGGC CCGGGTCGCC CCAAGTCTCC 102781 CGGTCTGAGA TCCACCCCGA GGCTGCGGAA CCCGCCCAGA CCCTCGACCG GAGAGAGCCC 102841 CAGTCACCTT TACCCGGTTT CATTTTCAGT TTAGGCCAAA ATCCCCGCGG GTTGGTCGGG 102901 GCGGGGCGGG GCTCGGGGGA CGGGGCTGAC CGCGGGGGCG GGGCCAGGGT CTCACATCAT 102961 CCAGAGGATG TATGGCTGCG ACGTGGGGCC CGACGGGCGC CTCCTCCGCG GGTATGACCA 103021 GTCCGCCTAC GACGGCAAGG ATTACATCGC CCTGAACGAG GATCTGCGCT CCTGGACCGC 103081 CGCGGACACG GCGGCTCAGA TCACCCAGCG CAAGTGGGAG GCGGCCCGTG AGGCGGAGCA 103141 GCTGAGAGCC TACCTGGAGG GCCTGTGCGT GGAGTGGCTC CGCAGATACC TGAAGAATGG 103201 GAAGGAGACG CTGCAGCGCG CGGGTACCAG GGGCAGTGGG GAGCCTTCCC CATCTCCTGT 103261 AGATCTCCCG GGATGGCCTC CCACGAGGAG GGGAGGAAAA TGGGATCAGC GCTAGAATAT 103321 CGCCCTCCCT TGAATGGAGA ATGGGATGAG TTTTCCTGAG TTTCCTCTGA GGGCCCCCTC 103381 TGCTCTCTAG GACAATTAAG GGATGAAGTC CTTGAGGAAA TGGAGGGGAA GACAGTCCCT 103441 AGAATACTGA TCAGGGGTCC CCTTTGACCA CTTTGACCAC TGCAGCAGCT GTGGTCAGGC 103501 TGCTGACCTT TCTCTCAGGC CTTGTTCTCT GCCTCACGCT CAATGTGTTT GAAGGTTTGA 103561 TTCCAGCTTT TCTGAGTCCT TCGGCCTCCA CTCAGGTCAG GACCAGAAGT CGCTGTTCCT 103621 CCCTCAGAGA CTAGAACTTT CCAATGAATA GGAGATTATC CCAGGTGCCT GTGTCCAGGC 103681 TGGCGTCTGG GTTCTGTGCC CCCTTCCCCA CCCCAGGTGT CCTGTCCGTT CTCAGGATGG 103741 TCACATGGGC GCTGTTGGAG TGTCGCAAGA GAGATACAAA GTGTCTGAAT TTTCTGACTC 103801 TTCCCGTCAG AACACCCAAA GACACACGTG ACCCACCATC CCGTCTCTGA CCATGAGGCC 103861 ACCCTGAGGT GCTGGGCCCT GGGCTTCTAC CCTGCGGAGA TCACACTGAC CTGGCAGTGG 103921 GATGGGGAGG ACCAAACTCA GGACACTGAG CTTGTGGAGA CCAGGCCAGC AGGAGATGGA 103981 ACCTTCCAGA AGTGGGCAGC TGTGGTGGTG CCTTCTGGAG AAGAGCAGAG ATACACGTGC 104041 CATGTGCAGC ACGAGGGGCT GCCGGAGCCC CTCACCCTGA GATGGGGTAA GGAGGGGGAT 104101 GAGGGGTGAT GTGTCTTCTC AGGGAAAGCA GAAGTCCTGG AGCCCTTCAG CCAGGTCAGG 104161 GCTGAGGCTT GGGGGTCAGG GCCCCTCACC TTCCCCTCCT TTCCCAGAGC CGTCTTCCCA 104221 GCCCACCATC CCCATCGTGG GCATCGTTGC TGGCCTGGCT GTCCTGGCTG TCCTAGCTGT 104281 CCTAGGAGCT GTGGTGGCTG TTGTGATGTG TAGGAGGAAG AGCTCAGGTA GGGAAGGGGT 104341 GAGGAGTGGG GTCTGGGTTT TCTTGTTCCA CTGGGAGTTT CAAGCCCCAG GTAGAAGTGT 104401 GCCCCACCTC GTTACTGGAA GCACCATCCA CACATGGGCC ATCCCAGCCT GGGACCCTGT 104461 GTGCCAGCAC TTACTCTGTT GTGAAGCACA TGACAATGAA GGACAGATGT ATCACCTTGA 104521 TGATTATGGT GTTGGGGTCC TTGATTCCAG CATTCATGAG TCAGGGGAAG GTCCCTGCTA 104581 AGGACAGACC TTAGGAGGGC AGTTGCTCCA GAACCCACAG CTGCTTTCCC CGTGTTTCCT 104641 GATCCTGCCC TGGGTCTGCA GTCATAGTTC TGGAAACTTC TCTTGGGTCC AAGACTAGGA 104701 GGTTCCCCTA AGATCGCATG GCCCTGACTC CTCCCTGTCC CCTCACAGGG CATTTTCTTC 104761 CCACAGGTGG AAAAGGAGGG AGCTGCTCTC AGGCTGCGTG TAAGTGATGG CGGTGGGCGT 104821 GTGGAGGAGC TCACCCACCC CATAATTCCT CTTGTCCCAC ATCTCCTGCG GGCTCTGACC 104881 AGGTCTTTTT TTTTGTTCTA CCCCAGCCAG CAACAGTGCC CAGGGCTCTG ATGAGTCTCT 104941 CATCGCTTGT AAAGGTGAGA TTCTGGGGAG CTGAAGTGGT CGGGGGTGGG GCAGAGGGAA 105001 AAGGCCTAGG TAATGGGGAT CCTTTGATTG GGACGTTTCG AATGTGTGGT GAGCTGTTCA 105061 GAGTGTGATC ACTTACCATG ACTGACCTGA ATTTGTTCAT GACTATTGTG TTCTGTAGCC 105121 TGAGACAGCT GCCTGTGTGG GACTGAGATG CAGGATTTCT TCACACCTCT CCTTTGTGAC 105181 TTCAAGAGCC TCTGGCATCT CTTTCTGCAA AGGCATCTGA ATGTGTCTGC GTTCCTGTTA 105241 GCATAATGTG AGGAGGTGGA CAGACAGCCC ACCCCCGTGT CCACCGTGAC CCCTGTCCCC 105301 ACACTGACCT GTGTTCCCTC CCCGATCATC TTTCCTGTTC CAGAGAAGTG GGCTGGATGT 105361 CTCCATCTCT GTCTCAACTT CATGGTGCGC TGAGCTGCAA CTTCTTACTT CCCTAATGAA 105421 GTTAGGAACC TGAATATAAA TTTGTTTTCT CAAATATTTG CTATGAAGGG TTGATGGATT 105481 AATTAAATAA GTCAATTCCT GGAAGTTGAG AGAGCAAATA AAGACCTGAG AACTTTCCAG 105541 AATCCGCATG TTCTCTGTGC TGAGTCTGTT GCAGGTGGGG GTGGGGAAGG CTGTGAGGAG 105601 CCGAGTGTGG ACGGGGGCCT GTGCCTAGTT GCTGTTCAGT TCTTCATGGG CTTTATGTAG 105661 TCAGTCCTTA GCTGGGTCAC CTTCACTGCT CCATTGTCCT TGTCCCTTCA GTGGAAACTT 105721 GTCCAGCAGG AGCTGTGACC ACAGAGGCTC ACACATCGCC CAGGGCAGCC CCTGCACACG 105781 GGAGTCCCTG TGCTTTCTGA GACAAATTTT CAGACCCATT CAGCTCCTGC CCTCCTTATA 105841 GGGCTCCTCT TCTGCTTTGG TCTCCTGCCC TCTCTCCCTT CCCTGATTCC AGTGATCTTC 105901 GTGCTGACTC CAATCCCAAC TCATGAATCT AAAGCAGAGC CTAATTTAGA TTTGTATTTG 105961 TTTGTAAAAT TGGGTCCATA GTCTAGAATT GTTCCTTCCT GAAGAGAGAA ACCTGATCGT 106021 GTGCTGCAGC GTGCAGGGCG GTTGGTGTGG GAGGAGGGAT AGGGGAGGGA GGACACACAA 106081 GCAGCCCTGC TGAGAAAAGT ACAGGCGGCC TCGGTGTCAG TGTGAGGGGA CCTTGTGCTG 106141 CAGCTGCCAC AAAACAGCAC TTGGCCTGAG GCTATGTTAA TAAAGATACT GGCTTTAGAA 106201 TAGGAGGTGC TCTACACTGA TCATTCAACT GACCTTTGTT GTCAGCCAGA CACAGGACAG 106261 AAAAGTTCTG CATCTGGGGA ACACCATTGA AGTAAAATCA GAAAAATATC TGAGCATATG 106321 CTCCAGTGGT AAGAGGCAGA CGATACATAC ACTATAACCA CAGTAAGAAA AGAAAGTGAT 106381 GGAAGGTGGT AAGTGCCATG AGGCAGGTGA TCCGGGTATG GGCAGTGGGG ACAGGGAAGG 106441 TGGCTGTTGG ACAGGAGTTG TCAATGTGTG CCTTGTTGCA AAGATGACCT TTGAGGAAAG 106501 ATTTGAGGGA CATGAGGATG TCTGGGGAAG TTCTTTCTAG GCAAGGAAAC ACAACTTCGT 106561 ATAGAAAGGT ATATACGAAG TTGTGCGGCC GCGTCGACCA ATTCTCATGT TTGACAGCTT 106621 ATCATCGAAT TTCTGCCATT CATCCGCTTA TTATCACTTA TTCAGGCGTA GCAACCAGGC 106681 GTTTAAGGGC ACCAATAACT GCCTTAAAAA AATTAGAAAA ACTCATCGAG CATCAAATGA 106741 AACTGCAATT TATTCATATC AGGATTATCA ATACCATATT TTTGAAAAAG CCGTTTCTGT 106801 AATGAAGGAG AAAACTCACC GAGGCAGTTC CATAGGATGG CAAGATCCTG GTATCGGTCT 106861 GCGATTCCGA CTCGTCCAAC ATCAATACAA CCTATTAATT TCCCCTCGTC AAAAATAAGG 106921 TTATCAAGTG AGAAATCACC ATGAGTGACG ACTGAATCCG GTGAGAATGG CAAAAGTTTA 106981 TGCATTTCTT TCCAGACTTG TTCAACAGGC CAGCCATTAC GCTCGTCATC AAAATCACTC 107041 GCATCAACCA AACCGTTATT CATTCGTGAT TGCGCCTGAG CGAGACGAAA TACGCGATCG 107101 CTGTTAAAAG GACAATTACA AACAGGAATC GAATGCAACC GGCGCAGGAA CACTGCCAGC 107161 GCATCAACAA TATTTTCACC TGAATCAGGA TATTCTTCTA ATACCTGGAA TGCTGTTTTT 107221 CCGGGGATCG CAGTGGTGAG TAACCATGCA TCATCAGGAG TACGGATAAA ATGCTTGATG 107281 GTCGGAAGAG GCATAAATTC CGTCAGCCAG TTTAGTCTGA CCATCTCATC TGTAACATCA 107341 TTGGCAACGC TACCTTTGCC ATGTTTCAGA AACAACTCTG GCGCATCGGG CTTCCCATAC 107401 AATCGATAGA TTGTCGCACC TGATTGCCCG ACATTATCGC GAGCCCATTT ATACCCATAT 107461 AAATCAGCAT CCATGTTGGA ATTTAATCGC GGCCTCGAGC AAGACGTTTC CCGTTGAATA 107521 TGGCTCATTT TAGCTTCCTT AGCTCCTGAA AATCTCGATA ACTCAAAAAA TACGCCCGGT 107581 AGTGATCTTA TTTCATTATG GTGAAAGTTG GAACCTCTTA CGTGCCGATC AACGTCTCAT 107641 TTTCGCCAAA AGTTGGCCCA GGGCTTCCCG GTATCAACAG GGACACCAGG ATTTATTTAT 107701 TCTGCGAAGT GATCTTCCGT CACAGGTATT TATTCGCGAT AAGCTCATGG AGCGGCGTAA 107761 CCGTCGCACA GGAAGGACAG AGAAAGCGCG GATCTGGGAA GTGACGGACA GAACGGTCAG 107821 GACCTGGATT GGGGAGGCGG TTGCCGCCGC TGCTGCTGAC GGTGTGACGT TCTCTGTTCC 107881 GGTCACACCA CATACGTTCC GCCATTCCTA TGCGATGCAC ATGCTGTATG CCGGTATACC 107941 GCTGAAAGTT CTGCAAAGCC TGATGGGACA TAAGTCCATC AGTTCAACGG AAGTCTACAC 108001 GAAGGTTTTT GCGCTGGATG TGGCTGCCCG GCACCGGGTG CAGTTTGCGA TGCCGGAGTC 108061 TGATGCGGTT GCGATGCTGA AACAATTATC CTGAGAATAA ATGCCTTGGC CTTTATATGG 108121 AAATGTGGAA CTGAGTGGAT ATGCTGTTTT TGTCTGTTAA ACAGAGAAGC TGGCTGTTAT 108181 CCACTGAGAA GCGAACGAAA CAGTCGGGAA AATCTCCCAT TATCGTAGAG ATCCGCATTA 108241 TTAATCTCAG GAGCCTGTGT AGCGTTTATA GGAAGTAGTG TTCTGTCATG ATGCCTGCAA 108301 GCGGTAACGA AAACGATTTG AATATGCCTT CAGGAACAAT AGAAATCTTC GTGCGGTGTT 108361 ACGTTGAAGT GGAGCGGATT ATGTCAGCAA TGGACAGAAC AACCTAATGA ACACAGAACC 108421 ATGATGTGGT CTGTCCTTTT ACAGCCAGTA GTGCTCGCCG CAGTCGAGCG ACAGGGCGAA 108481 GCCCTCGAGC TGGTTGCCCT CGCCGCTGGG CTGGCGGCCG TCTATGGCCC TGCAAACGCG 108541 CCAGAAACGC CGTCGAAGCC GTGTGCGAGA CACCGCGGCC GGCCGCCGGC GTTGTGGATA 108601 CCTCGCGGAA AACTTGGCCC TCACTGACAG ATGAGGGGCG GACGTTGACA CTTGAGGGGC 108661 CGACTCACCC GGCGCGGCGT TGACAGATGA GGGGCAGGCT CGATTTCGGC CGGCGACGTG 108721 GAGCTGGCCA GCCTCGCAAA TCGGCGAAAA CGCCTGATTT TACGCGAGTT TCCCACAGAT 108781 GATGTGGACA AGCCTGGGGA TAAGTGCCCT GCGGTATTGA CACTTGAGGG GCGCGACTAC 108841 TGACAGATGA GGGGCGCGAT CCTTGACACT TGAGGGGCAG AGTGCTGACA GATGAGGGGC 108901 GCACCTATTG ACATTTGAGG GGCTGTCCAC AGGCAGAAAA TCCAGCATTT GCAAGGGTTT 108961 CCGCCCGTTT TTCGGCCACC GCTAACCTGT CTTTTAACCT GCTTTTAAAC CAATATTTAT 109021 AAACCTTGTT TTTAACCAGG GCTGCGCCCT GTGCGCGTGA CCGCGCACGC CGAAGGGGGG 109081 TGCCCCCCCT TCTCGAACCC TCCCGGTCGA GTGAGCGAGG AAGCACCAGG GAACAGCACT 109141 TATATATTCT GOTTACACAC GATGCCTGAA AAAACTTCCC TTGGGGTTAT CCACTTATCC 109201 ACGGGGATAT TTTTATAATT ATTTTTTTTA TAGTTTTTAG ATCTTCTTTT TTAGAGCGCC 109261 TTGTAGGCCT TTATCCATGC TGGTTCTAGA GAAGGTGTTG TGACAAATTG CCCTTTCAGT 109321 GTGACAAATC ACCCTCAAAT GACAGTCCTG TCTGTGACAA ATTGCCCTTA ACCCTGTGAC 109381 AAATTGCCCT CAGAAGAAGC TGTTTTTTCA CAAAGTTATC CCTGCTTATT GACTCTTTTT 109441 TATTTAGTGT GACAATCTAA AAACTTGTCA CACTTCACAT GGATCTGTCA TGGCGGAAAC 109501 AGCGGTTATC AATCACAAGA AACGTGAAAA TAGCCCGCGA ATCGTCCAGT CAAACGACCT 109561 CACTGAGGCG GCATATAGTC TCTCCCGGGA TCAAAAACGT ATGCTGTATC TGTTCGTTGA 109621 CCAGATCAGA AAATCTGATG GCACCCTACA GGAACATGAC GGTATCTGCG AGATCCATGT 109681 TGCTAAATAT GCTGAAATAT TCGGATTGAC CTCTGCGGAA GCCAGTAAGG ATATACGGCA 109741 GGCATTGAAG AGTTTCGCGG GGAAGGAAGT GGTTTTTTAT CGCCCTGAAG AGGATGCCGG 109801 CGATGAAAAA GGCTATGAAT CTTTTCCTTG GTTTATCAAA CGTGCGCACA GTCCATCCAG 109861 AGGGCTTTAC AGTGTACATA TCAACCCATA TCTCATTCCC TTCTTTATCG GGTTACAGAA 109921 CCGGTTTACG CAGTTTCGGC TTAGTGAAAC AAAAGAAATC ACCAATCCGT ATGCCATGCG 109981 TTTATACGAA TCCCTGTGTC AGTATCGTAA GCCGGATGGC TCAGGCATCG TCTCTCTGAA 110041 AATCGACTGG ATCATAGAGC GTTACCAGCT GCCTCAAAGT TACCAGCGTA TGCCTGACTT 110101 CCGCCGCCGC TTCCTGCAGG TCTGTGTTAA TGAGATCAAC AGCAGAACTC CAATGCGCCT 110161 CTCATACATT GAGAAAAAGA AAGGCCGCCA GACGACTCAT ATCGTATTTT CCTTCCGCGA 110221 TATCACTTCC ATGACGACAG GATAGTCTGA GGGTTATCTG TCACAGATTT GAGGGTGGTT 110281 CGTCACATTT GTTCTGACCT ACTGAGGGTA ATTTGTCACA GTTTTGCTGT TTCCTTCAGC 110341 CTGCATGGAT TTTCTCATAC TTTTTGAACT GTAATTTTTA AGGAAGCCAA ATTTGAGGGC 110401 AGTTTGTCAC AGTTGATTTC CTTCTCTTTC CCTTCGTCAT GTGACCTGAT ATCGGGGGTT 110461 AGTTCGTCAT CATTGATGAG GGTTGATTAT CACAGTTTAT TACTCTGAAT TGGCTATCCG 110521 CGTGTGTACC TCTACCTGGA GTTTTTCCCA CGGTGGATAT TTCTTCTTGC GCTGAGCGTA 110581 AGAGCTATCT GACAGAACAG TTCTTCTTTG CTTCCTCGCC AGTTCGCTCG CTATGCTCGG 110641 TTACACGGCT GCGGCGAGCG CTAGTGATAA TAAGTGACTG AGGTATGTGC TCTTCTTATC 110701 TCCTTTTGTA GTGTTGCTCT TATTTTAAAC AACTTTGCGG TTTTTTGATG ACTTTGCGAT 110761 TTTGTTGTTG CTTTGCAGTA AATTGCAAGA TTTAATAAAA AAACGCAAAG CAATGATTAA 110821 AGGATGTTCA GAATGAAACT CATGGAAACA CTTAACCAGT GCATAAACGC TGGTCATGAA 110881 ATGACGAAGG CTATCGCCAT TGCACAGTTT AATGATGACA GCCCGGAAGC GAGGAAAATA 110941 ACCCGGCGCT GGAGAATAGG TGAAGCAGCG GATTTAGTTG GGGTTTCTTC TCAGGCTATC 111001 AGAGATGCCG AGAAAGCAGG GCGACTACCG CACCCGGATA TGGAAATTCG AGGACGGGTT 111061 GAGCAACGTG TTGGTTATAC AATTGAACAA ATTAATCATA TGCGTGATGT GTTTGGTACG 111121 CGATTGCGAC GTGCTGAAGA CGTATTTCCA CCGGTGATCG GGGTTGCTGC CCATAAAGGT 111181 GGCGTTTACA AAACCTCAGT TTCTGTTCAT CTTGCTCAGG ATCTGGCTCT GAAGGGGCTA 111241 CGTGTTTTGC TCGTGGAAGG TAACGACCCC CAGGGAACAG CCTCAATGTA TCACGGATGG 111301 GTACCAGATC TTCATATTCA TGCAGAAGAC ACTCTCCTGC CTTTCTATCT TGGGGAAAAG 111361 GACGATGTCA CTTATGCAAT AAAGCCCACT TGCTGGCCGG GGCTTGACAT TATTCCTTCC 111421 TGTCTGGCTC TGCACCGTAT TGAAACTGAG TTAATGGGCA AATTTGATGA AGGTAAACTG 111481 CCCACCGATC CACACCTGAT GCTCCGACTG GCCATTGAAA CTGTTGCTCA TGACTATGAT 111541 GTCATAGTTA TTGACAGCGC GCCTAACCTG GGTATCGGCA CGATTAATGT CGTATGTGCT 111601 GCTGATGTGC TGATTGTTCC CACGCCTGCT GAGTTGTTTG ACTACACCTC CGCACTGCAG 111661 TTTTTCGATA TGCTTCGTGA TCTGCTCAAG AACGTTGATC TTAAAGGGTT CGAGCCTGAT 111721 GTACGTATTT TGCTTACCAA ATACAGCAAT AGCAATGGCT CTCAGTCCCC GTGGATGGAG 111781 GAGCAAATTC GGGATGCCTG GGGAAGCATG GTTCTAAAAA ATGTTGTACG TGAAACGGAT 111841 GAAGTTGGTA AAGGTCAGAT CCGGATGAGA ACTGTTTTTG AACAGGCCAT TGATCAACGC 111901 TCTTCAACTG GTGCCTGGAG AAATGCTCTT TCTATTTGGG AACCTGTCTG CAATGAAATT 111961 TTCGATCGTC TGATTAAACC ACGCTGGGAG ATTAGATAAT GAAGCGTGCG CCTGTTATTC 112021 CAAAACATAC GOTCAATACT CAACCGGTTG AAGATACTTC GTTATCGACA CCAGCTGCCC 112081 CGATGGTGGA TTCGTTAATT GCGCGCGTAG GAGTAATGGC TCGCGGTAAT GCCATTACTT 112141 TGCCTGTATG TGGTCGGGAT GTGAAGTTTA CTCTTGAAGT GCTCCGGGGT GATAGTGTTG 112201 AGAAGACCTC TCGGGTATGG TCAGGTAATG AACGTGACCA GGAGCTGCTT ACTGAGGACG 112261 CACTGGATGA TCTCATCCCT TCTTTTCTAC TGACTGGTCA ACAGACACCG GCGTTCGGTC 112321 GAAGAGTATC TGGTGTCATA GAAATTGCCG ATGGGAGTCG CCGTCGTAAA GCTGCTGCAC 112381 TTACCGAAAG TGATTATCGT GTTCTGGTTG GCGAGCTGGA TGATGAGCAG ATGGCTGCAT 112441 TATCCAGATT GGGTAACGAT TATCGCCCAA CAAGTGCTTA TGAACGTGGT CAGCGTTATG 112501 CAAGCCGATT GCAGAATGAA TTTGCTGGAA ATATTTCTGC GCTGGCTGAT GCGGAAAATA 112561 TTTCACGTAA GATTATTACC CGCTGTATCA ACACCGCCAA ATTGCCTAAA TCAGTTGTTG 112621 CTCTTTTTTC TCACCCCGGT GAACTATCTG CCCGGTCAGG TGATGCACTT CAAAAAGCCT 112681 TTACAGATAA AGAGGAATTA CTTAAGCAGC AGGCATCTAA CCTTCATGAG CAGAAAAAAG 112741 CTGGGGTGAT ATTTGAAGCT GAAGAAGTTA TCACTCTTTT AACTTCTGTG CTTAAAACGT 112801 CATCTGCATC AAGAACTAGT TTAAGCTCAC GACATCAGTT TGCTCCTGGA GCGACAGTAT 112861 TGTATAAGGG CGATAAAATG GTGCTTAACC TGGACAGGTC TCGTGTTCCA ACTGAGTGTA 112921 TAGAGAAAAT TGAGGCCATT CTTAAGGAAC TTGAAAAGCC AGCACCCTGA TGCGACCTCG 112981 TTTTAGTCTA CGTTTATCTG TCTTTACTTA ATGTCCTTTG TTACAGGCCA GAAAGCATAA 113041 CTGGCCTGAA TATTCTCTCT GGGCCCACTG TTCCACTTGT ATCGTCGGTC TGATAATCAG 113101 ACTGGGACCA CGGTCCCACT CGTATCGTCG GTCTGATTAT TAGTCTGGGA CCACGGTCCC 113161 ACTCGTATCG TCGGTCTGAT TATTAGTCTG GGACCACGGT CCCACTCGTA TCGTCGGTCT 113221 GATAATCAGA CTGGGACCAC GGTCCCACTC GTATCGTCGG TCTGATTATT AGTCTGGGAC 113281 CATGGTCCCA CTCGTATCGT CGGTCTGATT ATTAGTCTGG GACCACGGTC CCACTCGTAT 113341 CGTCGGTCTG ATTATTAGTC TGGAACCACG GTCCCACTCG TATCGTCGGT CTGATTATTA 113401 GTCTGGGACC ACGGTCCCAC TCGTATCGTC GGTCTGATTA TTAGTCTGGG ACCACGATCC 113461 CACTCGTGTT GTCGGTCTGA TTATCGGTCT GGGACCACGG TCCCACTTGT ATTGTCGATC 113521 AGACTATCAG CGTGAGACTA CGATTCCATC AATGCCTGTC AAGGGCAAGT ATTGACATGT 113581 CGTCGTAACC TGTAGAACGG AGTAACCTCG GTGTGCGGTT GTATGCCTGC TGTGGATTGC 113641 TGCTGTGTCC TGCTTATCCA CAACATTTTG CGCACGGTTA TGTGGAC (Deleter construct) SEQ ID NO: 15 TTATTATCATGACATTAACCTATAAAAATAGGCGTATCACGAGGCCCTTTGTCACAGCTTGTCTGTAAGCGGATGCCGG GAGCAGACAAGCCCGTCAGGGCGCGTCAGCGGGTGTTGGCGGGTGTCGGGGCTGGCTTAACTATGCGGCATCAGAGCAG ATTGTACTGAGAGTGCACCATACCACAGCTTTTCAATTCAATTCATCATTTTTTTTTTATTCTTTTTTTTGATTTCGGT TTCTTTGAAATTTTTTTGATTCGGTAATCTCCGAACAGAAGGAAGAACGAAGGAAGGAGCACAGACTTAGATTGGTATA TATACGCATATGTAGTGTTGAAGAAACATGAAATTGCCCAGTATTCTTAACCCAACTGCACAGAACAAAAACCTGCAGG AAACGAAGATAAATCATGTCGAAAGCTACATATAAGGAACGTGCTGCTACTCATCCTAGTCCTGTTGCTGCCAAGCTAT TTAATATCATGCACGAAAAGCAAACAAACTTGTGTGCTTCATTGGATGTTCGTACCACCAAGGAATTACTGGAGTTAGT TGAAGCATTAGGTCCCAAAATTTGTTTACTAAAAACACATGTGGATATCTTGACTGATTTTTCCATGGAGGGCACAGTT AAGCCGCTAAAGGCATTATCCGCCAAGTACAATTTTTTACTCTTCGAAGACAGAAAATTTGCTGACATTGGTAATACAG TCAAATTGCAGTACTCTGCGGGTGTATACAGAATAGCAGAATGGGCAGACATTACGAATGCACACGGTGTGGTGGGCCC AGGTATTGTTAGCGGTTTGAAGCAGGCGGCAGAAGAAGTAACAAAGGAACCTAGAGGCCTTTTGATGTTAGCAGAATTG TCATGCAAGGGCTCCCTATCTACTGGAGAATATACTAAGGGTACTGTTGACATTGCGAAGAGCGACAAAGATTTTGTTA TCGGCTTTATTGCTCAAAGAGACATGGGTGGAAGAGATGAAGGTTACGATTGGTTGATTATGACACCCGGTGTGGGTTT AGATGACAAGGGAGATGCATTGGGTCAACAGTATAGAACCGTGGATGATGTGGTGTCTACAGGATCTGACATTATTATT GTTGGAAGAGGACTATTTGCAAAGGGAAGGGATGCTAAGGTAGAGGGTGAACGTTACAGAAAAGCAGGCTGGGAAGCAT ATTTGAGAAGATGCGGCCAGCAAAACTAAAAAACTGTATTATAAGTAAATGCATGTATACTAAACTCACAAATTAGAGC TTCAATTTAATTATATCAGTTATTACCCTATGCGGTGTGAAATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAG GAAATTGTAAACGTTAATATTTTGTTAAAATTCGCGTTAAATTTTTGTTAAATCAGCTCATTTTTTAACCAATAGGCCG AAATCGGCAAAATCCCTTATAAATCAAAAGAATAGACCGAGATAGGGTTGAGTGTTGTTCCAGTTTGGAACAAGAGTCC ACTATTAAAGAACGTGGACTCCAACGTCAAAGGGCGAAAAACCGTCTATCAGGGCGATGGCCCACTACGTGAACCATCA CCCTAATCAAGTTTTTTGGGGTCGAGGTGCCGTAAAGCACTAAATCGGAACCCTAAAGGGAGCCCCCGATTTAGAGCTT GACGGGGAAAGCCGGCGAACGTGGCGAGAAAGGAAGGGAAGAAAGCGAAAGGAGCGGGCGCTAGGGCGCTGGCAAGTGT AGCGGTCACGCTGCGCGTAACCACCACACCCGCCGCGCTTAATGCGCCGCTACAGGGCGCGTCGCGCCATTCGCCATTC AGGCTGCGCAACTGTTGGGAAGGGCGATCGGTGCGGGCCTCTTCGCTATTACGCCAGCTGGCGAAAGGGGGATGTGCTG CAAGGCGATTAAGTTGGGTAACGCCAGGGTTTTCCCAGTCACGACGTTGTAAAACGACGGCCAGTGAGCGCGCGTAATA CGACTCACTATAGGGCGAATTGGGTACCGCGAGACCTTCCGGGTCTCAGAAGTTCCTATACTTCAAAAGGAATAGGAAC TTCGGATCCGGGTAGGGGAGGCGCTTTTCCCAAGGCAGTCTGGAGCATGCGCTTTAGCAGCCCCGCTGGGCACTTGGCG CTACACAAGTGGCCTCTGGCCTCGCACACATTCCACATCCACCGGTAGGCGCCAACCGGCTCCGTTCTTTGGTGGCCCC TTCGCGCCACCTTCTACTCCTCCCCTAGTCAGGAAGTTCCCCCCCGCCCCGCAGCTCGCGTCGTGCAGGACGTGACAAA TGGAAGTAGCACGTCTCACTAGTCTCGTGCAGATGGACAGCACCGCTGAGCAATGGAAGCGGGTAGGCCTTTGGGGCAG CGGCCAATAGCAGCTTTGCTCCTTCGCTTTCTGGGCTCAGAGGCTGGGAAGGGGTGGGTCCGGGGGCGGGCTCAGGGGC GGGCTCAGGGGCGGGGCGGGCGCCCGAAGGTCCTCCGGAGGCCCGGCATTCTGCACGCTTCAAAAGCGCACGTCTGCCG CGCTGTTCTCCTCTTCCTCATCTCCGGGCCTTTCGACCGATCATCAAGCTTGATCCTCATGAAAAAGCCTGAACTCACC GCGACGTCTGTCGAGAAGTTTCTGATCGAAAAGTTCGACAGCGTCTCCGACCTGATGCAGCTCTCGGAGGGCGAAGAAT CTCGTGCTTTCAGCTTCGATGTAGGAGGGCGTGGATATGTCCTGCGGGTAAATAGCTGCGCCGATGGTTTCTACAAAGA TCGTTATGTTTATCGGCACTTTGCATCGGCCGCGCTCCCGATTCCGGAAGTGCTTGACATTGGGGAATTCAGCGAGAGC CTGACCTATTGCATCTCCCGCCGTGCACAGGGTGTCACGTTGCAAGACCTGCCTGAAACCGAACTGCCCGCTGTTCTGC AGCCGGTCGCGGAGGCCATGGATGCGATCGCTGCGGCCGATCTTAGCCAGACGAGCGGGTTCGGCCCATTCGGACCGCA AGGAATCGGTCAATACACTACATGGCGTGATTTCATATGCGCGATTGCTGATCCCCATGTGTATCACTGGCAAACTGTG ATGGACGACACCGTCAGTGCGTCCGTCGCGCAGGCTCTCGATGAGCTGATGCTTTGGGCCGAGGACTGCCCCGAAGTCC GGCACCTCGTGCACGCGGATTTCGGCTCCAACAATGTCCTGACGGACAATGGCCGCATAACAGCGGTCATTGACTGGAG CGAGGCGATGTTCGGGGATTCCCAATACGAGGTCGCCAACATCTTCTTCTGGAGGCCGTGGTTGGCTTGTATGGAGCAG CAGACGCGCTACTTCGAGCGGAGGCATCCGGAGCTTGCAGGATCGCCGCGGCTCCGGGCGTATATGCTCCGCATTGGTC TTGACCAACTCTATCAGAGCTTGGTTGACGGCAATTTCGATGATGCAGCTTGGGCGCAGGGTCGATGCGACGCAATCGT CCGATCCGGAGCCGGGACTGTCGGGCGTACACAAATCGCCCGCAGAAGCGCGGCCGTCTGGACCGATGGCTGTGTAGAA GTCGCGTCTGCGTTCGACCAGGCTGCGCGTTCTCGCGGCCATAGCAACCGACGTACGGCGTTGCGCCCTCGCCGGCAGC AAGAAGCCACGGAAGTCCGCCCGGAGCAGAAAATGCCCACGCTACTGCGGGTTTATATAGACGGTCCCCACGGGATGGG GAAAACCACCACCACGCAACTGCTGGTGGCCCTGGGTTCGCGCGACGATATCGTCTACGTACCCGAGCCGATGACTTAC TGGCGGGTGCTGGGGGCTTCCGAGACAATCGCGAACATCTACACCACACAACACCGCCTCGACCAGGGTGAGATATCGG CCGGGGACGCGGCGGTGGTAATGACAAGCGCCCAGATAACAATGGGCATGCCTTATGCCGTGACCGACGCCGTTCTGGC TCCTCATATCGGGGGGGAGGCTGGGAGCTCACATGCCCCGCCCCCGGCCCTCACCCTCATCTTCGACCGCCATCCCATC GCCGCCCTCCTGTGCTACCCGGCCGCGCGGTACCTTATGGGCAGCATGACCCCCCAGGCCGTGCTGGCGTTCGTGGCCC TCATCCCGCCGACCTTGCCCGGCACCAACATCGTGCTTGGGGCCCTTCCGGAGGACAGACACATCGACCGCCTGGCCAA ACGCCAGCGCCCCGGCGAGCGGCTGGACCTGGCTATGCTGGCTGCGATTCGCCGCGTTTACGGGCTACTTGCCAATACG GTGCGGTATCTGCAGTGCGGCGGGTCGTGGCGGGAGGACTGGGGACAGCTTTCGGGGACGGCCGTGCCGCCCCAGGGTG CCGAGCCCCAGAGCAACGCGGGCCCACGACCCCATATCGGGGACACGTTATTTACCCTGTTTCGGGCCCCCGAGTTGCT GGCCCCCAACGGCGACCTGTATAACGTGTTTGCCTGGGCCTTGGACGTCTTGGCCAAACGCCTCCGTTCCATGCACGTC TTTATCCTGGATTACGACCAATCGCCCGCCGGCTGCCGGGACGCCCTGCTGCAACTTACCTCCGGGATGGTCCAGACCC ACGTCACCACCCCCGGCTCCATACCGACGATATGCGACCTGGCGCGCACGTTTGCCCGGGAGATGGGGGAGGCTAACTG AGTCGACTAAGATCATAATCAGCCATACCACATTTGTAGAGGTTTTACTTGCTTTAAAAAACCTCCCACACCTCCCCCT GAACCTGAAACATAAAATGAATGCAATTGTTGTTGTTAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAAT AGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTT ATCATGTCTGGGAAGTTCCTATACTTCAAAAGGAATAGGAACTTCTTGTAGAGACCAACCGGGTCTCAGCTAGCTCCCT TTAGTGAGGGTTAATTGCGCGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATT CCACACAACATAGGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGGTAACTCACATTAATTGCGT TGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGG CGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTA TCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCC AGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAA AAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTC GTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTC ATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCA GCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCA GCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCT ACACTAGAAGGACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATC CGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAA GAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGAT TATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAAC TTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCC TGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGATC CACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTT ATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTT GTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAA GGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTT GGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCT GTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATAC GGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAG GATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACC AGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATAC TCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTAT TTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGGGTCCTTTTCATCACGTGCTATA AAAATAATTATAATTTAAATTTTTTAATATAAATATATAAATTAAAAATAGAAAGTAAAAAAAGAAATTAAAGAAAAAA TAGTTTTTGTTTTCCGAAGATGTAAAAGACTCTAGGGGGATCGCCAACAAATACTACCTTTTATCTTGCTCTTCCTGCT CTCAGGTATTAATGCCGAATTGTTTCATCTTGTCTGTGTAGAAGACCACACACGAAAATCCTGTGATTTTACATTTTAC TTATCGTTAATCGAATGTATATCTATTTAATCTGCTTTTCTTGTCTAATAAATATATATGTAAAGTACGCTTTTTGTTG AAATTTTTTAAACCTTTGTTTATTTTTTTTTCTTCATTCCGTAACTCTTCTACCTTCTTTATTTACTTTCTAAAATCCA AATACAAAACATAAAAATAAATAAACACAGAGTAAATTCCCAAATTATTCCATCATTAAAAGATACGAGGCGCGTGTAA GTTACAGGCAAGCGATCCGTCCTAAGAAACCA (REWRITE minimal payload pDT3.fa) SEQ ID NO: 16 CCCCGAAAAGTGCCACCTGGGTCCTTTTCATCACGTGCTATAAAAATAATTATAATTTAAATTTTTTAATATAAATATA TAAATTAAAAATAGAAAGTAAAAAAAGAAATTAAAGAAAAAATAGTTTTTGTTTTCCGAAGATGTAAAAGACTCTAGGG GGATCGCCAACAAATACTACCTTTTATCTTGCTCTTCCTGCTCTCAGGTATTAATGCCGAATTGTTTCATCTTGTCTGT GTAGAAGACCACACACGAAAATCCTGTGATTTTACATTTTACTTATCGTTAATCGAATGTATATCTATTTAATCTGCTT TTCTTGTCTAATAAATATATATGTAAAGTACGCTTTTTGTTGAAATTTTTTAAACCTTTGTTTATTTTTTTTTCTTCAT TCCGTAACTCTTCTACCTTCTTTATTTACTTTCTAAAATCCAAATACAAAACATAAAAATAAATAAACACAGAGTAAAT TCCCAAATTATTCCATCATTAAAAGATACGAGGCGCGTGTAAGTTACAGGCAAGCGATCCGTCCTAAGAAACCATTATT ATCATGACATTAACCTATAAAAATAGGCGTATCACGAGGCCCTTTCGTCTCGCGCGTTTCGGTGATGACGGTGAAAACC TCTGACACATGCAGCTCCCGGAGACGGTCACAGCTTGTCTGTAAGCGGATGCCGGGAGCAGACAAGCCCGTCAGGGCGC GTCAGCGCGTGTTGGCGGGTGTCGGGGCTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATAAA TTCCCGTTTTAAGAGCTTGGTGAGCGCTAGGAGTCACTGCCAGGTATCGTTTGAACACGGCATTAGTCAGGGAAGTCAT AACACAGTCCTTTCCCGCAATTTTCTTTTTCTATTACTCTTGGCCTCCTCTAGTACACTCTATATTTTTTTATGCCTCG GTAATGATTTTCATTTTTTTTTTTCCCCTAGCGGATGACTCTTTTTTTTTCTTAGCGATTGGCATTATCACATAATGAA TTATACATTATATAAAGTAATGTGATTTCTTCGAAGAATATACTAAAAAATGAGCAGGCAAGATAAACGAAGGCAAAGA TGACAGAGCAGAAAGCCCTAGTAAAGCGTATTACAAATGAAACCAAGATTCAGATTGCGATCTCTTTAAAGGGTGGTCC CCTAGCGATAGAGCACTCGATCTTCCCAGAAAAAGAGGCAGAAGCAGTAGCAGAACAGGCCACACAATCGCAAGTGATT AACGTCCACACAGGTATAGGGTTTCTGGACCATATGATACATGCTCTGGCCAAGCATTCCGGCTGGTCGCTAATCGTTG AGTGCATTGGTGACTTACACATAGACGACCATCACACCACTGAAGACTGCGGGATTGCTCTCGGTCAAGCTTTTAAAGA GGCCCTACTGGCGCGTGGAGTAAAAAGGTTTGGATCAGGATTTGCGCCTTTGGATGAGGCACTTTCCAGAGCGGTGGTA GATCTTTCGAACAGGCCGTACGCAGTTGTCGAACTTGGTTTGCAAAGGGAGAAAGTAGGAGATCTCTCTTGCGAGATGA TCCCGCATTTTCTTGAAAGCTTTGCAGAGGCTAGCAGAATTACCCTCCACGTTGATTGTCTGCGAGGCAAGAATGATCA TCACCGTAGTGAGAGTGCGTTCAAGGCTCTTGCGGTTGCCATAAGAGAAGCCACCTCGCCCAATGGTACCAACGATGTT CCCTCCACCAAAGGTGTTCTTATGTAGTGACACCGATTATTTAAAGCTGCAGCATACGATATATATACATGTGTATATA TGTATACCTATGAATGTCAGTAAGTATGTATACGAACAGTATGATACTGAAGATGACAAGGTAATGCATCATTCTATAC GTGTCATTCTGAACGAGGCGCGCTTTCCTTTTTTCTTTTTGCTTTTTCTTTTTTTTTCTCTTGAACTCGACGGATCTAT GCGGTGTGAAATACCGCACAGATGCGTCCTAGGGCGGCCGCATAACTTCGTATAGCATACATTATACGAAGTTATCCGG AACCGAGTACAAGCCCACGGTGCGCCTCGCCACCCGCGACGACGTCCCCAGGGCCGTCCGCACCCTCGCCGCCGCGTTC GCCGACTACCCCGCCACGCGCCACACCGTCGATCCGGACCGCCACATCGAGCGCGTGACCGAGCTGCAAGAACTCTTCC TCACGCGCGTCGGGCTCGACATCGGCAAGGTGTGGGTCGCGGACGACGGAGCCGCTGTGGCGGTCTGGACCACGCCGGA GAGCGTCGAAGCGGGGGCGGTGTTCGCCGAGATCGGCCCGCGCATGGCCGAGTTGAGCGGTTCCCGGCTGGCCGCGCAG CAACAGATGGAGGGCCTCCTGGCTCCGCACCGGCCCAAGGAGCCCGCGTGGTTCCTGGCCACCGTCGGAGTCTCGCCCG ACCACCAGGGCAAGGGTCTGGGCAGCGCCGTCGTGCTCCCCGGAGTGGAGGCGGCCGAGCGCGCCGGGGTGCCCGCCTT CCTGGAAACCTCCGCGCCCCGCAACCTCCCCTTCTACGAGCGGCTCGGCTTCACCGTCACCGCCGACGTCGAGGTGCCC GAAGGACCGCGCACCTGGTGCATGACCCGCAAGCCCGGTGCCGCATGCCCCACGCTACTGCGGGTTTATATAGACGGTC CCCACGGGATGGGGAAAACCACCACCACGCAACTGCTGGTGGCCCTGGGTTCGCGCGACGATATCGTCTATGTACCCGA GCCGATGACTTACTGGCGGGTGCTGGGGGCTTCCGAGACAATCGCGAACATCTACACCACACAACACCGCCTCGACCAG GGTGAGATATCGGCCGGGGACGCGGCGGTGGTAATGACAAGCGCCCAGATAACAATGGGTATGCCTTATGCCGTGACCG ACGCCGTTCTGGCTCCTCATATCGGGGGGGAGGCTGGTAGCTCACATGCCCCGCCCCCGGCCCTCACCCTCATCTTCGA CCGCCATCCCATCGCCGCCCTCCTGTGCTACCCGGCCGCGCGGTACCTTATGGGCAGCATGACCCCCCAGGCCGTGCTG GCGTTCGTGGCCCTCATCCCGCCGACCTTGCCCGGCACCAACATCGTGCTTGGGGCCCTGCCGGAGGACAGACACATCG ACCGCCTGGCCAAACGCCAGCGCCCCGGCGAGCGGCTGGACCTGGCTATGCTGGCTGCGATTCGCCGCGTTTACGGGCT ACTTGCCAATACGGTGCGGTATCTGCAGTGCGGCGGGTCGTGGCGGGAGGACTGGGGACAGCTTTCGGGGACGGCCGTG CCGCCCCAGGGTGCCGAGCCCCAGAGCAACGCGGGCCCACGACCCCATATCGGGGACACGTTATTTACCCTGTTTCGGG CCCCCGAGTTGCTGGCCCCCAACGGCGACCTGTATAACGTGTTTGCCTGGGCCTTGGACGTCTTGGCCAAACGCCTCCG TTCCATGCACGTCTTTATCCTGGATTACGACCAATCGCCCGCCGGCTGCCGGGACGCCCTGCTGCAACTTACCTCCGGG ATGGTCCAGACCCACGTCACCACCCCCGGCTCCATACCGACGATATGCGACCTGGCGCGCACGTTTGCCCGCGAGATGG GGGAGGCTAACGAGCTCGGCAGTGGAGAGGGCAGAGGAAGTCTGCTAACATGCGGTGACGTCGAGGAGAATCCTGGCCC AAGCCAGTTCGACATCCTGTGCAAGACCCCCCCCAAGGTGCTGGTGCGGCAGTTCGTGGAGAGATTCGAGAGGCCCAGC GGCGAGAAGATCGCCAGCTGTGCCGCCGAGCTGACCTACCTGTGCTGGATGATCACCCACAACGGCACCGCCATCAAGA GGGCCACCTTCATGAGCTACAACACCATCATCAGCAACAGCCTGAGCTTCGACATCGTGAACAAGAGCCTGCAGTTCAA GTACAAGACCCAGAAGGCCACCATCCTGGAGGCCAGCCTGAAGAAGCTGATCCCCGCCTGGGAGTTCACCATCATCCCT TACAACGGCCAGAAGCACCAGAGCGACATCACCGACATCGTGTCCAGCCTGCAGCTGCAGTTCGAGAGCAGCGAGGAGG CCGACAAGGGCAACAGCCACAGCAAGAAGATGCTGAAGGCCCTGCTGTCCGAGGGCGAGAGCATCTGGGAGATCACCGA GAAGATCCTGAACAGCTTCGAGTACACCAGCAGGTTCACCAAGACCAAGACCCTGTACCAGTTCCTGTTCCTGGCCACA TTCATCAACTGCGGCAGGTTCAGCGACATCAAGAACGTGGACCCCAAGAGCTTCAAGCTGGTGCAGAACAAGTACCTGG GCGTGATCATTCAGTGCCTGGTGACAGAAACCAAGACAAGCGTGTCCAGGCACATCTACTTTTTCAGCGCCAGAGGCAG GATCGACCCCCTGGTGTACCTGGACGAGTTTCTGAGGAACAGCGAGCCCGTGCTGAAGAGAGTGAACAGGACCGGCAAC AGCAGCAGCAACAAGCAGGAGTACCAGCTGCTGAAGGACAACCTGGTGCGCAGCTACAACAAGGCCCTGAAGAAGAACG CCCCCTACCCCATCTTCGCTATCAAGAACGGCCCTAAGAGCCACATCGGCAGGCACCTGATGACCAGCTTTCTGAGCAT GAAGGGCCTGACCGAGCTGACAAACGTGGTGGGCAACTGGAGCGACAAGAGGGCCTCCGCCGTGGCCAGGACCACCTAC ACCCACCAGATCACCGCCATCCCCGACCACTACTTCGCCCTGGTGTCCAGGTACTACGCCTACGACCCCATCAGCAAGG AGATGATCGCCCTGAAGGACGAAACCAACCCCATCGAGGAGTGGCAGCACATCGAGCAGCTGAAGGGCAGCGCCGAGGG CAGCATCAGATACCCCGCCTGGAACGGCATCATCAGCCAGGAGGTGCTGGACTACCTGAGCAGCTACATCAACAGGCGG ATCACCGGTTGCGTACGCGGATCCTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAAC GCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCCAT ACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGG GAGCTGGTTCACATGATCAACTGGGCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTC TAGAATGTGCCTGGCTAGAGATCCTGATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGTGAAGCTACTGTTTGC TCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATGTGTAGAGGGCATGGTGGAGATCTTCGACATGCTGCTGGCTACA TCATCTCGGTTCCGCATGATGAATCTGCAGGGAGAGGAGTTTGTGTGCCTCAAATCTATTATTTTGCTTAATTCTGGAG TGTACACATTTCTGTCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATCCACCGAGTCCTGGACAAGATCACAGA CACTTTGATCCACCTGATGGCCAAGGCAGGCCTGACCCTGCAGCAGCAGCACCAGCGGCTGGCCCAGCTCCTCCTCATC CTCTCCCACATCAGGCACATGAGTAACAAAGGCATGGAGCATCTGTACAGCATGAAGTGCAAGAACGTGGTGCCCCTCT ATGACCTGCTGCTGGAGGCGGCGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGGGGCATCCGTGGAGGAGAC GGACCAAAGCCACTTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAAAAGTATTACATCACGGGGGAGGCAGAG GGTTTCCCTGCCACAGCTGGCTCCGGCGAGGGCAGGGGAAGTCTTCTAACATGCGGGGACGTGGAGGAAAATCCCGGCC CAGTGAGCAAGGGTGAGGAGGATAACATGGCCTCTCTCCCAGCGACACATGAGTTACACATCTTTGGCTCCATCAACGG TGTGGACTTTGACATGGTGGGTCAGGGCACCGGCAATCCAAATGATGGTTATGAGGAGTTAAACCTGAAGTCCACCAAG GGCGACCTCCAGTTCTCCCCCTGGATTCTGGTCCCTCATATCGGGTATGGCTTCCATCAGTACCTGCCCTACCCTGACG GGATGTCGCCTTTCCAGGCCGCCATGGTAGATGGCTCTGGATACCAAGTCCATCGCACAATGCAGTTTGAAGATGGTGC CTCCCTTACTGTGAACTACCGCTACACCTACGAGGGAAGCCACATCAAAGGAGAGGCCCAGGTGAAGGGGACTGGTTTC CCTGCTGACGGTCCTGTGATGACCAACTCGCTGACCGCTGCGGACTGGTGCAGGTCGAAGAAGACTTACCCCAACGACA AAACCATCATCAGTACCTTTAAGTGGAGTTACACCACTGGAAATGGCAAGCGCTACCGGAGCACTGCGCGGACCACCTA CACCTTTGCCAAGCCAATGGCGGCTAACTATCTGAAGAACCAGCCGATGTACGTGTTCCGTAAGACGGAACTCAAGCAC TCCAAGACCGAGCTGAACTTCAAGGAGTGGCAAAAGGCGTTTACCGATGTGATGGGCATGGACGAGCTGTACAAGTGAA TTCGATCATAATCAGCCATACCACATTTGTAGAGGTTTTACTTGCTTTAAAAAACCTCCCACACCTCCCCCTGAACCTG AAACATAAAATGAATGCAATTGTTGTTGTTAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCA CAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGT CTGGCTCGAGGGAAGTTCCTATACTCTAGAAAGAATAGGAACTTCGGCGGACGCGTATAGATCAGGCGCGCCACAACTT CGTATAGAAAGGTATATACGAAGTTGTGCGGCCGCGTCGACCAATTCTCATGTTTGACAGCTTATCATCGAATTTCTGC CATTCATCCGCTTATTATCACTTATTCAGGCGTAGCAACCAGGCGTTTAAGGGCACCAATAACTGCCTTAAAAAAATTA GAAAAACTCATCGAGCATCAAATGAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGT TTCTGTAATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGCGATTCCGACTC GTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCAAGTGAGAAATCACCATGAGTGACGAC TGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTTTCCAGACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCA AAATCACTCGCATCAACCAAACCGTTATTCATTCGTGATTGCGCCTGAGCGAGACGAAATACGCGATCGCTGTTAAAAG GACAATTACAAACAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTGAATCAGG ATATTCTTCTAATACCTGGAATGCTGTTTTCCCTGGGATCGCAGTGGTGAGTAACCATGCATCATCAGGAGTACGGATA AAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAGTTTAGTCTGACCATCTCATCTGTAACATCATTGGCAA CGCTACCTTTGCCATGTTTCAGAAACAACTCTGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTG CCCGACATTATCGCGAGCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTCGAGCAAGAC GTTTCCCGTTGAATATGGCTCATTTTAGCTTCCTTAGCTCCTGAAAATCTCGATAACTCAAAAAATACGCCCGGTAGTG ATCTTATTTCATTATGGTGAAAGTTGGAACCTCTTACGTGCCGATCAACGTCTCATTTTCGCCAAAAGTTGGCCCAGGG CTTCCCGGTATCAACAGGGACACCAGGATTTATTTATTCTGCGAAGTGATCTTCCGTCACAGGTATTTATTCGCGATAA GCTCATGGAGCGGCGTAACCGTCGCACAGGAAGGACAGAGAAAGCGCGGATCTGGGAAGTGACGGACAGAACGGTCAGG ACCTGGATTGGGGAGGCGGTTGCCGCCGCTGCTGCTGACGGTGTGACGTTCTCTGTTCCGGTCACACCACATACGTTCC GCCATTCCTATGCGATGCACATGCTGTATGCCGGTATACCGCTGAAAGTTCTGCAAAGCCTGATGGGACATAAGTCCAT CAGTTCAACGGAAGTCTACACGAAGGTTTTTGCGCTGGATGTGGCTGCCCGGCACCGGGTGCAGTTTGCGATGCCGGAG TCTGATGCGGTTGCGATGCTGAAACAATTATCCTGAGAATAAATGCCTTGGCCTTTATATGGAAATGTGGAACTGAGTG GATATGCTGTTTTTGTCTGTTAAACAGAGAAGCTGGCTGTTATCCACTGAGAAGCGAACGAAACAGTCGGGAAAATCTC CCATTATCGTAGAGATCCGCATTATTAATCTCAGGAGCCTGTGTAGCGTTTATAGGAAGTAGTGTTCTGTCATGATGCC TGCAAGCGGTAACGAAAACGATTTGAATATGCCTTCAGGAACAATAGAAATCTTCGTGCGGTGTTACGTTGAAGTGGAG CGGATTATGTCAGCAATGGACAGAACAACCTAATGAACACAGAACCATGATGTGGTCTGTCCTTTTACAGCCAGTAGTG CTCGCCGCAGTCGAGCGACAGGGCGAAGCCCTCGAGCTGGTTGCCCTCGCCGCTGGGCTGGCGGCCGTCTATGGCCCTG CAAACGCGCCAGAAACGCCGTCGAAGCCGTGTGCGAGACACCGCGGCCGGCCGCCGGCGTTGTGGATACCTCGCGGAAA ACTTGGCCCTCACTGACAGATGAGGGGCGGACGTTGACACTTGAGGGGCCGACTCACCCGGCGCGGCGTTGACAGATGA GGGGCAGGCTCGATTTCGGCCGGCGACGTGGAGCTGGCCAGCCTCGCAAATCGGCGAAAACGCCTGATTTTACGCGAGT TTCCCACAGATGATGTGGACAAGCCTGGGGATAAGTGCCCTGCGGTATTGACACTTGAGGGGCGCGACTACTGACAGAT GAGGGGCGCGATCCTTGACACTTGAGGGGCAGAGTGCTGACAGATGAGGGGCGCACCTATTGACATTTGAGGGGCTGTC CACAGGCAGAAAATCCAGCATTTGCAAGGGTTTCCGCCCGTTTTTCGGCCACCGCTAACCTGTCTTTTAACCTGCTTTT AAACCAATATTTATAAACCTTGTTTTTAACCAGGGCTGCGCCCTGTGCGCGTGACCGCGCACGCCGAAGGGGGGTGCCC CCCCTTCTCGAACCCTCCCGGTCGAGTGAGCGAGGAAGCACCAGGGAACAGCACTTATATATTCTGCTTACACACGATG CCTGAAAAAACTTCCCTTGGGGTTATCCACTTATCCACGGGGATATTTTTATAATTATTTTTTTTATAGTTTTTAGATC TTCTTTTTTAGAGCGCCTTGTAGGCCTTTATCCATGCTGGTTCTAGAGAAGGTGTTGTGACAAATTGCCCTTTCAGTGT GACAAATCACCCTCAAATGACAGTCCTGTCTGTGACAAATTGCCCTTAACCCTGTGACAAATTGCCCTCAGAAGAAGCT GTTTTTTCACAAAGTTATCCCTGCTTATTGACTCTTTTTTATTTAGTGTGACAATCTAAAAACTTGTCACACTTCACAT GGATCTGTCATGGCGGAAACAGCGGTTATCAATCACAAGAAACGTAAAAATAGCCCGCGAATCGTCCAGTCAAACGACC TCACTGAGGCGGCATATAGTCTCTCCCGGGATCAAAAACGTATGCTGTATCTGTTCGTTGACCAGATCAGAAAATCTGA TGGCACCCTACAGGAACATGACGGTATCTGCGAGATCCATGTTGCTAAATATGCTGAAATATTCGGATTGACCTCTGCG GAAGCCAGTAAGGATATACGGCAGGCATTGAAGAGTTTCGCGGGGAAGGAAGTGGTTTTTTATCGCCCTGAAGAGGATG CCGGCGATGAAAAAGGCTATGAATCTTTTCCTTGGTTTATCAAACGTGCGCACAGTCCATCCAGAGGGCTTTACAGTGT ACATATCAACCCATATCTCATTCCCTTCTTTATCGGGTTACAGAACCGGTTTACGCAGTTTCGGCTTAGTGAAACAAAA GAAATCACCAATCCGTATGCCATGCGTTTATACGAATCCCTGTGTCAGTATCGTAAGCCGGATGGCTCAGGCATCGTCT CTCTGAAAATCGACTGGATCATAGAGCGTTACCAGCTGCCTCAAAGTTACCAGCGTATGCCTGACTTCCGCCGCCGCTT CCTGCAGGTCTGTGTTAATGAGATCAACAGCAGAACTCCAATGCGCCTCTCATACATTGAGAAAAAGAAAGGCCGCCAG ACGACTCATATCGTATTTTCCTTCCGCGATATCACTTCCATGACGACAGGATAGTCTGAGGGTTATCTGTCACAGATTT GAGGGTGGTTCGTCACATTTGTTCTGACCTACTGAGGGTAATTTGTCACAGTTTTGCTGTTTCCTTCAGCCTGCATGGA TTTTCTCATACTTTTTGAACTGTAATTTTTAAGGAAGCCAAATTTGAGGGCAGTTTGTCACAGTTGATTTCCTTCTCTT TCCCTTCGTCATGTGACCTGATATCGGGGGTTAGTTCGTCATCATTGATGAGGGTTGATTATCACAGTTTATTACTCTG AATTGGCTATCCGCGTGTGTACCTCTACCTGGAGTTTTTCCCACGGTGGATATTTCTTCTTGCGCTGAGCGTAAGAGCT ATCTGACAGAACAGTTCTTCTTTGCTTCCTCGCCAGTTCGCTCGCTATGCTCGGTTACACGGCTGCGGCGAGCGCTAGT GATAATAAGTGACTGAGGTATGTGCTCTTCTTATCTCCTTTTGTAGTGTTGCTCTTATTTTAAACAACTTTGCGGTTTT TTGATGACTTTGCGATTTTGTTGTTGCTTTGCAGTAAATTGCAAGATTTAATAAAAAAACGCAAAGCAATGATTAAAGG ATGTTCAGAATGAAACTCATGGAAACACTTAACCAGTGCATAAACGCTGGTCATGAAATGACGAAGGCTATCGCCATTG CACAGTTTAATGATGACAGCCCGGAAGCGAGGAAAATAACCCGGCGCTGGAGAATAGGTGAAGCAGCGGATTTAGTTGG GGTTTCTTCTCAGGCTATCAGAGATGCCGAGAAAGCAGGGCGACTACCGCACCCGGATATGGAAATTCGAGGACGGGTT GAGCAACGTGTTGGTTATACAATTGAACAAATTAATCATATGCGTGATGTGTTTGGTACGCGATTGCGACGTGCTGAAG ACGTATTTCCACCGGTGATCGGGGTTGCTGCCCATAAAGGTGGCGTTTACAAAACCTCAGTTTCTGTTCATCTTGCTCA GGATCTGGCTCTGAAGGGGCTACGTGTTTTGCTCGTGGAAGGTAACGACCCCCAGGGAACAGCCTCAATGTATCACGGA TGGGTACCAGATCTTCATATTCATGCAGAAGACACTCTCCTGCCTTTCTATCTTGGGGAAAAGGACGATGTCACTTATG CAATAAAGCCCACTTGCTGGCCGGGGCTTGACATTATTCCTTCCTGTCTGGCTCTGCACCGTATTGAAACTGAGTTAAT GGGCAAATTTGATGAAGGTAAACTGCCCACCGATCCACACCTGATGCTCCGACTGGCCATTGAAACTGTTGCTCATGAC TATGATGTCATAGTTATTGACAGCGCGCCTAACCTGGGTATCGGCACGATTAATGTCGTATGTGCTGCTGATGTGCTGA TTGTTCCCACGCCTGCTGAGTTGTTTGACTACACCTCCGCACTGCAGTTTTTCGATATGCTTCGTGATCTGCTCAAGAA CGTTGATCTTAAAGGGTTCGAGCCTGATGTACGTATTTTGCTTACCAAATACAGCAATAGCAATGGCTCTCAGTCCCCG TGGATGGAGGAGCAAATTCGGGATGCCTGGGGAAGCATGGTTCTAAAAAATGTTGTACGTGAAACGGATGAAGTTGGTA AAGGTCAGATCCGGATGAGAACTGTTTTTGAACAGGCCATTGATCAACGCTCTTCAACTGGTGCCTGGAGAAATGCTCT TTCTATTTGGGAACCTGTCTGCAATGAAATTTTCGATCGTCTGATTAAACCACGCTGGGAGATTAGATAATGAAGCGTG CGCCTGTTATTCCAAAACATACGCTCAATACTCAACCGGTTGAAGATACTTCGTTATCGACACCAGCTGCCCCGATGGT GGATTCGTTAATTGCGCGCGTAGGAGTAATGGCTCGCGGTAATGCCATTACTTTGCCTGTATGTGGTCGGGATGTGAAG TTTACTCTTGAAGTGCTCCGGGGTGATAGTGTTGAGAAGACCTCTCGGGTATGGTCAGGTAATGAACGTGACCAGGAGC TGCTTACTGAGGACGCACTGGATGATCTCATCCCTTCTTTTCTACTGACTGGTCAACAGACACCGGCGTTCGGTCGAAG AGTATCTGGTGTCATAGAAATTGCCGATGGGAGTCGCCGTCGTAAAGCTGCTGCACTTACCGAAAGTGATTATCGTGTT CTGGTTGGCGAGCTGGATGATGAGCAGATGGCTGCATTATCCAGATTGGGTAACGATTATCGCCCAACAAGTGCTTATG AACGTGGTCAGCGTTATGCAAGCCGATTGCAGAATGAATTTGCTGGAAATATTTCTGCGCTGGCTGATGCGGAAAATAT TTCACGTAAGATTATTACCCGCTGTATCAACACCGCCAAATTGCCTAAATCAGTTGTTGCTCTTTTTTCTCACCCCGGT GAACTATCTGCCCGGTCAGGTGATGCACTTCAAAAAGCCTTTACAGATAAAGAGGAATTACTTAAGCAGCAGGCATCTA ACCTTCATGAGCAGAAAAAAGCTGGGGTGATATTTGAAGCTGAAGAAGTTATCACTCTTTTAACTTCTGTGCTTAAAAC GTCATCTGCATCAAGAACTAGTTTAAGCTCACGACATCAGTTTGCTCCTGGAGCGACAGTATTGTATAAGGGCGATAAA ATGGTGCTTAACCTGGACAGGTCTCGTGTTCCAACTGAGTGTATAGAGAAAATTGAGGCCATTCTTAAGGAACTTGAAA AGCCAGCACCCTGATGCGACCACGTTTTAGTCTACGTTTATCTGTCTTTACTTAATGTCCTTTGTTACAGGCCAGAAAG CATAACTGGCCTGAATATTCTCTCTGGGCCCACTGTTCCACTTGTATCGTCGGTCTGATAATCAGACTGGGACCACGGT CCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGA CCACGGTCCCACTCGTATCGTCGGTCTGATAATCAGACTGGGACCACGGTCCCACTCGTATCGTCGGTCTGATTATTAG TCTGGGACCATGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTCGGTCTGA TTATTAGTCTGGAACCACGGTCCCACTCGTATCGTCGGTCTGATTATTAGTCTGGGACCACGGTCCCACTCGTATCGTC GGTCTGATTATTAGTCTGGGACCACGATCCCACTCGTGTTGTCGGTCTGATTATCGGTCTGGGACCACGGTCCCACTTG TATTGTCGATCAGACTATCAGCGTGAGACTACGATTCCATCAATGCCTGTCAAGGGCAAGTATTGACATGTCGTCGTAA CCTGTAGAACGGAGTAACCTCGGTGTGCGGTTGTATGCCTGCTGTGGATTGCTGCTGTGTCCTGCTTATCCACAACATT TTGCGCACGGTTATGTGGAC

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47.-111. (canceled)
 112. A method of integrating a DNA construct into a genome, the method comprising: a. contacting the genome from a sample with one or more agents, wherein the one or more agents are capable of cleaving the genome at a locus; b. integrating a first nucleic acid sequence into the genome at the locus; and c. integrating one or more second nucleic acid sequences into the first nucleic acid sequence in the genome, thereby integrating the DNA construct into the genome, wherein each of the one or more second nucleic acid sequences comprises a cargo sequence.
 113. The method of claim 112, wherein the cargo sequence comprises at least 1 kilobase.
 114. The method of claim 112, wherein the locus comprises a human genomic locus comprising Human Leukocyte Antigens (HLA), Adeno-Associated Virus Integration Site 1 (AAVS1), C-C Motif Chemokine Receptor type 5 (CCR5), human Reverse Orientation Splice Acceptor 26 (hROSA26), Cytochrome B-245 Beta Chain (CYBB), Cluster of Differentiation 40 Ligand (CD40LG), Cyclin-Dependent Kinase 6 (CDK6), Toll-Like Receptor (TLR8), T Cell Receptor Beta Constant 1 (TRBC1), Hypoxanthine Phosphoribosyltransferase (HPRT), or Homeobox A cluster (HOXA).
 115. The method of claim 112, wherein the locus comprises murine Reverse Orientation Splice Acceptor 26 (mROSA26).
 116. The method of claim 112, wherein the first nucleic acid sequence comprises a landing pad sequence, wherein the landing pad sequence comprises one or more genes, regulatory elements, or combinations thereof.
 117. The method of claim 116, wherein the one or more genes comprise a gene encoding estrogen receptor 2 (ERT2) or a variant thereof, a gene encoding P2A or a variant thereof, a gene encoding a Thymidine Kinase or a variant thereof, a gene encoding a recombinase or a variant thereof, a blasticidin resistance gene, a hygromycin resistance gene, or a gene encoding a fluorescent protein or a variant thereof.
 118. The method of claim 117, wherein the ERT2 gene or the variant thereof is fused with a gene encoding a recombinase or a variant thereof, wherein the recombinase or the variant thereof comprises a tyrosine recombinase, a Cre recombinase, a Flp recombinase, a variant thereof, or a combination thereof, wherein the recombinase is codon-optimized for mammals, and/or wherein the recombinase lacks CpG sites.
 119. The method of claim 117, wherein (i) expression of the ERT2 gene or the variant thereof is induced by tamoxifen; and/or (ii) expression of the gene encoding the recombinase or the variant thereof is induced by a gene expression system or doxycycline.
 120. The method of claim 117, wherein the fluorescent protein comprises a red fluorescent protein, a green fluorescent protein, a yellow fluorescent protein, a blue fluorescent protein, or a cyan fluorescent protein.
 121. The method of claim 116, wherein the one or more regulatory elements comprise a promoter, a terminator, a recombinase recognition site, or a combination thereof, wherein (i) the promoter comprises a universal chromatin opening element (UCOE), a human EF1α promoter, a phosphoglycerate kinase (PGK), or a combination thereof, (ii) the terminator comprises a simian virus 40 (SV40) terminator, a bovine growth hormone (bGH) terminator, a human growth hormone (hGH) terminator, a rabbit beta-globin (rbGlob), or a combination thereof, (iii) the recombinase recognition site comprises a Cre recognition site, a Flp recognition site, or a combination thereof, and/or (iv) the recombinase recognition site comprises one or more of a loxP or a variant thereof, a loxM or a variant thereof, a lox2722 or a variant thereof, a loxFAS or a variant thereof, a lox5171 or a variant thereof, a frt or a variant thereof, or a combination thereof.
 122. The method of claim 116, wherein the landing pad sequence comprises a sequence comprising SEQ ID NO: 2, SEQ ID NO: 5, SEQ ID NO: 6, or SEQ ID NO:
 7. 123. The method of claim 112, wherein the one or more second nucleic acid sequences are provided by one or more vectors configured to carry nucleic acid sequence that comprises approximately from 10 kilobases to 1,000 kilobases.
 124. The method of claim 123, wherein the one or more vectors comprise a marker, wherein the marker is devoid of a promoter and a start codon, and/or wherein the marker comprises a selectable marker comprising an antibiotic marker.
 125. The method of claim 112, wherein the genome in the sample is contained in a cell, wherein the contacting in step a) and the integrating in steps b) and c) are performed in the cell.
 126. The method of claim 125, wherein the cell comprises a mammalian cell comprising a human cell or a mouse cell; or a primary cell comprising an embryonic stem cell (ESC), a pluripotent stem cell (PSC), or an induced pluripotent stem cell (iPSC).
 127. The method of claim 112, wherein the one or more agents comprise a polypeptide, a polynucleotide, or a combination thereof, wherein (i) the polypeptide comprises a site-specific nuclease comprising an engineered homing endonuclease or meganuclease, a zinc-finger nuclease (ZFN), a transcription activator-like effector nuclease (TALEN), a clustered regularly interspaced short palindromic repeat (CRISPR), or a combination thereof, and/or (ii) the polynucleotide comprises a guide RNA (gRNA).
 128. The method of claim 112, wherein the one or more agents are delivered via a carrier comprising a vector, a messenger RNA (mRNA), a double stranded DNA (dsDNA), a single stranded DNA (ssDNA), or a plasmid.
 129. The method of claim 112, wherein the sample comprises a biological sample comprising a cell, tissue sample, or blood sample, wherein the sample is obtained from a subject comprising a human.
 130. The method of claim 112, wherein the integrating in steps b) and c) comprises sequential integration.
 131. The method of claim 112, wherein the integrating in steps b) and c) comprises homology-directed recombination (HR), and wherein the integrating comprises utilizing an inducible or constitutive site-specific recombinase Cre, a Flp recombinase, a self-excising recombinase, or a combination thereof. 